Current CounterACT Researchers & Projects

 

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Select project titles to get information on the abstracts, budgets, publications, patents, and contact information associated with each CounterACT-supported  grant from the NIH RePORTER database.

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Grant Type Toxidrome (category) Title PI / Project Lead Institution
UG3 Nerve Agent Identification and optimization of verapamil as a novel neuroprotective and anti-inflammatory agent for reducing long-term neurological morbidities following organophosphate-induced status epilepticus DESHPANDE, LAXMIKANT S VIRGINIA COMMONWEALTH UNIVERSITY
UG3 Nerve Agent Long-acting aldicarb hydrolase as a medical countermeasure for aldicarb poisoning ZHENG, FANG UNIVERSITY OF KENTUCKY
UG3 Vesicating Agent Development of small molecule inhibitors as anti-inflammatory agents and antidotes for arsenicals AUGELLI-SZAFRAN, CORINNE ELIZABETH SOUTHERN RESEARCH INSTITUTE
U54 Metabolic/Cellular Poison Advancing Novel Cyanide Countermeasures MACRAE, CALUM A BRIGHAM AND WOMEN'S HOSPITAL
U54 Nerve Agent UC Davis CounterACT Center of Excellence: Developing Therapeutic Strategies for Mitigating the Chronic Neurological Consequences of Acute Organophosphate Intoxication LEIN, PAMELA J UNIVERSITY OF CALIFORNIA AT DAVIS
U54 Vesicating Agent Rutgers University CounterACT Center of Excellence LASKIN, JEFFREY D RUTGERS BIOMEDICAL AND HEALTH SCIENCES
U54 Vesicating Agent Barrier Damage and The Immune CascadeNorthwestern University CounterACT Center of Excellence (NUCCX) LU, KURT NORTHWESTERN UNIVERSITY AT CHICAGO
U54 Vesicating Agent UAB Research Center of Excellence in Arsenicals ATHAR, MOHAMMAD UNIVERSITY OF ALABAMA AT BIRMINGHAM
U01 Anticoagulant Optimization of Bile Sequestrants to Treat Superwarfarin Poisoning FEINSTEIN, DOUGLAS L UNIVERSITY OF ILLINOIS AT CHICAGO
U01 Metabolic/Cellular Poison Optimization of a Combined Drug and Delivery Device for Treatment of Cyanide Poisoning PATTERSON, STEVEN E UNIVERSITY OF MINNESOTA
U01 Nerve Agent Novel Counteract Agents To Reduce Mortality And Morbidity Following Organophosphate Status Epilepticus DESHPANDE, LAXMIKANT S VIRGINIA COMMONWEALTH UNIVERSITY
U01 Nerve Agent Advanced Development of Drugs to Mitigate Parathion Intoxication LASKIN, JEFFREY D RUTGERS BIOMEDICAL AND HEALTH SCIENCES
U01 Nerve Agent Novel Antibody-Oxime Pairing to Reduce Circulating Organophosphate Levels. THOMPSON, CHARLES MARK HUMAN BIOMOLECULAR RESEARCH INSTITUTE
U01 Nerve Agent Novel pediatric anticonvulsants for nerve agents REDDY, DOODIPALA SAMBA TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR
U01 Nerve Agent Novel Water-Soluble Adjunct Anticonvulsants for Nerve Agents REDDY, DOODIPALA SAMBA TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR
U01 Nerve Agent Saracatinib and 1400W Counteract Nerve Agents-Induced Long-Term Neurotoxicity THIPPESWAMY, THIMMASETTAPPA IOWA STATE UNIVERSITY
U01 Nerve Agent Antiglutamatergic Therapy to Protect the Brain Against Nerve Agents BRAGA, MARIA F HENRY M. JACKSON FDN FOR THE ADV MIL/MED
U01 Nerve Agent Optimization of Substituted Phenoxyalkyl Pyridinium Oximes as Therapies for Organophosphate Poisoning CHAMBERS, JANICE ELAINE MISSISSIPPI STATE UNIVERSITY
U01 Pulmonary Agent Optimization of AEOL10150 treatment of sulfur mustard-induced lung toxidrome in a pig model DAY, BRIAN J NATIONAL JEWISH HEALTH
U01 Pulmonary Agent Advanced TRPA1 Inhibitor for the Treatment of Chlorine Inhalation Injury JORDT, SVEN-ERIC DUKE UNIVERSITY
U01 Pulmonary Agent Antidotes against HCI-induced chronic lung injury CATRAVAS, JOHN D OLD DOMINION UNIVERSITY
U01 Pulmonary Agent Novel lead compound advancement for mitigating halogen-induced mortality and morbidity. AHMAD, SHAMA UNIVERSITY OF ALABAMA AT BIRMINGHAM
U01 Pulmonary Agent Identification of AMD3100 (Plerixafor) as a potential lead compound for chlorine toxicity AGGARWAL, SAURABH UNIVERSITY OF ALABAMA AT BIRMINGHAM
U01 Ultra-potent synthetic opioid Development of Agents for Synthetic Opioid Overdose PRISINZANO, THOMAS EDWARD UNIVERSITY OF KENTUCKY
U01 Ultra-potent synthetic opioid Antibody-based countermeasures against fentanyl and its analogues PRAVETONI, MARCO UNIVERSITY OF WASHINGTON
U01 Vesicating Agent Translation of novel and repurposed drugs to address the acute and late effects of mustard exposure LU, KURT NORTHWESTERN UNIVERSITY AT CHICAGO
U01 Vesicating Agent Targeted Therapeutic Approaches to Counteract Toxicity from Phosgene Oxime Skin Exposure TEWARI-SINGH, NEERA MICHIGAN STATE UNIVERSITY
U01 Vesicating Agent Optimization of Novel Molecular Target-based Drugs for Arsenical Skin Injury ATHAR, MOHAMMAD UNIVERSITY OF ALABAMA AT BIRMINGHAM
U01 Vesicating Agent Dexamethasone as an Effective Therapy for Ocular Injuries by Vesicating Agents. AGARWAL, RAJESH UNIVERSITY OF COLORADO DENVER
U01 Vesicating Agent Turbo Eye Drops to Treat Ocular Toxicity and Blindness from Sulfur Mustard MOHAN, RAJIV RAVINDRA UNIVERSITY OF MISSOURI-COLUMBIA
U01 Vesicating Agent First Aid Medicine to Treat Vesicant Induced Corneal Injury CHANDLER, HEATHER OHIO STATE UNIVERSITY
R56 Pulmonary Agent Mast Cell Activation as a Common Mechanism of Pulmonary Toxicity by Chemical Threat Agents BROWN, JARED MICHAEL UNIVERSITY OF COLORADO DENVER
R56 Pulmonary Agent Discovery of phosgene and chlorine gas modes of action and therapeutic targets using chemoproteomic profiling strategies LIN, VIVIAN S BATTELLE PACIFIC NORTHWEST LABORATORIES
R56 Pulmonary Agent Mechanisms underlying mustard gas-induced conjunctival injury and use of lipid mediators as medical countermeasures DARTT, DARLENE A SCHEPENS EYE RESEARCH INSTITUTE
R56 Pulmonary Agent Unraveling the corneal and retinal mechanisms of chemical injury MOHAN, ROYCE UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
R56 Pulmonary Agent Mechanistic Understanding of Mustard Gas Toxicity in the Retina using a Minipig Model CHAURASIA, SHYAM SUNDER MEDICAL COLLEGE OF WISCONSIN
R56 Ultra-potent synthetic opioid Identifying novel molecular targets, signaling pathways and mechanisms underlying fentanyl overdose-induced severe respiratory depression and lethality in rats using TMT phosphoproteomics/proteomics PAN, YING-XIAN RUTGERS BIOMEDICAL AND HEALTH SCIENCES
R56 Ultra-potent synthetic opioid Dissecting the central and peripheral mechanisms to fentanyl induced respiratory depression MORON-CONCEPCION, JOSE A WASHINGTON UNIVERSITY
R56 Vesicating Agent Extracellular vesicles as mediators of injury in inhaled exposures to toxic chemicals. AHMAD, AFTAB UNIVERSITY OF ALABAMA AT BIRMINGHAM
R34 Vesicating Agent The Role of Macrophages in Vesicant Skin Injury and Repair KOH, TIMOTHY J UNIVERSITY OF ILLINOIS AT CHICAGO
R34 Vesicating Agent The Initiation of Vesicant Skin Injury at a Single Cell Level ANDERSEN, BOGI UNIVERSITY OF CALIFORNIA-IRVINE
R34 Vesicating Agent Oxidized lipids and microvesicle particles as effectors for chemical threats to skin TRAVERS, JEFFREY B WRIGHT STATE UNIVERSITY
R34 Vesicating Agent Explant human skin perfusion model to study mechanisms of chemical injury and mitigation EJAZ, ASIM UNIVERSITY OF PITTSBURGH AT PITTSBURGH
R21 Metabolic/Cellular Poison Treatment strategies for ocular toxicity from chloropicrin TEWARI-SINGH, NEERA MICHIGAN STATE UNIVERSITY
R21 Metabolic/Cellular Poison Hydrogen sulfide toxicity to the cornea MOHAN, RAJIV RAVINDRA UNIVERSITY OF MISSOURI-COLUMBIA
R21 Nerve Agent Refined uncharged Bis-Oximes for Rapid CNS Reactivation of OP-Inhibited hAChE. RADIC, ZORAN UNIVERSITY OF CALIFORNIA, SAN DIEGO
R21 Nerve Agent In Vivo Efficacy of Novel Uncharged Bis-Oximes in OP Poisoning Treatment RADIC, ZORAN UNIVERSITY OF CALIFORNIA, SAN DIEGO
R21 Nerve Agent Mitoapocynin, a novel NOX2 inhibitor, mitigates nerve agents induced longterm neurotoxicity THIPPESWAMY, THIMMASETTAPPA IOWA STATE UNIVERSITY
R21 Nerve Agent Converting human butyrylcholinesterase into a metalloenzyme for catalytic hydrolysis of organophosphates SHAFAAT, HANNAH S UNIVERSITY OF CALIFORNIA LOS ANGELES
R21 Nerve Agent High-throughput in vivo discovery of novel countermeasures against organophosphate-induced seizure and status epilepticus using zebrafish MCGRAW, CHRISTOPHER MASSACHUSETTS GENERAL HOSPITAL
R21 Nerve Agent Novel oxime antidotes for an organophosphate insecticide requiring bioactivation MEEK, EDWARD C MISSISSIPPI STATE UNIVERSITY
R21 Nerve Agent The role of adaptive immunity in organophosphate induced CNS injury ABDULLAH, LAILA ROSKAMP INSTITUTE, INC.
R21 Nerve Agent Novel behavioral screening tool for therapeutics against organophosphorus agents COLLINS, EVA-MARIA SCHOETZ SWARTHMORE COLLEGE
R21 Nicotine An Enzyme-Based Antidote for Acute Nicotine Toxicity JANDA, KIM SCRIPPS RESEARCH INSTITUTE, THE
R21 Pulmonary Agent Cationic CAMKIIN nanoparticles that reduce chlorine-induced airway oxidative stress SALEM, ALIASGER K UNIVERSITY OF IOWA
R21 Pulmonary Agent Repurposing thiosulfate for chlorine gas exposure DAY, BRIAN J NATIONAL JEWISH HEALTH
R21 Pulmonary Agent Cannabinoid-2 receptor signaling in vesicant induced lung injury NAGRE, NAGARAJA EASTERN VIRGINIA MEDICAL SCHOOL
R21 Pulmonary Agent Inhibition of soluble epoxide hydrolase protects against phosgene-induced lung injuries ACHANTA, SATYANARAYANA DUKE UNIVERSITY
R21 Pulmonary Agent Sickle Cell Trait Mice are More Susceptible to Chlorine Exposure and Haptoglobin Improves the Outcomes ALISHLASH, AMMAR UNIVERSITY OF ALABAMA AT BIRMINGHAM
R21 Ultra-potent synthetic opioid Restoring The Mechanical Properties of the Respiratory System as a Treatment of Fentanyl Overdose-Induced Hypoventilation using Kappa Agonists HAOUZI, PHILIPPE A CLEVELAND CLINIC LERNER COM-CWRU
R21 Ultra-potent synthetic opioid New brainstem targets for counteracting opioid induced apnea FELDMAN, JACK L UNIVERSITY OF CALIFORNIA LOS ANGELES
R21 Ultra-potent synthetic opioid Zebrafish Screens to Identify Agents which Reverse the Effects of Synthetic Opioids SCHIEFER, ISAAC T UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS
R21 Ultra-potent synthetic opioid Recruiting active expiration to overcome opioid-induced persistent apnea FELDMAN, JACK L UNIVERSITY OF CALIFORNIA LOS ANGELES
R21 Ultra-potent synthetic opioid Repurposing L-NAC to prevent fentanyl-induced respiratory depression LEWIS, STEPHEN JOHN CASE WESTERN RESERVE UNIVERSITY
R21 Ultra-potent synthetic opioid Synthetic Scavenger Medical Countermeasures for Fentanyl AVITAL-SHMILOVICI, MICHAL SRI INTERNATIONAL
R21 Vesicating Agent Development of a protein therapeutics to counteract mustard-induced skin injury LI, HAICHANG OHIO STATE UNIVERSITY
R21 Vesicating Agent Targeting Citrullination in Ocular Chemical Injury MOHAN, ROYCE UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
R21 Vesicating Agent Extracellular Vesicles derived from Mesenchymal Stem Cells as an Effective Medical Countermeasure against Mustard Induced Ocular Injury LEE, RYANG HWA TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR
R21 Vesicating Agent Antioxidant Eye Wash Formulations to Counter Ocular Chemical Threats LEBRUN, STEWART LEBRUN LABS, LLC
R21 Vesicating Agent Tissue Hypoxia and Topical Oxygen Therapy in Ocular Mustard Gas Injury YIN, JIA SCHEPENS EYE RESEARCH INSTITUTE
R01 Pulmonary Agent Halolipid-Neutrophil Extracellular Trap Axis in Halogen Lung Injury FORD, DAVID A SAINT LOUIS UNIVERSITY
R01 Pulmonary Agent Pulmonary cell fate and lung repair in rodent and porcine models of chlorine and phosgene inhalation injuries JORDT, SVEN-ERIC DUKE UNIVERSITY
R01 Pulmonary Agent Characterizing chemical threat agent exposures using a lung-on-a-chip platform and multi-omic analysis of common pathophysiological mechanisms MURPHY, SEAN VINCENT WAKE FOREST UNIVERSITY HEALTH SCIENCES
R01 Pulmonary Agent Pulmonary Pathophysiologic Mechanisms of Chloropicrin and Phosgene VAN WINKLE, LAURA S UNIVERSITY OF CALIFORNIA AT DAVIS
R01 Pulmonary Agent Pathophysiological Mechanisms of Chemical-Induced Acute Lung Injury LEIKAUF, GEORGE DOUGLAS UNIVERSITY OF CINCINNATI
R01 Pulmonary Agent Lipid and metabolic mechanisms responsible for phosgene and phosphorus trichloride exposure toxicity FORD, DAVID A SAINT LOUIS UNIVERSITY
R01 Pulmonary Agent Vascular injury and repair predict divergent late onset cardiovascular morbidities after chlorine and sulfur mustard exposure VERESS, LIVIA AGNES UNIVERSITY OF COLORADO DENVER
R01 Pulmonary Agent Mitochondrial DNA Injury is a Key Contributor to the Development of Chemical Lung Injury MATALON, SADIS UNIVERSITY OF ALABAMA AT BIRMINGHAM
R01 Ultra-potent synthetic opioid Transcriptomic single-cell profiling in breathing-specific parabrachial mu-opioid receptor neurons HAN, SUNG SALK INSTITUTE FOR BIOLOGICAL STUDIES
R01 Ultra-potent synthetic opioid Genetic Variation of Ultra-Potent Synthetic Opioid Sensitivity in Mice BUBIER, JASON A JACKSON LABORATORY
R01 Ultra-potent synthetic opioid Mechanism and Countermeasure of Carfentanil-induced Respiratory Disorder and Death XU, FADI LOVELACE BIOMEDICAL RESEARCH INSTITUTE
R01 Vesicating Agent The mechanism of vesicant-induced ocular injury GORBATYUK, MARINA UNIVERSITY OF ALABAMA AT BIRMINGHAM
R01 Vesicating Agent Toxic Mechanisms of Vesicating Chemicals in the Eye MCNUTT, PATRICK MICHAEL WAKE FOREST UNIVERSITY HEALTH SCIENCES
R01 Vesicating Agent Understanding Mustard Vesicants Distribution and Toxicity in the Eye Using In Vivo and In Silico Models TEWARI-SINGH, NEERA MICHIGAN STATE UNIVERSITY
R01 Vesicating Agent The Role of Master Epigenetic Regulators in Ocular Chemical Injury ZHANG, WENBO UNIVERSITY OF TEXAS MED BR GALVESTON
R01 Vesicating Agent Late/chronic corneal injury following threat chemical exposure MOHAN, RAJIV RAVINDRA UNIVERSITY OF MISSOURI-COLUMBIA
R01 Vesicating Agent Mitochondria and Mustard Damage at the Ocular Surface FINI, M ELIZABETH TUFTS MEDICAL CENTER
R01 Vesicating Agent Soluble epoxide hydrolase and epoxide fatty acid involvement in corneal injury after ammonia exposure: Mechanisms of injury and potential therapeutics using sEH inhibitors and biostable EpFA mimics. WATSKY, MITCHELL A AUGUSTA UNIVERSITY