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The purpose of this FOA is to support the expansion of the National Institute of Neurological Disorders and Stroke (NINDS) Human Cell and Data Repository. The repository will maintain the current collection of fibroblast and induced pluripotent stem cell (iPSC) lines as well as develop, characterize, expand and where appropriate genetically modify new high-quality iPSC, fibroblast cell lines and peripheral blood monocyte cells in accordance with the NINDS mission. The NINDS Human Cell and Data Repository will distribute human cell resources broadly to qualified academic and industry researchers.

The National Institute of Neurological Disorders and Stroke (NINDS) is soliciting applications for a Human Biospecimen and Data Repository for Biomarkers Research ("Biomarkers Repository") in Neurological Disorders. Collaborative teams combining expertise in neuroscience, biomarkers, biospecimen handling, and data management are encouraged. Experience in biomarker research, such as evaluation of batch effects, protocol development, and analyte quality control measures, is expected. Successful applications will include a detailed description of 1) Administrative Structure, 2) Research and Resource Plan, and 3) Data Management and Web-Based activities.

The Jointly Sponsored NIH Predoctoral Training Program in the Neurosciences (JSPTPN) supports broad and fundamental research training in the neurosciences via institutional NRSA research training grants (T32) at domestic institutions of higher education. Trainees appointed to this training grant are financially supported for either one or two years, during the first 2 years of their graduate research training. The primary objective is to prepare individuals for careers in neuroscience that have a significant impact on the health-related research needs of the Nation.

This Funding Opportunity Announcement (FOA) is issued as an initiative of the NIH Blueprint for Neuroscience Research.The Neuroscience Blueprint is a collaborative framework through which 15 NIH Institutes, Centers and Offices jointly support neuroscience-related research, with the aim of accelerating discoveries and reducing the burden of nervous system disorders (for further information, see http://neuroscienceblueprint.nih.gov/).The Neuroscience Blueprint is supporting a Lifespan Human Connectome Project (L-HCP) to extend the Human Connectome Project (HCP) (http://www.neuroscienceblueprint.nih.gov/connectome) to map connectivity in the developing, adult, and aging human brain.The goal of this FOA is to solicit grant applications that propose to extend the experimental protocols developed through the HCP to children in the 0-5 year old age range to investigate the structural and functional changes that occur in the brain during typical development.Related FOAs solicit applications that apply the HCP protocols to the 5-21 year old age range and to middle age and elderly adults to explore changes that occur during normal aging.

This Funding Opportunity Announcement (FOA) invites research grant applications focused on defining the central role of exosomes in the neuropathogenesis of Human Immunodeficiency Virus (HIV)-1 Associated Neurocognitive Disorders (HAND) and determining the potential use of exosomes as biomarkers for HAND or as delivery vehicles for CNS targeted therapeutics. Basic and translational research in domestic and international settings is of interest.Multidisciplinary research teams and collaborative alliances are encouraged but not required.

This Funding Opportunity Announcement (FOA) invites small research grant applications focused on defining the central role of exosomes in the neuropathogenesis of Human Immunodeficiency Virus (HIV)-1 Associated Neurocognitive Disorders (HAND) and determining the potential use of exosomes as biomarkers for HAND or as delivery vehicles for CNS targeted therapeutics. Basic and translational research in domestic and international settings is of interest.Multidisciplinary research teams and collaborative alliances are encouraged but not required.

This Funding Opportunity Announcement (FOA) encourages applications for Countermeasures Against Chemical Threats (CounterACT) Research Centers of Excellence (U54s). The mission of the CounterACT program is to foster and support research and development of new and improved therapeutics for chemical threats (see www.ninds.nih.gov/counteract). Chemical threats are toxic chemicals that could be used in a terrorist attack or accidentally released from industrial production, storage or shipping. They include traditional chemical warfare agents, toxic industrial chemicals, and pesticides.The scope of the research includes target and candidate identification and characterization, through candidate optimization and demonstration of in vivo efficacy, through Investigational New Drug (IND)-enabling studies required for advanced development. The Centers will contain at least three research projects supported by administrative and scientific cores, and a research education core.Each research project must include milestones that create discrete go or no-go decision points in a progressive translational study plan.

NIH is accepting administrative supplement requests to support projects that will establish or improve interoperability among NIH funded biomedical data repositories. Improved interoperability is expected to lead to increased efficiency of repositories operations and cost reductions, which are significant factors of the NIHs long-term sustainability plans for the biomedical data repositories.

The Office of AIDS Research, in collaboration with the NIH Institutes and Centers (ICs) named above, encourages applications for administrative supplements to fund innovative research on HIV and aging through clinical, translational, observational, or interventional studies in domestic or international settings. The specific types of NIH awards that can be supplemented are listed above. Supplemental projects must be within the scope of the parent grant. Topics of interest include HIV infection, HIV-associated conditions, HIV treatment, and/or biobehavioral or social factors associated with HIV/AIDS in the context of aging and/or in older adults.

The purpose of this FOA is to support the development of Mobilizing Research a research resource that would allow researchers to more efficiently and rapidly evaluate mobile and wireless (mHealth) technologies. This research resource is intended to develop an infrastructure that works with wireless carriers to create a registry of potential participants to facilitate mHealth research across a variety of observational and clinical research studies and settings, and for a range of diseases and populations. This FOA supports Mobilizing Research for development of the infrastructure and transition to sustainability. Therefore, the proposed integrated and centralized resource should be designed and operated in a way that will facilitate and enable its sustainable functioning in the near future.