K99/ R00 HEAL Initiative Advanced Postdoctoral-to-Independent Career Transition Award in PAIN and SUD Research

To support a cohort of new and well-trained independent investigators conducting Pain and/or Substance Use Disorder (SUD) research, in order to increase the independent investigator workforce in research areas supported by the NIH Helping to End Addiction Long-term (HEAL) Initiative®.

Program Announcement
K99/R00 Independent Clinical Trial Not Allowed - RFA-NS-22-022
K99/R00 Independent Basic Experimental Studies with Humans Required - RFA-NS-22-023

Due Dates for New Applications
February 10, 2023; June 9, 2023; October 11, 2023; February 9, 2024; June 11, 2024; October 11, 2024; February 11, 2025

Due Dates for Resubmission Applications
November 9, 2023; March 11, 2024; July 11, 2024; November 12, 2024; March 11, 2025

Institution Eligibility
U.S. domestic institutions

Additional Information

This NOFO is part of the NIH HEAL Initiative®, an aggressive, trans-agency effort to speed scientific solutions to stem the national opioid public health crisis. The overall goal of this NIH HEAL (Helping to End Addiction Long-term) Initiative® Advanced Postdoctoral-to-Independent Career Transition Award in Pain and substance use disorder (SUD) Research is to help ensure that a diverse pool of highly trained scientists is available to address the Nation's response to the ongoing opioid epidemic and assist with their transition to tenure-track or equivalent faculty positions and establishment of independent research programs. This program is intended to foster the development of creative, independent researchers who will help advance the mission of the NIH and of the NIH HEAL Initiative® in particular. 

Applications appropriate for this NOFO may propose biomedical research across the spectrum of Pain and SUD research areas. It is expected that the proposed research be rigorously designed, executed, analyzed, and interpreted (NIH Enhancing Reproducibility through Rigor and Transparency).

Applicants are strongly encouraged to consult with NIH scientific/research staff as early as possible before the due date when planning an application. Early contact provides an opportunity for NIH scientific/research staff to provide guidance on program scope and appropriateness of the proposed research and training for potential funding in response to this NOFO. NINDS program contacts are listed below; please refer to the Scientific/Research Contact(s) section of the NOFOs for program contacts in pain and SUD research areas of other NIH Institutes/Centers. 

The Importance of Project Originality and Project Ownership by the Candidate(pdf, 126 KB) 

Salary and Research Costs

For mentored (K99 phase) candidates at an extramural institution, NINDS will provide up to $75,000 per year for salary support, plus fringe, and up to $20,000 for research support costs. For applicants with medical degrees who are licensed to practice, NINDS will provide up to $125,000 per year for salary support. Applicants must commit a minimum of 9 person months effort to the K99/R00 research during both phases of the award (Note: Neurosurgeons must commit a minimum of 6 person months effort to the K99/R00 research during both phases of the award).

For independent (R00 phase) candidates at an extramural institution, NINDS will provide up to $249,000 of support per year (total costs). This amount includes salary, fringe benefits, research costs, and applicable indirect costs. Applicants must obtain an offer for a tenure-track or equivalent position by the end of the K99 phase to be eligible for R00 support.

See more information about NINDS requirements for transition to the independent (R00) phase(pdf, 123 KB).

Not sure whether your research qualifies as a clinical trial or basic experimental study with humans? 
Applicants are strongly advised to consult with NINDS program staff prior to submitting an application with human subjects to determine the appropriate funding opportunity. See the NIH definition of a clinical trial and NIH guidance for basic experimental studies with humans (pdf, 212 KB)for more information.


D.P. Mohapatra Ph.D. | Program Director, Division of Neuroscience 

Elizabeth Sypek, Ph.D. | Health Program Specialist, Division of Neuroscience