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Reissue of RFA-NS-20-010: The purpose of this funding opportunity announcement (FOA) is to support preclinical optimization and development of safe, effective, and non-addictive small molecule and biologic therapeutics to treat pain. The goal of the program is to accelerate the optimization and development of promising small molecule and biologic hits/leads towards clinical trials. Applicants must have a promising hit/lead, robust biological rationale for the intended approach, and identified assays for optimization of the agent. The scope of this program includes optimization and early development activities, IND-enabling studies, and assembly of Investigational New Drug (IND) application. This is a milestone-driven phased cooperative agreement program involving participation of NIH program staff in the development of the project plan and monitoring of research progress.

The purpose of this Notice is to extend RFA-MH-19-135, BRAIN Initiative: Development of Novel Tools to Probe Cell-Specific and Circuit-Specific Processes in Human and Non-Human Primate Brain (UG3/UH3 Clinical Trial Optional)

The purpose of this Notice is to extend RFA-MH-20-135, BRAIN Initiative: Tools to Facilitate High-Throughput Microconnectivity Analysis (R01 Clinical Trial Not Allowed)

The purpose of this notice is to inform applicants of a change to the Key Dates for RFA-NS-18-011 "Translational Neural Devices (UG3/UH3 Clinical Trial Required)". This Funding Opportunity Announcement has been extended by one council round. The dates have been modified to add a New Application Due Date of February 22, 2021.

The purpose of this notice is to inform applicants of a change to the Key Dates for RFA-NS-18-012 "Translational Neural Devices (U44 Clinical Trial Required)". This Funding Opportunity Announcement has been extended by one council round. The dates have been modified to add a New Application Due Date of February 22, 2021.

The purpose of this notice is to inform applicants of a change to the Key Dates for RFA-NS-18-021 "BRAIN Initiative: Next-Generation Invasive Devices for Recording and Modulation in the Human Central Nervous System (UG3/UH3 Clinical Trial Required)". This Funding Opportunity Announcement has been extended by one council round. The dates have been modified to add a New Application Due Date of February 22, 2021.

The purpose of this notice is to inform applicants of a change to the Key Dates for RFA-NS-18-022 "BRAIN Initiative: Next-Generation Invasive Devices for Recording and Modulation in the Human Central Nervous System (U44 Clinical Trial Required)". This Funding Opportunity Announcement has been extended by one council round. The dates have been modified to add a New Application Due Date of February 22, 2021.

The purpose of this notice is to inform applicants of a change to the Key Dates for RFA-NS-18-023 "BRAIN Initiative: Clinical Studies to Advance Next-Generation Invasive Devices for Recording and Modulation in the Human Central Nervous System (UH3 Clinical Trial Required)". This Funding Opportunity Announcement has been extended by one council round. The dates have been modified to add a New Application Due Date of February 22, 2021.

This FOA is intended to: (1) increase our understanding of how music positively affects the brain, body, and behavior and (2) use that knowledge to enhance health and/or treat specific diseases and disorders. Proposed R01 projects could investigate the mechanisms by which music affects the brain to improve health either in healthy or diseased states. Proposed R01 projects could also focus on the development or refinement of specific musical interventions relevant to the participating institutes, agencies, and offices. When appropriate, collaborations among basic researchers, technology developers, music intervention experts, or other clinical researchers are highly encouraged.

This FOA is intended to: (1) increase our understanding of how music positively affects the brain, body, and behavior and (2) use that knowledge to enhance health and/or treat specific diseases and disorders. R21 projects could propose exploratory investigations to define the mechanisms by which music affects the brain to improve health either in healthy or diseased states. Proposed R21 projects could explore the early stage development or refinement of specific musical interventions relevant to the participating institutes, agencies and offices. When appropriate, collaborations among basic researchers, technology developers, music intervention experts, or other clinical researchers are highly encouraged.