Focus On Epilepsy Research

Image of EEG. Focus On Epilepsies banner image.

NINDS Program Description

The epilepsies are a set of disorders characterized by recurring seizures, or disturbances in the electrical activity of the brain. Epilepsy affects people of all ages, from infants to the aged, and can result from many causes, including genetic variations, illness, head injury, or abnormal brain development. NIH/NINDS and its community-based research partners are dedicated to finding cures for the epilepsies and/or preventing epilepsy in individuals at risk for seizures.

 

Featured NINDS Epilepsy Research Initiatives

The NINDS established the Centers Without Walls program in 2010 to rapidly advance epilepsy research through promoting interdisciplinary, collaborative research. Three centers have been funded:

EPI 4K logoThe Epilepsy 4000 (Epi4K) collaborative has examined genetic data from 4,000 individuals in order to understand the genes underlying epilepsy. See an NIH news release about the center.

The Center for SUDEP Research (CSR)The Center for SUDEP Research (CSR) brings together extensive expertise to understand Sudden Unexplained Death in Epilepsy. See an NIH news release about the center.

The Epilepsy Bioinformatics Study for Antiepileptogenic Therapy (EpiBiosS4Rx) logoThe Epilepsy Bioinformatics Study for Antiepileptogenic Therapy (EpiBiosS4Rx) will use studies of animals and patients with traumatic brain injury (TBI) leading to post-traumatic epilepsy (PTE) in order to develop future clinical trials of epilepsy prevention therapies.

Estimates of Funding for Various Research, Condition, and Disease Categories

Research/Disease Areas* FY 2016
(Actual)
FY 2017
(Actual)
FY 2018
Estimated
(Enacted)
FY 2019
Estimated
Epilepsy $153 $154 $163 $152

Additional funding information on epilepsy research projects funded by the ICARE members, including federal and nonprofit organizations can be accessed at the Interagency Collaborative to Advance Research in Epilepsy Research Portfolio.


*Dollars in millions and rounded

Resources and Tools

This resource contains public and non-confidential chemical structures and biological data for compounds which have been screened for efficacy and toxicity in animal models of epilepsy and related seizure disorders as part of the Epilepsy Therapy Screening Program (ETSP) at the National Institute of Neurological Disorders and Stroke. 

This resource contains public and non-confidential chemical structures and biological data for compounds which have been screened for efficacy and toxicity in animal models of epilepsy and related seizure disorders as part of the Epilepsy Therapy Screening Program (ETSP) at the National Institute of Neurological Disorders and Stroke. 

The NINDS epilepsy common data elements provide data standards for clinical research in order to improve data quality and facilitate comparison and combination of data across studies.

ICARE provides an interagency forum for sharing information about ongoing and planned epilepsy research activities.

This is a set of resources by the American Epilepsy Society to facilitate basic epilepsy research.

The ERC provides information about grant and funding opportunities from non-profit and government organizations focused on epilepsy related research.