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Request Information: Seeking Feedback Research Priorities SCI 2020: Launching Decade Disruption Spinal Cord Injury SCI) Research Notice Number: NOT-NS-19-060 Key Dates Release Date: 14, 2019 Response Date: July 30, 2019 Related Announcements None Issued National Institute Biomedical Imaging Bioengineering NIBIB) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Neurological Disorders Stroke NINDS) National Institute Nursing Research NINR) Fogarty International Center FIC) Purpose spinal cord injury SCI) research community experienced great advances discovery research, technology development, promising clinical interventions the past decade. build upon advances maximize benefit persons SCI, NIH hosted conference February 12-13, 2019 titled ldquo;SCI 2020: Launching Decade Disruption Spinal Cord Injury Research”. purpose the conference to bring together broad range stakeholders including researchers, clinicians health care professionals, individuals SCI, industry partners, regulators, funding agency representatives break down existing communication silos. participants asked critically evaluate state the science, assess areas technological community readiness, build collaborations could change trajectory research clinical options people SCI. Six primary sessions featured brief presentations recent scientific advances critical research questions the future. Facilitators audience participation encouraged identify opportunities areas collaboration. North American Spinal Cord Injury Consortium other public members provided personal context individuals living SCI defining future research priorities. five final breakout sessions, stakeholders discussed identified key gaps priorities SCI research the next decade. open sessions both days the conference be viewed at https://videocast.nih.gov/summary.asp?live=30194&bhcp=1 and https://vid…. Information Requested: NIH Institutes above soliciting comments suggestions the top priorities identified the five SCI 2020 breakout sessions summarized below. collated responses be shared the public will included a meeting summary document prepared collaboration the Spinal Cord Injury Model Systems Knowledge Translation Center https://msktc.org/about). NIH Institutes encourage input all interested stakeholders, including researchers, clinicians health care providers, individuals SCI, patient advocates health advocacy organizations, scientific professional organizations, federal agencies, well other interested members the public. Responders this RFI also encouraged provide input how research research capacity building the priority areas be adopted low resource settings including low- middle-income countries. Organizations strongly encouraged submit single response reflects views their organization membership. Optional: Please indicate you a researcher, clinician health care provider, individual SCI, patient advocate, and/or interested party. you submitting response behalf an organization, please indicate name your organization. SCI 2020: Research Priorities: Theme A: Improve care SCI patients the acute trauma setting Develop optimized approach infrastructure managing acute SCI: Establish evidence-based medical guidelines improve care SCI the time injury, including on-site stabilization, transportation admittance the ER trauma center. Establish evidence-based medical guidelines improve care SCI inpatient settings until discharge. Evaluate differences care during early period weeks months) after injury contribute long-term outcomes. Define provide specialty clinical expertise needed sites provide acute trauma care SCI. Improve multi-directional education among clinicians, patients, family, community peers. Align preclinical studies clinical conditions: Optimize of preclinical biomarkers outcome measures clinical relevance. Define clinically-feasible intervention window promising therapeutic approaches. Theme B: Accelerate research development therapies repair, plasticity improved functional recovery post-acute chronic SCI Develop use state the art technologies transform way study plasticity, circuits repair human SCI, well animal models. Expand fundamental knowledge the cells, circuits responses interventions inform innovative combinatorial repair approaches using cutting edge tools technologies. Define specificity requirements axonal growth, synapse formation, cell replacement, pathway activity and/or reconstruction circuits support recovery all stages post-injury. Optimize efficiency the of data standards data-sharing opportunities bench bedside bedside bench including unpublished data). Theme C: Improve evidence for, implementation of, functional recovery neuromodulation use-dependent plasticity Encourage longitudinal treatment studies study designs are informed outcomes high priority individuals chronic SCI. Understand mechanisms action characterize variables predict responsiveness neuromodulation interventions both early post-acute chronic conditions. Facilitate data sharing aggregation enable data science research can inform clinical care improve cost effectiveness interventions target recovery. Utilize input individuals SCI identify are acceptable risk/benefit ratios clinical trials modeled around the FDA’s Patient Engagement efforts). Theme D: Improve knowledge the full range health impacts chronic SCI Employ multi-site multi-disciplinary studies, SCI consumer community input, preclinical evidence use common data elements to: Understand impact behavioral, lifestyle, environmental factors reduce morbidity mortality across lifespan people SCI, a special emphasis nutrition metabolism, activity/exercise, and lean/fat mass a biomarker obesity. Promote safe efficient care recovery bowel, bladder sexual function; understand infection systemic inflammation impact functions individuals SCI. Understand biology impact SCI systemic health emphasis stressors effect immune function, role sensory autonomic regulation, physical mental health outcomes. Theme E: Improve functional recovery after SCI assistive technology Demonstrate assistive devices be used promote independence improve recovery after discharge. Incorporate user input, comparative effectiveness research, data sharing strategies establish robust evidence adoption assistive technologies. Improve reliability stability devices tissue interfaces lower barriers adoption improve embodiment. Develop approaches assistive devices adapt changes physical developmental needs, abilities, priorities the user over lifespan. to Submit Response: Responses this RFI must submitted electronically. Responses be accepted through July 30, 2019. Responses voluntary may submitted anonymously. Respondents advised the Government under obligation acknowledge receipt the information received provide feedback respondents respect any information submitted. Responses be shared publicly an NIH website. Please not include any personally identifiable other information you not wish make public. proprietary, classified, confidential, sensitive information should included your response. request for information planning purposes only should be construed a solicitation as obligation the part the United States Government. NIH not any awards based responses this RFI pay the preparation any information submitted for Government's of such information. Inquiries Please direct inquiries to: Lyn Jakeman, PhD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-827-5832 Email: lyn.jakeman@nih.gov Carol Taylor-Burds, PhD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-1447 Email: carol.taylor-burds@nih.gov

Notice Intent Publish Funding Opportunity Announcement BRAIN Initiative: Proof Concept Development Early Stage Next Generation Human Brain Imaging R01 Clinical Trial Allowed) Notice Number: NOT-EB-19-010 Key Dates Release Date:May 09, 2019 Estimated Publication Date Funding Opportunity Announcement: June 03, 2019 First Estimated Application Due Date: September 03, 2019 Earliest Estimated Award Date: 20, 2020 Earliest Estimated Start Date: July 01, 2020 Related Announcements RFA-EB-17-003 Issued National Institute Biomedical Imaging Bioengineering NIBIB) National Eye Institute NEI) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Drug Abuse NIDA) National Institute Mental Health NIMH) National Institute Neurological Disorders Stroke NINDS) National Center Complementary Integrative Health NCCIH) Purpose NIH Brain Research through Advancing Innovative Neurotechnologies BRAIN) Initiative intends reissue RFA-EB-17-003, Proof Concept Development Early Stage Next Generation Human Brain Imaging R01 Clinical Trials Allowed), modifications. funding opportunity aims support early stage development entirely new novel noninvasive human brain imaging technologies methods will lead transformative advances our understanding the human brain. FOA solicits unusually bold potentially transformative approaches supports small scale, proof concept development based exceptionally innovative, original and/or unconventional concepts. FOA utilize R01 activity code. Notice being provided allow potential applicants sufficient time develop meaningful collaborations responsive projects. Notice encourages investigators expertise insights this area noninvasive human brain imaging technologies methods begin consider applying this new FOA. Research Initiative Details TBD Funding Information Estimated Total Funding TBD Expected Number Awards TBD Estimated Award Ceiling TBD Primary CFDA Numbers TBD Anticipated Eligible Organizations Public/State Controlled Institution Higher Education Private Institution Higher Education Nonprofit 501(c)(3) IRS Status than Institution Higher Education) Nonprofit without 501(c)(3) IRS Status than Institution Higher Education) Small Business For-Profit Organization than Small Business) State Government Indian/Native American Tribal Government Federally Recognized) County governments City township governments Special district governments Independent school districts Public housing authorities/Indian housing authorities Indian/Native American Tribally Designated Organization Native American tribal organizations than Federally recognized tribal governments) U.S. Territory Possession Indian/Native American Tribal Government than Federally Recognized) Non-domestic non-U.S.) Entity Foreign Organization) Regional Organization Eligible Agencies the Federal Government Applications not being solicited this time.  Inquiries Please direct inquiries to: Shumin Wang, PhDNational Institute Biomedical Imaging Bioengineering NIBIB)301-594-9001shumin.wang@nih.gov

Notice Intent Publish Funding Opportunity Announcement BRAIN Initiative: Development Next Generation Human Brain Imaging Tools Technologies U01 Clinical Trial allowed) Notice Number: NOT-EB-19-011 Key Dates Release Date: 09, 2019 Estimated Publication Date Funding Opportunity Announcement: June 03, 2019 First Estimated Application Due Date: September 03, 2019 Earliest Estimated Award Date: 20, 2020 Earliest Estimated Start Date: July 01, 2020 Related Announcements RFA-EB-17-004 Issued National Institute Biomedical Imaging Bioengineering NIBIB) National Eye Institute NEI) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Drug Abuse NIDA) National Institute Mental Health NIMH) National Institute Neurological Disorders Stroke NINDS) National Center Complementary Integrative Health NCCIH) Purpose NIH Brain Research through Advancing Innovative Neurotechnologies BRAIN) Initiative intends reissue RFA-EB-17-004, Development Next Generation Human Brain Imaging Tools Technologies U01 Clinical Trials Allowed), modifications. funding opportunity aims support full development entirely new next generation noninvasive human brain imaging tools methods will lead transformative advances our understanding the human brain. FOA seeks innovative applications are ready full-scale development breakthrough technologies the intention delivering working tools. FOA utilize U01 activity code. Notice being provided allow potential applicants sufficient time develop meaningful collaborations responsive projects. Notice encourages investigators expertise insights this area noninvasive human brain imaging technologies methods begin consider applying this new FOA. Research Initiative Details TBD Funding Information Estimated Total Funding TBD Expected Number Awards TBD Estimated Award Ceiling TBD Primary CFDA Numbers TBD Anticipated Eligible Organizations Public/State Controlled Institution Higher Education Private Institution Higher Education Nonprofit 501(c)(3) IRS Status than Institution Higher Education) Nonprofit without 501(c)(3) IRS Status than Institution Higher Education) Small Business For-Profit Organization than Small Business) State Government Indian/Native American Tribal Government Federally Recognized) County governments City township governments Special district governments Independent school districts Public housing authorities/Indian housing authorities Indian/Native American Tribally Designated Organization Native American tribal organizations than Federally recognized tribal governments) U.S. Territory Possession Indian/Native American Tribal Government than Federally Recognized) Non-domestic non-U.S.) Entity Foreign Organization) Regional Organization Eligible Agencies the Federal Government Applications not being solicited this time   Inquiries Please direct inquiries to: Shumin Wang, PhDNational Institute Biomedical Imaging Bioengineering NIBIB)shumin.wang@nih.gov

Notice Extend Expiration Date PA-18-141 Mechanisms, Models, Measurement, & Management Pain Research R01 Clinical Trial Optional)" Notice Number: NOT-NS-19-061 Key Dates Release Date: 7, 2019 Related Announcements PA-18-141 Issued National Institute Neurological Disorders Stroke NINDS) National Cancer Institute NCI) National Institute Aging NIA) National Institute Arthritis Musculoskeletal Skin Diseases NIAMS) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Dental Craniofacial Research NIDCR) National Institute Drug Abuse NIDA) National Institute Nursing Research NINR) National Institute Minority Health Health Disparities NIMHD) National Center Complementary Integrative Health NCCIH) Purpose purpose this notice to inform interested applicants the expiration Date PA-18-141 ""Mechanisms, Models, Measurement, amp; Management Pain Research R01 Clinical Trial Optional)" be extended one Council round changes shown bold italics below). Funding Opportunity Announcement been modified add additional Application due date of June 5, 2019 new applications) July 5, 2019, renewal, resubmission, revision applications) and additional AIDS Application Due Date of September 7, 2019. Currently Reads: Part 1. Overview Key Dates: Application Due Date(s) Standard dates , 5:00 PM local time applicant organization. All types non-AIDS applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. AIDS Application Due Date(s) Standard AIDS dates 7, 2018, September 7, 2018, January 7, 2019 May 7, 2019) apply, 5:00 PM local time applicant organization. All types AIDS AIDS-related applicationsallowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. Scientific Merit Review Standard dates apply Advisory Council Review Standard dates apply Earliest Start Date Standard dates apply Expiration Date 8, 2019 Modified Read: Part 1. Overview Key Dates: Application Due Date(s) Standard dates ), 5:00 PM local time applicant organization. All types non-AIDS applications allowed this funding opportunity announcement due these dates. AIDS Application Due Date(s) Standard AIDS dates 7, 2018, September 7, 2018, January 7, 2019 May 7, 2019, September 7, 2019?) apply, 5:00 PM local time applicant organization. Alltypes AIDS AIDS-related applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. Scientific Merit Review Standard dates apply Advisory Council Review Standard dates apply Earliest Start Date Standard dates apply Expiration Date September 8, 2019 other aspects this FOA remain unchanged. Inquiries Please direct inquiries to: Michael Oshinsky, PhD National Institute Neurological Disorders amp; Stroke NINDS) Telephone: 301-496-9964 Email:michael.oshinsky@nih.gov

Notice Extend Expiration Date PA-18-159 Mechanisms, Models, Measurement, & Management Pain Research R21 Clinical Trial Optional)" Notice Number: NOT-NS-19-062 Key Dates Release Date: 7, 2019 Related Announcements PA-18-159 Issued National Institute Neurological Disorders Stroke NINDS) National Cancer Institute NCI) National Institute Aging NIA) National Institute Arthritis Musculoskeletal Skin Diseases NIAMS) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Dental Craniofacial Research NIDCR) National Institute Drug Abuse NIDA) National Institute Nursing Research NINR) National Institute Minority Health Health Disparities NIMHD) National Center Complementary Integrative Health NCCIH) Purpose purpose this notice to inform interested applicants the expiration Date PA-18-159 ""Mechanisms, Models, Measurement, & Management Pain Research R21 Clinical Trial Optional)" be extended one Council round changes shown bold italics below). Funding Opportunity Announcement been modified add additional Application due date of June 16, 2019 new applications), July 16, 2019 resubmission applications) and additional AIDS Application Due Date of September 7, 2019. Currently Reads: Part 1. Overview Key Dates: Application Due Date(s) Standard dates), 5:00 PM local time applicant organization. All types non-AIDS applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. AIDS Application Due Date(s) Standard AIDS dates 7, 2018, September 7, 2018, January 7, 2019 May 7, 2019) apply, 5:00 PM local time applicant organization. Alltypes AIDS AIDS-related applicationsallowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. Scientific Merit Review Standard dates apply Advisory Council Review Standard dates apply Earliest Start Date Standard dates apply Expiration Date 8, 2019 Modified Read: Part 1. Overview Key Dates: Application Due Date(s) Standard dates  ( June 16, 2019 new applications), July 16, 2019 resubmission applications) ), 5:00 PM local time applicant organization. All types non-AIDS applications allowed this funding opportunity announcement due these dates. AIDS Application Due Date(s) Standard AIDS dates 7, 2018, September 7, 2018, January 7, 2019 May 7, 2019, September 7, 2019) apply, 5:00 PM local time applicant organization. Alltypes AIDS AIDS-related applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. Scientific Merit Review Standard dates apply Advisory Council Review Standard dates apply Earliest Start Date Standard dates apply Expiration Date September 8, 2019 other aspects this FOA remain unchanged. Inquiries Please direct inquiries to: Michael Oshinsky, PhD National Institute Neurological Disorders & Stroke NINDS) Telephone: 301-496-9964 Email:michael.oshinsky@nih.gov

Notice Extend Expiration Date PAR-18-711 Career Transition Award NINDS Intramural Clinician-Scientists K22 Clinical Trial Allowed)" Notice Number: NOT-NS-19-063 Key Dates Release Date: 7, 2019 Related Announcements PAR-18-711 Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this notice to inform interested applicants the expiration Date PAR-18-711 Career Transition Award NINDS Intramural Clinician-Scientists K22 Clinical Trials Allowed)" be extended one Council round changes shown bold italics below).  Funding Opportunity Announcement been modified add additional New Application Due date of June 12, 2019 and resubmission application due date of July 12, 2019. Currently Reads: Part 1. Overview Key Dates: Application Due Date(s) Standard dates , 5:00 PM local time applicant organization. All types non-AIDS applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. Scientific Merit Review Standard dates apply Advisory Council Review Standard dates apply Earliest Start Date Standard dates apply Expiration Date 8, 2019 Modified Read: Part 1. Overview Key Dates: Application Due Date(s) Standard dates , 5:00 PM local time applicant organization. All types non-AIDS applications allowed this funding opportunity announcement due these dates. Scientific Merit Review Standard dates apply Advisory Council Review Standard dates apply Earliest Start Date Standard dates apply Expiration Date July 13, 2019 other aspects this FOA remain unchanged. Inquiries Please direct inquiries to: Stephen Korn, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-4188 Email: korns@ninds.nih.gov

Notice Extend Expiration Date PAR-18-710 Career Transition Award NINDS Intramural Clinician-Scientists K22 Clinical Trial Required)" Notice Number: NOT-NS-19-065 Key Dates Release Date: 7, 2019 Related Announcements PAR-18-710 Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this notice to inform interested applicants the expiration Date PAR-18-710 Career Transition Award NINDS Intramural Clinician-Scientists K22 Clinical Trial Required)" be extended one Council round changes shown bold italics below).  Funding Opportunity Announcement been modified add additional New Application Due date of June 12, 2019 and resubmission application due date of July 12, 2019. Currently Reads: Part 1. Overview Key Dates: Application Due Date(s) Standard dates , 5:00 PM local time applicant organization. All types non-AIDS applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. Scientific Merit Review Standard dates apply Advisory Council Review Standard dates apply Earliest Start Date Standard dates apply Expiration Date 8, 2019 Modified Read: Part 1. Overview Key Dates: Application Due Date(s) Standard dates , 5:00 PM local time applicant organization. All types non-AIDS applications allowed this funding opportunity announcement due these dates. Scientific Merit Review Standard dates apply Advisory Council Review Standard dates apply Earliest Start Date Standard dates apply Expiration Date July 13, 2019 other aspects this FOA remain unchanged. Inquiries Please direct inquiries to: Stephen Korn, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-4188 Email: korns@ninds.nih.gov

Notice Clarification RFA-NS-18-043, Discovery Validation Novel Targets Safe Effective Pain Treatment R01 Clinical Trial Allowed)" Notice Number: NOT-AT-19-024 Key Dates Release Date: 7, 2019 Related Announcements RFA-NS-18-043 Issued National Center Complementary Integrative Health NCCIH) Purpose purpose this Notice to clarify Research Objectives” section for RFA-NS-18-043, Discovery Validation Novel Targets Safe Effective Pain Treatment R01 Clinical Trial Allowed)”. below revisions effective immediately apply the July 11, 2019 Application Due Date. Part 2. Full Text Announcement Section I. Funding Opportunity Description Research Objectives Currently reads: Applications identify targets devices, such peripheral nerve, spinal cord, deep brain stimulators focus identifying electrophysiological signatures acute chronic pain. Validation these targets large animals nonhuman primates should considered. Revised read: Applications identify validate targets devices such invasive non-invasive nerve stimulators, or acupoint-based other transcutaneous peripheral stimulations acute chronic pain. Applications identify either nervous system targets non-neural targets e.g., connective tissues, lymphatic, glymphatic targets) pain. Validation these targets large animals nonhuman primates should considered. Applications propose discovery validation targets any sensory systems e.g., olfaction, vision, audition, somatosensation, interoception, etc.) acute chronic pain. includes targets pharmacological well non-pharmacological approaches e.g., mind-body approaches, natural products, devices). Studies focused the efficacy effectiveness a therapeutic molecule a type treatment, such yoga acupuncture, pain not responsive this RFA, even this only part the application. other aspects this FOA remain unchanged. Inquiries Please direct inquiries to: Inna Belfer, MD, PhD National Center Complementary Integrative Health NCCIH) Telephone: 301-435-1573 Email: inna.belfer@nih.gov Michael L. Oshinsky, PhD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-9964 Email: michael.oshinsky@nih.gov

Notice Clarification RFA-NS-18-042, Discovery Validation Novel Targets Safe Effective Pain Treatment R21 Clinical Trial Allowed)" Notice Number: NOT-AT-19-026 Key Dates Release Date: 7, 2019 Related Announcements RFA-NS-18-042 Issued National Center Complementary Integrative Health NCCIH) National Institute Neurological Disorders Stroke NINDS) Purpose purpose this Notice to clarify Research Objectives” section for RFA-NS-18-042, Discovery Validation Novel Targets Safe Effective Pain Treatment R21 Clinical Trial Allowed)”. below revisions effective immediately apply the July 11, 2019 Application Due Date. Part 2. Full Text Announcement Section I. Funding Opportunity Description Research Objectives Currently reads: Applications identify targets devices, such peripheral nerve, spinal cord, deep brain stimulators focus identifying electrophysiological signatures acute chronic pain. Validation these targets large animals nonhuman primates should considered. Revised read: Applications identify validate targets devices such invasive non-invasive nerve stimulators, or acupoint-based other transcutaneous peripheral stimulations acute chronic pain. Applications identify either nervous system targets non-neural targets e.g., connective tissues, lymphatic, glymphatic targets) pain. Validation these targets large animals nonhuman primates should considered. Applications propose discovery validation targets any sensory systems e.g., olfaction, vision, audition, somatosensation, interoception, etc.) acute chronic pain. includes targets pharmacological well non-pharmacological approaches e.g., mind-body approaches, natural products, devices). Studies focused the efficacy effectiveness a therapeutic molecule a type treatment, such yoga acupuncture, pain not responsive this RFA, even this only part the application. other aspects this FOA remain unchanged. Inquiries Please direct inquiries to: Inna Belfer, MD, PhD National Center Complementary Integrative Health NCCIH) Telephone: 301-435-1573 Email: inna.belfer@nih.gov Michael L. Oshinsky, PhD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-9964 Email: michael.oshinsky@nih.gov

Request Information: Research Plan Rehabilitation Notice Number: NOT-HD-19-006 Key Dates Release Date: April 23, 2019 Response Date: June 17, 2019 Related Announcements NOT-HD-15-032 Issued Eunice Kennedy ShriverNational Institute Child Health Human Development NICHD) National Center Complementary Integrative Health NCCIH) National Cancer Institute NCI) National Eye Institute NEI) National Institute Arthritis Musculoskeletal Skin Diseases NIAMS) National Institute Biomedical Imaging Bioengineering NIBIB) National Institute Deafness Other Communication Disorders NIDCD) National Institute Diabetes Digestive Kidney Diseases NIDDK) National Institute Neurological Disorders Stroke NINDS) National Institute Nursing Research NINR) Purpose TheEunice Kennedy ShriverNational Institute Child Health Human Development NICHD), National Center Medical Rehabilitation Research inviting comments suggestions guide revision the Research Plan Rehabilitation behalf the Trans NIH Medical Rehabilitation Coordinating Committee. Background 2016, National Institutes Health published Research Plan Rehabilitation outlined priorities the Institutes Centers advance rehabilitation science https://www.nichd.nih.gov/sites/default/files/publications/pubs/Documen…). Since time, NIH promoted multiple initiatives, workshops, funding opportunities aimed advancing priorities within research plan. Moreover, National Center Medical Rehabilitation Research theEunice Kennedy ShriverNational Institute Child Health Human Development presented annual updates the changes the portfolio following publication the research plan the National Advisory Board Medical Rehabilitation Research https://www.nichd.nih.gov/about/advisory/nabmrr). Information Requested NIH Medical Rehabilitation Coordinating Committee beginning update the research plan, required the 21stCentury Cures Act 42 USC 285g-4), is seeking guidance the community stakeholders involved this research. Specifically, NIH requests feedback the following: communitys perception progress towards achieving priorities specified the research plan, Potential priorities areas research consider the update the research plan, Current priorities should retained continued, Emerging areas science will impact research plan rehabilitation, Potential focus areas concentrated work medical rehabilitation research. feedback garnered this request information be reported the 2019 meeting the National Advisory Board Medical Rehabilitation Research will incorporated the update the Research Plan Rehabilitation is planned 2021. to Submit Response comments must submitted electronically Rehabilitation1@mail.nih.gov. Responses longer 300 words Microsoft or PDF format) must received 11:59:59 ET) the response date noted above.Please indicate RFI Reponse" the subject line the email.You receive electronic confirmation acknowledging receipt your response. Responses this RFI voluntary. not include any proprietary, classified, confidential, trade secret, sensitive information your response. responses be reviewed NIH staff, individual feedback not provided any responder. U.S. Government use information submitted response this RFI its discretion. U.S. Government reserves right use any submitted information public NIH websites, reports, summaries the state the science, any possible resultant solicitation(s), grant(s), cooperative agreement(s), in development future funding opportunity announcements. RFI for information planning purposes only shall be construed a solicitation, grant, cooperative agreement, as obligation the part the Federal Government, NIH, individual NIH Institutes Centers provide support any ideas identified response it. Government not pay the preparation any information submitted for U.S. Governments of such information. basis claims against U.S. Government shall arise a result a response this request information from Governments of such information. Inquiries Please direct inquiries to: Alison N. Cernich, PhD Eunice Kennedy ShriverNational Institute Child Health Human Development NICHD) Telephone: 301-496-0295 Email: Rehabilitation@nih.gov