University of Virginia, Charlottesville, VA
Dr. Jaideep Kapur has a long-standing interest in understanding the neurobiological mechanisms underlying prolonged self-sustaining seizures (i.e., status epilepticus). His laboratory studies rapid plasticity of GABA and glutamate-mediated neurotransmission, and also focuses on regulation of seizures by hormonal fluctuations. For this project, he proposes mapping the neuronal circuits that are active during frontal lobe seizures using tools and technologies developed by the NIH BRAIN Initiative. This work could potentially open novel targets for seizure therapy by neuromodulation, resection, or drug treatment.