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This is a Notice of Funding Opportunity (NOFO) for a Limited Competition that will invite applications from eligible organizations to apply. Please see Section III. Eligibility, for additional information. In accordance with NIH standard peer-review processes, the applications will be peer-reviewed, and only meritorious applications will be considered for funding. This NOFO will renew the HEALthy Brain and Child Development (HBCD) Research Project Sites.The HBCD Study is a nationwide, multi-site, longitudinal study that follows children from birth through childhood. The study examines brain and behavioral development, with a focus on how prenatal substance exposure affects health outcomes.The HBCD Consortium consists of three highly integrated components: (1) a set of linked Research Project Sites, (2) a single overall Consortium Administrative Core (HCAC); and (3) a single central Data Coordinating Center (HDCC). As such, this NOFO runs in parallel with a companion NOFO that solicits applications for the HCAC and the HDCC (RFA-DA-27-014). It is expected that investigators, upon funding, will work jointly with NIH scientific staff to assist, guide, coordinate, and participate in project activities.

This is a Notice of Funding Opportunity (NOFO) is for a Limited Competition that will invite applications from eligible organizations to apply. Please see Section III. Eligibility, for additional information. In accordance with NIH standard peer-review processes, the applications will be peer-reviewed, and only meritorious applications will be considered for funding. This NOFO will renew the HEALthy Brain and Child Development (HBCD) Consortium Administrative Core (HCAC) and Data Coordinating Center (HDCC).The HBCD Study is a nationwide, multi-site, longitudinal study that follows children from birth through childhood. The study examines brain and behavioral development, with a focus on how prenatal substance exposure affects health outcomes.The HBCD Consortium consists of three highly integrated components: (1) a set of linked Research Project Sites, (2) a single overall HCAC; and (3) a single central HDCC. As such, this NOFO runs in parallel with a companion NOFO that solicits applications for linked research sites (RFA-DA-27-013). It is expected that investigators, upon funding, will work jointly with NIH scientific staff to assist, guide, coordinate, or participate in project activities.

The purpose of the NINDS Child Neurology Career Development Program (CNCDP) is to facilitate and support the research career development of physicians specialized in Child Neurology who have made a commitment to independent research careers. The CNCDP is a single national program, implemented by one or more PD/PIs, together with an advisory committee composed of basic and clinical investigators who have a strong record of funded research and successful training of physicianscientists. The CNCDP will generally provide three consecutive years of support to individuals to provide them with the knowledge, tools and research experience that will enable them to develop a significant research project funded by an individual career development award or research grant.

pNINDS will extend this funding opportunity for one more receipt date and Council./p

This Notice of Funding Opportunity (NOFO) invites applications to serve as the National Institute of Neurological Disorders and Stroke (NINDS) Human Biospecimen and Data Repository in Neurological Disorders. This repository will maintain the current collection of biospecimens as well as support expansion of the collection in accordance with the NINDS mission. The NINDS Human Biospecimen and Data Repository will distribute biospecimens broadly to qualified academic and industry researchers to advance basic, translational and clinical research in neurological disorders.

pUpdating the receipt date./p

The purpose of this NOFO is to establish the NIH Blueprint for Neuroscience Research Coordination Center for Interoception Research (BPCCIR). Interoception, for the purpose of this NOFO, encompasses the processes by which an organism or a person senses, interprets, integrates, and regulates signals that represent the internal states. The goals of the NBCCIR are to: 1) promote a multidisciplinary approach for interoception research, and 2) bridge the gap between brain and body studies through a cooperative agreement funding mechanism, U24. This NOFO aims to foster interactions within the broad community of interoception researchers, rather than focusing on disease-specific subdisciplines. Specifically, the NOFO will support efforts to: 1) establish and maintain a multidisciplinary team of interoception researchers to oversee and guide NBCCIR activities; 2) create and support digital communication platforms to facilitate networking, collaborations, and information dissemination; 3) plan, organize, and host at least one scientific meeting per year that will include NIH-funded interoception researchers, trainees, and other stakeholders; 4) identify challenges and future technological and scientific opportunities for the field of interoception and develop common terminology, data standards, and common data elements; and 5) generate metrics of success and plans to ensure the sustainability of the interoception research community.

The objective of this Notice of Funding Opportunity (NOFO) is to invite new and renewal applications for the Rare Diseases Clinical Research Consortia (RDCRC) that comprise the Rare Diseases Clinical Research Network (RDCRN). The RDCRCs are intended to advance and improve diagnosis, management, and treatment of numerous, diverse rare diseases through highly collaborative, multi-site, patient-centric, translational and clinical research. Special emphasis will be placed on the early and timely identification of individuals with rare diseases and clinical trial readiness.

The purpose of this announcement is to encourage grant applications for investigator-initiated prospective observational comparative effectiveness research (CER) to the National Institute of Neurological Disorders and Stroke (NINDS). The study must address questions within the mission and research interests of the NINDS and may evaluate preventive strategies, diagnostic approaches, or interventions including drugs, biologics, and devices, or surgical, behavioral, and rehabilitation therapies. Information about the mission and research interests of the NINDS can be found at the NINDS website (https://www.ninds.nih.gov/). Studies proposed should provide a cost-effective means of collecting data with a meaningful bearing on current clinical practice. Awards made under this FOA will initially support a milestone-driven planning phase (UG3) for up to 2 years, with possible transition to a observational study phase of up to five years (UH3). Only UG3 projects that have met the scientific milestones and feasibility requirements may transition to the UH3 phase. The UG3/UH3 application must be submitted as a single application, following the instructions described in this FOA. The UG3 phase for observational studies will permit both scientific and operational planning activities. Scientific planning activities include small-scale data collection to assess the feasibility and/or acceptability of data collection, storage, and planned analyses. Operational planning activities include, at a minimum, development of recruitment and retention strategies, case report forms, data management system and other tools for data and quality management. The UH3 phase of the award will support the conduct of investigator-initiated observational study.

The Joint NINDS/NIMH Exploratory Neuroscience Research Grant program supports exploratory and innovative research projects, which fall within the missions of the NINDS and NIMH. Awards will provide support for the early and conceptual stages of projects. These studies often assess the feasibility of a novel avenue of investigation and involve considerable risk, but have the potential to bring about breakthroughs in the understanding of important areas of neuroscience, or to the development of novel techniques, agents, methodologies, or models, of high value to the neuroscience community. While this funding opportunity also accepts clinical trials, only applications proposing mechanistic clinical trials or studies or basic experimental studies with humans (BESH) will be considered for funding. For information on the types of clinical trial that are within scope of this funding opportunity announcement, refer to Funding Opportunity Description, below.