Archived Clinical Research Datasets

Archived Clinical Research Datasets

The data from NINDS-supported clinical trials are an important scientific resource, made available to the wider scientific community, while ensuring that the confidentiality and privacy of study participants are protected.  NINDS requires all investigators seeking access to data from archived NINDS-supported trials to agree to certain terms and conditions. 

NINDS Dataset Citation

It is important to credit the researchers for their work. NINDS asks all data recipients to choose one of the two citation statements when publishing new analysis received datasets.

  1. This research is based on the National Institute of Neurologic Disease and Stroke’s Archived Clinical Research data (Full Title, PI, and grant number) received from the Archived Clinical Research Dataset web site.
  2. The (Full Title, PI, and grant number) data and analyses presented in this (manuscript/poster/publication) are based on the research files downloaded from the Archived Clinical Research web site of the National Institute of Neurologic Disease and Stroke.

Procedures for Requesting Archived Datasets

To request a dataset, please complete the NINDS Data Request Form (fillable PDF, 929 KB) and send it to the NINDS Clinical Research Liaison at CRLiaison@ninds.nih.gov.

Procedures for Submitting Datasets

If your study was funded by NINDS and you are ready to submit the results, please complete the Archiving Materials Form and Checklist (fillable PDF, 2.7 MB) and send it to the NINDS Clinical Research Liaison at CRLiaison@ninds.nih.gov

Archived datasets are available for the following studies:

Study Title Short Name Principal Investigator NCT Number
ALS
Clinical Trial Ceftriaxone in Subjects With Amyotrophic Lateral Sclerosis (ALS) Ceftriaxone-ALS Merit E. Cudkowicz, MD  NCT00349622
Clinical Trial of Topiramate in ALS Topiramate-ALS Christopher S. Coffey, PhD N/A
STROKE
A Randomized Trial of Unruptured Brain Arteriovenous Malformation (ARUBA) ARUBA J.P. Mohr, MS, MD  NCT00389181
Antihypertensive Treatment of Acute Cerebral Hemorrhage-II (ATACH-II) ATACH-II Adnan I. Qureshi, M.D. NCT01176565 
Arm Rehabilitation Study After Stroke (ICARE) ICARE Carolee J. Winstein, PhD NCT00871715
Asymptomatic Carotid Atherosclerosis Study (ACAS) ACAS James F. Toole, MD N/A
Carotid Revascularization Endarterectomy Versus Stenting Trial (CREST) CREST Thomas G. Brott, MD NCT00004732
Field Administration of Stroke Therapy - Magnesium (FAST-MAG) Trial FAST-MAG Jeffrey L. Saver, MD NCT00059332
Heparinoids in the Treatment of Acute Cerebral Infarction  Heparinoids-ACI Jose Biller, MD N/A
High-Dose Albumin Therapy for Neuroprotection in Acute Ischemic Stroke (ALIAS) Part 1 Trial ALIAS 1 Myron Ginsberg, MD NCT00235495
High-Dose Albumin Therapy for Neuroprotection in Acute Ischemic Stroke (ALIAS) Part 2 Trial ALIAS 2 Myron Ginsberg, MD NCT00235495
Insulin Resistance Intervention after Stroke (IRIS) IRIS Walter N. Kernan, M.D.  NCT00091949
Clot Lysis: Evaluating Accelerated Resolution of Intraventricular Hemorrhage Phase III (CLEAR III) CLEAR III Daniel F. Hanley, MD NCT00784134
Interventional Management of Stroke (IMS) III IMS III Joseph Broderick, MD NCT00359424
Extracranial/Intracranial Arterial Anastomosis Study (ECIC) ECIC Henry J. Barnett, MD N/A
Ethnic/ Racial Variations of Intracerebral Hemorrhage (ERICH) ERICH Daniel Woo, MD, MS NCT01660672
Locomotor Experience Applied Post-Stroke (LEAPS) LEAPS Pamela W. Duncan, PhD, PT NCT00243919
Minimally Invasive Surgery and rtPA for Intracerebral Hemorrhage Evacuation (MISTIE) MISTIE Daniel F. Hanley, MD NCT00224770
Minimally Invasive Surgery Plus Rt-PA for ICH Evacuation Phase III (MISTIE-III) MISTIE-III Daniel F. Hanley, MD NCT01827046
North American Symptomatic Carotid Endarterectomy Trial (NASCET) NASCET Henry J, Barnett, MD  N/A
Phase 2-B Study of Tenecteplase (TNK) in Acute Ischemic Stroke (TNK-S2B) TNK-S2B Elliott Clarke Haley, MD NCT00252239
Naloxone treatment of Acute Ischemic Stroke Naloxone-Stroke Harold P. Adams, MD N/A
Stenting vs. Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis (SAMMPRIS) SAMMPRIS Marc I. Chimowitz, MBChB NCT00576693
Phase II Study of Nicardipine Treatment of Acute Ischemic Stroke Nicardipine-AIS   N/A
Reasons for Geographic and Racial Differences in Stroke (REGARDS) REGARDS Virginia J. Howard, PhD N/A
Secondary Prevention of Small Subcortical Strokes (SPS3) SPS3 Oscar Benavente, M.D. NCT00059306
Trial of ORG 10172 in Acute Stroke (TOAST)  TOAST Harold P. Adams, MD N/A
Tissue Plasminogen Activator for Acute Ischemic Stroke tPA AIS Steven R. Levine, MD N/A
Vitamin Intervention for Stroke Prevention Trial (VISP) VISP James F. Toole, MD N/A
Endovascular Therapy Following Imaging Evaluation for Ischemic Stroke 3 (DEFUSE 3) DEFUSE 3 Gregory Albers, MD NCT02586415
Platelet-Oriented Inhibition in New TIA and Minor Ischemic Stroke (POINT)  POINT S. Claiborne Johnston, MD, PhD  NCT00991029
Safety Evaluation of 3K3A-APC in Ischemic Stroke (RHAPSODY, NN104) RHAPSODY Patrick D. Lyden, MD NCT02222714
The CTA Spot Sign Score in Acute Cerebral Hemorrhage  (SCORE-IT). An ATACH-2 Ancillary study SCORE-IT Jonathan Rosand, MD N/A
Telerehabilitation in the Home Versus Therapy In-Clinic for Patients With Stroke Stroke TeleRehab Steven C. Cramer, MD NCT02360488
Warfarin Versus Aspirin in Reduced Cardiac Ejection Fraction (WARCEF)  WARCEF  Shunichi Homma, MD NCT00041938
PARKINSON
Deprenyl and Tocopherol Anti Oxidative Therapy of Parkinsonism (DATATOP)  DATATOP Ira Shoulson, MD   N/A
Earlier versus Later Levodopa Therapy in Parkinson Disease (ELLDOPA) ELLDOPA Stanley Fahn, MD, PhD  NCT00004733
NET-PD FS1 Minocycline and Creatine in early Parkinson's Disease NET-PD FS1 Karl Kieburtz, MD, MPH NCT00063193
NET-PD FS-TOO Pilot Study of CoQ10 and GPI 1485 in early Parkinson's Disease NET-PD FS2 Karl Kieburtz, MD, MPH NCT00076492
NET-PD LS-1 Creatine in Parkinson's Disease NET-PD LS1 Karl Kieburtz, MD, MPH  NCT00449865
A Multicenter, Randomized, Double-Blind, Double Dummy, Parallel Group Study Comparing TV-1203/Carbidopa (TV-1203/CD) Dispersible Tablets with Levodopa/Carbidopa (LD/CD) Tablets in Advanced Parkinson’s Disease (PD) Patients with Motor Fluctuations" (PD-DOC RAPID) PD-DOC RAPID Parkinson Group  
Double blind Controlled Trial of Nigral Grafting in PD PD-Nigral Grafting C. Warren Olanow, MD  NCT00004387
Effects of CoEnzyme Q10 in Early Parkinson's Disease (QE2) PD-DOC QE2 Clifford Shults, MD NCT00004731
A Longitudinal Follow-up of the PRECEPT Study Cohort (PostCEPT) PostCEPT Roger M. Kurlan, MD NCT00605163
Parkinson Research Examination of CEP-1347 Trial (PRECEPT)  PRECEPT Ira Shoulson, MD   NCT00040404
Study in Parkinson's Disease of Exercise (SPARX) SPARX Margaret Schenkman, PT, PhD NCT01506479
NET-PD FS-ZONE Pioglitazone in Early Parkinson's Disease NET-PD FS ZONE Karl Kieburtz, MD, MPH NCT01280123
Rasagiline Mesylate (TVP-1012) in Early PD Monotherapy (TEMPO)  PD-DOC TEMPO   NCT00203164
Trial of Rasagiline in Levodopa-treated Patients with Parkinson (PRESTO) PD-DOC PRESTO Ira Shoulson, MD NCT00203034
Phase 3 Double-blind Placebo-controlled Parallel Group Study of Isradipine as a Disease Modifying Agent in Subjects With Early Parkinson Disease STEADY-PD III Robert Holloway, MD MPH NCT02168842
EPILEPSY
Rapid Anticonvulsant Medication Prior to Arrival Trial (RAMPART) RAMPART Robert Silbergleit, MD NCT00809146
OTHER DISEASE AREAS
Enteral Levetiracetam For Seizure Control in Pediatric Cerebral Malaria (LVT1) Phase I and II LVT1 Gretchen L. Birbeck, MD, MPH NCT01660672 
Thymectomy Trial in Non-Thymomatous Myasthenia Gravis Patients Receiving Prednisone Therapy (MGTX) MGTX Gil Wolfe, MD  Henry Kaminski, MD NCT00294658
Neurotrophin-3 gene therapy for Charcot-Marie-Tooth 1A (Phase I/IIa Trial of scAAV1.tMCK.NTF3 for Treatment of CMT1A) scAAV1.tMCK.NTF3 Zarife Sahenk, MD., PhD. NCT03520751
The Childhood and Adolescent Migraine Prevention (CHAMP) study CHAMP Christopher S. Coffey, PhD NCT01581281
Safety, Tolerability, and Activity Study of Ibudilast in Subjects With Progressive Multiple Sclerosis NN102 SPRINT - MS  Robert J Fox, MD, FAAN NCT0198294
Extremely Low Gestation Age Newborn (ELGAN) (pdf, 162 kb) ELGAN Karl Kuban, MD, MS N/A
Spinal Muscular Atrophy (SMA) Biomarkers Study in the Immediate Postnatal Period of Development SMA-NN101 Stephen J Kolb, MD, PhD NCT01736553

Questions?

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