Research Program Award (R35)
Cleveland Clinic Lerner Research Institute, Cleveland, OH
Dr. Lathia’s research is focused on understanding how cancer stem cells interact with their surrounding microenvironment as well as one another. In particular, his team is exploring the role that myeloid-derived suppressor cells (MDSCs) play in suppressing anti-tumor immunity. Here, his team plans to use glioblastoma as a model for neurological disorders to identify the cellular and molecular mechanisms that control how MDSCs are formed and how they respond to microenvironmental cues. Lastly, this research program aims to evaluate pre-clinical MDSC targeting in combination with immune-activating therapies.