To support a cohort of new and well-trained, independent investigators from diverse backgrounds conducting Pain and/or Substance Use Disorder (SUD) research, in order to promote a diverse pool of available independent investigators working in research areas supported by the NIH Helping to End Addiction Long-term (HEAL) Initiative®.
Due Dates for New Applications
February 10, 2023; June 9, 2023; October 11, 2023
February 9, 2024; June 11, 2024; October 11, 2024
February 11, 2025
Due Dates for Resubmission Applications
November 9, 2023; March 11, 2024; July 11, 2024; November 12, 2024; March 11, 2025
U.S. citizens or permanent residents; research doctorate holders; individuals from diverse backgrounds
U.S. domestic institutions
This NOFO is part of the NIH HEAL Initiative®, an aggressive, trans-agency effort to speed scientific solutions to stem the national opioid public health crisis. The purpose of this NIH HEAL Initiative® Pathway to Independence Award (K99/R00) program is to support a cohort of new and well-trained, independent investigators from diverse backgrounds (e.g. see NOT-OD-20-031, Notice of NIH’s Interest in Diversity) conducting Pain and/or SUD research and assist with their transition to tenure-track or equivalent faculty positions and establishment of independent research programs, in order to promote a diverse pool of available independent investigators working in research areas supported by the NIH HEAL Initiative®. This program is intended to foster the development of creative, independent researchers who will help advance the mission of the NIH and of the NIH HEAL Initiative® in particular.
Applications appropriate for this NOFO may propose biomedical research across the spectrum of Pain and SUD research areas. It is expected that the proposed research be rigorously designed, executed, analyzed, and interpreted (NIH's Enhancing Reproducibility through Rigor and Transparency).
Applicants are strongly encouraged to consult with NIH scientific/research staff as early as possible before the due date when planning an application. Early contact provides an opportunity for NIH scientific/research staff to provide guidance on program scope and appropriateness of the proposed research and training for potential funding in response to this NOFO. NINDS program contacts are listed below; please refer to the Scientific/Research Contact(s) section of the NOFOs for program contacts in pain and SUD research areas of other NIH Institutes/Centers.
Salary and Research Costs
For mentored (K99 phase) candidates at an extramural institution, NINDS will provide up to $75,000 per year for salary support, plus fringe, and up to $20,000 for research support costs. For applicants with medical degrees who are licensed to practice, NINDS will provide up to $125,000 per year for salary support. Applicants must commit a minimum of 9 person months effort to the K99/R00 research during both phases of the award (Note: Neurosurgeons must commit a minimum of 6 person months effort to the K99/R00 research during both phases of the award).
For independent (R00 phase) candidates at an extramural institution, NINDS will provide up to $249,000 of support per year (total costs). This amount includes salary, fringe benefits, research costs, and applicable indirect costs. Applicants must obtain an offer for a tenure-track or equivalent position by the end of the K99 phase to be eligible for R00 support.
Not sure whether your research qualifies as a clinical trial or basic experimental study with humans?
Applicants are strongly advised to consult with NINDS program staff prior to submitting an application with human subjects to determine the appropriate funding opportunity. See the NIH definition of a clinical trial and NIH guidance for basic experimental studies with humans (pdf, 212 KB)for more information.