Rigor & Transparency

Experimental and analytical rigor, measures to reduce bias, and transparency of reporting are the foundations for quality scientific research. Attention to principles of good study design and transparent reporting are essential to enable the scientific community as well as the community at large to assess the value of scientific findings. This is also important for peer reviewers to properly advise NINDS on grant applications. Over the past few years NIH, in general, and NINDS, in particular, have taken measures to improve transparency in scientific reporting.  Here we provide information on these activities.

Improving the Quality of NINDS-Supported Preclinical and Clinical Research through Rigorous Study Design and Transparent Reporting: NINDS Notice NOT-NS-023

Enhancing Reproducibility through Rigor and Transparency: NIH Notice NOT-OD-15-103

Implementing Rigor and Transparency in NIH and AHRQ Research Grant Applications: NIH Notice NOT-OD-16-011

June 20, 2012 Optimizing the Predictive Value of Preclinical Research: Workshop Summary  (Archived)

Landis et al, 2012 Nature A call for transparent reporting to optimize the predictive value of preclinical research

Collins & Tabak 2014 Nature Policy: NIH plans to enhance reproducibility

Hewitt et al, 2017 ILAR J Accelerating Biomedical Discoveries through Rigor and Transparency

Open Mike: Bolstering Trust in Science through Rigorous Standards (October 30, 2015)

Open Mike: Updates on Addressing Rigor in Your NIH Applications (January 11, 2016)

Open Mike: Scientific Rigor in NIH Grant Applications (January 28, 2016)

Open Mike: Scientific Premise in NIH Grant Applications (January 28, 2016)

NINDS Director's Message: Rigor Not Mortis - Strengthening the Quality of Neuroscience Research (April 5, 2017)

NINDS Applicant Guidelines: Improving the Quality of NINDS-Supported Preclinical and Clinical Research (pdf, 67 kb)

NIH Applicant Guidelines: Rigor and Reproducibility

NIH Reviewer Guidelines: Research Project Grant and Mentored Career Development Applications (pdf, 160 kb)

Rigor and Reproducibility: Training Modules and Online Course

NIH: Rigor and Reproducibility

Resource Chart: Rigor and Reproducibility in NIH Applications (pdf, 90 kb)

Shai Silberberg, Ph.D.
NINDS Director of Research Quality

Devon Crawford, Ph.D.
NINDS Health Program Specialist