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Notice Announcing Creation a Dedicated NINDS Biomarkers Repository Biospecimen Banking NINDS Biomarkers Projects Notice Number: NOT-NS-15-046 Key Dates Release Date:   November 3, 2015 Related Announcements PAR-14-259 PAR-14-340 RFA-NS-15-010 Issued National Institute Neurological Disorders Stroke NINDS)  Purpose National Institute Neurological Disorders Stroke NINDS) announcing creation a dedicated NINDS Biomarkers Repository, will housed curated Indiana University. NINDS releasing Notice order underscore 1) important dates activities those currently banking samples data biomarkers projects 2) inform future banking projects the need include budget their projects/applications order ensure ability bank the NINDS Repository. Biomarker collections already banked under NINDS Biomarkers Programs, including not limited the Parkinson's Disease Biomarkers Program PDBP), BioFIND, PREDICT-HD Huntington's Disease) Frontotemporal Lobar Degeneration due MAPT FTLD-MAPT) be transferred Indiana University their existing biobanks example, the case PDBP, Coriell Institute Medical Research). Background Identification validation biomarkers neurological disorders enable early diagnosis well provide information disease progression targets therapeutic development. Challenges biomarkers identification include lack standardization collection, storage, distribution protocols biospecimens, limited sample availability. overcome obstacles, National Institute Neurological Disorders Stroke NINDS) establishing dedicated Human Biomarkers Repository. date, NINDS several programs collect human biospecimens associated clinical data biomarkers research, including not limited Parkinson’s Disease PD), Huntington’s Disease HD), Traumatic Brain Injury, Fronto-temporal Lobar Degeneration FTLD); types activities likely expand include disorders. Considering significant potential biomarkers neurological disease, NINDS creating Biomarkers Repository provide dedicated infrastructure across NINDS portfolio towards advancement biomarker discovery validation. Description Timeline Requirements This Resource new biomarkers sample associated data collections be banked via grant Indiana University. Sample types include DNA, Plasma, Serum, Whole Blood, Cerebrospinal Fluid CSF), RNA. Collections limited DNA gene discovery, Immortalized Peripheral Stem Cells IPSC) Fibroblast lines be housed a separate, dedicated repository. Note in order accomplish transition this resource: future banking, funds planned grant application should allocated offset of cost biospecimen banking this resource. strategy this budget item should developed collaboration the Program Director/Principal Investigator the Biomarkers Repository your Program Official. you planning bank Biomarkers samples the future, please contact Program Official. Coriell no longer accepting requests current projects biomarkers collection kits of October 23, 2015) will stop accepting biospecimen submissions November 30, 2015. Indiana University begin accepting requests collection kits biomarkers projects November 2, 2015 will begin accepting biospecimen submissions December 1, 2015 specific instructions regarding particular existing banking project a planned project, please contact Program Official, the NINDS contact listed below. order manage resource a fiscally responsible manner, potential users this resource advised contact NINDS program staff advance submission a grant which resource be utilized banking samples. Inquiries Please direct inquiries to: Katrina Gwinn, MD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-5745 Email: gwinnk@ninds.nih.gov

Request Information RFI): Inviting Comments Suggestions the Priorities specified the NIH-wide Rehabilitation Research Plan Notice Number: NOT-HD-15-032 Key Dates Release Date: November 3, 2015 Response Date:  December 11, 2015 Related Announcements NOT-HD-19-006 Issued National Cancer Institute NCI) National Eye Institute NEI) National Heart, Lung, Blood Institute NHLBI) National Institute Aging NIA) National Institute Arthritis Musculoskeletal Skin Diseases NIAMS) National Institute Biomedical Imaging Bioengineering NIBIB) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Diabetes Digestive Kidney Diseases NIDDK) National Institute Mental Health NIMH) National Institute Neurological Disorders Stroke NINDS) National Institute Nursing Research NINR) National Center Complementary Integrative Health NCCIH) National Center Advancing Translational Sciences NCATS) Office Behavioral Social Sciences Research OBSSR) Office Disease Prevention ODP) Office Dietary Supplements ODS) Office Research Women’s Health ORWH) Purpose Notice a time-sensitive Request Information RFI) inviting comments suggestions the priorities specified the NIH-wide Rehabilitation Research Plan. NOTE: is important read entire RFI notice ensure adequate response prepared to a full understanding how response be utilized. Background response a legislative requirement Public Law), NIH developing 5-year NIH-wide Research Plan define priorities the area Rehabilitation Research is intended benefit individuals temporary chronic limitations physical, cognitive, sensory function require rehabilitation care. leadership staff the participating Institutes, Centers, Offices ICOs) contributing the proposed direction content the Research Plan, input the National Advisory Board Medical Rehabilitation Research. priorities included below identify crosscutting areas research exemplify breadth the ICO's priorities aims the area Rehabilitation Research help us achieve NIH mission seek fundamental knowledge the nature behavior living systems the application that knowledge enhance health, lengthen life, reduce illness disability. Rehabilitation Research Plan aimed improving health function individuals functional limitations and/or temporary chronic disability are result illness injury. purpose goal the Rehabilitation Research Plan not reference specific disease applications this work to highlight major trans-NIH themes. Research Plan intended be complete late August 2016. NIH-wide Rehabilitation Research Plan Priorities I. Rehabilitation across lifespan 1) Move toward more comprehensive understanding the effects disability functional limitations across lifespan. Determine through longitudinal population studies natural history conditions cause disability common secondary conditions develop over life course. Identify test strategies address care needs delivery the individual disability moves childhood adolescence, adolescence adulthood, adulthood late life. Determine factors affect rehabilitation service delivery an individual disability ages, including health disparities the effects multiple chronic health conditions. Advance understanding the role modifiable lifestyle health behaviors e.g., nutrition, physical activity, sleep) effectiveness rehabilitation interventions secondary prevention chronic health conditions individuals disability. Examine symptoms e.g., pain, cognitive impairment) sequelae e.g., depression) may associated a disability; evaluate interventions address symptoms sequelae. 2)  Encourage investigation rehabilitation interventions the pediatric population. Develop rehabilitation interventions take account developmental level maturation biological systems. Evaluate utility interventions developed adult populations, include family community involvement, improving rehabilitation outcomes infants, children, adolescents. Determine effect the transition adulthood health outcomes interventions individuals aging disability their family. Provide new directions flexible mobility systems, prosthetics, orthotics pediatric populations have grow their devices. Investigate impact health disparities the implementation effectiveness rehabilitation interventions. II. Family Community 1) Examine impact sociodemographic influences, including geography, socioeconomic status, education, culture, etc. rehabilitation success. 2) Develop self-management strategies can implemented community settings help individuals better understand manage disability achieve/maintain positive quality life independence. 3) Examine stressors challenges experienced caregivers individuals a disability, including impact these stressors challenges the health the caregiver the care recipient. Develop interventions address stress, burden, other adverse outcomes caregivers. III. Technology and development 1) Advance use telehealth rehabilitation assessment, delivery adherence monitoring. Examine novel telehealth platforms delivery remote locations clinics in-home protocols evaluate equivalence person-to-person treatments. Determine feasibility an in-home telehealth assessment treatment protocol. Explore use telehealth address disparities increase access either specialty general protocols rehabilitation specific populations. Encourage health services research test validate delivery methods, treatment approaches, quality life economic benefits telemedicine individuals disability. Develop tools new technology assist the care monitoring individuals disabilities. Support technology development incorporates telemetry remote access the acquisition, analysis monitoring data relevant rehabilitation. 2) Advance use assistive technologies AT), non-invasive sensors, mHealth approaches rehabilitation science. Identify methods incorporate needs requirements stakeholder groups end users technology design outcome evaluation. Better define metrics outcomes interest the of technologies rehabilitation medicine research. Enhance effective of or sensors monitoring adherence rehabilitation therapies. Integrate mHealth approaches self-management chronic conditions; determine best practices provision information providers alert systems. Support development noninvasive sensor technologies the detection, monitoring quantitation rehabilitation relevant data. Integrate developmental aging considerations device assistive technology development allow flexibility application. 3) Provide evidence base device fabrication implementation individuals disabilities Support development neuroprostheses neuroengineering systems, invasive non-invasive biologic control systems, robotics rehabilitation sensory motor), intelligent hardware software the control devices. Examine safety utility non-commercial e.g., non-profit, open source) motor sensory prosthetic design, especially the pediatric population, effectiveness these devices compared those in commercial settings. Identify solutions improved integration functionality neural prostheses biomaterials enhance rehabilitation. Improve control mechanisms end effectors attachments existing devices augment usage adherence. Encourage use computational models the design development new rehabilitation technologies including assistive technologies) for evaluating functional outcomes. IV. Research design methodology 1) Improve design methodology rehabilitation investigations especially the area clinical trials. Better define pathway clinical trials clinical trial designs may most appropriate rehabilitation medicine research propose initiatives focused these methodologies. Enhance development methodologies allow consideration individual treatment effects patient-oriented outcomes. Expand research toward understanding mechanisms action integration preclinical modeling research inform rehabilitation practice trial design. Explore use existing databases registries mechanisms discovery. Determine optimal practices clinical translation implementation enhance reach utilization evidence based approaches. 2) Develop precision medicine approaches relevant rehabilitation medicine Advance understanding omic genomic, epigenomic, proteomic, metabolomic, etc.) underpinnings plasticity response rehabilitation interventions. Characterize biomarkers improve prescription interventions. Encourage better understanding environmental barriers biological comorbidities might impede rehabilitation adherence efficacy a rehabilitation intervention. Examine psychosocial influences associated rehabilitation interventions e.g., social withdrawal, lack social support, difficulty adjusting disability). 3) Standardization approaches data elements interest Provide evidence base specific interventions treatment approaches an emphasis validated protocols associated improved outcomes particular conditions cut across populations individuals disability e.g., spasticity, bowel bladder control, gait disturbance). Continue develop, validate, encourage use common data elements metrics sponsored projects expand available knowledge base provide aggregation data secondary analyses. Harmonize terminology standards rehabilitation research ensure comparability findings across studies. Support development dissemination shared standards consensus recommendations measurable outcome assessment tools. Information Requested RFI seeks input stakeholders throughout scientific research community the general public regarding above proposed priorities the NIH-wide Rehabilitation Research Plan. NIH seeks comments any all of, not limited to, following topics: * Potential benefits, challenges, areas consideration the proposed priority areas. * Compatibility the proposed priorities the NIH mission * Compatibility the framework the NIH Rehabilitation Research Plan available models rehabilitation research * Comprehensive trans-NIH research themes rehabilitation have been captured the Priority Areas      * Future opportunities emerging research needs to Submit Response comments must submitted electronically Rehabilitation1@mail.nih.gov. Responses longer 300 words MS or pdf format) must received 11:59:59 ET) December 11, 2015. will an electronic confirmation acknowledging receipt your response. Responses this RFI voluntary. not include any proprietary, classified, confidential, trade secret, sensitive information your response. responses be reviewed NIH staff, individual feedback not provided any responder. Government use information submitted response this RFI its discretion. Government reserves right use any submitted information public NIH websites, reports, summaries the state the science, any possible resultant solicitation(s), grant(s), cooperative agreement(s), in development future funding opportunity announcements. RFI for information planning purposes only shall be construed a solicitation, grant, cooperative agreement, as obligation the part the Federal Government, NIH, individual NIH Institutes Centers provide support any ideas identified response it. Government not pay the preparation any information submitted for Government's of such information. basis claims against U.S. Government shall arise a result a response this request information from Government's of such information. look forward your input hope you share RFI document your colleagues. Inquiries Please direct inquiries to: National Center Medical Rehabilitation Research NCMRR) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) Email: Rehabilitation1@mail.nih.gov

Notice Informational Webinar PAR-15-345 BRAIN Initiative: Pre-Applications Industry Partnerships Provide Early Access Devices Stimulation Recording the Human Central Nervous System X02)" Notice Number: NOT-NS-15-043 Key Dates Release Date:   October 15, 2015   Related Announcements PAR-15-345 RFA-NS-16-009 RFA-NS-16-010     Issued National Institute Neurological Disorders Stroke NINDS) Purpose Notice to inform potential applicants Brain Research through Advancing Innovative Neurotechnologies BRAIN) Initiative Funding Opportunity Announcement Next-Generation Invasive Devices Recording Modulation the Human Central Nervous System RFA-NS-16-009 RFA-NS-16-010) a webinar provide technical assistance the optional pre-application, PAR-NS-15-345 BRAIN Initiative:  Pre-Applications Industry Partnerships Provide Early Access Devices Stimulation Recording the Human Central Nervous System X02). webinar optional not required submission PAR-NS-15-345, RFA-NS-16-009, RFA-NS-16-010. Webinar Information Date: Friday, October 30, 2015 Time: 3:30 PM EDT Duration: 1 hour register the webinar, to submit questions, please email BRAIN-FOAs@nih.gov Wednesday, October 28, 2015. Inquiries Please direct inquiries to: Stephanie Fertig, MBA National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-1779 Email: BRAIN-FOAs@nih.gov

Notice Intent Publish Funding Opportunity Announcement the Blueprint Neuroscience Research: Training Computational Neuroscience, Biology Model Back Again T90/R90) Notice Number: NOT-DA-15-081 Key Dates Release Date: October 9, 2015 Estimated Publication Date Announcement: January 2016   First Estimated Application Due Date: March 2016  Earliest Estimated Award Date:   July 2017 Earliest Estimated Start Date:   August 2017 Related Announcements RFA-DA-11-005  Issued National Eye Institute NEI) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Biomedical Imaging Bioengineering NIBIB) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Dental Craniofacial Research NIDCR) National Institute Drug Abuse NIDA) National Institute Environmental Health Sciences NIEHS) National Institute Mental Health NIMH) National Institute Neurological Disorders Stroke NINDS) National Institute Nursing Research NINR) National Center Complementary Integrative Health NCCIH) Office Behavioral Social Sciences Research OBSSR) Purpose NIH Blueprint Neuroscience Research intends reissue a Funding Opportunity Announcement FOA) the ldquo;Training Computational Neuroscience: Biology Model Back Again T90/R90)” RFA-DA-11-005). Notice being provided allow potential applicants sufficient time develop meaningful training program collaborations will link research training research education responsive applications.  FOA expected be published the end Winter 2016 an anticipated application due date Spring 2016. Awards provide to 5 years support. reissued FOA expected be largely similar the previous versions. Known changes consist revised instructions reflect policy changes recommended the Biomedical Workforce Working Group of the Advisory Committee the Director, NIH, well instructions regarding changes SF 424 application forms. FOA utilize T90/R90 activity code. Brief details the planned FOA provided below. Full details be available the reissued FOA. Research Initiative Details purpose this FOA to establish new research training research education programs computational neuroscience, to support continuation meritorious existing programs, undergraduate predoctoral level students. is intended programs provide research training research education both experimental neuroscience in theories principles the physical, computer, mathematical, engineering sciences are necessary develop models, test experimentally, use experimental data refine models normal disordered neural systems processes. Programs further expected stimulate interactions among training faculty multiple disciplines departments to foster development an integrated curriculum computational neuroscience the applicant institution. Training computational neuroscience the undergraduate level optimal establishing ldquo;pipeline” computational neuroscientists attracting students the quantitative sciences apply disciplines neuroscience research questions early their careers, conversely, undergraduates the biological behavioral sciences acquire sufficient education the quantitative sciences pursue research using computational neuroscience methods. institutional predoctoral program full-time research training support graduate students enrolled a relevant doctoral degree program also expected. predoctoral research training component must include NRSA eligible trainees may also include non-NRSA eligible predoctoral participants students). Trainees must the opportunity carry supervised research training computational neuroscience. primary objective this program must to develop students’ research skills knowledge preparation a research career computational neuroscience. APPLICATIONS NOT BEING SOLICITED THIS TIME. Inquiries Please direct inquiries to: Mimi Ghim, PhD  National Institute Drug Abuse NIDA)  Telephone: 301-402-1918 Email:  ghimm@mail.nih.gov

Notice an Additional Application Due Date PAR-13-343 NeuroNEXT Clinical Trials U01)" Notice Number: NOT-NS-15-042 Key Dates Release Date: September 17, 2015  Related Announcements PAR-13-343    Issued National Institute Neurological Disorders Stroke NINDS) Purpose Notice adds additional application due date extends expiration date PAR-13-343 NeuroNEXT Clinical Trials U01)", one funding cycle. Part 1. Key Dates Currently FOA reads: Application Due Date(s) December 2, 2013; April 2, 2014; August 1, 2014; December 2, 2014; April 3, 2015; August 3, 2015; December 3, 2015, 5:00 PM local time applicant organization. Scientific Merit Review February 2014; June 2014; October 2014; February 2015; June 2015; October 2015; February 2016; June 2016 Advisory Council Review 2014; October 2014; January 2015; 2015, October 2015; January 2016; 2016 Earliest Start Date July 1, 2014; December 1, 2014; 1, 2015; July 1, 2015; December 1, 2015; 1, 2016; July 1, 2016 Expiration Date December 4, 2015   FOA reads: Application Due Date(s) December 2, 2013; April 2, 2014; August 1, 2014; December 2, 2014; April 3, 2015; August 3, 2015; December 3, 2015; April 4, 2016, 5:00 PM local time applicant organization. Scientific Merit Review February 2014; June 2014; October 2014; February 2015; June 2015; October 2015; February 2016; June 2016 Advisory Council Review 2014; October 2014; January 2015; 2015, October 2015;  January 2016; 2016; October 2016 Earliest Start Date July 1, 2014; December 1, 2014; 1, 2015; July 1, 2015; December 1, 2015; 1, 2016; July 1, 2016; December 1, 2016 Expiration Date April 5, 2016 other aspects this FOA remain unchanged. Inquiries Please direct inquiries to: Elizabeth McNeil, MD MSc National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-9135 Email: mcneilde@ninds.nih.gov

Notice Correction NOT-NS-15-040 Notice Pre-application Informational Webinar RFA-NS-16-002 NINDS Morris K. Udall Centers Excellence Parkinson's Disease Research Program P50)'" Notice Number: NOT-NS-15-041 Key Dates Release Date:   September 11, 2015 Related Announcements NOT-NS-15-040 RFA-NS-16-002       Issued National Institute Neurological Disorders Stroke NINDS)    Purpose Notice to correct registration email address NOT-NS-15-040 quot;Notice Pre-application Informational Webinar RFA-NS-16-002 NINDS Morris K. Udall Centers Excellence Parkinson's Disease Research Program P50)'" Currently registration email address reads: sieber@ninds.nih.gov corrected registration email address reads: sieberb@ninds.nih.gov  Inquiries Please direct inquiries to: Beth-Anne Sieber, PhD National Institute Neurological Disorders Stroke NINDS) Telephone: nbsp;301-496-5680 Email: sieberb@ninds.nih.gov

Notice Pre-application Informational Webinar RFA-NS-16-002 NINDS Morris K. Udall Centers Excellence Parkinson's Disease Research Program P50)" Notice Number: NOT-NS-15-040 Key Dates Release Date:   September 4, 2015 Related Announcements NOT-NS-15-041 RFA-NS-16-002 Issued National Institute Neurological Disorders Stroke NINDS) Purpose Notice to inform potential applicants RFA-NS-16-002 a webinar provide related information the NINDS Morris K. Udall Centers Excellence Parkinson's Disease Research Program. intent the webinar to provide overview the initiative to address questions pertinent the preparation responsive applications. webinar directed primarily toward applicants the December 15, 2015 application due date; investigators considering future application the NINDS Udall Centers program also welcome participate. webinar optional not required application submission. Webinar Information Date: Monday, September 21, 2015 Time: 2:00pm EDT Duration: 1 hour register the webinar, to submit advance questions, please e-mail sieberb@ninds.nih.gov  Friday, September 18, 2015; please include Udall Webinar" the subject line. Every effort be to answer questions during webinar itself; however, due time constraints responses be provided after webinar concludes. Applicants strongly encouraged discuss proposals the Program Officer early the application development process. Inquiries Please direct programmatic inquiries to: Beth-Anne Sieber, PhD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-5680 Email: sieberb@ninds.nih.gov Please direct review-related inquiries to: Birgit Neuhuber, PhD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-3562 Email: neuhuber@ninds.nih.gov

NINDS Announces Interest Large Randomized Emergency Care Clinical Trials Notice Number: NOT-NS-15-039 Key Dates Release Date:   August 27, 2015  Related Announcements NOT-HL-15-262  PAR-13-278 Issued National Institute Neurological Disorders Stroke NINDS) Purpose National Institute Neurological Disorders Stroke NINDS) announces interest applications large, simple, randomized clinical trials neurologic related emergency care adults, address significant public health issues. trials must take place the pre-hospital and/or emergency department settings. NINDS particularly interested multi-site clinical trial applications simple pragmatic trials assessing novel interventions comparative effectiveness.  funded, proposed clinical trials be implemented a planned trans-federal emergency care network entitled Strategies Innovate Emergency Care Clinical Trials Network SIREN) NOT-NS-15-021, NOT-NS-15-022, NOT-NS-15-023) estimated start date March 2017). Since emergency care stroke incorporated the NIH StrokeNet program PAR-14-220), NINDS interested trials addressing neurologic emergencies than stroke the SIREN program.     Applications emergency care clinical trials should submitted the funding opportunity announcement PAR-13-278, NINDS PHASE III Investigator-Initiated Multi-Site Clinical Trials U01). Potential applicants strongly encouraged contact NINDS further information discussion. Inquiries Please direct inquiries to: Dr. Robin Conwit National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-9135 Email: conwitr@ninds.nih.gov

Notice Participation Additional NIH Components PAR-15-292 " Emerging Global Leader Award K43)" Notice Number: NOT-TW-15-004 Key Dates Release Date:   August 26, 2015  Related Announcements PAR-15-292     Issued Fogarty International Center FIC) National Human Genome Research Institute NHGRI) National Institute Dental Craniofacial Research NIDCR) National Institute Environmental Health Sciences NIEHS) National Institute Mental Health NIMH) National Institute Neurological Disorders Stroke NINDS) Office Research Women’s Health ORWH) Purpose Notice to inform potential applicants additional NIH components participate Program Announcement PAR-15-292 to detail additional interest NHGRI. following changes been to reflect participation NIDCR, NINDS ORWH this FOA to detail additional interest NHGRI: Part 1. Overview Information Components Participating Organizations Fogarty International Center FIC) National Human Genome Research Institute NHGRI) National Institute Dental Craniofacial Research NIDCR) National Institute Environmental Health Sciences NIEHS) National Institute Mental Health NIMH) National Institute Neurological Disorders Stroke NINDS) Office Research Women’s Health ORWH) Part 2. Section 1. Funding Opportunity Description Interests Participating NIH Institutes, Centers Offices: National Human Genome Research Institute NHGRI) interested applications individuals pursuing careers researchers the area the ethical, legal, social implications ELSI) genetics genomics research the of genetics clinical settings.  specific research topic proposed should apply across broad spectrum diseases conditions should be specific just disease, except the extent a particular disease serve a model broader applicability.  Examples topics appropriate exploration be found the ELSI Research Priorities website at: http://www.genome.gov/27543732. NHGRI also support applications individuals are developing methods research resources that support, or conducting basic translational research in: genomic sciences, informatics, implementation genomics clinical care genomic medicine), cost-effectiveness genomic interventions. specific research topic proposed should apply across broad spectrum diseases and health conditions should be specific just disease, except the extent a particular disease serve a model broader applicability.  Projects that capitalize unique opportunities use, models, diseases conditions are difficult study the U.S. because prevalence other factors will considered.  Examples such conditions might include, are limited to, sickle cell disease thalassemias, apoA associated kidney disease, and severe adverse drug reactions higher frequency outside U.S., such Stevens Johnson Syndrome SJS). National Institute Dental Craniofacial Research NIDCR) interested applications a research focus dental, oral, craniofacial conditions occur frequently the LMIC are a high public health burden; research addressing health disparities dental, oral, craniofacial conditions; research achieve national regional goals oral dental health such those articulated the World Health Organization. Examples include, are limited to: working local communities establish best means delivering preventive oral health care; establishing successful approaches deliver fluoride a local population, particularly areas without potable water; studying oral pre-malignant lesions associated betel nut use; studying interplay genes environment dental, oral, craniofacial health leveraging environments specific the country. program these topics responsive goals 2, 3, 4 the NIDCR Strategic Plan http://www.nidcr.nih.gov/research/ResearchPriorities/StrategicPlan/). National Institute Neurological Disorders Stroke NINDS) interested supporting mechanistic, epidemiological, prevention, translational clinical research across spectrum neurological, neuromuscular neurovascular diseases disorders all ages. addition prevalent neurological disorders stroke, NINDS also interested supporting research areas rare neglected neurological diseases are relevant the Low- Middle-Income Countries NINDS Disorder Index http://www.ninds.nih.gov/disorders/disorder_index.htm). Office Research Women’s Health ORWH) mission to improve health women, has strides doing by ensuring women diverse populations included all clinical studies, sex gender influences health disease explored, that women the opportunity advance biomedical careers. ORWH assess applications their ability directly fulfill goals 4.0 6.0 the NIH Strategic Plan Women’s Health Sex Differences Research, can found at: http://orwh.od.nih.gov/research/strategicplan/ORWH_StrategicPlan2020_Vo…. Section VII. Agency Contacts other aspects the FOA remain unchanged. Scientific/Research Contacts: Jean E. McEwen, J.D., Ph.D. National Human Genome Research Institute NHGRI) Telephone: 301-402-4997 Email: mcewenj@mail.nih.gov Jeff Schloss, Ph.D. National Human Genome Research Institute NHGRI) Telephone: 301-496-7531 Email: schlossj@exchange.nih.gov Lynn King, Ph.D. National Institute Dental Craniofacial Research NIDCR) Telephone: 301-594-5006 Email: Lynn.King@nih.gov Claudia S. Moy, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-9135 Email: moyc@ninds.nih.gov Jennifer Plank-Blazinet, Ph.D. Office Research Women’s Health ORWH) Telephone: 301-496-8931 Email: Jennifer.plank@nih.gov Financial/Grants Management Contact(s) Diana Rutberg National Institute Dental Craniofacial Research NIDCR) Telephone: 301-504-4798 Email: rutbergd@mail.nih.gov Tijuanna E. DeCoster, PhD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-9231 Email: decostert@mail.nih.gov Inquiries Please direct inquiries to: Christine Jessup, Ph.D. Fogarty International Center FIC) Telephone: 301-496-1653 Email: Christine.Jessup@nih.gov

Request Information: Input the Development the Federal Pain Research Strategy Notice Number: NOT-NS-16-038 Key Dates Release Date: August 12, 2015 Response Date: September 18, 2015 Related Announcements None     Issued National Institute Neurological Disorders Stroke NINDS)   Purpose behalf HHS, in response provisions the Patient Protection Affordable Care Act, NIH established Interagency Pain Research Coordinating Committee IRPCC) coordinate pain research efforts within HHS across Federal Agencies. IPRCC developing strategic plan pain research across federal agencies.  panel experts convene provide recommendations key pain research areas move field forward the ultimate goal relieve pain improve pain care through evidence based studies enhancing federal research agenda.  key areas prevention acute chronic pain, acute pain acute pain management, transition acute chronic pain, chronic pain chronic pain management, disparities pain pain care provide framework development the strategy upon important cross-cutting elements be addressed. Background information the IPRCC, membership, responsibilities details the planning process develop research strategy, themes the working groups, cross cutting elements be addressed each working group be found http://iprcc.nih.gov/. Information Requested Request Information RFI) invites public comment input the development the federal pain research strategy.  your comments any all these specific areas, ask you consider broad research opportunities needs could the greatest benefit advancing pain research the ultimate goal relieving pain improving pain care. Such broad research opportunities needs include, are limited to: major challenges opportunities revolutionizing we understand, prevent, assess, diagnose manage acute chronic pain. Transformative areas research where new discoveries related areas research have greatest benefit advancing pain research. Transformative areas research where new discoveries related areas research have greatest benefit developing new therapies pharmacologic non-pharmacologic therapies innovative approaches pain management scientific advances could result a quantum leap the care acute chronic pain conditions. New technical capabilities tools can a significant impact pain research clinical practice the next ten years. potential collaborative efforts between relevant non-pain researchers pain researchers. potential expansion the pain research community. potential collaboration within across federal agencies. role potential federal agencies support pain research expanding enhancing pipeline new basic, translational, clinical researchers. Potential areas Public-Private Partnerships – partnerships will allow federal agencies support pain research work collaboratively both public private entities advance research improve public health. inform development the strategic plan, input being sought broad research opportunities, including those listed above they relate research priorities each the following specific thematic areas across continuum pain for disparities pain pain care, the task force address: Prevention acute chronic pain Acute pain acute pain management transition acute chronic pain Chronic pain chronic pain management Disparities pain pain care To Submit Response Click following link access RFI form submit response: http://iprcc.nih.gov/FPRS/RFI assure consideration, responses must received Friday, September 18, 2015. Responses this RFI voluntary. Any personal identifiers be removed responses compiled. Proprietary, classified, confidential, sensitive information should be included your response. RFI for planning purposes only is a solicitation applications an obligation the part the United U.S.) Government provide support any ideas identified response it. Please note the U.S. government not pay the preparation any comment submitted for use that comment. Inquiries Please direct inquiries to: Linda Porter, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone: 301-451-4460 Email: porterl@ninds.nih.gov