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Notice Extension Expiration Date PAR-14-286 NINDS CREATE Bio Discovery Track: Optimization Preparation Development Biotechnology Products Biologics U01)" Notice Number: NOT-NS-17-011 Key Dates Release Date: February 3, 2017 Related Announcements PAR-14-286 Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this Notice to inform interested applicants the expiration date the Funding Opportunity Announcement FOA) PAR-14-286 quot;NINDS CREATE Bio Discovery Track: Optimization Preparation Development Biotechnology Products Biologics U01)" be extended one receipt cycle. additional non-AIDS application due date July 18, 2017, AIDS AIDS-related applications due date September 7, 2017 been added this FOA. FOA expires September 8, 2017. Key Dates table updated accordingly: Part 1. Overview Information nbsp; Key Dates nbsp; Application Due Date(s) October 21, 2014; February 11, 2015; August 11, 2015; February 11, 2016; August 11, 2016; February 8, 2017; July 18, 2017, 5:00 PM local time applicant organization. All types non-AIDS applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. AIDS Application Due Date(s) January 7, 2015; 7, 2015; September 7, 2015; 7, 2016; September 7, 2016; May 7, 2017; September 7, 2017, 5:00 PM local time applicant organization. types AIDS AIDS-related applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. Scientific Merit Review February 2015; June 2015; November 2015; June 2016; November 2016; June 2017; November 2017 Advisory Council Review 2015; October 2015; January 2016; October 2016; January 2017; October 2017; January 2018 Earliest Start Date(s) July 2015 Expiration Date September 8, 2017 other aspects the FOA remain unchanged. Inquiries Please direct inquiries to: Chris Boshoff, Ph.D., National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-1779 Email: chris.boshoff@nih.gov

Notice Reissuance PAR-16-106 Change Due Dates R21 Applications the Assessment Zika Virus ZIKV) Complications Notice Number: NOT-HD-16-036 Key Dates Release Date: December 14, 2016 Related Announcements NOT-HD-16-033 PAR-16-106     Issued Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Eye Institute NEI) National Heart, Lung, Blood Institute NHLBI) National Institute Allergy Infectious Diseases NIAID) National Institute Biomedical Imaging Bioengineering NIBIB) National Institute Dental Craniofacial Research NIDCR) National Institute Mental Health NIMH) National Institute Neurological Disorders Stroke NINDS) Division Program Coordination, Planning Strategic Initiatives, Office Research Infrastructure Programs ORIP) Purpose Eunice Kennedy Shriver National Institute Child Health Human Development NICHD), other NIH Institutes Centers ICs) listed above, announces PAR-16-106 quot;Rapid Assessment Zika Virus ZIKV) Complications R21)" being reissued. reissued FOA use standard application due dates, the timeframes review, council award dates now align standard NIH practices.  the reissuance the FOA, Zika-related R21 applications no longer accepted a rolling basis.  last day submit quot;rapid" R21 under PAR-16-106 be January 13, 2017.  After date, R21 applications be submitted the reissued FOA standard due dates. goal PAR-16-106 been respond quickly the public health emergency, reviewing applications rapidly, making timely awards support much needed projects.  a result this effort grants awarded support number highly meritorious projects were particularly urgent time-sensitive.  participating ICs) intend continue commitment supporting Zika research, applications no longer accepted a rolling basis. every NIH Institute Office had participated PAR-16-106 participate the re-issued FOA, there other FOAs support Zika projects related their research interests priorities.  example, PA-16-141 invites applications the quot;Development Anima Models Related Biological Materials Research R21).”  NOT-HL-16-466 lists FOAs addressing Zika virus related blood supply safety transfusion research. Zika-related FOAs be found searching NIH Guide Grants Contracts at: http://grants.nih.gov/funding/index.htm. addition, Zika-related applications also submitted response one the NIH-wide parent FOAs. Potential applicants strongly encouraged contact Scientific/Research staff before submitting application determine whether not proposed work within intended scope this program. Inquiries Please direct inquiries to: Nahida Chakhtoura MD, MsGH Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) Telephone: 301-435-6872 Email: nahida.chakhtoura@nih.gov Julia L. Zehr, Ph. D. National Institute Mental Health NIMH) Telephone: 301-443-1617 Email: zehrj@mail.nih.gov Wong, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone:  301-496-1431 Email:  wongm@ninds.nih.gov Lillian Shum, PhD National Institute Dental Craniofacial Research NIDCR) Telephone: 301-594-0618 Email:  ShumL@mail.nih.gov Mark Challberg, PhD National Institute Allergy Infectious Diseases NIAID) Phone: 301-496-7453 Email: MCHALLBERG@niaid.nih.gov George McKie, DVM, PhD National Eye Institute NEI) Telephone: 301-435-8152 Email: mckiegeo@nei.nih.gov Šeila Selimovic, Ph.D. National Institute Biomedical Imaging Bioengineering NIBIB) Telephone: 301-451-4577 Email:  Seila.Selimovic@nih.gov  Simone Glynn, M.D., M.P.H. National Heart, Lung, Blood Institute NHLBI) Telephone: 301-435-0065 Email: glynnsa@nhlbi.nih.gov Stephanie Murphy, V.M.D., Ph.D. Office Research Infrastructure Programs Telephone: 301-451-7818 Email: stephanie.murphy@nih.gov

Notice an Informational Webinar RFA-NS-17-017 Frontotemporal Degeneration FTD) Sequencing Consortium: Discovery, Replication Validation UG3/UH3)" Notice Number: NOT-NS-17-010 Key Dates Release Date: December 12, 2016   Related Announcements RFA-NS-17-017        Issued National Institute Neurological Disorders Stroke NINDS) Purpose National Institute Neurological Disorders Stroke NINDS) hold pre-application informational webinar December 20, 2016 11:00-1:00 pm ET the Funding Opportunity Announcement FOA) RFA-NS-17-017, entitled quot;Frontotemporal Degeneration FTD) Sequencing Consortium: Discovery, Replication Validation UG3/UH3)". webinar provide brief introduction the FOA, highlight key apsects requirements the different phases this grant mechanism. Information how join webinar video audio coordinates, including passwords) provided below: Join WebEx meeting nbsp; https://nih.webex.com/join/sutherlandmnih.gov nbsp; |  622 274 563 nbsp; nbsp; nbsp; Join phone  1-650-479-3208 Call-in toll number US/Canada)  1-877-668-4493 Call-in toll-free number US/Canada)  Access code: 622 274 563  Global call-in numbers  |  Toll-free calling restrictions  nbsp; Participation this webinar, although encouraged, optional is required the submission an application. Inquiries Please direct inquiries to: Margaret Sutherland, PhD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-5680 Email: sutherlandm@ninds.nih.gov

Notice Encourage Eligible NIH BRAIN Initiative Awardees Apply Administrative Supplements Promote Diversity, PA-16-288 " Research Supplements Promote Diversity Health Related Research Admin Supp)" Notice Number: NOT-MH-17-008 Key Dates Release Date: December 6, 2016 Related Announcements notice supersedes NOT-MH-17-004 PA-16-288 RFA-MH-15-200 RFA-MH-15-225 RFA-NS-15-003 RFA-NS-15-004 RFA-NS-15-005 RFA-NS-15-006 RFA-NS-15-008 RFA-EB-15-006 RFA-EY-16-001 RFA-MH-16-750 RFA-MH-16-775 RFA-MH-16-810 RFA-MH-16-815 RFA-NS-16-006 RFA-NS-16-007 RFA-NS-16-008 RFA-NS-16-009 RFA-NS-16-010 Issued National Institute Mental Health NIMH) National Institute Biomedical Imaging Bioengineering NIBIB) National Eye Institute NEI) National Institute Neurological Disorders Stroke NINDS) Purpose revised Notice replaces NOT-MH-17-004 include four institutes participating the administrative supplement notice. Notice  encourages eligible awardees the BRAIN Initiative community apply administrative supplements response PA-16-288, Research Supplements Promote Diversity Health-Related Research."  NIH a strong interest the diversity the NIH-funded workforce NOT-OD-15-053 details) encourages institutions diversify student populations enhancing participation individuals groups identified nationally underrepresented the biomedical, clinical, behavioral, social sciences NOT-OD-15-089 categories definitions). BRAIN Initiative 2025 report stated the BRAIN Initiative should a catalyst will drive outstanding young people enter area their most creative career stage."  NIH diversity supplement program offers opportunity existing BRAIN awardees request additional funds train mentor next generation researchers underrepresented groups will contribute advancing goals the BRAIN Initiative. Principal Investigators PIs) active BRAIN Initiative research program grants thus encouraged identify individuals groups nationally underrepresented support mentor under auspices the administrative supplement program promote diversity. Individuals the identified groups eligible throughout continuum high school the faculty level. activities proposed the supplement application must fall within scope the parent grant, both advance objectives the parent grant support research training professional development the supplement candidate. BRAIN Initiative PIs strongly encouraged incorporate training activities will help prepare supplement candidate conduct rigorous research relevant the goals the BRAIN Initiative 2025 Report. Educational goals the NIH component the BRAIN Initiative BRAIN 2025: Scientific Vision) include acquisition quantitative skills, appropriate and integration newly developed tools, technologies methods developed under BRAIN Initiative, consideration the ethical implications neuroscience research. BRAIN 2025 Report notes individuals should obtain robust grounding quantitative reasoning, principles, techniques during training.  special focus training quantitative neuroscience, i.e. theory statistics biologists, exposing physicists, engineers statisticians experimental neuroscience. BRAIN 2025 Report strongly encourages scientists cross traditional areas expertise conduct interdisciplinary research, acknowledges need attract investigators faculty recruits neuroscience quantitative disciplines, e.g., statistics, computer science, physics, mathematics, engineering.   facilitate identification applications, first sentence the application's Project Summary should state following: parent grant a BRAIN Initiative award. PI submitting administrative supplement enhance diversity response NOT-MH-17-004. Awarding Institutes have specific practices diversity research supplement requests augment requirements described PA-16-288.  Therefore, consultation the Program Official the qualifying BRAIN award the individual named under Inquiries below strongly encouraged.  Supplement applications be evaluated the BRAIN Initiative research training committee, committee Program staff the Institutes Centers participating the NIH BRAIN Initiative.  Applications be considered according the following schedule: Application Due Date                                    Funding Decision December 1, 2016 February 15, 2017          March 31, 2017 February 16, 2017 March 30, 2017              15, 2017 April 1, 2017 May 31, 2017                          July 15, 2017 tracking purposes, applicants encouraged inform Dr. Nancy Desmond via email Nancy.Desmond@nih.gov) a diversity supplement application submitted. Please include PI name grant number this email. Inquiries Please direct inquiries to: Nancy L Desmond, Ph.D. National Institute Mental Health NIMH) Telephone: 301-443-3107 Email: Nancy.Desmond@nih.gov

Collaborative Research Computational Neuroscience CRCNS) Innovative Approaches Science Engineering Research Brain Function Notice Number: NOT-MH-17-003 Key Dates Release Date: December 5, 2016 Related Announcements None     Issued National Institute Mental Health NIMH) National Institute Neurological Disorders Stroke NINDS) National Institute Drug Abuse NIDA) National Institute Deafness Other Communication Disorders NIDCD) National Eye Institute NEI) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Biomedical Imaging Bioengineering NIBIB) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Center Complementary Integrative Health NCCIH) Purpose Notice announces reissue a joint initiative, Collaborative Research Computational Neuroscience CRCNS), among nine National Science Foundation NSF) Directorates Offices DOs), nine participating National Institutes Health NIH) Institutes Centers ICs).  CRCNS announcement released under NSF 16-607 https://www.nsf.gov/pubs/2016/nsf16607/nsf16607.htm). announcement supersedes NSF 15-595:  Collaborative Research Computational Neuroscience CRCNS) – Innovative Approaches Science Engineering Research Brain Function. German Federal Ministry Education Research Bundesministerium für Bildung und Forschung, BMBF http://www.bmbf.de/), French National Research Agency Agence Nationale de la Recherche, ANRS http://www.agence-nationale-recherche.fr), the U.S.-Israel Binational Science Foundation BSF http://www.bsf.org.il) are formal partners this program, along the NSF the NIH.  NIH, CRCNS now affiliated the NIH Blueprint Neuroscience Research http://neuroscienceblueprint.nih.gov). Computational neuroscience provides theoretical foundation a rich set technical approaches understanding complex neurobiological systems, building the theory, methods, findings computer science, neuroscience, numerous disciplines.  Through CRCNS program, participating NSF DOs, NIH ICs, BMBF, ANRS BSF support innovative interdisciplinary collaborative research make significant advances the understanding structures functions the nervous system, mechanisms underlying nervous system disorders, computational strategies used the nervous system. participating agencies recognize need research focuses integrating computational models methods neuroscience.  solicitation designed encourage new collaborations this interface.  Appropriate scientific areas investigations those are currently supported NSF NIH, related the missions the agencies.  participating this broadly based program cooperation between agencies, NIH focus creating new research teams biomedical quantitative scientists explore questions directly relevant the missions participating NIH ICs. classes proposals be considered response this solicitation: Research proposals - describing collaborative research projects Data Sharing Proposals - enable sharing data other resources Domestic international projects be considered. detailed the solicitation, international components collaborative projects be funded parallel the participating agencies.  Opportunities parallel funding available US-German Research Proposals, US-German Data Sharing Proposals; US-French Research Proposals, US-French Data Sharing Proposals, US-Israeli Research Proposals, US-Israeli Data Sharing Proposals, multilateral proposals involving United States 2 more partnering countries Germany, France, and/or Israel). Appropriate scientific areas investigations those related the mission participating funding agencies.  Questions concerning particular project’s focus, direction relevance a participating funding agency should addressed the appropriate person the list agency contacts the NSF Program Solicitation NSF 16-607, https://www.nsf.gov/pubs/2016/nsf16607/nsf16607.htm ). computational research supported under program must impact on, relate biological processes, optimally generate hypotheses are testable biological studies.  is expected that:  1) applications include collaborations among computational and/or modeling experts, theorists, experimental neuroscientists; 2) collaborations involve dynamic and, possibly, protracted period model theory development refinement, intense interaction among scientists engineers different disciplines; 3) development testing new models theories provide framework the design experiments the generation new hypotheses can help reveal mechanisms underlying normal disease states the nervous system, 4) development distribution professional quality software tools e.g., modeling algorithms analytic tools). Award Information Award sizes research projects expected range approximately 100,000 250,000 per year direct costs, durations three five years.  awards be the smaller end this range; award exceed 250,000 per year direct costs.  Applicants strongly discouraged requesting greater budgets are necessary the activities being proposed.  is estimated data sharing projects range approximately 25,000 100,000 cumulative award size a one- three-year project.  Estimated program budget, number awards average award size duration subject the availability funds. Upon conclusion the review process, meritorious applications be recommended funding either participating NSF DOs NIH ICs, the option the agencies, the applicant.  Data sharing proposals be funded only NSF.  Subsequent grant administration procedures be accordance the individual policies the awarding agency. Eligibility Information Limit Number Proposals per PI Collaborator: 2 response this solicitation, investigator participate PI Collaborator no than proposals per review cycle.  the event a PI Collaborator does appear either these roles more two proposals, proposals include person a PI Collaborator be returned without review.  limit applies all PIs Collaborators, based inside outside the United States. Proposal Preparation Submission Instructions Applications submitted response this announcement should prepared submitted accordance the general guidelines contained the NSF Grant Proposal Guide GPG).  Applications must submitted the NSF, to NIH.  complete text the GPG available electronically the NSF Web Site at: http://www.nsf.gov/publications/pub_summ.jsp?ods_key=gpg. nbsp; Applicants reminded identify announcement number 16-607) the program announcement block the NSF Cover Sheet Proposal the National Science Foundation.  Compliance this announcement critical determining relevant proposal processing guidelines.  Failure submit information delay processing. Budgetary Information Cost sharing not required NSF proposals submitted under Program Solicitation.  Budgets should include travel funds the PI team members attend annual CRCNS Principal Investigators' meeting. NIH Process those proposals are selected potential funding participating NIH ICs, PI be required resubmit proposal an NIH-approved format directly the Center Scientific Review http://www.csr.nih.gov/) the NIH.  PIs invited resubmit NIH receive further information resubmission procedures the NIH.  applicant not allowed increase proposed budget change scientific content the application the resubmission the NIH.  applicants be expected utilize Multiple Program Director/Principal Investigator option the NIH http://grants.nih.gov/grants/multi_PI/) appropriate.  NIH applications be entered the NIH IMPAC II system.  results the review be presented the involved IC's National Advisory Councils the second level review.  Subsequent the Council reviews, NIH ICs make funding determinations selected awards be made.  Subsequent grant administration procedures NIH awardees, including those related New Early Stage Investigators http://grants.nih.gov/grants/new_investigators/) be accordance the policies NIH.  Applications selected NIH funding use NIH R01 funding mechanism. Inquiries Written telephone inquiries encouraged.  Please the NSF program announcement names contact information each the participating NSF DOs and/or NIH ICs at https://www.nsf.gov/pubs/2016/nsf16607/nsf16607.htm

Notice NINDS Participation RFA-HL-18-002 Perinatal Stroke R01)" Notice Number: NOT-NS-17-009 Key Dates Release Date: November 23, 2016 Related Announcements RFA-HL-18-002  Issued National Institute Neurological Disorders Stroke NINDS)  Purpose purpose this Notice to inform potential applicants the National Institute Neurological Disorders Stroke NINDS) participate, effective immediately, RFA-HL-18-002 quot;Perinatal Stroke R01)".  following italicized changes updates RFA-HL-18-002 made indicate participation NINDS this FOA our priority research areas. Part 1. Overview Information Components Participating Organizations National Heart, Lung, Blood Institute NHLBI) National Institute Neurological Disorders Stroke NINDS) Catalog Federal Domestic Assistance CFDA) Number(s) 93.839, 93.853 Part 2. Full Text Announcement Section I. Funding Opportunity Description Research Scope NINDS addition the studies mentioned within Research Scope this FOA, NINDS like emphasize interest studies address mechanisms repair recovery perinatal stroke.  Part 2. Section II. Award Information Funds Available Anticipated Number Awards number awards contingent upon NIH appropriations the submission a sufficient number meritorious applications. NHLBI intends commit total costs 3,000,000 per year fiscal years 2018 through 2021 support to 6 awards NINDS intends commit total costs 500,000 per year fiscal years 2018 through 2021 support 1 award. Part 2. Section VII. Agency Contacts Scientific/Research Contact(s) Jim Koenig, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-1431 Email: jim.koenig@nih.gov Financial/Grants Management Contact(s) Tijuana Decoster, PhD National Institute Neurological Disorders amp; Stroke NINDS) Telephone: 301-496-9531 Email: decostert@mail.nih.gov other aspects this FOA remain unchanged. Inquiries Please direct inquiries to: Jim Koenig, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-1431 Email: jim.koenig@nih.gov

Rescinded: Notice Encourage Eligible NIMH BRAIN Initiative Awardees Apply PA-16-288 Research Supplements Promote Diversity Health-Related Research Admin Supp)" Notice Number: NOT-MH-17-004 Key Dates Release Date: November 18, 2016 Rescinded December 6, 2016) Related Announcements NOT-MH-17-008 RFA-MH-15-200 RFA-MH-15-225 RFA-NS-15-003 RFA-NS-15-004 RFA-NS-15-005 RFA-NS-15-006 RFA-NS-15-008 RFA-EB-15-006 RFA-EY-16-001 RFA-MH-16-750 RFA-MH-16-775 RFA-MH-16-810 RFA-MH-16-815 RFA-NS-16-006 RFA-NS-16-007 RFA-NS-16-008 RFA-NS-16-009 RFA-NS-16-010 Issued National Institute Mental Health NIMH) National Institute Biomedical Imaging Bioengineering NIBIB) National Eye Institute NEI) National Institute Neurological Disorders Stroke NINDS) Purpose Notice to encourage eligible awardees the BRAIN Initiative community apply administrative supplements response PA-16-288, Research Supplements Promote Diversity Health-Related Research."  NIH a strong interest the diversity the NIH-funded workforce NOT-OD-15-053 details) encourages institutions diversify student populations enhancing participation individuals groups identified nationally underrepresented the biomedical, clinical, behavioral, social sciences NOT-OD-15-089 categories definitions). BRAIN Initiative 2025 report stated the BRAIN Initiative should a catalyst will drive outstanding young people enter area their most creative career stage."  NIH diversity supplement program offers opportunity existing BRAIN awardees request additional funds train mentor next generation researchers underrepresented groups will contribute advancing goals the BRAIN Initiative. Program Directors/Principal Investigators PDs/PIs) active BRAIN Initiative research program grants thus encouraged identify individuals groups nationally underrepresented support mentor under auspices the administrative supplement program promote diversity. Individuals the identified groups eligible throughout continuum high school the faculty level. activities proposed the supplement application must fall within scope the parent grant, both advance objectives the parent grant support research training professional development the supplement candidate. BRAIN Initiative PDs/PIs strongly encouraged incorporate research education activities will help prepare supplement candidate conduct rigorous research relevant the goals the BRAIN Initiative 2025 Report. Educational goals the NIH component the BRAIN Initiative BRAIN 2025: Scientific Vision) include acquisition quantitative skills, appropriate and integration newly developed tools, technologies methods developed under BRAIN Initiative, consideration the ethical implications neuroscience research. BRAIN 2025 Report notes individuals should obtain robust grounding quantitative reasoning, principles, techniques during training.  special focus training quantitative neuroscience, i.e. theory statistics biologists, exposing physicists, engineers statisticians experimental neuroscience. BRAIN 2025 Report strongly encourages scientists cross traditional areas expertise conduct interdisciplinary research, acknowledges need attract investigators faculty recruits neuroscience quantitative disciplines, e.g., statistics, computer science, physics, mathematics, engineering.   facilitate identification applications, first sentence the application's Project Summary should state following: parent grant a BRAIN Initiative award. PD/PI submitting administrative supplement enhance diversity response NOT-MH-17-004. Awarding Institutes have specific practices diversity research supplement requests augment requirements described PA-16-288.  Therefore, consultation the Program Official the qualifying BRAIN award the individual named under Inquiries below strongly encouraged.  Supplement applications be evaluated the BRAIN Initiative research training committee, committee Program staff the Institutes Centers participating the NIH BRAIN Initiative.  Applications be considered according the following schedule: Application Due Date                                    Funding Decision December 1, 2016 February 15, 2017          March 31, 2017 February 16, 2017 March 30, 2017              15, 2017 April 1, 2017 May 31, 2017                          July 15, 2017 tracking purposes, applicants encouraged inform Dr. Nancy Desmond via email Nancy.Desmond@nih.gov) a diversity supplement application submitted. Please include PD/PI name grant number this email. Inquiries Please direct inquiries to: Nancy L Desmond, Ph.D. National Institute Mental Health NIMH) Telephone: 301-443-3107 Email: Nancy.Desmond@nih.gov

Notice Intent Publish Funding Opportunity Announcement Zika Virus ZIKV) Complications R21) Notice Number: NOT-HD-16-033 Key Dates Release Date: November 17, 2016 Estimated Publication Date Announcement: December 2016-January 2017   First Estimated Application Due Date: February 16, 2017   Earliest Estimated Award Date: October-November 2017  Earliest Estimated Start Date: December 2017 Related Announcements NOT-HD-16-036 PAR-16-106 Issued National Institutes Health NIH) National Eye Institute NEI) National Institute Allergy Infectious Diseases NIAID) National Institute Biomedical Imaging Bioengineering NIBIB) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Dental Craniofacial Research NIDCR) National Institute Neurological Disorders Stroke NINDS) Purpose Eunice Kennedy Shriver National Institute Child Health Human Development NICHD), other NIH Institutes Centers ICs) listed above, intends re-issue Funding Opportunity Announcement FOA) solicit applications research Zika Virus ZIKV) Complications. FOA replace PAR-16-106."Rapid Assessment Zika Virus ZIKV) Complications R21)" had issued provide expedited rapid) funding mechanism response the Zika virus public health emergency.  goal that initiative to respond quickly the public health emergency, reviewing applications rapidly, making timely awards support much needed projects.  a result this effort grants awarded support number highly meritorious projects were particularly urgent time-sensitive.  participating ICs intend continue commitment supporting Zika research, applications no longer accepted a rolling basis.  Instead re-issued FOA use standard application due dates the timeframes review, council award dates now align standard NIH practices. purpose this Funding Opportunity Announcement FOA) to solicit exploratory/developmental research projects Zika virus ZIKV) its complications.  ZIKV a single-stranded RNA virus the Flaviviridae family. is transmitted humans primarily through bites infected Aedes mosquitos, though both perinatal/in utero sexual transmission been reported.  Initially discovered 1947, has reported the Americas since 2014, a major outbreak Brazil starting 2015.  Disease seen about 20% infected people is usually self-limited.  However, possible association between ZIKV infection pregnant women severe microcephaly their babies been very concerning prompted World Health Organization declare potential complication public health emergency. Additionally virus been found blood, fueling growing concerns the risk transfusion-transmission with particular concern over severe outcomes at risk transfusion recipient populations such women are pregnant.  Notice being provided allow potential applicants sufficient time develop meaningful collaborations responsive projects.  FOA expected be published December 2016-January 2017 an expected application due date February 2017. FOA utilize Exploratory/Developmental Research Grant R21) activity code. Details the planned FOA provided below. Research Initiative Details Notice encourages investigators expertise insights appropriate areas science begin consider applying this new FOA. FOA solicit research projects determine whether ZIKV infection causes microcephaly other congenital abnormalities babies the potential rapid spread ZIKV the United States.  Additionally, research quantify risk the blood supply affected regions the potential clinical impact transfusion-transmission the Zika virus urgently needed inform strategies reduce prevent Zika transmission blood transfusion. Areas high priority include, are limited to, following: Demonstrate causative role infection pregnancy ZIKV the etiology fetal microcephaly, structural brain defects, other congenital malformations Basic research understand ZIKV infection pathogenesis transmission the fetus, immune responses immunological interactions other flaviviruses Population-based studies characterize epidemiology ZIKV infection the mother-infant dyad Clinical studies improve understanding the mechanisms risks maternal-to-child transmission ZIKV Strategies prevent transmission ZIKV the fetus after infection the mother Studies determine optimal screening and management ZIKV infection pregnant women in exposed fetuses Studies understand mechanisms which ZIKV affects developing nervous system other organ systems Development novel diagnostic, vaccine therapeutic strategies against Zika Studies Guillain-Barré Syndrome GBS), encephalitis encephalomyelitis associated ZIKV infection determine disease course outcomes, causality, disease mechanisms, effectiveness current treatments to develop novel treatments. Translational research the neurodevelopmental consequences infants exposure Zika Virus ZIKV) during pregnancy the early postnatal period better understanding potential ZIKV alter developing central nervous system social, cognitive, emotional, behavioral outcomes relevant mental health. Studies understand mechanisms which ZIKV affects developing nervous system infants, particularly brain regions associated social, cognitive, affective function more detailed list IC areas interest be found PAR-16-106. NOTE:  Clinical trials outside scope this FOA.   APPLICATIONS NOT BEING SOLICITED THIS TIME. Inquiries Please direct inquiries to: Nahida Chakhtoura MD, MsGH Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) Telephone: 301-435-6872 Email: nahida.chakhtoura@nih.gov Wong, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone:  301-496-1431 Email:  wongm@ninds.nih.gov Lillian Shum, PhD National Institute Dental Craniofacial Research NIDCR) Telephone: 301-594-0618 Email:  ShumL@mail.nih.gov Mark Challberg, PhD National Institute Allergy Infectious Diseases NIAID) Phone: 301-496-7453 Email: MCHALLBERG@niaid.nih.gov George McKie, DVM, PhD National Eye Institute NEI) Telephone: 301-435-8152 Email: mckiegeo@nei.nih.gov Šeila Selimovic, Ph.D. National Institute Biomedical Imaging Bioengineering NIBIB) Telephone: 301-451-4577 Email:  Seila.Selimovic@nih.gov 

Notice Informational Webinar the NIH Blueprint Diversity Specialized Predoctoral Postdoctoral Advancement Neuroscience D-SPAN) Award F99/K00) Notice Number: NOT-NS-17-008 Key Dates Release Date: November 8, 2016   Related Announcements RFA-NS-17-009 Issued National Institute Neurological Disorders Stroke NINDS)  Purpose Notice to inform potential applicants mentors to the RFA-NS-17-009 quot;NIH Blueprint Diversity Specialized Predoctoral Postdoctoral Advancement Neuroscience D-SPAN) Award F99/K00)" an upcoming informational webinar preparing applications this award. webinar optional not required submission RFA-NS-17-009. purpose the NIH Blueprint Diversity Specialized Predoctoral Postdoctoral Advancement Neuroscience D-SPAN) Award to support defined pathway across career stages outstanding graduate students are diverse backgrounds underrepresented neuroscience research. two-phase award facilitate completion the doctoral dissertation transition talented graduate students strong neuroscience research postdoctoral positions, will provide career development opportunities relevant their long-term career goal becoming independent neuroscience researchers. the F99/K00 award, individuals receive to 6 years combined support both phases, includes to 2 years the F99 fellowship phase up 4 years the K00 career development phase. Webinar Information Informational Webinar the NIH Blueprint Diversity Specialized Predoctoral Postdoctoral Advancement Neuroscience D-SPAN) Award F99/K00) January 18, 2017 1:00 - 3:00 p.m. Eastern Time webinar take through process putting together application the NIH Blueprint Diversity Specialized Predoctoral Postdoctoral Advancement Neuroscience D-SPAN) Award. webinar go through part the application, including eligibility, specific aims research strategy, sponsor co-sponsor information, letters reference support, the certification letter. second half the webinar be question answer session attendees. register the webinar, please follow following link: https://nih.webex.com/nih/onstage/g.php?MTID=eed329c2becd5b4115d7ab479c…. registration link available the bottom the page. Inquiries Please direct inquiries to: Michelle Jones-London, PhD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-451-7966 Email: jonesmiche@ninds.nih.gov

Notice Intent Publish Funding Opportunity Announcement Blueprint Neurotherapeutics Network BPN): Small Molecule Drug Discovery Development Disorders the Nervous System UG3/UH3) Notice Number: NOT-NS-17-005 Key Dates Release Date: October 27, 2016 Estimated Publication Date Announcement: February 14, 2017     First Estimated Application Due Date: August 11, 2017  Earliest Estimated Award Date: February 2018   Earliest Estimated Start Date: March 2018  Related Announcements None     Issued National Institute Neurological Disorders Stroke NINDS) National Eye Institute NEI) National Institute Aging NIA) National Institute Dental Craniofacial Research NIDCR) National Institute Drug Abuse NIDA) National Institute Mental Health NIMH) Purpose NIH announces intention reissue PAR-14-293 investigators seeking support the Blueprint Neurotherapeutics BPN) Network.  Applicants be encouraged utilize customized set contract resources, consultants the BPN Network help advance neuroscience-focused drug discovery development projects the clinic. Notice provided allow potential applicants sufficient time develop meaningful collaborations responsive projects. This FOA utilize UG3/UH3 activity code. Details the planned FOA provided below. FOA expected be published February 2017 an expected application due date August 2017.   Research Initiative Details facilitate drug discovery development the neuroscience community, NIH Blueprint Neuroscience Research http://neuroscienceblueprint.nih.gov/) established Blueprint Neurotherapeutics BPN) Network, collection contract service providers consultants extensive industry experience the areas pharmacology, medicinal chemistry, pharmacokinetics, toxicology, GMP synthesis, formulation development, Phase clinical safety testing. list consultants contract service providers be viewed http://neuroscienceblueprint.nih.gov/bpdrugs/bpn.htm. planned reissue Funding Opportunity Announcement FOA) encourage applications investigators seeking funding through UG3/UH3 phased cooperative agreement mechanism help advance drug discovery development projects the clinic.  Applicants be encouraged build customized utilization BPN services their applications. be eligible the BPN, applicant must well-validated bioactive compound(s) hand; BPN does support screening hit compounds. Projects enter BPN during Discovery Development may seek support through phase I/first-in-human testing. Discovery involves iterative medicinal chemistry improve potency ADMET properties compounds, toward goal identifying clinical candidate. During Development, clinical candidate undergoes preclinical toxicology testing required an IND manufacturing, ultimately advancing phase I/first-in-human testing. BPN Development activities include chemical manufacturing controls CMC), formulation development, toxicology studies, regulatory support, phase I/first-in-human testing. NIH assemble customized Lead Development Team each project accepted the program. Lead Development Team typically be co-chaired the Program Director/Principal Investigator PD/PI) a consultant extensive industry expertise identified supported the NIH. Lead Development Team also include members the PD/PI's team, NIH-hired consultants additional expertise, NIH staff. Lead Development Team plan coordinate work supported the cooperative agreement award conducted BPN contractors. projects enter BPN begin a preparatory phase UG3) up one year, can used complete any studies required meet Discovery Development entry criteria to engage Lead Development Team establishing detailed research plan, go/no-go milestones, all subsequent work. Applicants strongly encouraged consult NIH program staff plans an application being developed. Consultations include conference calls NIH program staff webinars. Early contact provides opportunity NIH program staff discuss program scope, entry criteria, goals, to provide information guidance how develop competitive application. It's recommended applicants contact NIH staff least 8 weeks before receipt date. additional information the BPN, please see    http://neuroscienceblueprint.nih.gov/bpdrugs/index.htm APPLICATIONS NOT BEING SOLICITED THIS TIME. Inquiries Please direct inquiries to: Charles Cywin, PhD National Institute Neurological Disorders Stroke NINDS) Telephone:301-496-1779 Email: cywincl@ninds.nih.gov