Manideep Chavali, Ph.D.

K99/R00 Pathway to Independence Award
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photo of Manideep Chavali

Dr. Manideep Chavali is a postdoctoral scholar in the Department of Regenerative Medicine at the University of California, San Francisco. Through joint mentorship from Drs. David Rowitch and Stephen Fancy, Dr. Chavali’s research will examine how congenital heart disease (CHD) can lead to abnormal neonatal white matter development. Specifically, Dr. Chavali will elucidate the mechanisms by which oligodendrocyte progenitor cells regulate white matter vascular development and how the resulting vascular network provides metabolic support to protect neonatal brains exposed to chronic hypoxemia, as is typical in CHD. To do this work, he will utilize a novel mouse model of CHD, spatial transcriptomics, live imaging approaches, and cutting-edge proteomics techniques. His work will improve our understanding of how CHD can cause white matter metabolic dysfunction, maturation delay, and injury. Dr. Chavali received his PhD from Stony Brook University and his Bachelor of Technology in chemical engineering from the National Institute of Technology, Warangal.