Research Program Award (R35)
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Institution
Brigham and Women's Hospital,
Boston, MA
Awarded Project
Genetic Analysis of Neurodegeneration
Dr. Feany’s research is focused on defining the molecular mechanisms of neuronal dysfunction and death in common neurodegenerative disorders, including Parkinson’s disease, using a variety of in vivo and cellular models. This research program will use a combination of Drosophila and mouse genetics, together with patient-derived cell models, to unravel the cellular signaling cascades involved in neuronal cell autonomous responses to alpha-synuclein toxicity as well as non-cell autonomous control of neuronal toxicity by glia.