Notice Intent Publish Funding Opportunity Announcement Human Studies Target Identification, Biomarkers Disease Mechanisms Specific Small Blood Lymphatic Vessels the CNS Retina R01) Notice Number: NOT-NS-17-031 Key Dates Release Date: June 20, 2017 Estimated Publication Date Announcement: October 2017 First Estimated Application Due Date: December 2017 Earliest Estimated Award Date: July 2018 Earliest Estimated Start Date: July 2018 Related Announcements RFA-NS-18-004 Issued National Institute Neurological Disorders Stroke NINDS) NIH Blueprint Neuroscience Research
http://neuroscienceblueprint.nih.gov) National Center Advancing Translational Sciences NCATS) National Center Complementary Integrative Health NCCIH) National Eye Institute NEI) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Biomedical Imaging Bioengineering NIBIB) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Drug Abuse NIDA) National Institute Dental Craniofacial Research NIDCR) National Institute Environmental Health Sciences NIEHS) National Institute Mental Health NIMH) National Institute Nursing Research NINR) Office Behavioral Social Sciences Research OBSSR) Purpose NIH Blueprint Neuroscience Research intends promote new initiative publishing Funding Opportunity Announcement FOA) solicit applications research facilitate development tools technology non-invasive imaging profiling human CNS small blood lymphatic vessels to investigate using novel approaches role CNS physiology including sleep, development aging), disease repair processes, their responses therapy. Notice being provided allow potential applicants sufficient time develop meaningful collaborations responsive projects. FOA expected be published October 2017 an expected application due date December 2017. FOA utilize R01 activity code. Details the planned FOA provided below. Research Initiative Details Notice encourages investigators expertise insights mechanistic, technology development, clinical studies focused small blood lymphatic vessels the Central Nervous System CNS, including retina) begin consider applying this new FOA. Multidisciplinary teams complementary expertise CNS cutting-edge imaging, neurovascular biology, immunology, biomarker development be encouraged these investigators encouraged apply this application. Studies focused biomarker development small vessel vascular contributions cognitive impairment dementia VCID) mechanistic basis diffuse white matter disease VCID be in scope the new announcement, they covered earlier FOAs RFA-NS-16-019,
https://grants.nih.gov/grants/guide/rfa-files/RFA-NS-16-019.html; RFA-NS-16-020,
https://grants.nih.gov/grants/guide/rfa-files/RFA-NS-16-020.html; RFA-NS-16-021,
https://grants.nih.gov/grants/guide/rfa-files/RFA-NS-16-021.html). However, topics still high interest the NINDS applicants apply under Parent R01 R21 mechanisms. FOA enable development translation humans novel tools, technology, biomarkers, non-invasive imaging techniques, targets, order structurally functionally characterize CNS small blood lymphatic vessels, well diagnose treat dysfunction, across life span. scientific area cuts across several CNS diseases within NIH Blueprint Institutes mission, such lacunar stroke, CNS microbleeds, traumatic brain injury, brain edema, CNS infection, schizophrenia, depression, anxiety, stress, other psychiatric diseases, drug alcohol abuse, retinal vasculopathy, periodontal disease nerve damage, childhood small vessel CNS vasculitis, CNS complications preeclampsia, chronic pain, spinal cord disorders, many disorders, includes complementary integrative health approaches. Studies animal models be considered of scope. Applicants strongly encouraged consult NINDS program staff below) plans an application being developed. APPLICATIONS NOT BEING SOLICITED THIS TIME. Inquiries Please direct inquiries to: Francesca Bosetti, Pharm.D., Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-1431 Email:
frances@mail.nih.gov