Research Program Award (R35)
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Institution
Johns Hopkins University,
Baltimore, MD
Awarded Project
EEG Biomarkers Derived from Dynamical Network Models Enable Rapid Paths to Accurate Diagnosis and Effective Treatment of Epilepsy
Accurately diagnosing epilepsy and then finding an effective treatment can take years to a lifetime, during which patients and families suffer from the stigma of epilepsy, side-effects of ineffective AEDs, extensive and costly hospital stays, poor outcomes of irreversible surgical treatment, and/or less than satisfactory stimulation therapies whose efficacies are physiologically unmeasurable. Dr. Sarma’s research program aims to establish novel EEG biomarkers and computational tools that will enable rapid and accurate diagnosis of epilepsy followed by a rapid path to an effective treatment. Such a program entails major advances in conceptual knowledge of how epileptic cortical networks behave and change during stimulation treatment.