Javits Award
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Dr. Tsai has dedicated her career to understanding the role of cyclin-dependent kinase 5 (Cdk5) in the brain, and discovered that preventing the generation of p25 by calpain cleavage of p35 protects from neurodegeneration by reducing Aβ toxicity. Her latest project will use genetic mouse models and human iPSCs to test the hypothesis that p25-mediated dysregulation of Cdk5 plays a key role in microglia-mediated neuroinflammation and neurodegeneration in Alzheimer’s disease.