Archived Clinical Research Datasets

Archived Clinical Research Datasets

The data from NINDS-supported clinical trials are an important scientific resource, made available to the wider scientific community, while ensuring that the confidentiality and privacy of study participants are protected.  NINDS requires all investigators seeking access to data from archived NINDS-supported trials to agree to certain terms and conditions. 

NINDS Dataset Citation

It is important to credit the researchers for their work. NINDS asks all data recipients to choose one of the two citation statements when publishing new analysis received datasets.

  1. This research is based on the National Institute of Neurologic Disease and Stroke’s Archived Clinical Research data (Full Title, PI, and grant number) received from the Archived Clinical Research Dataset web site.
  2. The (Full Title, PI, and grant number) data and analyses presented in this (manuscript/poster/publication) are based on the research files downloaded from the Archived Clinical Research web site of the National Institute of Neurologic Disease and Stroke.

Procedures for Requesting Archived Datasets

To request a dataset, please complete the NINDS Data Request Form (fillable PDF, 929 KB) and send it to the NINDS Clinical Research Liaison at CRLiaison@ninds.nih.gov.

Procedures for Submitting Datasets

If your study was funded by NINDS and you are ready to submit the results, please complete the Archiving Materials Form and Checklist (fillable PDF, 2.7 MB) and send it to the NINDS Clinical Research Liaison at CRLiaison@ninds.nih.gov

Questions?

Please e-mail us at CRLiaison@ninds.nih.gov

Additional NIH/ NINDS data and biorepositories

Archived datasets are available for the following studies:

Trial Acronym Official Trial Title Principal Investigator Primary Disease Category Secondary Disease Focus (if applicable) Research Type Trial Completion Year Allocation Phase Participant Age Group
ALIAS 1 A Phase III Randomized Multicenter Clinical Trial Of High-Dose Human Albumin Therapy For Neuroprotection In Acute Ischemic Stroke Part 1 Trial Myron Ginsberg, MD Stroke, Ischemic Interventional 2010 Randomized III Adult
ALIAS 2 A Phase III Randomized Multicenter Clinical Trial Of High-Dose Human Albumin Therapy For Neuroprotection In Acute Ischemic Stroke Part 2 Trial Myron Ginsberg, MD Stroke, Ischemic Interventional 2013 Randomized III Adult
ARUBA A Randomized Trial of Unruptured Brain Arteriovenous Malformations J.P. Mohr, MD Cerebral Arteriovenous Malformation Stroke Intervention 2015 Randomized III Adult
ATACH-II Antihypertensive Treatment of Acute Cerebral Hemorrhage-II : A Phase III Randomized Multicenter Clinical Trial of Blood Pressure Reduction for Hypertension in Acute Intracerebral Hemorrhage Adnan I. Qureshi, MD Hemorrhage, Intracerebral Acute Hypertensive Response Interventional 2016 Randomized III Adult
Ceftriaxone-ALS Clinical Trial Ceftriaxone in Subjects With Amyotrophic Lateral Sclerosis Merit E. Cudkowicz, MD Amyotrophic Lateral Sclerosis Intervention 2012 Randomized III Adult
CHAMP Amitriptyline and Topiramate in the Prevention of Childhood Migraine; The Childhood and Adolescent Migraine Prevention Study Scott W. Powers, PhD and Andrew D. Hershey, MD Migraine Interventional 2016 Randomized III Pediatric
CLEAR III Clot Lysis: Evaluating Accelerated Resolution of Intraventricular Hemorrhage Phase III Daniel F. Hanley, MD Hemorrhage, Intraventricular Interventional 2016 Randomized III Adult
CREST Carotid Revascularization Endarterectomy Versus Stenting Trial Thomas G. Brott, MD Atherosclerosis Stroke Interventional 2016 Randomized IV Adult
DATATOP Deprenyl and Tocopherol Anti Oxidative Therapy of Parkinsonism Ira Shoulson, MD Parkinson's Disease Early Stage PD Interventional Pre 1990 Randomized III Adult
DEFUSE 3 Endovascular Therapy Following Imaging Evaluation for Ischemic Stroke 3 Gregory Albers, MD Stroke, Acute Cerebral Infarction Interventional 2017 Randomized III Adult
ECIC Extracranial/Intracranial Arterial Anastomosis Study Henry J. Barnett, MD Stroke Interventional pre 1990 Randomized III Adult
ELGAN Extremely Low Gestational Age Newborn Study Karl Kuban, MD and T. Michael O'Shea MD Low Gestational Age Development Prospective Observational 2004 NA NA Pediatric/Neonatal
LDOPA Earlier Versus Later Levodopa Therapy in Parkinson's Disease Stanley Fahn, MD, PhD Parkinson's Disease Interventional 2004 Randomized III Adult
ERICH Ethnic/ Racial Variations of Intracerebral Hemorrhage Daniel Woo, MD, MS Hemorrhage, Intracerebral Observational 2017 Case Control NA Adult
ESSETT A Multicenter, Randomized, Blinded, Comparative Effectiveness Study of Fosphenytoin, Valproic Acid, or Levetiracetam in the Emergency Department Treatment of Patients With Benzodiazepine-refractory Status Epilepticus Robert Silbergleit, MD, James Chamberlain. MD, and Jordan Elm, MD Epilepsy Seizure Benzodiazepine Refractory Status Epilepticus Interventional 2019 Randomized III Adult
FAST-MAG Field Administration of Stroke Therapy - Magnesium Trial: A Randomized, Double-Blind, Placebo Controlled Trial of Neuroprotective Magnesium Sulfate Therapy for Acute Stroke Initiated Within 2 Hours of Onset by Paramedics in the Field Jeffrey L. Saver, MD Cerebrovascular Accident Stroke Interventional 2013 Randomized III Adult
Heparinoids-ACI Heparinoids in the Treatment of Acute Cerebral Infarction  Jose Biller, MD Stroke, Ischemic Interventional pre 1990 Non Randomized NA Adult
ICARE Interdisciplinary Comprehensive Arm Rehab Evaluation Stroke Initiative Carolee J. Winstein, PhD Stroke Interventional 2014 Randomized III Adult
IMS III Interventional Management of Stroke Trial: A Phase III Clinical Trial Examining Whether a Combined Intravenous and Intra-Arterial Approach to Recanalization is Superior to Standard IV Rt-PA Alone Joseph Broderick, MD Stroke Interventional 2013 Randomized III Adult
IRIS Insulin Resistance Intervention after Stroke Trial Walter N. Kernan, MD Stroke Myocardial Infarction Interventional 2015 Randomized III Adult
LEAPS Locomotor Experience Applied Post Stroke Pamela W. Duncan, PhD Stroke Interventional 2012 Randomized III Adult
LVT1 A Dose-Escalation, Safety And Feasibility Study Of Enteral Levetiracetam For Seizure Control In Pediatric Cerebral Malaria Gretchen L. Birbeck, MD, MPH Epilepsy Seizure Cerebral Malaria Interventional 2013 Non Randomized I / II Pediatric
MGTX A Multi-Center, Single-Blind, Randomized Study Comparing Thymectomy to No Thymectomy in Non-Thymomatous Myasthenia Gravis Patients Receiving Prednisone Gil Wolfe, MDand Henry Kaminski, MD Myasthenia Gravis Interventional 2015 Randomized III Pediatric
MISTIE Minimally Invasive Surgery and rtPA for Intracerebral Hemorrhage Evacuation Daniel F. Hanley, MD Hemorrhage, Intracerebral Interventional 2013 Randomized II Adult
MISTIE-III Minimally Invasive Surgery Plus Rt-PA for ICH Evacuation Phase III Daniel F. Hanley, MD Hemorrhage, Intracerebral Interventional 2018 Randomized III Adult
Naloxone-Stroke High Dose Intravenous Naloxone for the Treatment of Acute Ischemic Stroke Harold P. Adams, MD Stroke Interventional pre 1990 Non Randomized NA Adult
NASCET North American Symptomatic Carotid Endarterectomy Trial Henry J, Barnett, MD Stroke Carotid Endarterectomy Observational pre 1999 Case Study NA Adult
NET-PD FS ZONE A Multi-Center, Double-Blind, Placebo-Controlled Phase II Study of Pioglitazone in Early Parkinson's Disease Karl Kieburtz, MD, MPH Parkinson's Disease Interventional 2014 Randomized II Adult
NET-PD FS1 A Multi-center, Double-blind, Pilot Study of Minocycline and Creatine in Subjects With Early Untreated Parkinson's Disease Karl Kieburtz, MD, MPH Parkinson's Disease Interventional 2006 Randomized II Adult
NET-PD FS2 A Multi-center, Double-blind , Pilot Study of CoQ10 and GPI 1485 in Subjects With Early Untreated Parkinson's Disease Karl Kieburtz, MD, MPH Parkinson's Disease Interventional 2005 Randomized II Adult
NET-PD LS1 A Multicenter, Double-blind, Parallel Group, Placebo Controlled Study of Creatine in Subjects with Treated Parkinson's Disease Long Term Study Karl Kieburtz, MD, MPH Parkinson's Disease Interventional 2014 Randomized III Adult
Nicardipine-AIS Phase II Study of Nicardipine Treatment of Acute Ischemic Stroke D. Rosenbaum, MD, J. Zabramski, MD, J. Frey, MD, F. Yatsu, MD, J. Marler, MD, R. Spetzler, MD, and J. Grotta, MD Stroke, Ischemic Interventional pre 1990 Non Randomized II Adult
NN102 SPRINT - MSA A Phase 2 Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety, Tolerability and Activity of Ibudilast (MN-166) in Subjects With Progressive Multiple Sclerosis Robert J Fox, MD Multiple Sclerosis Interventional 2017 Randomized II Adult
PD-DOC PRESTO A Multicenter, US and Canada, Double Blind, Randomized, Placebo-Controlled, Parallel Group Study, for the Efficacy, Tolerability and Safety of Rasagiline Mesylate in Levodopa Treated Parkinson's Disease Patients With Motor Fluctuations Ira Shoulson, MD Parkinson's Disease Interventional 2003 Randomized III Adult
PD-DOC QE2 Effects of CoEnzyme Q10 in Early Parkinson's Disease Clifford Shults, MD Parkinson's Disease Interventional 2003 Randomized II Adult
PD-DOC RAPID A Multicenter, Randomized, Double-Blind, Double Dummy, Parallel Group Study Comparing TV-1203/Carbidopa Dispersible Tablets with Levodopa/Carbidopa Tablets in Advanced Parkinson’s Disease Patients with Motor Fluctuations Parkinson Group Parkinson's Disease Interventional 2005 Randomized III Adult
PD-DOC TEMPO A Bi-national, Multicenter, Double-Blind, Randomized Study to Evaluate the Safety and Tolerability of Rasagiline Mesylate in Advanced Parkinson's Disease Patients With Motor Fluctuations Treated With Chronic Levodopa/Carbidopa Therapy Siyu Liu, MD Parkinson's Disease Interventional 2006 Non Randomized III Adult
PD-Nigral Grafting Phase II Double Blind Controlled Trial of Nigral Grafting in Patients with Parkinson's Disease C. Warren Olanow, MD Parkinson's Disease Interventional 1996 Randomized II Adult
POINT Platelet-Oriented Inhibition in New Transient Ischemic Attack and Minor Ischemic Stroke Trial S. Claiborne Johnston, MD, PhD Transient Ischemic Attack Stroke Interventional 2018 Randomized III Adult
PostCEPT A Longitudinal Follow-up of the PRECEPT Study Cohort Roger M. Kurlan, MD Parkinson's Disease Observational 2010 NA NA Adult
PRECEPT A Randomized, Double-Blind, Placebo-Controlled Dose-Finding Study to Assess the Efficacy and Safety of CEP-1347 in Patients with Parkinson's Disease Ira Shoulson, MD Parkinson's Disease Interventional 2005 Randomized II / III Adult
RAMPART A Double-blind Randomized Clinical Trial of the Efficacy of IM Midazolam Versus IV Lorazepam in the Pre-hospital Treatment of Status Epilepticus by Paramedics Robert Silbergleit, MD Status Epilepticus Interventional 2011 Randomized III Adult
REGARDS Reasons for Geographic and Racial Differences in Stroke George. Howard, MD Cerebrovascular Disorders Epidemiology pre 2000 Cohort NA Adult
RHAPSODY (NN014) A Multi-Center, Phase 2 Study Using A Continual Reassessment Method To Determine The Safety And Tolerability Of 3K3A-APC In Combination With tPA, Mechanical Thrombectomy Or Both In Moderate To Severe Acute Ischemic Stroke Patrick D. Lyden, MD Stroke Ischemic Stroke Interventional 2017 Randomized II Adult
SAMMPRIS Stenting vs. Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis Marc I. Chimowitz, MBChB Stroke, Ischemic Transient Ischemic Attack Interventional 2013 Randomized III Adult
SCORE-IT The CTA Spot Sign Score in Acute Cerebral Hemorrhage. An ATACH-2 Ancillary study Jonathan Rosand, MD Stroke Observational Randomized Adult
SHINE Stroke Hyperglycemia Insulin Network Effort Trial Protocol: A Randomized, Blinded, Efficacy Trial of Standard vs. Intensive Hyperglycemia Management in Acute Stroke Karen C. Johnston, MD Stroke, Acute Ischemic Hyperglycemia Interventional 2018 Randomized III Adult
SMA-NN101 Spinal Muscular Atrophy Biomarkers Study in the Immediate Postnatal Period of Development Stephen J Kolb, MD, PhD Spinal Muscular Atrophy Observational 2015 NA NA Pediatric/Neonatal
SPARX Exploratory Study of Different Doses of Endurance Exercise in People with Parkinson's Disease Margaret Schenkman, PT, PhD Parkinson's Disease Interventional 2016 Randomized II Adult
SPS3 Secondary Prevention of Small Subcortical Strokes Trial Oscar Benavente, MD Cerebrovascular Accident Hypertension Interventional 2012 Randomized III Adult
STEADY-PD III Phase 3 Double-blind Placebo-controlled Parallel Group Study of Isradipine as a Disease Modifying Agent in Subjects With Early Parkinson Disease Tanya Simuni, MD, FAAN Parkinson's Disease Interventional 2018 Randomized III Adult
Stroke TeleRehab Telerehabilitation in the Home Versus Therapy In-Clinic for Patients With Stroke: An Assessor-blind, Randomized, Non-inferiority Trial Steven C. Cramer, MD Stroke Interventional 2018 Randomized I / II Adult
SURE-PD3 A Randomized, Double-blind, Placebo-controlled Trial of Urate-elevating Inosine Treatment to Slow Clinical Decline in Early Parkinson's Disease Michael A. Schwarzschild, MD, PhD Parkinson's Disease Interventional 2019 Randomized III Adult
TNK-S2B Phase 2B Study of Tenecteplase in Acute Ischemic Stroke Elliott Clarke Haley, MD Stroke Interventional 2009 Randomized II Adult
TOAST Low Molecular Weight Heparinoid, ORG 10172 (Danaparoid), and Outcome After Acute Ischemic Stroke: A Randomized Controlled Trial Harold P. Adams, MD Stroke Interventional 1997 Randomized III Adult
Topiramate-ALS Amitriptyline and Tamitriptyline and Topiramate in the Prevention of Childhood Migraine Trial Scott Powers, MD and Andrew Hershey, MD Migraine Amyotrophic Lateral Sclerosis Intervention pre 2000 Randomized III Pediatric
tPA AIS Tissue Plasminogen Activator for Acute Ischemic Stroke Steven R. Levine, MD Stroke, Ischemic Interventional 1994 Randomized III / IV Adult
VISP Vitamin Intervention for Stroke Prevention Randomized Controlled Trial James F. Toole, MD Stroke Interventional 2003 Randomized III Adult
WARCEF Warfarin Versus Aspirin in Reduced Cardiac Ejection Fraction Trial AShunichi Homma, MD Heart Disease Stroke Interventional 2014 Randomized III Adult