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Guidance Submitting Applications the Roadmap Molecular Libraries Assay Development High-Throughput Screening Program: PAR-08-024 Notice Number: NOT-RM-09-008 Key Dates Release Date: January 2, 2009 Issued The National Institute Neurological Disorders Stroke NINDS), http://www.ninds.nih.gov/), behalf the Roadmap Molecular Libraries Initiative. purpose this notice to provide additional guidance investigators preparing applications the Assay Development High-Throughput Screening Program PAR-08-024 http://grants.nih.gov/grants/guide/pa-files/PAR-08-024.html). Background: Roadmap Assay Development High Throughput Screening HTS) Program serves a key incubator funding development assay projects HTS will eligible advance the Molecular Libraries Probe Production Centers Network MLPCN; https://mli.nih.gov/mli/mlpcn/mlpcn-probe-production-centers/) completed. HTS-ready assays then screened a Network Center against Molecular Libraries Small Molecule Repository MLSMR; http://mli.nih.gov/mlsmr/index.php), promising small molecule hits further developed molecular probes. present, projects funded the Assay Development HTS Program eligible rapid entry the MLPCN Year 2 the R21 award. year 2 Investigators asked submit Fast Track request screening the Program Director is based their progress report the end Year 1 the award. Roadmap Molecular Libraries Project Team provides technical review these requests a monthly basis, placing emphasis project readiness the need probes the proposed target. Upon approval this Project Team projects immediately assigned a Network Screening Center implementation, the investigator awarded 25,000 direct costs) be used facilitating effective collaboration between assay provider the assigned Center the HTS probe development project. CLARIFICATION: the present notice, NIH advising applicants the PAR-08-024 Program they not need request Year 2 funding the R21 application order enter MLPCN their assay project after preparation completed funded Year 1 the award). R21 applications be limited a Year 1 request funding assay development to 100,000 direct costs), will still able enter MLPCN the assays HTS-ready using Fast Track request process described the preceding section. Upon approval this request the Project Team, investigators funded the R21 receive 25,000 direct costs) via Roadmap Supplement, be used previously described) establishing effective Investigator:Center collaboration. Inquiries Further information regarding eligibility the PAR-08-024 Program, information preparing Fast Track requests MLPCN entry, be obtained contacting Mark Scheideler, Ph.D., Program Director the Roadmap Assay Development HTS Fast Track Programs, the following email address: scheidelerm@ninds.nih.gov