Dr. Michael Wheeler is an instructor in neurology at Brigham and Women’s Hospital. Under the mentorship of Dr. Francisco Quintana, Dr. Wheeler’s research aims will investigate a novel molecular pathway in astrocytes, with the aim of better understanding the control of central nervous system inflammation in multiple Sclerosis (MS). Specifically, he will examine the mechanisms that regulate astrocyte pro-inflammatory activities, which are not responsive to the therapeutic approaches currently available for MS. He will define a novel disease-associated astrocyte population, identify the molecular mechanisms that control it, and evaluate the therapeutic value of its pharmacologic manipulation. To accomplish this, he will utilize single-cell RNA sequencing, mouse models, and spatial transcriptomic approaches. Dr. Wheeler’s work will aid in identifying mechanisms of disease pathogenesis and novel therapies in multiple sclerosis (MS). Dr. Wheeler received his Bachelor of Arts from Johns Hopkins and his PhD from the University of Virginia.