Find Funding Opportunities

The National Institute of Mental Health (NIMH) and the National Institute of Neurological Disorders and Stroke (NINDS) are soliciting applications for research that will make use of neuroimaging techniques to monitor structural, functional, and metabolic correlates of human immunodeficiency virus/central nervous system (HIV/CNS) disease. Advanced structural and functional neuroimaging techniques are providing new opportunities to identify clinically significant abnormalities and relate them to neurological and neuropsychological dysfunction. As new and improved therapeutic interventions are becoming available for controlling HIV disease progression, the importance of non-invasive monitoring of HIV/CNS disease is necessary for treatment response monitoring.

The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), the National Institute of Dental and Craniofacial Research (NIDCR), the National Institute of Allergy and Infectious Diseases (NIAID), the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), the National Institute of Environmental Health Sciences (NIEHS), the National Institute on Deafness and other Communication Disorders (NIDCD), the National Eye Institute (NEI), the National Heart, Lung and Blood Institute (NHLBI), the National Institute of Neurological Disorders and Stroke (NINDS), the National Institute of Mental Health (NIMH), and the Office of Research on Women"s Health invite applications for research on the genetic bases and molecular pathways of target organ damage in rheumatic and autoimmune diseases. The applications may be for individual research projects (R01), for a group of independent research projects that use the interactive research project grant (IRPG) mechanism, or for exploratory/developmental grants (R21). The research should be specifically targeted towards identification and evaluation of cellular and molecular pathways involved in organ damage and on the genetic basis for target organ involvement in autoimmunity. This Request for Applications (RFA) solicits basic, translational and clinical research projects, but not epidemiological or clinical treatment projects.

The National Institutes of Health (NIH) is continuing to make a special effort to stimulate research in educational institutions that provide baccalaureate training for a significant number of the Nation"s research scientists but that have not been major recipients of NIH support. Since Fiscal Year (FY) 1985, Congressional appropriations for the NIH have included funds for this initiative, which NIH has implemented through the Academic Research Enhancement Award (AREA) program and an annual Request For Applications. Based on the expectation that funds will continue to be available each year, since 1997 the NIH invites applications for AREA grants (R15) through a standing, ongoing Program Announcement (PA).

The National Institute of Allergy and Infectious Diseases (NIAID), the National Cancer Institute (NCI), the National Center for Research Resources (NCRR), the National Eye Institute (NEI), the National Heart, Lung and Blood Institute (NHLBI), the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), the National Institute of Dental and Craniofacial Research (NIDCR), the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), the National Institute of Mental Health (NIMH), the National Institute of Neurological Disorders and Stroke (NINDS), and the Office of Research on Women"s Health (ORWH) invite applications for research project grants to develop new methods for in vivo imaging of the immune system in small animal models of human autoimmune diseases. Support will be provided for the development of high- resolution imaging technologies to visualize active processes of immune cells in vivo, including instrumentation and computational improvements, and the design, development, synthesis and testing of new contrast agents. These projects will require the coordinated effort of experts in imaging and immunology to develop innovative approaches for imaging immune cell movement, behavior and functions in vivo using animal models of human autoimmune diseases. Of particular interest are studies designed to specifically label and follow lymphocytes and other immune effector cells at various activation states throughout an ongoing immune response.

The National Institute of Environmental Health Sciences (NIEHS), National Institute of Allergy and Infectious Diseases (NIAID), National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institute of Arthritis, Musculoskeletal, and Skin Diseases (NIAMS), National Institute of Child Health and Human Development (NICHD), National Institute on Deafness and other Communication Disorders (NIDCD), National Eye Institute (NEI), National Heart, Lung and Blood Institute (NHLBI), National Institute of Neurological Disorders and Stroke (NINDS), National Institute of Mental Health (NIMH), National Institute of Dental and Craniofacial Research (NIDCR), and the Office of Research on Women's Health (ORWH) invite applications for innovative investigator-initiated basic or population based research to determine the role of environmental and infectious agents in the initiation and/or exacerbation of autoimmune diseases. Three specific areas of interest are: 1) the role of exposure to environmental and/or infectious agents in the development of autoimmune diseases, including timing of exposure; 2) the role of genetic factors in modulating the induction or perpetuation of autoimmune diseases by environmental or infectious agents and 3) the interaction of hormones and gender differences with environmental or infectious agents in development of autoimmune diseases. It is anticipated that research fostered by this RFA will lead to the development of more extensive hypothesis-driven mechanistically-oriented research projects.

The Brain Molecular Anatomy Project (BMAP) is a multi-institute initiative that supports research on the genomics of the nervous system, with initial efforts focussing on the discovery of new genes and the study of gene expression patterns in mouse and human brains. This initiative will provide the capability to quantify and track the expression of tens of thousands of genes in space and time, and will generate enormous amounts of such data.

The purpose of this initiative is to stimulate research to increase understanding of the role of fusin co-factors in HIV infection of the CNS and to identify and develop analogs and related compounds of these co-factors as potential therapeutic agents.

This request for applications (RFA) will solicit research grants directed toward expanding the use of SIV-infected non-human primates to address the effects of this virus on the CNS to increase understanding of the resulting pathology and identify therapeutic targets for prevention and/or treatment of the functional and neurological consequences.

The objective of this Program Announcement (PA) is to stimulate research on the relative roles of environmental, endogenous neurochemical and genetic factors in the cause of neurodegenerative diseases. The results of these investigations should help clarify the part xenobiotics play in the etiology of these diseases.

The purpose of this Request for Applications (RFA) is to solicit applications for research projects to develop objective and standardized criteria and new, cost- effective, high-throughput phenotyping tools and methods to assess specific components of nervous system function and complex behaviors in the laboratory mouse. Projects supported under this RFA will develop and apply high-throughput phenotyping protocols to evaluate standard inbred strains of mice, and deposit the data so generated into databases of quantitative behavioral, physiological, pharmacological, and neuroanatomical profiles across different strains. These diverse phenotyping tools and assays will provide invaluable endpoints for the comprehensive characterization of nervous system function and complex behaviors in mouse mutants, and will facilitate the genetic analysis of these complex traits. Protocols, assays, assessment criteria, data on reference strains, and other material and information generated in projects funded under this RFA will be made widely available to the scientific community. This RFA is part of a broader NIH initiative to support large-scale functional genetic studies and characterize the murine nervous system and behavior. Techniques and data generated under this RFA will be available to support this broader initiative.