Research Program Award (R35)
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Institution
Mayo Clinic,
Rochester, MN
Awarded Project
How microglia sense and regulate neuronal activity in the adult brain
Dr. Long-Jun Wu’s research is focused on neuroimmune interactions, particularly microglia function, in health and disease. His team employs genetic animal models along with a combination of advanced tools such as two-photon imaging, electrophysiology and awake-behavioral studies. The long-term vision of Dr Wu’s research is to identify and manipulate microglia-specific therapeutic targets that will complement existing treatment of neurological disorders, including epilepsy, pain, stroke, neurodegeneration and autoimmune diseases.