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Notice Extend Expiration Date PA-18-159 Mechanisms, Models, Measurement, amp; Management Pain Research R21 Clinical Trial Optional)" Notice Number: NOT-NS-20-022 Key Dates Release Date: December 18, 2019 Related Announcements PA-18-159 Issued National Institute Neurological Disorders Stroke NINDS) National Institute Aging NIA) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Dental Craniofacial Research NIDCR) National Institute Drug Abuse NIDA) National Institute Nursing Research NINR) National Institute Minority Health Health Disparities NIMHD) National Center Complementary Integrative Health NCCIH) National Cancer Institute NCI) Purpose purpose this notice to inform interested applicants a change the Key Dates PA-18-159 ""Mechanisms, Models, Measurement, amp; Management Pain Research R21 Clinical Trial Optional)". Four additional receipt dates been added changes shown bold italics below). Funding Opportunity Announcement been modified add following New Application due dates: February 16, 2020, June 16, 2020, October 16, 2020, February 16, 2021 (new applications) and March 16, 2020, July 16, 2020, November 16, 2020, and March 16, 2021 (renewal, resubmission, revision applications) AIDS Application Due Dates of May 7, 2020, September 7, 2020, January 7, 2021, and May 7, 2021. Additionally, effective immediately, NIAMS no longer participating PA-18-159 will accept applications response PA-18-159. Currently Reads: Part 1. Overview Components Participating Organizations National Cancer Institute NCI) National Institute Nursing Research NINR) National Institute Aging NIA) National Institute Arthritis Musculoskeletal Skin Diseases NIAMS) National Institute Drug Abuse NIDA) National Institute Dental Craniofacial Research NIDCR) National Institute Neurological Disorders Stroke NINDS) National Center Complementary Integrative Health NCCIH) National Institute Minority Health Health Disparities NIMHD) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) Catalog Federal Domestic Assistance CFDA) Number(s) 93.361; 93.866; 93.846; 93.279; 93.121; 93.853; 93.213; 93.307; 93.393, 93.865 Key Dates: Application Due Date(s) Standard dates apply, 5:00 PM local time applicant organization. All types non-AIDS applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. AIDS Application Due Date(s) Standard AIDS dates apply, 5:00 PM local time applicant organization. All types AIDS AIDS-related applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. Scientific Merit Review Standard dates apply Advisory Council Review Standard dates apply Earliest Start Date Standard dates apply Expiration Date January 8, 2020 Modified Read: Part 1. Overview Components Participating Organizations National Cancer Institute NCI) National Institute Nursing Research NINR) National Institute Aging NIA) National Institute Drug Abuse NIDA) National Institute Dental Craniofacial Research NIDCR) National Institute Neurological Disorders Stroke NINDS) National Center Complementary Integrative Health NCCIH) National Institute Minority Health Health Disparities NIMHD) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) Catalog Federal Domestic Assistance CFDA) Number(s) 93.361; 93.866; 93.279; 93.121; 93.853; 93.213; 93.307; 93.393, 93.865 Key Dates: Application Due Date(s) Standard dates apply, 5:00 PM local time applicant organization. All types non-AIDS applications allowed this funding opportunity announcement due these dates. AIDS Application Due Date(s) Standard AIDS dates apply, 5:00 PM local time applicant organization. All types AIDS AIDS-related applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. Scientific Merit Review Standard dates apply Advisory Council Review Standard dates apply Earliest Start Date Standard dates apply Expiration Date 8, 2021 other aspects this FOA remain unchanged. Inquiries Please direct inquiries to: Michael Oshinsky, PhD National Institute Neurological Disorders amp; Stroke NINDS) Telephone: 301-496-9964 Email:michael.oshinsky@nih.gov Martha Matocha, PhD National Institute Nursing Research NINR) Telephone: 301-594-2775 Email: matocham@mail.nih.gov

Request Information: Curing Epilepsies 2020: Setting Research Priorities Notice Number: NOT-NS-20-025 Key Dates Release Date: December 13, 2019 Response Date: February 20, 2020 Related Announcements None Issued National Institute Neurological Disorders Stroke NINDS ) Purpose purpose this Request Information RFI) to seek broad input scientists, clinicians, patients, families, caregivers, advocates, the broader epilepsy community the most important new ongoing challenges opportunities epilepsy research. Input be considered updating 2014 Epilepsy Research Benchmarks setting Epilepsy Research Priorities the Curing Epilepsies 2020 Conference. Background Since 2000, NINDS worked the epilepsy community identify priorities research. 2000, 2007 2013, NINDS sponsored Curing Epilepsy conferences partnership nongovernmental organizations other Federal agencies assess state epilepsy research identify needs new directions. conferences led the development subsequent revisions the Epilepsy Research Benchmarks, series goals research toward cures the epilepsies, defined no seizures, side effects, the prevention epilepsy those risk. Since initial development 2000, Benchmarks brought attention goals such preventing epileptogenesis, addressing aspects epilepsy beyond seizures, confronting challenge sudden unexpected death epilepsy SUDEP). Benchmarks meant engage entire epilepsy community advancing research, including NIH, NIH grantees other researchers, epilepsy professional organizations, the epilepsy patient community. NINDS particular considers Benchmarks planning new investments epilepsy research has also worked epilepsy researchers serve Benchmarks Stewards track promote progress. The ICARE Epilepsy Research Portfolio tracks research funding towards benchmarks the federal nonprofit members the Interagency Collaborative Advance Research Epilepsy ICARE). April 13-15, 2020, NINDS sponsor fourth public conference, Curing Epilepsies 2020: Setting Research Priorities" reassess state epilepsy research. conference include scientific sessions major topics the field will culminate a discussion possible updates the Epilepsy Research Benchmarks. new goal the conference be each benchmark area develop several key gap priorities address research areas needing substantial focused effort order make significant advances. gap priorities focus areas where is currently limited research knowledge and/or where collaborative community efforts make significant scientific progress the next 5-7 years toward cures the epilepsies. information submitted response this RFI be used the benchmark stewards committee revise update the 2014 Epilepsy Research Benchmarks. draft revisions the benchmarks recommended gap priorities be presented the public further input the Curing Epilepsies 2020 conference, will take place April 13-15, 2020, the main NIH campus Bethesda, MD Register attend at Curing Epilepsies 2020. Registration free open the public). Information Requested NINDS soliciting input all interested stakeholders, including researchers, health care providers, individuals epilepsy, patient advocates health advocacy organizations, scientific professional organizations, federal agencies, well other interested members the public. Organizations strongly encouraged submit single response reflects views their organization membership a whole. Please provide perspectives the following topics: Comments suggestions regarding current 2014 epilepsy research benchmarks -- examples include comments benchmarks could removed because have achieved and/or no longer priorities, the current benchmarks be revised, any new research questions should included, based scientific progress since 2013. New ongoing research priority challenges opportunities. Identify most promising areas research the community should focus concerted efforts based knowledge gaps research needs, which significantly advanced the next 5-7 years. priorities should areas epilepsy research require concerted coordinated effort will transform significantly advance research the area. to Submit Response assure consideration, responses must received February 20, 2020, should submitted electronically.  Responses voluntary may submitted anonymously. Respondents advised the Government under obligation acknowledge receipt the information received provide feedback respondents respect any information submitted. Responses be shared publicly the Curing Epilepsies 2020 conference. Please not include any personally identifiable other information you not wish make public. proprietary, classified, confidential, sensitive information should included your response. request for planning purposes only should be construed a solicitation as obligation the part the United States Government. NIH not any awards based responses this RFI pay the preparation any information submitted for Government's of such information. Inquiries Please direct inquiries to: Miriam Leenders, PhDNational Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-1917 Email: miriam.leenders@nih.gov

Notice Extension the Response Date NOT-NS-19-080 Solicitation Nominations the 2020 National Institute Neurological Disorders Stroke NINDS) Landis Award Outstanding Mentorship" Notice Number: NOT-NS-20-028 Key Dates Release Date: December 3, 2019 Related Announcements NOT-NS-19-080 Issued National Institute Neurological Disorders Stroke NINDS) Purpose notice extends response date NOT-NS-19-080 Solicitation Nominations the 2020 National Institute Neurological Disorders Stroke NINDS) Landis Award Outstanding Mentorship." following sections NOT-NS-19-080 been updated: Key Dates Current Response Date: December 01, 2019 New Response Date: December 15, 2019 other aspects the RFI remain same. Inquiries Please direct inquiries to: Stephen Korn, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-4188 Email: korns@ninds.nih.gov

Request Information RFI) Resources needed Facilitate Use Macaques Biomedical Research Notice Number: NOT-OD-20-016 Key Dates Release Date: November 22, 2019 Response Date: January 06, 2020 Related Announcements None Issued Office AIDS Research OAR) National Eye Institute NEI) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Allergy Infectious Diseases NIAID) National Institute Environmental Health Sciences NIEHS) National Institute Deafness Other Communication Disorders NIDCD) Division Program Coordination, Planning Strategic Initiatives, Office Research Infrastructure Programs ORIP) Purpose Request Information RFI) seeks input current challenges key bottlenecks the of macaques animal models biomedical research. principal objectives include identification the needs particular macaques, species-specific biologic reagents, genetic behavioral analytic tools technologies, other crucial resources, would advance use macaques research, facilitate translation research using model the clinic. Background Nonhuman primates NHP) the closest evolutionary relatives humans. anatomical, physiological, developmental, immunological, cognitive, genetic, reproductive, social similarity between humans NHPs NHPs indispensable resource studying human health disease. macaque one the most commonly used NHP models worldwide. Experimental studies macaques provided insights numerous areas human health disease. recent report the Office Research Infrastructure Programs indicates the high demand the of macaques biomedical research continue the foreseeable future link). NIH seeking stakeholder feedback guide development priorities accelerate research using macaques models human diseases, to facilitate translation these findings human conditions treatment. notice seeks solicit public comment the challenges, gap areas bottlenecks experienced the macaque research community. Feedback obtained through Notice other outreach efforts help inform development research infrastructure priorities biomedical research involving macaques a model organism. Information Requested Stakeholder feedback requested any all the following topics: Access appropriate animals your study e.g. age, pathogen free status, etc.). Key biological reagents tools need be developed facilitate use the various macaque species animal models accelerate translation results. Additional characterization selected macaque models. For, example characterization the immune system different ages, characterization the microbiome different ages, reference genomes specific species annotation the reference genome. Development Core facilities. so, types services should provided? Improvement data, reagent sample sharing within macaque research community. Optimization standardization procedures within macaque research community. Key areas NIH become involved to facilitate research using macaques. Submitting Response comments must submitted electronically to http://grants.nih.gov/grants/rfi/rfi.cfm?ID=94 by 01/06/2020. request for information planning purposes only should be construed a solicitation as obligation the part the Federal Government. NIH does intend make any awards based responses this RFI to otherwise pay the preparation any information submitted for Government's of such information. NIH use information submitted response this RFI its discretion will provide comments any responder's submission. However, responses the RFI be reflected future funding opportunity announcements. information provided be analyzed may aggregated presentations reports. Respondents advised the Government under obligation acknowledge receipt the information received provide feedback respondents respect any information submitted. proprietary, classified, confidential, sensitive information should included your response. Government reserves right use any non-proprietary technical information any resultant solicitation(s). Inquiries Please direct inquiries to: Brenda Fredericksen, Ph.D. Office AIDS Research OAR) Telephone:  240-669-5566 Email:  RhesusMacaqueRFI@nih.gov

Notice Correction the instructions submitting applications PAR-19-171, Comparative Effectiveness Research Clinical Neurosciences UG3/UH3 Clinical Trial Allowed).” Notice Number: NOT-NS-20-019 Key Dates Release Date: November 18, 2019 Related Announcements PAR-19-171 Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this Notice to correct instructions submitting applications PAR-19-171, Comparative Effectiveness Research Clinical Neurosciences UG3/UH3 Clinical Trial Allowed)." changes shown in Bold Italics below. notice be effective the February 19, 2020 due date subsequent due dates. Currently Reads: Part 2. Full Text Announcement Section I. Funding Opportunity Description Applicants should take note the following special requirements considerations: Scope. scope this FOA includes prospective observational studies example, studies typical care multiple treatment modalities used, natural experiments changes medical care policies, studies where care differs based geography, cohort-based studies, among others). Modified Read: Part 2. Full Text Announcement Section I. Funding Opportunity Description Applicants should take note the following special requirements considerations: Scope. scope this FOA includes prospective observational studies example, studies typical care multiple treatment modalities used, natural experiments changes medical care policies, studies where care differs based geography, cohort-based studies, among others). Limited studies outcomes are included typical care be included e.g., limited implementation neuropsychological studies), relevant the proposed hypothesis. other aspects this FOA remain unchanged. Inquiries Please direct inquiries to: Adam L. Hartman, MD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-9135 E-mail: adam.hartman@nih.gov

Notice Change Key Dates PAR-18-420 NINDS Exploratory Clinical Trials U01 Clinical Trial Required)" Notice Number: NOT-NS-20-017 Key Dates Release Date: November 08, 2019 Related Announcements PAR-18-420 Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this notice to inform interested applicants a change the Key Dates PAR-18-420 NINDS Exploratory Clinical Trials U01 Clinical Trial Required)" changes shown below italics). Funding Opportunity Announcement been modified add following New Application Due Dates: February 5, 2020, June 5, 2020, October 5, 2020, February 5, 2021, Revision, Resubmission Renewal dates: March 5, 2020, July 5, 2020, November 5, 2020, March 5, 2021, and AIDS application Due Dates: May 7, 2020, September 7, 2020, January 7, 2021 May 7, 2021. Currently Reads: Part 1. Overview Key Dates: Application Due Date(s) Standard dates apply 5:00 PM local time applicant organization. All types non-AIDS applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. AIDS Application Due Date(s) Standard AIDS dates apply, 5:00 PM local time applicant organization. All types AIDS AIDS-related applications allowed this funding opportunity announcement due these dates. first AIDS due date this FOA May 7, 2018. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. Scientific Merit Review Standard dates apply Advisory Council Review Standard dates apply Earliest Start Date Standard dates apply Expiration Date January 8, 2020 Modified Read: Part 1. Overview Key Dates: Application Due Date(s) Standard dates apply 5:00 PM local time applicant organization. All types non-AIDS applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. AIDS Application Due Date(s) Standard AIDS dates apply, 5:00 PM local time applicant organization. All types AIDS AIDS-related applications allowed this funding opportunity announcement due these dates. first AIDS due date this FOA May 7, 2018. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. Scientific Merit Review Standard dates apply Advisory Council Review Standard dates apply Earliest Start Date Standard dates apply Expiration Date 8, 2021 other aspects this FOA remain unchanged. Inquiries Please direct inquiries to: Peter Gilbert, ScM National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-0870 Email: pgilbert@nih.gov

Notice Change Key Dates PAR-18-422 NINDS Efficacy Clinical Trials U01 Clinical Trial Required)" Notice Number: NOT-NS-20-018 Key Dates Release Date: November 08, 2019 Related Announcements PAR-18-422 Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this notice to inform interested applicants a change the Key Dates PAR-19-422 NINDS Efficacy Clinical Trials U01 Clinical Trial Required)" changes shown below italics). Funding Opportunity Announcement been extended one additional council round. dates been modified add following New Application Due Date: February 5, 2021, Revision, Resubmission Renewal date: March 5, 2021, and AIDS application Due Date: May 7, 2021. Currently Reads: Part 1. Overview Key Dates: Application Due Date(s) Standard dates apply 5:00 PM local time applicant organization. All types non-AIDS applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. AIDS Application Due Date(s) Standard AIDS dates apply, 5:00 PM local time applicant organization. All types AIDS AIDS-related applications allowed this funding opportunity announcement due these dates. first AIDS due date this FOA May 7, 2018. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. Scientific Merit Review Standard dates apply Advisory Council Review Standard dates apply Earliest Start Date Standard dates apply Expiration Date January 8, 2021 Modified Read: Part 1. Overview Key Dates: Application Due Date(s) Standard dates apply 5:00 PM local time applicant organization. All types non-AIDS applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. AIDS Application Due Date(s) Standard AIDS dates apply, 5:00 PM local time applicant organization. All types AIDS AIDS-related applications allowed this funding opportunity announcement due these dates. first AIDS due date this FOA May 7, 2018. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. Scientific Merit Review Standard dates apply Advisory Council Review Standard dates apply Earliest Start Date Standard dates apply Expiration Date 8, 2021 other aspects this FOA remain unchanged. Inquiries Please direct inquiries to: Peter Gilbert, ScM National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-0870 Email: pgilbert@nih.gov

Notice Change salary allowance K99 awardees PA-19-090 NIH Pathway Independence Award Parent K99/R00 Independent Basic Experimental Studies Humans Required)” Notice Number: NOT-NS-20-016 Key Dates Release Date: November 06, 2019 Related Announcements PA-19-090 Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this notice to inform community NINDS changing funding allowance K99/R00 applications NINDS. change apply new NINDS K99/R00 awards on after September 2019 NINDS Advisory Council meeting.   Currently, NINDS provides to 100,000 salary plus appropriate fringe benefit costs, plus to 20,000 research expenses) during K99 phase clinician-scientists are licensed practice clinically. will remain unchanged. all awardees are licensed practice clinically, NINDS currently provides to 50,000 salary plus appropriate fringe benefit costs, plus to 20,000 research expenses) during K99 phase. Effective awards at after September 2019 NINDS Advisory Council meeting , NINDS increase amount provided salary this cohort awardees up 75,000, maintain allowances the current amounts, during K99 phase. other NINDS policies regard the K99/R00 award remain unchanged. Inquiries Please direct inquiries to: Stephen Korn, Ph.D. NINDS, Office Training amp; Workforce Development Telephone: 301-496-4188 Email: korns@ninds.nih.gov

Notice Change salary allowance NINDS K99 awardees PA-19-129 NIH Pathway Independence Award Parent K99/R00 Independent Clinical Trial Required)" Notice Number: NOT-NS-20-007 Key Dates Release Date: November 05, 2019 Related Announcements PA-19-129 Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this notice to inform community NINDS changing funding allowance K99/R00 applications NINDS. change apply new NINDS K99/R00 awards at after September 2019 NINDS Advisory Council meeting.     Currently, NINDS provides to 100,000 salary plus appropriate fringe benefit costs, plus to 20,000 research expenses) during K99 phase clinician-scientists are licensed practice clinically. will remain unchanged. all awardees are licensed practice clinically, NINDS currently provides to 50,000 salary plus appropriate fringe benefit costs, plus to 20,000 research expenses) during K99 phase. Effective awards at after September 2019 NINDS Advisory Council meeting, NINDS increase amount provided salary this cohort awardees up 75,000, maintain allowances the current amounts, during K99 phase. other NINDS policies regard the K99/R00 award remain unchanged. Inquiries Please direct inquiries to: Stephen Korn, Ph.D. NINDS, Office Training amp; Workforce Development Telephone: 301-496-4188 Email: korns@ninds.nih.gov

Notice Change salary allowance NINDS K99 awardees PA-19-130 NIH Pathway Independence Award Parent K99/R00 Independent Clinical Trial Allowed)" Notice Number: NOT-NS-20-008 Key Dates Release Date: November 05, 2019 Related Announcements PA-19-130 Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this notice to inform community NINDS changing funding allowance K99/R00 applications NINDS. change apply new NINDS K99/R00 awards at after September 2019 NINDS Advisory Council meeting.   Currently, NINDS provides to 100,000 salary plus appropriate fringe benefit costs, plus to 20,000 research expenses) during K99 phase clinician-scientists are licensed practice clinically. will remain unchanged. all awardees are licensed practice clinically, NINDS currently provides to 50,000 salary plus appropriate fringe benefit costs, plus to 20,000 research expenses) during K99 phase. Effective awards at after September 2019 NINDS Advisory Council meeting, NINDS increase amount provided salary this cohort awardees up 75,000, maintain allowances the current amounts, during K99 phase. other NINDS policies regard the K99/R00 award remain unchanged. Inquiries Please direct inquiries to: Stephen Korn,Ph.D. NINDS, Office Training amp; Workforce Development Telephone: 301-496-4188 Email: korns@ninds.nih.gov nbsp;