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Notice Extension Expiration Date PAR-18-543 CREATE Bio Development Track: Nonclinical Early-Phase Clinical Development Biologics U44 Clinical Trial Optional)" Notice Number: NOT-NS-20-056 Key Dates Release Date: April 28, 2020 Related Announcements PAR-18-543 Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this Notice to inform interested applicants the expiration date the Funding Opportunity Announcement FOA) PAR-18-543 CREATE Bio Development Track: Nonclinical Early-Phase Clinical Development Biologics U44 Clinical Trial Optional)" be extended. additional non-AIDS application due date February 12, 2021 AIDS AIDS-related applications due date May 7, 2021 been added this FOA. FOA expires May 8, 2021. Changes shown in bold italics below. Key Dates table updated accordingly: Part 1. Overview Information Key Dates Application Due Date(s) February 20, 2018, July 18, 2018, February 13, 2019, July 18, 2019, February 13, 2020, July 20, 2020), 5:00 PM local time applicant organization. All types non-AIDS applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. AIDS Application Due Date(s) 7, 2018; September 7, 2018; 7, 2019; September 7, 2019; 7, 2020; September 7, 2020, 5:00 PM local time applicant organization. All types AIDS AIDS-related applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. Scientific Merit Review June 2018; November 2018; June 2019; November 2019; June 2020; November 2020 Advisory Council Review October 2018; January 2019; October 2019; January 2020; October 2020; January 2021 Earliest Start Date December 2018 Expiration Date September 8, 2020 nbsp; Modified Read: Application Due Date(s) February 20, 2018, July 18, 2018, February 13, 2019, July 18, 2019, February 13, 2020, July 20, 2020), and February 12, 2021 by 5:00 PM local time applicant organization. All types non-AIDS applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. AIDS Application Due Date(s) 7, 2018; September 7, 2018; 7, 2019; September 7, 2019; 7, 2020; September 7, 2020, May 7, 2021 by 5:00 PM local time applicant organization. All types AIDS AIDS-related applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. Scientific Merit Review June 2018; November 2018; June 2019; November 2019; June 2020; November 2020, June 2021 Advisory Council Review October 2018; January 2019; October 2019; January 2020; October 2020; January 2021, October 2021 Earliest Start Date December 2018 Expiration Date 8, 2021 other aspects this FOA remain unchanged. Inquiries Please direct inquiries to: Chris Boshoff, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-1779 Email: chris.boshoff@nih.gov

Notice Correction Key Dates RFA-NS-20-029 BRAIN Initiative: Exploratory Team-Research BRAIN Circuit Programs - eTeamBCP U01 Clinical Trials Optional)" Notice Number: NOT-NS-20-063 Key Dates Release Date: April 28, 2020 Related Announcements RFA-NS-20-029 Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this notice to notify potential applicants a correction the Key Dates RFA-NS-20-029 BRAIN Initiative: Exploratory Team-Research BRAIN Circuit Programs - eTeamBCP U01 Clinical Trials Optional)". Advisory Council Review Earliest Start Dates been modified show correct dates. Changes show in bold italics below. changes effective immediately. Currently Reads: Part 1. Overview Information Key Dates Advisory Council Review January 2022 January 2023 Earliest Start Date February 2022 February 2023 Modified Read: Part 1. Overview Information Key Dates Advisory Council Review January 2021 January 2022 Earliest Start Date February 2021 February 2022 other aspects this FOA remain unchanged. Inquiries Please direct inquiries to: Karen K David, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-9964 Email:BRAINCircuits@nih.gov

Notice Change the Award Project Period PAR-19-197 Summer Research Education Experience Program R25 Clinical Trial Allowed)" Notice Number: NOT-NS-20-050 Key Dates Release Date: April 27, 2020 Related Announcements PAR-19-197 Issued National Institute Neurological Disorders Stroke NINDS) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Biomedical Imaging Bioengineering NIBIB) National Institute Drug Abuse NIDA) National Institute Environmental Health Sciences NIEHS) Purpose purpose this notice to notify potential applicants a change the Award Project Period PAR-19-197 "Summer Research Education Experience Program R25 Clinical Trial Allowed)". Additional language been added clarify funds be requested a minimum 8 weeks a maximum 15 weeks during summer academic break. Changes the FOA shown below bold italics. changes be effective the March 17, 2021 receipt date. Currently Reads: Part 2. Full Text Announcement Section II. Award Information Award Project Period project period up five years be requested. Modified Read: Part 2. Full Text Announcement Section II. Award Information Award Project Period project period up five years be requested. Funds be requested a minimum 8 weeks a maximum 15 weeks during summer academic break. other aspects this FOA remain unchanged. Inquiries Please direct inquiries to: Lauren Ullrich, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone: 301-451-7964 Email: lauren.ullrich@nih.gov

Notice Change Key Dates PAR-19-211 NINDS Institutional Research Training Program T32)" Notice Number: NOT-NS-20-059 Key Dates Release Date: April 24, 2020 Related Announcements PAR-19-211 Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this notice to inform interested applicants a change one the receipt dates PAR-19-211 NINDS Institutional Research Training Program T32)". Specifically, May 27, 2020 receipt date been changed to June 29, 2020. Changes shown below in bold italics. Currently Reads: Part 1. Overview Information Key Dates Application Due Date(s) 29, 2019; June 29, 2020; 26, 2021, 5:00 PM local time applicant organization. All types non-AIDS applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. Modified Read: Part 1. Overview Information Key Dates Application Due Date(s) 29, 2019; June 29, 2020; 26, 2021, 5:00 PM local time applicant organization. All types non-AIDS applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. other aspects this FOA remain unchanged. Inquiries Please direct inquiries to: Stephen Korn, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-4188 Email: korns@ninds.nih.gov

Notice Change Key Dates PAR-19-228 Institutional Translational Research Training Program T32)" Notice Number: NOT-NS-20-060 Key Dates Release Date: April 24, 2020 Related Announcements PAR-19-228 Issued National Institute Neurological Disorders Stroke NINDS) National Institute Aging NIA) Purpose purpose this notice to inform interested applicants a change one the receipt dates PAR-19-228 NINDS Institutional Research Training Program T32)". Specifically, May 27, 2020 receipt date been changed to June 29, 2020. Changes shown below in bold italics. Currently Reads: Part 1. Overview Information Key Dates Application Due Date(s) 29, 2019; 27, 2020; 26, 2021, 5:00 PM local time applicant organization. All types non-AIDS applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. Modified Read: Part 1. Overview Information Key Dates Application Due Date(s) 29, 2019; June 29, 2020; 26, 2021, 5:00 PM local time applicant organization. All types non-AIDS applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. other aspects this FOA remain unchanged. Inquiries Please direct inquiries to: Stephen Korn, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-4188 Email: korns@ninds.nih.gov

Notice Change Key Dates PAR-20-076 Jointly Sponsored Ruth L. Kirschstein National Research Service Award Institutional Predoctoral Training Program the Neurosciences T32 Clinical Trial Allowed)" Notice Number: NOT-NS-20-061 Key Dates Release Date: April 24, 2020 Related Announcements PAR-20-076 Issued National Institute Neurological Disorders Stroke NINDS) National Institute Aging NIA) National Institute Drug Abuse NIDA) National Institute General Medical Sciences NIGMS) National Institute Mental Health NIMH) Purpose purpose this notice to inform interested applicants a change one the receipt dates PAR-20-076 Jointly Sponsored Ruth L. Kirschstein National Research Service Award Institutional Predoctoral Training Program the Neurosciences T32 Clinical Trial Allowed)". Specifically, May 26, 2020 receipt date been changed to June 29, 2020. Changes shown below in bold italics. Currently Reads: Part 1. Overview Information Key Dates Open Date Earliest Submission Date) April 26, 2020 Application Due Date(s) 26, 2020; 25, 2021; 25, 2022 applications due 5:00 PM local time applicant organization. All types non-AIDS applications allowed this funding opportunity announcement due the listed date(s). Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. Modified Read: Part 1. Overview Information Key Dates Open Date Earliest Submission Date) 29, 2020 Application Due Date(s) June 29, 2020; 25, 2021; 25, 2022 applications due 5:00 PM local time applicant organization. All types non-AIDS applications allowed this funding opportunity announcement due the listed date(s). Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. other aspects this FOA remain unchanged. Inquiries Please direct inquiries to: Stephen Korn, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-4188 Email: korns@ninds.nih.gov

Notice Change Expiration Date Cancellation Final Three Receipt Dates RFA-NS-19-016 HEAL Initiative: Translational Devices Treat Pain UG3/UH3 Clinical Trial Optional)." Notice Number: NOT-NS-20-047 Key Dates Release Date: April 14, 2020 Related Announcements RFA-NS-19-016 Issued National Institute Neurological Disorders Stroke NINDS) National Eye Institute NEI) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Arthritis Musculoskeletal Skin Diseases NIAMS) National Institute Biomedical Imaging Bioengineering NIBIB) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Dental Craniofacial Research NIDCR) National Institute Diabetes Digestive Kidney Diseases NIDDK) National Institute Drug Abuse NIDA) National Institute Mental Health NIMH) National Institute Nursing Research NINR) National Center Complementary Integrative Health NCCIH) National Center Advancing Translational Sciences NCATS) National Cancer Institute NCI) applications this funding opportunity announcement should fall within mission the Institutes/Centers. following NIH Offices co-fund applications assigned those Institutes/Centers. Office Research Women's Health ORWH) Purpose purpose this notice to inform interested applicants a change the expiration date cancellation the final three receipt dates RFA-NS-19-016 HEAL Initiative: Translational Devices Treat Pain UG3/UH3 Clinical Trial Optional)." Effective immediately, June 22, 2020, October 21, 2020, February 21, 2021 receipt dates been eliminated, the new expiration date this Funding Opportunity Announcement be April 16, 2020 earlier previously published). Changes the Key Dates section shown below. Part. 1 Overview Information Key Dates Currently Reads: Application Due Date(s) New Dates January 9, 2019, March 22, 2019, 20, 2019, June 21, 2019, October 21, 2019, February 21, 2020, June 22, 2020, October 21, 2020, February 21, 2021 , 5:00 PM local time applicant organization. All types non-AIDS applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. Scientific Merit Review New Dates April 2019, June 2019, June 2019, November 2019, March 2020, June 2020, November 2020, March 2021, June 2021 Advisory Council Review New Dates May 2019, August 2019, August 2019, January 2020, 2020, August 2020, January 2021, 2021, August 2021 Earliest Start Date New Dates July 2019, October 2019, October 2019, March 2020, July 2020, October 2020, March 2021,July 2021, October 2021 Expiration Date February 23, 2021 Modified Read: Application Due Date(s) New Dates January 9, 2019, March 22, 2019, 20, 2019, June 21, 2019, October 21, 2019, February 21, 2020 5:00 PM local time applicant organization. All types non-AIDS applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. Scientific Merit Review New Dates April 2019, June 2019, June 2019, November 2019, March 2020, June 2020 Advisory Council Review New Dates May 2019, August 2019, August 2019, January 2020, 2020, August 2020 Earliest Start Date New Dates July 2019, October 2019, October 2019, March 2020, July 2020, October 2020 Expiration Date April 16, 2020 other aspects this FOA remain unchanged. Inquiries Please direct inquiries to: Nick Langhals, PhD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-1779 Email:nick.langhals@nih.gov

Notice Change Expiration Date Cancellation Final Three Receipt Dates RFA-NS-19-017 HEAL Initiative: Translational Devices Treat Pain U44 Clinical Trial Optional)." Notice Number: NOT-NS-20-048 Key Dates Release Date: April 14, 2020 Related Announcements RFA-NS-19-017 Issued National Institute Neurological Disorders Stroke NINDS) National Eye Institute NEI) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Arthritis Musculoskeletal Skin Diseases NIAMS) National Institute Biomedical Imaging Bioengineering NIBIB) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Dental Craniofacial Research NIDCR) National Institute Diabetes Digestive Kidney Diseases NIDDK) National Institute Drug Abuse NIDA) National Institute Mental Health NIMH) National Institute Nursing Research NINR) National Center Complementary Integrative Health NCCIH) National Center Advancing Translational Sciences NCATS) National Cancer Institute NCI) applications this funding opportunity announcement should fall within mission the Institutes/Centers. following NIH Offices co-fund applications assigned those Institutes/Centers. Office Research Women's Health ORWH) Purpose purpose this notice to inform interested applicants a change the expiration date cancellation the final three receipt dates RFA-NS-19-017 HEAL Initiative: Translational Devices Treat Pain U44 Clinical Trial Optional)." Effective immediately, June 22, 2020, October 21, 2020, February 21, 2021 receipt dates been eliminated, the new expiration date this Funding Opportunity Announcement be April 16, 2020 earlier previously published). Changes the Key Dates section shown below. Part. 1 Overview Information Key Dates Currently Reads: Application Due Date(s) New Dates January 9, 2019, March 22, 2019, 20, 2019, June 21, 2019, October 21, 2019, February 21, 2020, June 22, 2020, October 21, 2020, February 21, 2021 , 5:00 PM local time applicant organization. All types non-AIDS applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. Scientific Merit Review New Dates April 2019, June 2019, June 2019, November 2019, March 2020, June 2020, November 2020, March 2021, June 2021 Advisory Council Review New Dates May 2019, August 2019, August 2019, January 2020, 2020, August 2020, January 2021, 2021, August 2021 Earliest Start Date New Dates July 2019, October 2019, October 2019, March 2020, July 2020, October 2020, March 2021,July 2021, October 2021 Expiration Date February 23, 2021 Modified Read: Application Due Date(s) New Dates January 9, 2019, March 22, 2019, 20, 2019, June 21, 2019, October 21, 2019, February 21, 2020 5:00 PM local time applicant organization. All types non-AIDS applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. Scientific Merit Review New Dates April 2019, June 2019, June 2019, November 2019, March 2020, June 2020 Advisory Council Review New Dates May 2019, August 2019, August 2019, January 2020, 2020, August 2020 Earliest Start Date New Dates July 2019, October 2019, October 2019, March 2020, July 2020, October 2020 Expiration Date April 16, 2020 other aspects this FOA remain unchanged. Inquiries Please direct inquiries to: Nick Langhals, PhD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-1779 Email:nick.langhals@nih.gov

Notice Change Expiration Date Cancellation Final Three Receipt Dates RFA-NS-19-018 HEAL Initiative: Clinical Devices Treat Pain UH3 Clinical Trial Optional)." Notice Number: NOT-NS-20-049 Key Dates Release Date: April 14, 2020 Related Announcements RFA-NS-19-018 Issued National Institute Neurological Disorders Stroke NINDS) National Eye Institute NEI) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Arthritis Musculoskeletal Skin Diseases NIAMS) National Institute Biomedical Imaging Bioengineering NIBIB) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Dental Craniofacial Research NIDCR) National Institute Diabetes Digestive Kidney Diseases NIDDK) National Institute Drug Abuse NIDA) National Institute Mental Health NIMH) National Institute Nursing Research NINR) National Center Complementary Integrative Health NCCIH) National Center Advancing Translational Sciences NCATS) National Cancer Institute NCI) applications this funding opportunity announcement should fall within mission the Institutes/Centers. following NIH Offices co-fund applications assigned those Institutes/Centers. Purpose purpose this notice to inform interested applicants a change the expiration date cancellation the final three receipt dates RFA-NS-19-018 HEAL Initiative: Clinical Devices Treat Pain UH3 Clinical Trial Optional)." Effective immediately, June 22, 2020, October 21, 2020, February 21, 2021 receipt dates been eliminated, the new expiration date this Funding Opportunity Announcement be April 16, 2020 earlier previously published). Changes the Key Dates section shown below. Part. 1 Overview Information Key Dates Currently Reads: Application Due Date(s) New Dates January 9, 2019, March 22, 2019, 20, 2019, June 21, 2019, October 21, 2019, February 21, 2020, June 22, 2020, October 21, 2020, February 21, 2021 , 5:00 PM local time applicant organization. All types non-AIDS applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. Scientific Merit Review New Dates April 2019, June 2019, June 2019, November 2019, March 2020, June 2020, November 2020, March 2021, June 2021 Advisory Council Review New Dates May 2019, August 2019, August 2019, January 2020, 2020, August 2020, January 2021, 2021, August 2021 Earliest Start Date New Dates July 2019, October 2019, October 2019, March 2020, July 2020, October 2020, March 2021,July 2021, October 2021 Expiration Date February 23, 2021 Modified Read: Application Due Date(s) New Dates January 9, 2019, March 22, 2019, 20, 2019, June 21, 2019, October 21, 2019, February 21, 2020 5:00 PM local time applicant organization. All types non-AIDS applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. Scientific Merit Review New Dates April 2019, June 2019, June 2019, November 2019, March 2020, June 2020 Advisory Council Review New Dates May 2019, August 2019, August 2019, January 2020, 2020, August 2020 Earliest Start Date New Dates July 2019, October 2019, October 2019, March 2020, July 2020, October 2020 Expiration Date April 16, 2020 other aspects this FOA remain unchanged. Inquiries Please direct inquiries to: Nick Langhals, PhD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-1779 Email:nick.langhals@nih.gov

Notice Change Expiration Date RFA-EB-18-003 Notice Number: NOT-EB-20-009 Key Dates Release Date: April 14, 2020 Related Announcements RFA-EB-18-003 Issued National Institute Biomedical Imaging Bioengineering NIBIB) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Dental Craniofacial Research NIDCR) National Institute Neurological Disorders Stroke NINDS) National Center Complementary Integrative Health NCCIH) National Center Advancing Translational Sciences NCATS) National Cancer Institute NCI) Purpose purpose this notice to inform interested applicants a change the expiration date cancellation the final three receipt dates RFA-EB-18-003 " HEAL Initiative: Translational Development Devices Treat Pain U18 Clinical Trial Allowed)." Effective immediately, June 22, 2020, October 21, 2020, February 21, 2021 receipt dates been eliminated, the new expiration date this Funding Opportunity Announcement be April 16, 2020 earlier previously published). Inquiries Please direct inquiries to: Michael B. Wolfson National Institute Biomedical Imaging Bioengineering NIBIB) Telephone: 301-451-4778 Email: Michael.Wolfson@nih.gov