Outcomes Data

Funding Outcomes for NINDS R01 Applications

Training and Career Development Outcome Data

Funding Outcomes for NINDS R01 Applications

Each fiscal year (FY), NINDS establishes a payline for all percentiled R01 grants and funds all applications that score within that payline with very rare exception (FY15 payline: 14th percentile). Figure 1 illustrates all competing R01 applications, grants and bridge awards for FY 2015. The data shown represent three categories of investigators: experienced investigators who have had NIH grants in the past, New Investigators (NI) who previously have not had a substantial independent NIH research award, and Early Stage Investigators (ESI)  who are NIs and are within 10 years of completing their terminal research degree or residency training.   As part of the effort to maintain a consistent payline, NINDS also works to stabilize the number of R01 equivalent grants funded each year (Figure 2).

Figures 3 and 4 show new (Type 1) and renewal (Type 2) applications and awards respectively. Success rates for renewal applications are significantly higher than those for new applications (Table 1).

When resources are available, NINDS supports a limited number of applications with scores outside the payline. These include applications that are high priorities to NINDS; bridge awards to cover a known, productive lab during a brief period of funding uncertainty (Figure 5); and awards to assist in the transition to independence for investigators in early stages of their careers.  In recent years, NINDS has funded additional R01 applications from New (Figure 6) and Early Stage Investigators (Figure 7) with percentiles beyond the payline, based on funds available.  In accordance with NIH policy, NINDS aims to support R01s from these early career scientists at success rates equivalent to those of established investigators submitting new R01 applications. Figure 8 shows the number of experienced, New Investigator or Early Stage Investigator applications that received an award.

Figure 1 illustrates all competing R01 applications, grants and bridge awards for FY 2015
Figure 1. Competing applications, grants, and bridge awards for all investigators: experienced, new and early stage.  Cumulative data are shown for all competing R01 applications (green bars), awarded grants (R01 and R37; blue bars), and bridge awards (R56; red bars) for all categories of investigators in Fiscal Year 2015 (FY15).  Dashed line indicates the payline (14th percentile) for FY15.  Note:  Data include two applications that were not funded at the 4th and 9th percentile due to overlap with awarded R01s from the same investigators.

 

Number of R01 equivalent grants (R01, R23, R29, R37, and DP2 activity codes) funded by NINDS in fiscal years 1997-2015.
Figure 2. Number of R01 equivalent grants (R01, R23, R29, R37, and DP2 activity codes) funded by NINDS in fiscal years 1997-2015.

 

All new (Type 1) R01 applications (green bars), awarded grants (R01 and R37; blue bars), and bridge awards (R56; red bars) for FY15.
Figure 3: All new (Type 1) R01 applications (green bars), awarded grants (R01 and R37; blue bars), and bridge awards (R56; red bars) for FY15. 

 

All renewal (Type 2) R01 applications (green bars), awarded grants (R01 and R37; blue bars), and bridge awards (R56; red bars) for FY15.
Figure 4: All renewal (Type 2) R01 applications (green bars), awarded grants (R01 and R37; blue bars), and bridge awards (R56; red bars) for FY15. 

 

R01 Success rates for new and renewal applications.
Table 1: R01 Success rates for new and renewal applications. Source: NIH Report (https://report.nih.gov/success_rates/Success_ByActivity.cfm)

 

FY15 R01 applications (green bars), awarded grants (R01 and R37; blue bars), and bridge awards (R56; red bars) for experienced investigators, defined as those who have received previous R01-level funding from NIH.
Figure 5: FY15 R01 applications (green bars), awarded grants (R01 and R37; blue bars), and bridge awards (R56; red bars) for experienced investigators, defined as those who have received previous R01-level funding from NIH.

 

FY15 R01 applications (green bars), and awarded grants (R01 and R37; blue bars) for New Investigator applications. An application is eligible for `New Investigator’ status if all of the PIs on the application are New Investigators.
Figure 6: FY15 R01 applications (green bars), and awarded grants (R01 and R37; blue bars) for New Investigator applications. An application is eligible for `New Investigator’ status if all of the PIs on the application are New Investigators. New Investigators are defined as those who have NOT had previous R01-level funding from NIH.

 

FY15 R01 applications (green bars), awarded grants (R01 and R37; blue bars), and bridge awards (R56; red bars) for Early Stage Investigator applications.
Figure 7: FY15 R01 applications (green bars), awarded grants (R01 and R37; blue bars), and bridge awards (R56; red bars) for Early Stage Investigator applications. An application is eligible for ‘Early Stage Investigator’ status if all of the PIs on the application are Early Stage Investigators. Early Stage Investigators are defined as New Investigators within 10 years of completing their research training who have not had previous R01-level funding from NIH.

 

FY15 R01 applications (green bars), awarded grants (R01 and R37; blue bars), and bridge awards (R56; red bars) for Early Stage Investigator applications.
Figure 8: FY15 awards made to Early Stage Investigator (ESI; red bars), experienced (blue bars), or New Investigator (NI; grey bars) applications.

 

Training and Career Development Outcome Data

Mentored Career Development Awards

Outcomes for K08 and K23 Awardees

In May of 2012, NINDS completed an examination of several outcome and demographic measurements for NINDS K08 and K23 awardees. The specific cohort of awardees used is cited on each table.

Three outcome measures were examined:

1. Obtained an NIH R01 - the primary goal of the mentored K award is to develop a strong independent research program supported by NIH funding.

2. Obtained significant independent funding from any source (e.g. NIH, other U.S. Gov't., private foundation, pharmaceutical/biotech, etc.).

3. Published a peer reviewed original research paper (excludes reviews and case reports) between January 2010 and May 2012. This metric was used as an indicator of who was still involved in research two to seven years after the termination of his/her K award, regardless of funding activity.

In addition, we examined the impact of the NINDS K02 on R01 success among K08 and K23 awardees. The NINDS K02 is awarded to independent investigators who, following a period of successful mentored training, need additional skills, knowledge and preliminary data to compete successfully for an R01.

Finally, in late 2007, NIH instituted a policy that required that a certain number of early stage investigators (ESI) and/or new investigators (NI) obtain R01s. The result of this mandate is that paylines have been higher for ESI/NI investigators than for established investigators. We looked at how this change in policy influenced "time to first R01" for NINDS K08 and K23 awardees.

Outcomes for Pediatric Neurologist and Neurosurgeon K Awardees

In November of 2012, NINDS completed an examination of several outcome and demographic measurements for pediatric neurologist and neurosurgeon K02, K08, and K23 awardees. The specific cohort is cited in each table.

Three outcome measures were examined:

1. Obtained an NIH R01 - the primary goal of the mentored K award is to develop a strong independent research program supported by NIH funding.

2. Obtained significant independent funding from any source (e.g. NIH, other U.S. Gov't., private foundation, pharmaceutical/biotech, etc.).

3. Published a peer reviewed original research paper (excludes reviews and case reports) between January 2010 and November 2012. This metric was used as an indicator of who was still involved in research after termination of his/her K award, regardless of funding activity.

K Award Applicant Success Rates