ONETOX - The Neural Exposome




ONETOX | Neural Exposome and Toxicology Programs


Graphical representation of exogenous, endogenous, and behavioral factors that influence neural systems and neural health outcomes.

It is widely acknowledged that most diseases and disorders cannot be attributed to genetic factors alone. Coined by Chris Paul Wild in 2005 (Wild, C.P. 2005 Cancer Epidemiol Biomarkers Prev. 14(8):1847-50), the term “exposome” describes the totality of internal and external exposures across the lifespan that affect human health. The “Neural Exposome” are those exposures that have an impact on neurological disease and disorders, and overall nervous system health. The exposures described in the exposome not only include environmental chemical and biological toxins, but also psychosocial factors and internal factors such as diet and the microbiome, and these exposures may occur anytime from in utero to late in life. A better understanding of how these exposomic factors interact with genes will lead to identifying more precise and effective intervention strategies, especially because many of the exposures are potentially modifiable.

The overall goal of ONETOX is to enhance basic, translational, and clinical NIH research on the effect of the neural exposome on nervous system diseases and disorders by fostering more collaborative research within the neuroscience research community. ONETOX provides information and tools to help break down barriers to research between different scientific disciplines which can be used to establish productive team science for targeted funding opportunities. Because of the large number and different kinds of exposures within the Neural Exposome that occur across the lifespan, ONETOX collaborates with many different Institutes and Centers across the NIH to obtain a full understanding of how these exposomic factors affect brain and nervous system health.


Resources and Tools


David A. Jett, Ph.D. | Director, ONETOX

Neel Dhruv, Ph.D. | Health Program Specialist

Amir Tamiz, Ph.D. | Director, Division of Translational Research

Funding Opportunities 

Neural Exposome Funding Opportunities

Neural Exposome Notices and Other Funding Announcements

News & Events

Request for Information on Interdisciplinary Research Opportunities that Bridge Neuroscience and Environmental Health Science

Tamiz AP, Koroshetz WJ, Dhruv NT, Jett DA. 2022. A focus on the neural exposome. Neuron. PMID: 35349785.

Neuroscience 2021: Environmental Factors in Alzheimer’s Disease and Related Dementias | November 9, 2021

Neuroscience 2021: Social Factors in Neurological Diseases and Disorders | November 10, 2021


Related Topics 

Comparative Toxicogenomic Database (CTD)
The Comparative Toxicogenomic Database (CTD) launched in 2004 is a well-known publicly available resource for curated data on the linkage between human exposures and how they influence genes, biology, and human health.

NeurotoxKB provides information on potential neurotoxicants that is compiled and manually curated along with supporting evidence from published scientific studies.

Environmental Neuroscience Reports:
The National Academies of Sciences Engineering Medicine Environmental Neuroscience: Advancing the Understanding of How Chemical Exposures Impact Brain Health and Disease: Proceedings of a Workshop 

Integrating the Science of Aging and Environmental Health Research: Proceedings of a Workshop