Dr. Michael A. Moskowitz’s research centers on the role of neurovascular regulation in stroke and migraine and the extent to which inflammation, inflammatory molecules, and pathways modify models of these diseases. In this collaborative project with Dr. Matthias Nahrendorf, the group aims to dissect the role of skull marrow niche cells in inflammation and brain health in a mouse model of ischemic stroke. This project will expand upon Dr. Moskowitz and team’s recent discovery of skull hematopoietic niches that are directly connected to the central nervous system via hundreds of tiny channels through the cerebral cortex. Through this project, Drs. Moskowitz and Nahrendorf hope to shed the light on how cells produced from skull bone marrow contribute to post-stroke immune responses.