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The National Institute on Aging (NIA), in collaboration with the National Institute of Child Health and Human Development (NICHD), the National Institute on Deafness and Other Communication Disorders (NIDCD), the National Institute of Dental and Craniofacial Research (NIDCR), the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), the National Eye Institute (NEI), and the National Institute of Neurological Disorders and Stroke (NINDS), invites grant applications in the area of age-related changes in multiple sensory systems. A major goal of aging research is directed toward the public health issue of maintaining functional independence of the elderly individual. Aside from specific diseases, sensory declines represent a broad category of normal age-related changes that can lead to diminished quality of life for the elderly individual, loss of independence, and increased costs for society as a whole. Although declines in single sensory systems have been studied, there is less information about the effects of concurrent changes in multiple systems, at either the population or basic science level. The purpose of this program announcement is to stimulate research investigating: (1) the prevalence and extent of concurrent declines in multiple sensory systems in the elderly, (2) the effects such declines might have on the functional capacities of the individual, and (3) the underlying mechanisms responsible for commonalities in age-related sensory changes at central nervous system, cellular, molecular or genetic levels.

The National Heart, Lung, and Blood Institute (NHLBI), National Institute of Dental and Craniofacial Research (NIDCR), National Institute of Allergy and Infectious Diseases (NIAID), National Institute on Deafness and Other Communication Disorders (NIDCD), National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institute of General Medical Sciences (NIGMS), National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institute of Child Health and Human Development (NICHD), National Institute of Neurological Disorders and Stroke (NINDS), National Institute of Nursing Research (NINR), and Office of Research on Women"s Health (ORWH) invite research grant applications to conduct studies on microbial biofilms leading to improved strategies and technologies to diagnose, prevent and treat biofilm-associated infectious diseases.

The National Institute of Nursing Research (NINR), National Institute of Neurological Disorders and Stroke (NINDS), National Institute on Aging (NIA), National Institute on Deafness and Other Communication Disorders (NIDCD), and the National Center for Medical Rehabilitation Research (NCMRR) of the National Institute of Child Health and Human Development (NICHD) seek research applications that address effective nonpharmacological approaches to managing the initial events and subsequent symptoms of a stroke. This research would focus on reducing the impairments, preventing secondary complications, and improving the functional independence and the quality of life for the individual following a stroke.

The objective of this initiative is to establish collaborative teams of closely interacting investigators with diverse, complementary areas of expertise to elucidate the molecular genetic mechanisms of thrombosis in the arterial and cerebral vasculature. The overall goal is to stimulate innovative multidisciplinary research to expedite progress in understanding the pathogenesis of thrombosis in both the arterial and cerebral vasculature and to facilitate the application of new findings for better detection, prevention, and treatment.

Research at the borders of disciplines and from fresh perspectives often produces surprising and exciting results. Increasingly, teams of scientists from diverse disciplines converge on a common research questions. Individuals who can independently bridge different disciplines, as well as those who are able to function as leading members of multi-disciplinary research teams are playing ever more valuable roles at the forefront of biomedicine. The purpose of the Mentored Quantitative Research Career Development Award (K25) is to engender and foster such activities by supporting the career development of investigators with quantitative scientific and engineering backgrounds outside of biology or medicine who have made a commitment to focus their research endeavors on behavioral and biomedical research (basic or clinical). This mechanism is aimed at research-oriented scientists with experience at the level of junior faculty (e.g., early to mid-levels of assistant professor or research assistant professor ranks). This award provides support for a period of supervised study and research for professionals with such backgrounds who have the potential to integrate their expertise with biomedicine and develop into productive investigators.

The sponsoring organizations are jointly offering this Program Announcement (PA). Although this PA applies to several agencies, it will be administered according to National Institutes of Health (NIH) policies and procedures. This PA is one of the steps the NIH is taking to develop an on-going, multi-agency, comprehensive program in research ethics. Other steps include the "Short-Term Courses in Research Ethics" (T15), PA-99-051 (http://www.nih.gov/grants/guide/pa-files/PA-99-051.html), and the "Mentored Scientist Development Award in Research Ethics" (K01), PA-99-050 (http://www.nih.gov/grants/guide/pa-files/PA-99-050.html), both published in the NIH Guide for Grants and Contracts, January 22, 1999.

The purpose of this request for applications (RFA) is to establish facilities for large-scale mutagenesis and phenotyping of nervous system functions and complex behaviors in the laboratory mouse. Neuroscience-focused mutagenesis and phenotyping facilities established by this RFA are expected to serve as a national resource by producing a bank of mouse strains that harbor a wide range of mutations affecting murine nervous system function and behavior. Data and biomaterials produced in projects supported under this RFA will be made widely available to the scientific community.

The purpose of this five-year research grant program is to enhance our understanding of the etiology, extent, services, treatment, management, and prevention of child neglect. This Request for Applications (RFA) is intended to stimulate the development of programs of child neglect research at institutions that currently have strong research programs in related areas (e.g., child development, injury prevention, developmental neurobiology, child abuse, substance abuse, population research, craniofacial and dental public health, health services) but are not engaged in extensive research focusing on child neglect. A second goal of this RFA is to bring the expertise of researchers from the child health, education, and juvenile justice fields into the child neglect research field and to promote their collaborations with each other and with child neglect and child abuse researchers.

In response to the recommendations of the Rat Genome Advisory Committee and the Report of the NIH Model Organism Database Workshop (http://www.nhlbi.nih.gov/) the NIH proposes to establish a Rat Genome Database (RGDB). The objective of this RFA is to establish a database that will collect, consolidate, and integrate data generated from ongoing rat genetic, genomic, and related research efforts, and to make these data widely available to the scientific community.

The purpose of this RFA is to support the development of technologies that will facilitate the generation of a complete set of full-length human cDNAs as well as other mammalian cDNAs. Current methods of cDNA clone and library production favor shorter, more heavily represented genes. In addition, although current methodology for isolating mRNA for use in cDNA construction works well with cell lines, reliable methodologies for extraction of high quality mRNA from tissues remains a challenge. Use of human tissues may be necessary to achieve the goal of a complete set of human cDNA clones. Finally, reliable, high-throughput methods to determine whether clones contain a copy of the full transcript, the full coding region, or a partial transcript are needed. This RFA is intended to support innovative research projects aimed at solving one or more of the problems currently associated with the production of a complete set of full-length human cDNA clones and full-length cDNA clones from other mammals.