Current CounterACT Researchers & Projects

 

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Select project titles to get information on the abstracts, budgets, publications, patents, and contact information associated with each CounterACT-supported  grant from the NIH RePORTER database.

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Grant Type Toxidrome (category) Title PI / Project Lead Institution
K01 Ultra-potent synthetic opioid Investigation into nTS mu opioid receptor mechanisms contributing to fentanyl-induced cardiorespiratory depression RUYLE, BRIAN C WASHINGTON UNIVERSITY
R01 Ultra-potent synthetic opioid Genetic Variation of Ultra-Potent Synthetic Opioid Sensitivity in Mice BUBIER, JASON A JACKSON LABORATORY
R01 Ultra-potent synthetic opioid Mechanism and Countermeasure of Carfentanil-induced Respiratory Disorder and Death XU, FADI LOVELACE BIOMEDICAL RESEARCH INSTITUTE
R01 Ultra-potent synthetic opioid Investigating the mechanistic consequences of fentanyl-induced hypoxia and cardiorespiratory collapse GARCIA, ALFREDO J UNIVERSITY OF CHICAGO
R01 Ultra-potent synthetic opioid Development of computational and AI/ML tools to accelerate discovery of vaccines and antibodies against nitazenes and fentanyl analogs PRAVETONI, MARCO UNIVERSITY OF WASHINGTON
R01 Pulmonary Agent Characterizing chemical threat agent exposures using a lung-on-a-chip platform and multi-omic analysis of common pathophysiological mechanisms MURPHY, SEAN VINCENT WAKE FOREST UNIVERSITY HEALTH SCIENCES
R01 Pulmonary Agent Pulmonary Pathophysiologic Mechanisms of Chloropicrin and Phosgene VAN WINKLE, LAURA S UNIVERSITY OF CALIFORNIA AT DAVIS
R01 Pulmonary Agent Pathophysiological Mechanisms of Chemical-Induced Acute Lung Injury LEIKAUF, GEORGE DOUGLAS UNIVERSITY OF CINCINNATI
R01 Pulmonary Agent Lipid and metabolic mechanisms responsible for phosgene and phosphorus trichloride exposure toxicity FORD, DAVID A SAINT LOUIS UNIVERSITY
R01 Pulmonary Agent Vascular injury and repair predict divergent late onset cardiovascular morbidities after chlorine and sulfur mustard exposure VERESS, LIVIA AGNES UNIVERSITY OF COLORADO DENVER
R01 Pulmonary Agent Electrophilic Halogenated Fatty Aldehydes Target Erythrocytes to Mediate Halogen Toxicity FORD, DAVID A SAINT LOUIS UNIVERSITY
R01 Pulmonary Agent Identifying mechanisms of lung toxicity from skin exposure to vesicants TEWARI-SINGH, NEERA HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCES
R01 Pulmonary Agent Role of proteolytic extracellular vesicles in halogen gas dependent chronic lung injury PATEL, RAKESH P UNIVERSITY OF ALABAMA AT BIRMINGHAM
R01 Pulmonary Agent Mast Cell Activation as a Common Mechanism of Pulmonary Toxicity by Chemical Threat Agents BROWN, JARED MICHAEL UNIVERSITY OF COLORADO DENVER
R01 Pulmonary Agent Preserving lung integrity and harnessing inflammation to treat vesicant-induced lung injury CAI, CHUANXI UNIVERSITY OF VIRGINIA
R01 Pulmonary Agent Studying The Mechanisms of Delayed Lung Injury Post-Arsenical Exposures SUROLIA, RANU UNIVERSITY OF ALABAMA AT BIRMINGHAM
R01 Vesicating Agent The mechanism of vesicant-induced ocular injury GORBATYUK, MARINA WAKE FOREST UNIVERSITY HEALTH SCIENCES
R01 Vesicating Agent Understanding Mustard Vesicants Distribution and Toxicity in the Eye Using In Vivo and In Silico Models TEWARI-SINGH, NEERA MICHIGAN STATE UNIVERSITY
R01 Vesicating Agent The Role of Master Epigenetic Regulators in Ocular Chemical Injury ZHANG, WENBO UNIVERSITY OF TEXAS MED BR GALVESTON
R01 Vesicating Agent Immune Mechanisms of Chronic Ocular Damage after Acute Exposure to Nitrogen Mustard CHEN, YIHE SCHEPENS EYE RESEARCH INSTITUTE
R01 Vesicating Agent Mitochondria and Mustard Damage at the Ocular Surface FINI, M ELIZABETH TUFTS MEDICAL CENTER
R01 Vesicating Agent Pathophysiology of Chronic and Delayed Mustard Gas Keratopathy DJALILIAN, ALI R UNIVERSITY OF ILLINOIS AT CHICAGO
R01 Vesicating Agent Soluble epoxide hydrolase and epoxide fatty acid involvement in corneal injury after ammonia exposure: Mechanisms of injury and potential therapeutics using sEH inhibitors and biostable EpFA mimics. WATSKY, MITCHELL A AUGUSTA UNIVERSITY
R01 Vesicating Agent Single cell determinants of corneal injury progression following mustard exposure MCNUTT, PATRICK MICHAEL WAKE FOREST UNIVERSITY HEALTH SCIENCES
R01 Vesicating Agent Corneal and Schwann cell mechanisms in vesicant injury MOHAN, ROYCE UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
R01 Vesicating Agent The Role of Sirt6 in Acrolein-Induced Ocular Injury LIU, HUA UNIVERSITY OF TEXAS MED BR GALVESTON
R01 Pulmonary Agent Mitochondrial DNA Injury is a Key Contributor to the Development of Chemical Lung Injury MATALON, SADIS UNIVERSITY OF ALABAMA AT BIRMINGHAM
R01 Ultra-potent synthetic opioid µ-opioid receptor activation of the carotid body mitigates OIRD by fentanyl PRABHAKAR, NANDURI R UNIVERSITY OF CHICAGO
R01 Nerve Agent Mechanisms of Neurodegeneration in a Nerve Agent Model THIPPESWAMY, THIMMASETTAPPA IOWA STATE UNIVERSITY
R01 Nerve Agent MALDI Imaging of Acute Organophosphate Exposure in KIKO Mice TRESSLER, CAITLIN JOHNS HOPKINS UNIVERSITY
R01 Nerve Agent Impaired Sleep as a Target for Intervention Following Acute Organophosphate Intoxication ANACLET, CHRISTELLE UNIVERSITY OF CALIFORNIA AT DAVIS
R21 Ultra-potent synthetic opioid Functional efficacy of cannabidiol in modulating the adverse effects of heroin in primates. KO, MEI-CHUAN UNIVERSITY OF PITTSBURGH AT PITTSBURGH
R21 Ultra-potent synthetic opioid Macrocyclic Arenes as Sequestrants for Drugs of Abuse ISAACS, LYLE D UNIV OF MARYLAND, COLLEGE PARK
R21 Ultra-potent synthetic opioid Cardiorespiratory Pharmacodynamics of Fentanyl-Xylazine HEERDT, PAUL MARK YALE UNIVERSITY
R21 Ultra-potent synthetic opioid Xylazine and fentanyl effects on rat breathing, metabolism, and thermoregulation COTTEN, JOSEPH F MASSACHUSETTS GENERAL HOSPITAL
R21 Ultra-potent synthetic opioid Fentanyl and Xylazine Interactions: Toxicity Produced by Tranq-Dope SMITH, MARK A DAVIDSON COLLEGE
R21 Pulmonary Agent Defining molecular target of arsine gas-induced acute kidney injury and associated morbidity SRIVASTAVA, RITESH KUMAR UNIVERSITY OF ALABAMA AT BIRMINGHAM
R21 Pulmonary Agent Electrophilic Fatty Acids Reduce Chlorine-Lung Toxicity via Inhibition of Macrophage Activation GOW, ANDREW J RUTGERS BIOMEDICAL AND HEALTH SCIENCES
R21 Pulmonary Agent Medical countermeasures to chlorine exposure based on GABA(A) receptor targeting ARNOLD, ALEXANDER UNIVERSITY OF WISCONSIN MILWAUKEE
R21 Vesicating Agent Extracellular Vesicles derived from Mesenchymal Stem Cells as an Effective Medical Countermeasure against Mustard Induced Ocular Injury LEE, RYANG HWA TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR
R21 Vesicating Agent Antioxidant Eye Wash Formulations to Counter Ocular Chemical Threats LEBRUN, STEWART LEBRUN LABS, LLC
R21 Vesicating Agent Tissue Hypoxia and Topical Oxygen Therapy in Ocular Mustard Gas Injury YIN, JIA SCHEPENS EYE RESEARCH INSTITUTE
R21 Vesicating Agent Cytoprotective and Pro-regenerative Neuropeptide as Countermeasure to Mustard Gas Ocular Damage CHEN, YIHE SCHEPENS EYE RESEARCH INSTITUTE
R21 Vesicating Agent DSP nanoparticles for treating nitrogen mustard induced corneal injury XU, QINGGUO VIRGINIA COMMONWEALTH UNIVERSITY
R21 Vesicating Agent Targeting Corneal Schwann cells to counteract against toxin injury MOHAN, ROYCE UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
R21 Nerve Agent Converting human butyrylcholinesterase into a metalloenzyme for catalytic hydrolysis of organophosphates SHAFAAT, HANNAH S UNIVERSITY OF CALIFORNIA LOS ANGELES
R21 Nerve Agent High-Throughput in Vivo Discovery of Novel Countermeasures Against Organophosphate-Induced Seizure and Status Epilepticus Using Zebrafish MCGRAW, CHRISTOPHER NORTHWESTERN UNIVERSITY AT CHICAGO
R21 Nerve Agent The role of adaptive immunity in organophosphate induced CNS injury ABDULLAH, LAILA ROSKAMP INSTITUTE, INC.
R21 Nerve Agent Novel behavioral screening tool for therapeutics against organophosphorus agents COLLINS, EVA-MARIA SCHOETZ SWARTHMORE COLLEGE
R21 Nerve Agent Inhibiting mPGES-1 as a countermeasure to mitigate organophosphate-induced neurotoxicity JIANG, JIANXIONG UNIVERSITY OF TENNESSEE HEALTH SCI CTR
R21 Nerve Agent Inflammation and white matter microstructural alterations after OP exposure MARINI, ANN M HENRY M. JACKSON FDN FOR THE ADV MIL/MED
R21 Anticoagulant Development of novel anticoagulant antidotes using zebrafish SHAVIT, JORDAN A UNIVERSITY OF MICHIGAN AT ANN ARBOR
R34 Vesicating Agent The Role of Macrophages in Vesicant Skin Injury and Repair KOH, TIMOTHY J UNIVERSITY OF ILLINOIS AT CHICAGO
R34 Vesicating Agent Oxidized lipids and microvesicle particles as effectors for chemical threats to skin TRAVERS, JEFFREY B WRIGHT STATE UNIVERSITY
R34 Vesicating Agent Explant human skin perfusion model to study mechanisms of chemical injury and mitigation EJAZ, ASIM UNIVERSITY OF PITTSBURGH AT PITTSBURGH
R34 Vesicating Agent Coordinated cytoskeletal and cell adhesion dynamics in vesicant induced skin injury WU, XIAOYANG UNIVERSITY OF CHICAGO
R34 Vesicating Agent Integrated spatial omics to elucidate conserved inflammatory mechanisms of vesicant-induced skin injury PRIDEAUX, BRENDAN UNIVERSITY OF TEXAS MED BR GALVESTON
R56 Vesicating Agent Skin cell heterogeneity in sensitivity to mustard-induced cell death ANDERSEN, BOGI UNIVERSITY OF CALIFORNIA-IRVINE
R56 Ultra-potent synthetic opioid Combining Experiments, Simulations, and AI to Interrogate the Pharmacology of Fentanyl and Nitazene Derivatives SHEN, JANA UNIVERSITY OF MARYLAND BALTIMORE
R56 Pulmonary Agent Targeting the endocannabinoid signaling in chemical threat agents-induced lung injury NAGRE, NAGARAJA OLD DOMINION UNIVERSITY
R56 Vesicating Agent Mechanistic Understanding of Mustard Gas Toxicity in the Retina using a Minipig Model CHAURASIA, SHYAM SUNDER MEDICAL COLLEGE OF WISCONSIN
R56 Metabolic/Cellular Poison Mechanisms of Cyanide-Induced Neurotoxicity and Purine Dysregulation NATH, ANJALI BETH ISRAEL DEACONESS MEDICAL CENTER
U01 Vesicating Agent Optimization of Novel Molecular Target-based Drugs for Arsenical Skin Injury ATHAR, MOHAMMAD UNIVERSITY OF ALABAMA AT BIRMINGHAM
U01 Pulmonary Agent Novel lead compound advancement for mitigating halogen-induced mortality and morbidity. AHMAD, SHAMA UNIVERSITY OF ALABAMA AT BIRMINGHAM
U01 Vesicating Agent Turbo Eye Drops to Treat Ocular Toxicity and Blindness from Sulfur Mustard MOHAN, RAJIV RAVINDRA UNIVERSITY OF MISSOURI-COLUMBIA
U01 Vesicating Agent First Aid Medicine to Treat Vesicant Induced Corneal Injury CHANDLER, HEATHER OHIO STATE UNIVERSITY
U01 Nerve Agent Novel pediatric anticonvulsants for nerve agents REDDY, DOODIPALA SAMBA TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR
U01 Nerve Agent Saracatinib and 1400W Counteract Nerve Agents-Induced Long-Term Neurotoxicity THIPPESWAMY, THIMMASETTAPPA IOWA STATE UNIVERSITY
U01 Nerve Agent Antiglutamatergic Therapy to Protect the Brain Against Nerve Agents BRAGA, MARIA F HENRY M. JACKSON FDN FOR THE ADV MIL/MED
U01 Nerve Agent Optimization of Substituted Phenoxyalkyl Pyridinium Oximes as Therapies for Organophosphate Poisoning CHAMBERS, JANICE ELAINE MISSISSIPPI STATE UNIVERSITY
U01 Anticoagulant Optimization of Bile Sequestrants to Treat Superwarfarin Poisoning FEINSTEIN, DOUGLAS L UNIVERSITY OF ILLINOIS AT CHICAGO
U2C Vesicating Agent Wake Forest University Vesicant Exposure Resource and Coordination Core MCNUTT, PATRICK MICHAEL WAKE FOREST UNIVERSITY HEALTH SCIENCES
U54 Vesicating Agent Rutgers University CounterACT Center of Excellence LASKIN, JEFFREY D RUTGERS BIOMEDICAL AND HEALTH SCIENCES
U54 Vesicating Agent Barrier Damage and The Immune CascadeNorthwestern University CounterACT Center of Excellence (NUCCX) LU, KURT NORTHWESTERN UNIVERSITY AT CHICAGO
U54 Nerve Agent UC Davis CounterACT Center of Excellence: Developing Therapeutic Strategies for Mitigating the Chronic Neurological Consequences of Acute Organophosphate Intoxication LEIN, PAMELA J UNIVERSITY OF CALIFORNIA AT DAVIS
UG3 Vesicating Agent Development of small molecule inhibitors as anti-inflammatory agents and antidotes for arsenicals AUGELLI-SZAFRAN, CORINNE ELIZABETH UNIVERSITY OF ALABAMA AT BIRMINGHAM
UG3 Vesicating Agent Synthetic Melanin for Accelerating Wound Repair LU, KURT NORTHWESTERN UNIVERSITY AT CHICAGO
UG3 Pulmonary Agent Identification and optimization of medical countermeasures for phosgene inhalation injuries ACHANTA, SATYANARAYANA DUKE UNIVERSITY
UG3 Vesicating Agent Fenofibrate microemulsion for treating nitrogen mustard induced corneal injury XU, QINGGUO VIRGINIA COMMONWEALTH UNIVERSITY
UG3 Metabolic/Cellular Poison Platinum Based Countermeasures and Combinations with Protective Agents DAVISSON, VINCENT JO PURDUE UNIVERSITY
UG3 Nerve Agent Novel Anticonvulsants for Nerve Agents and Refractory Status Epilepticus REDDY, DOODIPALA SAMBA TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR
UH3 Nerve Agent Identification and optimization of verapamil as a novel neuroprotective and anti-inflammatory agent for reducing long-term neurological morbidities following organophosphate-induced status epilepticus DESHPANDE, LAXMIKANT S VIRGINIA COMMONWEALTH UNIVERSITY
UH3 Nerve Agent Long-acting aldicarb hydrolase as a medical countermeasure for aldicarb poisoning ZHENG, FANG UNIVERSITY OF KENTUCKY