Debjani Mandal, Ph.D.

Dr. Debjani Mandal is a Staff Scientist in the Neurosurgery Unit for Pituitary and Inheritable Diseases of the Surgical Neurology Branch. She received her Undergraduate, Master’s degree and Ph.D. in Bio Science and was a faculty member at IICB, Calcutta (CSIR Institute) in India. During her tenure-ship she mentored graduate and postgraduate students and her research focused on metabolites and ion translocation across the cell and organelles membrane at different model systems. Dr. Mandal continued her work on membrane transporter during postdoctoral training at Johns Hopkins University School of Medicine and identified critical residues that could alter the substrate specificity of the transporter.  Before joining at NINDS she worked as a senior research associate at USUHS, Bethesda, and later became a staff scientist in the Dept. of Biochemistry and Molecular Biology and her interest laid on structure function studies of human multidrug resistance protein for the rational design of mechanism-based inhibitors and therapeutics. Presently, Dr. Mandal is exploring therapeutic targets of Cushing and VHL disease at biochemical and molecular aspects, focusing on transcriptomic data of patient sample, and metabolic reprograming.