CounterACT Researchers & Projects

CounterACT Researchers & Projects

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Abstracts, budgets, and contact information for all CounterACT-supported  projects are available via the NIH RePORTER database


Research Centers of Excellence (U54)

UAB Research Center of Excellence in Arsenicals
Mohammad Athar, PhD
University of Alabama at Birmingham
U54ES030246

UMDNJ/Rutgers University CounterACT Research Center of Excellence 
Jeffrey D. Laskin, PhD
RBHS-School of Public Health
U54AR055073

Novel Anticonvulsant and Neuroprotective Therapies for TETS and OP Intoxication 
Pamela J. Lein, PhD
University of California, Davis
U54NS079202

Advancing Novel Cyanide Countermeasures
Calum MacRae, MD, PhD
Brigham and Women's Hospital
U54NS112107

Development of Antidotes for Toxic Gases
Carl W. White, MD
University of Colorado, Denver
U54ES027698

 


Individual Research Projects (U01)

Extracellular RNA as Therapeutic Target After Toxic Chemical Inhalation
Aftab Ahmad, PhD
University of Alabama, Birmingham
U01ES025069

Targeting Cardiopulmonary Calpains to Mitigate Toxicity of Halogen Gases
Shama Ahmad, PhD
University of Alabama, Birmingham
U01ES028182

Blocking Arsenicals-induced Cutaneous Injury
Mohammad Athar, PhD
University of Alabama, Birmingham
U01NS095678

Development of the Vitamin B12 Analog Cobinamide as a Hydrogen Sulfide Antidote 
Gerry R. Boss, MD
University of California, San Diego
U01NS087964

Sodium Tetrathionate as a Cyanide Antidote 
Gerry R. Boss, MD 
University of California, San Diego
U01NS105057

Antiglutamatergic Therapy to Protect the Immature Brain Against Nerve Agents 
Maria F.M. Braga, DDS, PhD
Henry M Jackson Foundation for the Advancement of Military Medicine
U01NS102135

Identification of Novel Brain-Penetrating Phenoxyalkyl Pyridinium Oxime Countermeasures
Janice E. Chambers, PhD
Mississippi State University
U01NS107127

Optimization of AEOL10150 Treatment of Sulfur Mustard-Induced Lung Toxidrome in a Pig Model 
Brian J. Day, PhD  
National Jewish Health
U01ES029430

Novel Counteract Agents to Reduce Mortality and Morbidity Following Organophosphate Status Epilepticus 
Robert J. DeLorenzo, MPH, MD, PhD
Virginia Commonwealth University
U01NS105058

Intralipid: A Novel Frontline Countermeasure for Brodifacoum Poisoning
Douglas L. Feinstein, PhD  
University of Illinois, Chicago
U01NS083457

Neurosteroids as a Standard Medical Countermeasure for OP Poisoning 
Kelvin W. Gee, PhD    
University of California, Irvine
U01NS102131

Improved Therapeutics for the Resurrection of the Aged Form of  Acetylcholinesterase 
Christopher Hadad, PhD    
Ohio State University
U01NS112101

Methylene Blue an an Antidote Against Hydrogen Sulfide Intoxication
Philippe Haouzi, MD
Pennsylvania State University Hershey Medical Center
U01NS097162

Cucurbituril Type Receptors as Sequestration Agents for Drugs of Abuse
Lyle D. Isaacs, PhD
University of Maryland, College Park
R01GM132345

Immunotherapy to Counteract Lethal Doses of Carfentanil
Kim Janda, PhD
Scripps Research Institute
U01DA046323

TIE2 Activation for the Treatment of Chemical-induced Acute Lung Injury
Christopher D. Kontos, PhD
Duke University
U01ES028187

Developing Drugs to Mitigate Parathion Intoxication
Jeffrey D. Laskin, PhD
RBHS-School of Public Health
U01NS079249

Advanced Development of Drugs to Mitigate Parathion Intoxication
Jeffrey D. Laskin, PhD
RBHS-School of Public Health
U01NS108956

Functional Genomics of Chemical-induced Acute Lung Injury 
George D. Leikauf, PhD    
University of Pittsburgh, Pittsburgh
U01ES015675

Amelioration of Vesicant-induced Skin Injury by High Dose 25-Hydroxyvitamin D 
Kurt Lu, MD
Northwestern University, Chicago 
U01AR064144

Bromine Inhalation Induced Lung Injury: Novel Mechanisms and Treatment Strategies
Sadis Matalon, PhD
University of Alabama, Birmingham
U01ES026458

CIALIS® Reverses Halogen Induced Injury to Pregnant Animals and Their Offspring
Sadis Matalon, PhD
University of Alabama, Birmingham
U01ES027697

Neuroprotective Effects of AEOL 10150 Against Organophosphate Toxicity
Manisha N. Patel, PhD
University of Colorado, Denver
U01NS083422

Nitrite Dependent Protection Against Cl2 Gas Toxicity Role of Chlorinated Lipids
Rakesh Patel, PhD
University of Alabama, Birmingham
U01ES023759

Cyanide/Azide Detoxification by New Cobalt Complexes and NO Donors
James Peterson, PhD
University of Pittsburgh at Pittsburgh
U01NS109793

Accelerate AChE Reactivator Design by Mechanistic Neutron Scattering Studies
Zoran Radic, PhD
University of California, San Diego
U01NS083451

Neurosteroid Treatment for OP Intoxication
Doodipala S. Reddy, PhD
Texas A&M University Health Science Center
U01NS083460

Development of IM Formulation of (2S,3S)-SPD for Nerve Agent Seizures
Michael A. Rogawski, MD, PhD
University of California, Davis
U01NS112102

Thioredoxin Mimicry: Novel Treatment of Toxicant-mediated Inhalational Lung Injury
Garry J. Southan, PhD
Radikal Therapeutics, Inc.
U01ES024097

Molecular Imaging of Chemical Threats and Countermeasures
Charles M. Thompson, PhD
University of Montana
U01NS092495

Anticholinergic and Antiepileptic Therapies for Chlorine Toxicity
Livia A. Veress, MD
University of Colorado, Denver
U01NS102101

 


Small Business Innovation Research (SBIR)

Cyanalyzer a Medical Laboratory Device for the Rapid Diagnosis of Cyanide Exposure 
Randy Jackson, PhD
Seacoast Science, Inc.
R44NS097066

Zwitterionic Oxime (RS194B) to Reverse Advanced Symptoms and Lethality of Organophosphate Pesticide Exposure
Yvonne Rosenberg, PhD
Plantvax, Inc.
R43NS108879

 


Exploratory/Developmental Projects (R21)

Examining Novel Fentalogs: Pharmacological Characteristics and Reversibility
Jessica P. Anand, PhD
University of Michigan, Ann Arbor
R03DA048129

MicroRNAs in Skin Inflammation and Wounding by Mustard Vesicants
Rajesh Agarwal, PhD
University of Colorado, Denver
R21AR074929

Targeting the Glutamatergic System to Counteract Soman Toxicity in Immature Rats
Maria F.M. Braga, DDS, PhD
Henry M Jackson Foundation for the Advancement of Military Medicine
R21NS094131

Antidotes Against Hydrochloric Acid-induced Chronic Lung Injury
John D. Catravas, PhD
Old Dominion University
R21ES029309

Antidotes Against Mustard-Induced Chronic Lung Injury
John D. Catravas, PhD
Old Dominion University
R21ES030528

Identification of Novel Brain-Penetrating Oxime Antidotes for Phorate Toxicity
Janice E. Chambers, PhD
Mississippi State University
R21NS108954

Effects of Acute Administration of the Phenothiazinium Chromophore Methylene Blue During Life Threatening Cyanide Intoxication
Philippe Haouzi, MD
Pennsylvania State University Hershey Medical Center
R21NS098991

Treatment of Persistent Chlorine-induced Small Airway Disease 
Gary W. Hoyle, PhD   
University of Louisville
R21ES027391

Mitochondrial Targeted Biofuels as Countermeasures Against Chemical Threats 
Todd J. Kilbaugh, MD   
Children's Hospital of Philadelphia
R21NS103826

The Carboxylesterase Knockout Mouse as a Model to Evaluate the Efficacy of Delayed Medical Countermeasures Against Soman Exposure 
Lucy Lange, PhD    
Geneva Foundation
R21NS103820

Soman-induced neuropathology in Gottingen minipig: large animal model assessment for MCM 
Lucy Lange, PhD    
Geneva Foundation
R21NS110556

Identifying Molecular Targets for the Proconvulsant Activity of TETS 
Pamela J. Lein, PhD
University of California, Davis
R21NS110647

Formulation and Encapsulation of Enzyme Countermeasures Against Organophosphorus Compounds
Thomas J. Magliery, PhD
Ohio State University
R21NS084899

Amelioration of Soman-induced Neuropathology with NAAG-related Compounds
Joseph T. McCabe, PhD
Henry M Jackson Foundation for the Advancement of Military Medicine
R21NS089488

Nanomedicine Approach to Counteract Acrolein-Induced Blindness and Toxicity to the Eye
Rajiv R. Mohan, PhD
University of Missouri-Columbia
R21EY030233

Turbo Eye Drops to Treat Ocular Toxicity and Blindness from Sulfur Mustard
Rajiv R. Mohan, PhD
University of Missouri-Columbia
R21EY030234

Computationally Designed Stable Artificial Phosphotriesterases for Detoxification of Organophosphorus Agents
Jin K. Montclare, PhD
New York University
R21NS103831

Microneedles for Emergency Treatment of Synthetic Opioid Overdose
Roger J. Narayan, MD, PhD
North Carolina State University, Raleigh
R21DA040916

An Approach Toward Antidotes for Phosphine
Linda Pearce, PhD
University of Pittsburgh, Pittsburgh
R21ES029310

New Chelating (decorporating) Agents for Azide
Linda Pearce, PhD
University of Pittsburgh, Pittsburgh
R21NS098989

Overlay Independent X-ray Data Analysis for Enhanced Oxime OP-ChE Reactivation
Zoran Radic, PhD
University of California, San Diego
R21NS098998

Epigenetic Attenuation of Long-term Effects of Nerve Agents
Doodipala S. Reddy, PhD
Texas A&M University Health Science Center
R21NS099009

Phosgene Oxime Cutaneous Toxicity and Mechanisms to Identify Therapeutic Targets
Neera Tewari-Singh, PhD
University of Colorado, Denver
R21AR073544

Toxin-specific and Symptomatic Drugs in Combination with Novel Neuroprotectants Effectively Counteract DFP-induced Long-term Neurotoxicity
Thimmasettappa Thippeswamy, PhD
Iowa State University
R21NS099007

Saracatinib Mitigates OP nerve agent-induced Long-term Neurotoxicity
Thimmasettappa Thippeswamy, PhD
Iowa State University
R21NS110648

 


Contracts, Inter-Agency Agreements, and Other Resources

CounterACT Preclinical Development Facility (CPDF) 
Carol Green, PhD, DABT
SRI International
N01NS62369


Interagency Agreements (IAAs) between the National Institutes of Health and the Department of Defense
Chemicals Affecting Skin, Eyes & Mucous Membranes - Toxic Vesicants and Industrial Chemicals
Chemicals Affecting the Nervous System - Anticonvulsants and Neuroprotectants
Cyanide Diagnostics and Efficacy Testing of Next Generation Cyanide Antidotes
Chemicals Affecting the Respiratory Tract - Pulmonary Toxicants
James F. Dillman, PhD

U.S. Army Medical Research Institute of Chemical Defense