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This funding opportunity announcement (FOA), in support of the NIH Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative, aims to support full development of entirely new or next generation noninvasive human brain imaging tools and methods that will lead to transformative advances in our understanding of the human brain. The FOA seeks innovative applications that are ready for full-scale development of breakthrough technologies with the intention of delivering working tools within the timeframe of the BRAIN Initiative (BRAIN 2025: A Scientific Vision, http://braininitiative.nih.gov/). This FOA represents the second stage of the tool/technology development effort that started with RFA-MH-14-217 and RFA-MH-15-200.

This Funding Opportunity Announcement (FOA) intends to assemble a group of Specialized Collaboratories that will adopt scalable technology platforms and streamlined workflows to accelerate progress towards establishing reference cell atlases of human brain and/or non-human primate brains. A central goal of this and the three companion FOAs is to build a brain cell census resource that can be widely used throughout the research community.

This Funding Opportunity Announcement (FOA) intends to support a Brain Cell Data Center (BCDC) that will work with other BICCN Centers and interested researchers to establish a web-accessible information system to capture, store, analyze, curate, and display all data and metadata on brain cell types, and their connectivity. The BCDC is expected to: (1) lead the effort to establish spatial and semantic standards for managing heterogeneous brain cell census data types and information; (2) lead the effort to collect and register multimodal brain cell census data to common brain coordinate systems; (3) generate searchable 2D and 3D digital brain atlases for cell census data; and (4) generate a unified and comprehensive brain cell knowledge base that integrates all existing brain cell census data and information across diverse repositories. A central goal of this and the three companion FOAs is to build a brain cell census resource that can be widely used throughout the research community.

This Funding Opportunity Announcement (FOA) intends to assemble a group of Comprehensive Centers that will adopt scalable technology platforms and streamlined workflows to generate a comprehensive 3D brain cell reference atlas encompassing molecular, anatomical, and physiological annotations of brain cell types in mouse, and incorporate additional genetic and other advanced cell-specific targeting approaches and tools to facilitate this goal. A central goal of this and the three companion FOAs is to build a brain cell census resource that can be widely used throughout the research community.

This Funding Opportunity Announcement (FOA) intends to support Specialized Collaboratory that will adopt scalable technology platforms and streamlined workflows to generate a comprehensive 3D brain cell reference atlas encompassing molecular, anatomical, and physiological annotations of brain cell types in mouse, and incorporate additional genetic and other advanced cell-specific targeting approaches and tools to facilitate this goal. A central goal of this and the three companion FOAs is to build a brain cell census resource that can be widely used throughout the research community.

This FOA invites applications for the Microphysiological Systems (MPS) for Disease Modeling and Efficacy Testing Program to develop highly reproducible and translatable in vitro models for preclinical efficacy studies through discovery and validation of translatable biomarkers, development of standardized methods for preclinical efficacy testing and definitive efficacy testing of candidate therapeutics using best practices and rigorous study design. An essential feature will be a multidisciplinary approach that brings together experts in bioengineering, microfluidics, material science, "omic" sciences, computational biology, disease biology, pathology, electrophysiology, pharmacology, biostatistics and clinical science.

This Funding Opportunity Announcement (FOA) invites applications for Center Core Grants that provide resources and facilities shared by a minimum of six NINDS-supported investigators from one or more organizations, and supporting a wider base of neuroscience research. The proposed Centers should offer services and expertise that would be difficult or impractical to support in individual labs. The Centers are expected to capitalize on economies and synergies associated with shared resources, and to foster a collaborative environment among neuroscientists at host institutions.

The purpose of this Funding Opportunity Announcement (FOA) is to support high quality and impactful conferences/scientific meetings that are convened by data science related organizations whose missions focus on biomedical data science. This FOA, which uses the NIH conference cooperative agreement program (U13), is part of the NIH-wide initiative, Big Data to Knowledge (BD2K). Data science related organizations have a critical role in advancing biomedical data science but often depend on meetings to carry out their work. This FOA will support high quality conferences or meetings that are relevant to the biomedical data science needs of the participating Institutes and Centers of the National Institutes of Health. For the purpose of this FOA, a conference is defined as a gathering, such as in the form of a symposium, seminar, scientific meeting, workshop, or any other organized and formal meeting where persons assemble to coordinate, exchange, and disseminate information, or to explore or clarify a defined subject, problem, or area of knowledge. Applicants representing data science related organizations may request support for one or a series of meetings over multiple years that address areas of data science aligned with the goals of the NIH BD2K program.

The purpose of the Fogarty Emerging Global Leader Award is to provide research support and protected time (three to five years) to an early career research scientist from a low- or middle-income country (LMIC) who holds a junior faculty position at an LMIC academic or research institution, as defined by the World Bank (http://data.worldbank.org/about/country-classifications/country-and-len…, including low-income, lower-middle-income, and upper-middle-income countries). This intensive, mentored research career development experience is expected to lead to an independently funded research career at the LMIC institution or in another LMIC. This Funding Opportunity Announcement (FOA) invites applications from LMIC scientists from any health-related discipline who propose career development activities and a research project that is relevant to the health priorities of their country under the mentorship of LMIC and U.S. mentors.

The purpose of this award is to support outstanding scientific training of highly promising postdoctoral candidates with outstanding mentors. Candidates are eligible to apply for support from this program from ~12 months prior to the start of the proposed postdoctoral position to within 12 months after starting in postdoctoral position. Based on the early timeframe of eligibility, and the discouragement of inclusion of preliminary data, this NINDS F32 seeks to foster early, goal-directed planning and to encourage applications for bold and/or innovative projects by the candidate that have the potential for significant impact. Applications are expected to incorporate strong training in quantitative reasoning and the quantitative principles of experimental design and analysis. Support by this program is limited to the first 3 years of a candidate's activity in a specific laboratory or research environment, so as to further encourage early fellowship application and timely completion of mentored training of the postdoctoral candidate in a single environment.