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Request Information: Input the National Institute Neurological Disorders Stroke Strategic Planning Process Notice Number: NOT-NS-19-079 Key Dates Release Date: July 31, 2019 Response Date: October 01, 2019 Related Announcements NOT-NS-20-010 Issued National Institute Neurological Disorders Stroke NINDS) Purpose National Institute Neurological Disorders Stroke NINDS) embarking an institute-wide strategic planning process. goal the process to tune our practices policies our vision mission, order better serve anticipate needs the research patient communities the public. mission NINDS to seek fundamental knowledge the brain nervous system to that knowledge reduce burden neurological disease. Based this mission, NINDS formulated broad Strategic Goals a starting point the planning process: Strategic Goals a model excellence supporting performing paradigm-changing, innovative, rigorous neuroscience research. a model excellence funding conducting neuroscience research training career development programs ensuring vibrant, talented, diverse neuroscience work force. Promote timely dissemination accurate rigorous information scientific discoveries their implications neurological health. Create sustain supportive work culture the NINDS work force facilitate reward analogous efforts the outside neuroscience community. purpose this time-sensitive RFI to solicit input concrete means accomplish strategic goals over next 5-10 years. NINDS use responses collected part this RFI inform planning process, help identify relevant experts stakeholders, to formulate prioritize objectives action plans achieving Strategic Goal. resulting NINDS-wide Strategic Plan be posted draft form additional public comment before implementation. Information Requested: NINDS invites input stakeholders, experts, communities, members the public, including not limited researchers trainees across academia, industry, government; health care providers health advocacy organizations; nongovernmental, scientific professional organizations; federal agencies. any all the Strategic Goals stated above, please provide perspective expertise any the following points: Opportunities for, challenges facing, progress neuroscience research neurological health Emerging scientific organizational trends, advances, techniques, perspectives NINDS should account in planning process Recommendations steps, actions, activities, opportunities will enable NINDS make rapid progress toward achieving goal recommendations make, please consider indicating appropriate objective success criteria, including quantitative qualitative benchmarks milestones gauging progress the corresponding domain Successes, shortcomings, impacts existing NINDS policies, practices, partnerships, strategies, activities Stakeholders experts NINDS should consult the process strategic planning strategy implementation High-priority objectives you not reflected among four stated strategic planning goals Any topic you find relevant the development the NINDS institute-wide strategic plan input provide be available the committees taskforces charged carrying the planning implementation processes NINDS. Optional: Please indicate you a primary investigator, trainee, researcher, health care provider, patient advocate, science administrator, other interested party. you submitting response behalf an organization membership a whole, please indicate name your organization. Organizations strongly encouraged submit single response reflects views their organization membership a whole. to Submit Response Responses this RFI must submitted electronically. ensure full consideration, responses must received 10/1/2019. Responses this RFI voluntary. not include any proprietary, classified, confidential, trade secret, sensitive information your response. responses be reviewed NIH staff, individual feedback not provided any responder. U.S. Government use information submitted response this RFI its discretion. RFI for information planning purposes only shall be construed a solicitation, grant, cooperative agreement, as obligation the part the Federal Government, NIH, individual NIH Institutes Centers provide support any ideas identified response it. Government not pay the preparation any information submitted for U.S. Government’s of such information. basis claims against U.S. Government shall arise a result a response this request information from Government’s of such information. provided information be analyzed may appear, summary form, removing personally identifying sensitive information, reports other publicly accessible resources. Inquiries Please direct inquiries to: NINDS Strategic Planning Email: NINDSStrategicPlan@nih.gov

Solicitation Nominations the 2020 National Institute Neurological Disorders Stroke NINDS) Landis Award Outstanding Mentorship Notice Number: NOT-NS-19-080 Key Dates Release Date: July 29, 2019 Related Announcements NOT-NS-20-028 Issued National Institute Neurological Disorders Stroke NINDS) Purpose Excellent mentorship superior training critical the development exceptional future scientists. recognize crucial role great mentors play the development future leaders neuroscience, National Institute Neurological Disorders Stroke NINDS) created Landis Award Outstanding Membership. award provides 100,000.00 direct costs) up five 5) faculty members are considered be outstanding mentors trainers help foster research career development additional students post-doctorates. NINDS hopes this tangible award impress upon scientific community a whole, faculty institutional leaders particular, high value NINDS places outstanding training mentorship the need faculty institutions emphasize dedication mentorship addition outstanding research accomplishments. Selection this award based nomination those have first-hand knowledge an individual's outstanding mentorship. Current former trainees nominate faculty members have served their mentors. Faculty members nominated two more mentees then invited submit additional information needed the selection process. Eligible individuals this award must in tenure-track equivalent faculty position hold active NINDS R01, R35, U01, U54, P01 DP1 at least year left their grant June 2020. full details the award, the selection process be found at Landis Mentor Award. Because outstanding mentors exist each career stage, have different levels mentorship accomplishments, NINDS rotates eligibility requirements year. 2018, NINDS awards junior faculty mentors the 5th - 12th year the start their first tenure track equivalent position). 2019, NINDS awards mid-career faculty mentors the 13th - 20th year the start their first tenure track equivalent position). two cohorts Landis Awardees be found at Landis Mentor Award. this notice, NINDS invites nominations outstanding mentors are 21 years more the start their first tenure-track equivalent faculty position i.e., start date their first tenure-track equivalent faculty position in calendar year 1998 earlier). Nomination Nominations the NINDS Landis Mentor Award be accepted ONLY current former trainees the nominated individual. nominate current former mentor, individuals should click on Landis Mentor Award and complete a nomination form by December 15, 2019. following information be requested: Nominator's name current position Name individual being nominated nominee) Current institution email address nominee Start date nominee's first tenure-track equivalent position Relationship nominator nominee dates mentorship, position nominator mentored nominee e.g. Former Current Graduate Student, Postdoctoral Fellow, etc.]) Statement describing basis the nomination. description should include: made/makes nominated individual exceptional mentor/trainer; are specific examples extraordinary dedication mentorship personally experienced witnessed; does individual to ensure trainees conduct highest quality research respect scientific premise, experimental design analysis; were specific nominee activities influenced nominator's growth a neuroscientist. a nomination be considered, of above information must provided via nomination form found at Landis Mentor Award. Inquiries Please direct inquiries to: Stephen Korn National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-4188 Email: korns@ninds.nih.gov

Request Information RFI): Guidance Current Education Curricula Health Care Professionals Regarding Pain Opioid Misuse Use Disorder Notice Number: NOT-DA-19-054 Key Dates Release Date: July 05, 2019 Response Date: September 01, 2019 Related Announcements None Issued National Institute Drug Abuse NIDA)National Institute Aging NIA) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Dental Craniofacial Research NIDCR) National Institute Neurological Disorders Stroke NINDS) National Institute Nursing Research NINR) National Center Complementary Integrative Health NCCIH)National Institute Biomedical Imaging Bioengineering NIBIB) Purpose RFI seeks input stakeholders throughout scientific research medical education community the general public regarding CoEPEs program, general pain education, opioid misuse use disorder education curriculum. Stakeholders interest include are limited to: health care professionals providing pain treatment, students medical, dental nursing schools, residents, fellows, teaching faculty, medical dental associations, education accrediting agencies. Background Chronic pain affects 100 million American adults costs nation to 635 billion year medical treatment lost productivity. response this public health concern the 2011 Institute Medicine report Relieving Pain America,” Department Health Human Services DHHS) created National Pain Strategy NPS). Among priorities recommendations outlined the NPS, plan identified need educate health care professionals pain, pain treatment, its interaction opioid misuse use disorder. Specifically, NPS recommended steps improve discipline-specific core competencies, including basic knowledge, assessment, effective team-based care, empathy, cultural competency. plan encouraged educational program accreditation bodies professional licensure boards require pain teaching clinician learning the undergraduate, graduate, residency continuous education levels. NPS also endorsed development a web-based pain education portal would contain up-to-date, comprehensive, easily accessed educational materials. training efforts should made coordination current DHHS efforts develop tools providers recognize risk factors symptoms opioid disorders. National Institute Health NIH) Pain Consortium established enhance pain research promote collaboration among researchers across many NIH Institutes Centers have programs activities addressing pain. line the education recommendations outlined the NPS, Pain Consortium created supports Centers Excellence Pain Education CoEPEs; https://painconsortium.nih.gov/Funding_Research/CoEPEs). CoEPEs act hubs the development, evaluation, distribution pain management curriculum resources medical, dental, nursing, pharmacy other schools enhance improve health care professionals taught pain its treatment. modules intended educate health care professionals the different types pain resulting various forms surgery, pain conditions, comorbidities, acute chronic pain treatment, opioid disorder. Information Requested RFI seeks input stakeholders throughout scientific research medical education community the general public regarding CoEPEs program, general pain, opioid misuse opioid disorder education curriculum. Stakeholders interest include are limited to: health care professionals providing pain treatment, students medical, dental, pharmacy, physical therapy nursing schools, residents, fellows, teaching faculty, medical associations, physical therapy occupational therapy associations education accrediting agencies. NIH seeks information response any all the following topics interest: nature your institution’s current curriculum pain conditions, pain treatment, opioid misuse/use disorder, overdose. Include details topics covered these categories, this training content delivered, intended audience, general goals, the particular Learning Management System LMS; e.g., Moodle), any, your institution uses manage any related training content. Information the highest priority needs training resources infrastructure needs related pain conditions, pain treatment, opioid misuse/use disorder, overdose. Topics training resources needs include are limited to: multidisciplinary approach pain assessment/management and/or empathy cultural competency content related pain conditions, pain treatment, opioid misuses/use disorder. Input the current CoEPEs education content, including whether modules being using your institution, whether fit curricular needs your institution, recommended content future development, suggestions the format e.g., explicit didactic goals, video duration, etc), any comments may enhance accessibility utilization these CoEPEs modules. Comments the importance endorsement educational program accreditation bodies professional licensure incorporate training pain OUD CoEPEs utilization your institution’s education curricula. to Submit Response: Responses this RFI be accepted through September 1, 2019. Responses this RFI must submitted electronically via email to: paineducation@nih.gov Responses this RFI voluntary. not include any proprietary, classified, confidential, trade secret, sensitive information your response. responses be reviewed NIH staff, individual feedback not provided any responder. Government use information submitted response this RFI its discretion. Government reserves right use any submitted information public NIH websites, reports, summaries the state the science, any possible resultant solicitation(s), grant(s), cooperative agreement(s), in development future funding opportunity announcements. RFI for information planning purposes only shall be construed a solicitation, grant, cooperative agreement, as obligation the part the Federal Government, NIH, individual NIH Institutes Centers provide support any ideas identified response it. Government not pay the preparation any information submitted for Government’s of such information. basis claims against U.S. Government shall arise because a response this request information from Government’s of such information. NIH looks forward your input we hope you share RFI document your colleagues. Inquiries Please direct inquiries to: Shelley Su, PhD National Institute Drug Abuse Telephone: 301-402-3869 Email:paineducation@nih.gov

Notice Change Application Types Allowed RFA-NS-18-021 BRAIN Initiative: Next-Generation Invasive Devices Recording Modulation the Human Central Nervous System UG3/UH3 Clinical Trial Required)" Notice Number: NOT-NS-19-072 Key Dates Release Date: June 28, 2019 Related Announcements RFA-NS-18-021 Issued National Institute Neurological Disorders Stroke NINDS) National Institute Deafness Other Communication Disorders NIDCD) Purpose purpose this notice to inform applicants revision applications be accepted response RFA-NS-18-021 BRAIN Initiative: Next-Generation Invasive Devices Recording Modulation the Human Central Nervous System UG3/UH3 Clinical Trial Required)". Changes listed below bold italics). notice be effective the October 21, 2019 due date subsequent due dates. Currently Reads: Section II. Award Information Application Types Allowed? New Resubmission Modified Read: Section II. Award Information Application Types Allowed New Resubmission Revision other aspects this FOA remain unchanged.? Inquiries Please direct inquiries to: Nick Langhals, PhD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-1779 Email: nick.langhals@nih.gov

Notice Change Application Types Allowed RFA-NS-18-022 BRAIN Initiative: Next-Generation Invasive Devices Recording Modulation the Human Central Nervous System U44 Clinical Trial Required)" Notice Number: NOT-NS-19-073 Key Dates Release Date: June 28, 2019 Related Announcements RFA-NS-18-022 Issued National Institute Neurological Disorders Stroke NINDS) National Institute Deafness Other Communication Disorders NIDCD) Purpose purpose this notice to inform applicants revision applications be accepted response RFA-NS-18-022 BRAIN Initiative: Next-Generation Invasive Devices Recording Modulation the Human Central Nervous System U44 Clinical Trial Required)". Changes listed below bold italics). notice be effective the October 21, 2019 due date subsequent due dates. Currently Reads: Section II. Award Information Application Types Allowed? New Resubmission Modified Read: Section II. Award Information Application Types Allowed New Resubmission Revision other aspects this FOA remain unchanged.? Inquiries Please direct inquiries to: Nick Langhals, PhD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-1779 Email: nick.langhals@nih.gov

Notice Change Application Types Allowed RFA-NS-18-023 BRAIN Initiative: Clinical Studies Advance Next-Generation Invasive Devices Recording Modulation the Human Central Nervous System UH3 Clinical Trial Required)" Notice Number: NOT-NS-19-074 Key Dates Release Date: June 28, 2019 Related Announcements RFA-NS-18-023 Issued National Institute Neurological Disorders Stroke NINDS)National Institute Deafness Other Communication Disorders NIDCD) Purpose purpose this notice to inform applicants revision applications be accepted response RFA-NS-18-023 BRAIN Initiative: Clinical Studies Advance Next-Generation Invasive Devices Recording Modulation the Human Central Nervous System UH3 Clinical Trial Required)". Changes listed below bold italics). notice be effective the October 21, 2019 due date subsequent due dates. Currently Reads: Section II. Award Information Application Types Allowed? New Resubmission Modified Read: Section II. Award Information Application Types Allowed New Resubmission Revision other aspects this FOA remain unchanged. Inquiries Please direct inquiries to: Nick Langhals, PhD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-1779 Email: nick.langhals@nih.gov

Notice Correction Application Submission Information PAR-18-543 CREATE Bio Development Track: Nonclinical Early-Phase Clinical Development Biologics U44 Clinical Trial Optional)" Notice Number: NOT-NS-19-070 Key Dates Release Date: June 19, 2019 Related Announcements PAR-18-543 Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this Notice to inform potential applicants a correction the Application Submission Information for PAR-18-543 , CREATE Bio Development Track: Nonclinical Early-Phase Clinical Development Biologics U44 Clinical Trial Optional) ". Application Submission Information Section been modified include information was erroneously omitted. notice be effective the July 18, 2019 receipt date subsequent due dates. correction applies the sentence below written in bold italics) the Page Limitations Section IV.2. Content Form Application Submission. page limitations described the SF424 R&R) SBIR/STTR Application Guide the Table Page Limits must followed. sentence corrected read: page limitations described the SF424 R&R) SBIR/STTR Application Guide the Table Page Limits must followed. this specific FOA, Research Strategy section limited 30 pages. other aspects this FOA remain unchanged. Inquiries Please direct inquiries to: Chris Boshoff, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-1779 Email: chris.boshoff@nih.gov

Notice Allow Requests Budget Increases NINDS Research Program Award R35) Notice Number: NOT-NS-19-058 Key Dates Release Date: June 12, 2019 Related Announcements RFA-NS-19-037 Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this Notice to inform current future recipients the NINDS R35 Research Program Award RPA) the opportunity request budget increase based exceptional circumstances the year five 5) administrative review. RPA provides long-term support Principal Investigators PIs) consolidating NINDS research support a single funding vehicle up eight years a fixed level is generally commensurate the PI’s funding over prior four years. greater funding stability provides recipients increased freedom flexibility, allowing to more adventurous their research, take greater risks, embark upon research breaks new ground, undertake research projects require longer timeframe, and/or extend previous discoveries new directions. Under exceptional circumstances, will consider requests budget increases the year five administrative review capitalize groundbreaking scientific findings. Although RPA budget exceed 750K direct costs DC) per year, requests increases 50K DC increments, a maximum 150K DC, be considered discussed the NINDS Advisory Council. approved, increase extend the duration the award. evaluating proposed budget increase, factors NINDS consider include: 1) PI’s support including non-NIH non-Federal funding); 2) career stage the PI; 3) progress the research program during first four years the R35 award; 4) size the initial R35 award. PIs significant support generally receive budget increases. specific guidance be provided R35-funded investigators advance the Year 5 administrative review. Inquiries Please direct inquiries to: Anna Taylor, Ph.D. National Institute Neurological Disorders Stroke NINDS) / Division Extramural Activities DEA) Telephone: 301-827-3565 Email: Anna.Taylor@nih.gov

Notice Intent Publish Funding Opportunity Announcement NIH Blueprint Neuroscience Research Education Program Translational Devices R25) Notice Number: NOT-NS-19-068 Key Dates Release Date: June 12, 2019 Estimated Publication Date Funding Opportunity Announcement: August 16, 2019 First Estimated Application Due Date: December 16, 2019 Earliest Estimated Award Date: June 01, 2020 Earliest Estimated Start Date: July 01, 2020 Related Announcements None Issued National Institute Neurological Disorders Stroke NINDS) National Eye Institute NEI) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Biomedical Imaging Bioengineering NIBIB) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Dental Craniofacial Research NIDCR) National Institute Drug Abuse NIDA) National Institute Environmental Health Sciences NIEHS) National Institute Mental Health NIMH) National Institute Nursing Research NINR) National Center Complementary Integrative Health NCCIH) applications this funding opportunity announcement should fall within mission the Institutes/Centers. following NIH Offices co-fund applications assigned those Institutes/Centers. Office Behavioral Social Sciences Research OBSSR) Purpose National Institute Neurological Disorders Stroke NINDS), other NIH Institutes Centers the NIH Blueprint Neuroscience Research consortium, intends promote new initiative publishing Funding Opportunity Announcement FOA) solicit applications develop comprehensive set short courses draws lessons learned academia industry is aimed filling translational knowledge gap the academic investigator small business communities. courses should address unique challenges inherent developing translating novel devices diagnose treat nervous system disorders. Notice being provided allow potential applicants sufficient time develop meaningful collaborations responsive projects anticipation the FOA. FOA expected be published the summer 2019 an expected application due date the winter 2019. FOA utilize R25 activity code. Details the planned FOA provided below. Research Initiative Details Notice encourages investigators expertise insights successful development translation medical devices diagnose treat nervous system disorders begin consider applying this new FOA. Applicants be encouraged develop creative education activities focused 1) steps required successful device development translation eg, animal model selection, good laboratory practices, quality systems, regulatory activities, clinical trial design, etc.), 2) common technical strategic challenges, 3) providing resources mentors each stage the process. education activities be expected address broad audience, including post-doctoral fellows, independent academic researchers, small business entrepreneurs. Applications be expected describe critical aspects of a program plan including, not limited to, course details, location, personnel, educational environment/facilities, recruitment diversity strategies. should also address to incorporate responsible conduct research ethical considerations developing translating devices, course evaluation methods, dissemination plans make course materials widely available. Funding Information Estimated Total Funding 250,000 direct costs Expected Number Awards 1 Estimated Award Ceiling 250,000 direct costs Primary CFDA Numbers TBD Anticipated Eligible Organizations Public/State Controlled Institution Higher Education Private Institution Higher Education Nonprofit 501(c)(3) IRS Status than Institution Higher Education) Small Business For-Profit Organization than Small Business) State Government Indian/Native American Tribal Government Federally Recognized) County governments Independent school districts Public housing authorities/Indian housing authorities Indian/Native American Tribally Designated Organization Native American tribal organizations than Federally recognized tribal governments) U.S. Territory Possession Indian/Native American Tribal Government than Federally Recognized) Non-domestic non-U.S.) Entity Foreign Organization) Regional Organization Eligible Agencies the Federal Government Applications not being solicited this time. Inquiries Please direct inquiries to: Kari Ashmont, PhD National Institute Neurological Disorders Stroke NINDS) 301-496-1779 kari.ashmont@nih.gov

Notice Change Key Dates PAR-18-710 Career Transition Award NINDS Intramural Clinician-Scientists K22 Clinical Trial Required)" Notice Number: NOT-NS-19-066 Key Dates Release Date: June 6, 2019 Related Announcements PAR-18-710 Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this notice to inform interested applicants a change the Key Dates PAR-18-710 Career Transition Award NINDS Intramural Clinician-Scientists K22 Clinical Trial Required)" changes shown bold italics below). Funding Opportunity Announcement been modified add following New Application Due dates: October 12, 2019, February 12, 2020; June 12, 2020; October 12, 2020; February 12, 2021; June 12, 2021 and resubmission application due dates: November 12, 2019; March 12, 2020; July 12, 2020; November 12, 2020; March 12, 2021; July 12, 2021. Currently Reads: Part 1. Overview Key Dates: Application Due Date(s) Standard dates , 5:00 PM local time applicant organization. All types non-AIDS applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. Scientific Merit Review Standard dates apply Advisory Council Review Standard dates apply Earliest Start Date Standard dates apply Expiration Date July 13, 2019 Modified Read: Part 1. Overview Key Dates: Application Due Date(s) Standard dates , 5:00 PM local time applicant organization. All types non-AIDS applications allowed this funding opportunity announcement due these dates. Scientific Merit Review Standard dates apply Advisory Council Review Standard dates apply Earliest Start Date Standard dates apply Expiration Date July 13, 2021 other aspects this FOA remain unchanged. Inquiries Please direct inquiries to: Stephen Korn, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-4188 Email: korns@ninds.nih.gov