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Notice New Budget Limitation PAR-18-657 Countermeasures Against Chemical Threats CounterACT) Research Centers Excellence U54 Clinical Trial Optional)" Notice Number: NOT-NS-20-085 Key Dates Release Date: July 8, 2020 Related Announcements PAR-18-657 - Countermeasures Against Chemical Threats CounterACT) Research Centers Excellence U54 Clinical Trial Optional) NOT-NS-18-072 - Rescinded - Notice New Budget Limitation PAR-18-657 Countermeasures Against Chemical Threats CounterACT) Research Centers Excellence U54 Clinical Trial Optional) Issued National Institute Neurological Disorders Stroke NINDS) National Eye Institute NEI) National Institute Arthritis Musculoskeletal Skin Diseases NIAMS) National Institute Drug Abuse NIDA) National Institute Environmental Health Sciences NIEHS) Purpose purpose this notice to inform applicants a change the Application Budgets PAR-18-657 "Countermeasures Against Chemical Threats CounterACT) Research Centers Excellence U54 Clinical Trial Optional)". notice updates, supercedes replaces previous notice, NOT-NS-18-072 "Notice New Budget Limitation PAR-18-657 Countermeasures Against Chemical Threats CounterACT) Research Centers Excellence U54 Clinical Trial Optional)". Specifically, application budgets be reduced 2 million direct costs per yearto 1.75 million direct costs per year. notice be effective the October 8, 2020 receipt date. Change shown below bold italics. Currently Reads: Section II. Award Information Award Budget Application budgets not exceed 2.0 million direct costs per year. applications not need request maximum budget the size duration the awards vary because nature scope research programs vary. Modified Read: Section II. Award Information Award Budget Application budgets not exceed 1.75 million direct costs per year. applications not need request maximum budget the size duration the awards vary because nature scope research programs vary. other aspects this FOA remain unchanged. Inquiries Please direct inquiries to: David A. Jett, Ph.D. National Institute Neurological Disorder Stroke NINDS) Telephone: 301-496-6035 Email:jettd@ninds.nih.gov

Notice Clarification Application Types Allowed PAR-20-111 Blueprint Neurotherapeutics Network BPN): Small Molecule Drug Discovery Development Disorders the Nervous System U44 Clinical Trial Optional)" Notice Number: NOT-NS-20-091 Key Dates Release Date: July 7, 2020 Related Announcements PAR-20-111 - Blueprint Neurotherapeutics Network BPN): Small Molecule Drug Discovery Development Disorders the Nervous System U44 Clinical Trial Optional) Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this notice to clarify Application Types Allowed PAR-20-111 "Blueprint Neurotherapeutics Network BPN): Small Molecule Drug Discovery Development Disorders the Nervous System U44 Clinical Trial Optional). Activity Code section Part 1. Overview Information) been modified remove following text "U44Small Business Innovation Research SBIR) Cooperative Agreements - Phase II". text being removed be consistent Section II. Award Information stating only New Fast-Track) applications be accepted response this Funding Opportunity Announcement FOA). change be effective the August 11, 2020 receipt date subsequent due dates.Changes the FOA shown below. Currently Reads: Part 1. Overview Information Activity Code U44Small Business Innovation Research SBIR) Cooperative Agreements - Phase II U44Small Business Innovation Research SBIR) Cooperative "Agreement – Fast Track" Modified Read: Part 1. Overview Information Activity Code U44Small Business Innovation Research SBIR) Cooperative "Agreement – Fast Track" other aspects this FOA remain unchanged. Inquiries Please direct inquiries to: Charles Cywin, PhD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-1779 Email:charles.cywin@nih.gov

Notice Change Key Dates RFA-NS-20-030 Research Program Award R35 Clinical Trial Optional)" Notice Number: NOT-NS-20-092 Key Dates Release Date: July 7, 2020 Related Announcements RFA-NS-20-030 - Research Program Award R35 Clinical Trial Optional) Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this notice to inform interested applicants a change the Key Dates RFA-NS-20-030 "Research Program Award R35 Clinical Trial Optional)". July 31, 2020 receipt date been moved August 14, 2020. Changes shown below bold italics. Currently Reads: Part 1. Overview Information Key Dates Letter Intent Due Date(s) July 1, 2020 Application Due Date(s) July 31, 2020 late applications be accepted this Funding Opportunity Announcement. applications due 5:00 PM local time applicant organization. Alltypes non-AIDS applicationsallowed this funding opportunity announcement due the listed date(s). Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. Expiration Date August 01, 2020 Modified Read: Part 1. Overview Information Key Dates Letter Intent Due Date(s) July 21, 2020 Application Due Date(s) August 14, 2020 late applications be accepted this Funding Opportunity Announcement. applications due 5:00 PM local time applicant organization. Alltypes non-AIDS applicationsallowed this funding opportunity announcement due the listed date(s). Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. Expiration Date August 15, 2020 other aspects this FOA remain unchanged. Inquiries Please direct inquiries to: Anna Taylor, Ph.D.National Institute Neurological Disorders Stroke NINDS)Telephone: 301-827-3565Email:anna.taylor@nih.gov

Notice Participation PA-18-358, NINDS Exploratory Neuroscience Research Grant R21- Clinical Trial Optional)" Notice Number: NOT-MH-20-034 Key Dates Release Date: July 7, 2020 Related Announcements PA-18-358,NINDS Exploratory Neuroscience Research Grant R21- Clinical Trial Optional) Issued National Institute Mental Health NIMH) National Institute Neurological Disorders Stroke NINDS) Purpose purpose this Notice to inform potential applicants NIMH's participation, effective immediately, PA-18-358, " NINDS Exploratory Neuroscience Research Grant R21- Clinical Trial Optional)" the next receipt date October 16, 2020. following sections PA-18-358 been updated reflect participation NIMH this Notice: Part 1. Overview Information Components Participating Organizations National Institute Neurological Disorders Stroke NINDS) National Institute Mental Health NIMH) Section Funding Opportunity Description Areas scientific interest the NIMH reflect Neuroscience areas priority detailed the NIMH Strategic Plan found within following divisions offices. Division Neuroscience Basic Behavioral Science DNBBS) supports research programs basic neuroscience, genetics, resource technology development, drug discovery. Examples priorities include are limited these topics: Discover novel mechanisms nervous system development across genes, proteins, cells circuitry) signaling properties underlie emergence cognition, emotion, social behavior. Develop use innovative strategies, including genome-wide comparative approaches, discover genes gene regulatory mechanisms underlying brain functions includingcognition, emotion, social behavior. Discover cellular molecular mechanisms whereby hormones immune molecules modulate signaling brain circuits relevant emotion regulation, cognition, social behavior. Develop empirically evaluate computational theoretical models address plasticity brain circuits during development impacting cognitive, affective, social behaviors. Research elucidate genomic risk factors underlie mental disorders. Division Translational Research DTR) supports research translates knowledge basic science discover etiology, pathophysiology, trajectory mental disorders develops effective interventions children adults. Examples priorities include are limited these topics: Delineate specific neural circuits contributing one more major mental disorders subtypes mental disorders. Identify mechanisms e.g., biological, behavioral, environmental) confer vulnerability psychiatric illnesses. Discover novel targets future therapeutic intervention identifying causal relationships between neural circuits symptom expression. Delineate neurobehavioral mechanisms responsible the development psychopathology, including critical sensitive periods brain development the effects sex, behavior, experience the brain. Assess mechanisms action efficacious interventions the brain bench, pre-clinical context, computational models. Division AIDS Research DAR) supports research basic clinical neuroscience HIV infection. Examples priorities include are limited these topics: Understand decipher a molecular level, HIV associated neuroimmune dysregulation impacts neuronal receptors, neuroendocrine milieu, neurotransmitters synaptic plasticity the context HIV anti-retroviral therapy. Pre-clinical research studies target neuroimmune dysregulation, blood brain barrier disruption altered neuronal circuitry individuals living HIV to decipher potential CNS toxicities associated anti-retroviral therapy other emergent treatments HIV cure. Support use state-of-the-art epi)genetic approaches identify validate viral host genetic factors influence pathophysiology manifestations HIV-induced CNS dysfunction. Define characterize HIV persistence the CNS the context suppressive highly active antiretroviral therapy foster translational research enable eradication HIV the brain. Office Technology Development Coordination OTDC): Supports basic applied research related the development scientific tools, technologies, approaches related brain behavioral research. Any Clinical Trial research submitted NIMH under R21 mechanism must follow guidance noted NIMH NOT-MH-19-006. is, NIMH supports hypothesis-driven mechanistic clinical trial studies basic and/or translational discovery research health human subjects in pathobiology, pathophysiology psychopathology mental disorders in HIV infection the central nervous system CNS). goal to address basic questions to interrogate concept biology, behavior, pathophysiology will provide insight to understanding mental health mental disorders. https://www.nimh.nih.gov/funding/opportunities-announcements/clinical-t…. Inquiries Please direct inquiries to: Susan Koester, Ph.D.National Institute Mental Health NIMH)Telephone:301-443-3563Email: koesters@mail.nih.gov

Notice Change Key Dates PAR-18-617 NINDS Exploratory Clinical Trials Small Business R42 Clinical Trial Required)" Notice Number: NOT-NS-20-078 Key Dates Release Date: June 29, 2020 Related Announcements PAR-18-617 - NINDS Exploratory Clinical Trials Small Business R42 Clinical Trial Required) Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this notice to inform interested applicants a change the Key Dates PAR-18-617 "NINDS Exploratory Clinical Trials Small Business R42 Clinical Trial Required)". Funding Opportunity Announcement been extended one additional council round. dates been modified add following New Application Due Date:April 5, 2021. Changes shown below bold italics. Currently Reads: Part 1. Overview Key Dates: Application Due Date(s) Standard dates apply , 5:00 PM local time applicant organization. *** Note new SBIR/STTR Standard Due Dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. Scientific Merit Review Standard dates apply Advisory Council Review Standard dates apply Earliest Start Date Standard dates apply Expiration Date January 6, 2021 Modified Read: Part 1. Overview Key Dates: Application Due Date(s) Standard dates apply , 5:00 PM local time applicant organization. *** Note new SBIR/STTR Standard Due Dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. Scientific Merit Review Standard dates apply Advisory Council Review Standard dates apply Earliest Start Date Standard dates apply Expiration Date April 6, 2021 other aspects this FOA remain unchanged. Inquiries Please direct inquiries to: Emily Caporello, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-1778 Email:Emily.caporello@nih.gov

Notice Change Key Dates PAR-18-618 NINDS Exploratory Clinical Trials Small Business R44 Clinical Trial Required)" Notice Number: NOT-NS-20-079 Key Dates Release Date: June 29, 2020 Related Announcements PAR-18-618 - NINDS Exploratory Clinical Trials Small Business R44 Clinical Trial Required) Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this notice to inform interested applicants a change the Key Dates PAR-18-618 "NINDS Exploratory Clinical Trials Small Business R44 Clinical Trial Required)". Funding Opportunity Announcement been extended one additional council round. dates been modified add following New Application Due Date:April 5, 2021. Changes shown below bold italics. Currently Reads: Part 1. Overview Key Dates: Application Due Date(s) Standard dates apply , 5:00 PM local time applicant organization. *** Note new SBIR/STTR Standard Due Dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. Scientific Merit Review Standard dates apply Advisory Council Review Standard dates apply Earliest Start Date Standard dates apply Expiration Date January 6, 2021 Modified Read: Part 1. Overview Key Dates: Application Due Date(s) Standard dates apply , 5:00 PM local time applicant organization. *** Note new SBIR/STTR Standard Due Dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. Scientific Merit Review Standard dates apply Advisory Council Review Standard dates apply Earliest Start Date Standard dates apply Expiration Date April 6, 2021 other aspects this FOA remain unchanged. Inquiries Please direct inquiries to: Emily Caporello, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-1778 Email:Emily.caporello@nih.gov

Notice Extend Eligibility Submission Diversity K22 Applications due COVID–related Disruptions Notice Number: NOT-NS-20-076 Key Dates Release Date: June 26, 2020 Related Announcements PAR-18-469 - NINDS Advanced Postdoctoral Career Transition Award Promote Diversity Neuroscience Research K22-No Independent Clinical Trials) PAR-18-468 - NINDS Advanced Postdoctoral Career Transition Award Promote Diversity Neuroscience Research K22-Clinical Trial Required) Issued National Institute Neurological Disorders Stroke NINDS) Purpose Under normal circumstances, individuals must no than 5 years cumulative postdoctoral research experience i.e. research experience subsequent completion the doctorate) the relevant due date be eligible apply the NINDS K22 Advanced Postdoctoral Career Transition Award Promote Diversity Neuroscience Research. NINDS understands COVID-19 caused major disruption the ability many individuals make progress their research. Though subject future updates, NINDS will provide least 2-receipt cycle extension roughly 8 additional months) eligibility individuals whose eligibility apply the K22, under normal eligibility rules including resubmission policy defined NOT-OD-18-197), expiring between June/July 2020 February/March 2021 inclusive these dates). addition, those normally have eligible apply the June/July 2021 receipt date have 1-receipt cycle roughly 4 months) extension. Example 1: Under normal eligibility rules, final due date which individual apply the K22 June/July 12, 2020. individual now eligible apply the K22 June/July, 2020, October/November 2020 February/March 2021. Example 2: Under normal eligibility rules, final due date which individual apply the K99/R00 February/March 12, 2021. individual now eligible apply the K22 through October/November, 2021 due dates. Example 3: Under normal eligibility rules, final due date which individual apply the K22 June/July 12, 2021. individual now eligible apply the K22 through October/November, 2021 due dates. Example 4: Under normal eligibility rules, final due date which individual apply the K22 February/March 12, 2020. individual no longer eligible the K22. Example 5: individual applied the K22 the February/March, 2020 due date and, under normal eligibility rules, still within eligibility window the June/July, 2020 due date; however, summary statement this individual released after June/July due date. Because review this applicant’s initial submission not completed time the applicant resubmit the June/July 2020 due date, individual does receive extension eligibility is longer eligible apply the K22. Inquiries Please direct inquiries to: Michelle Jones-London, Ph.D. National Institute Neurological Disorders Stroke NINDS)E-mail: NINDSDivesrityTraining@mail.nih.gov

Notice Change Key Dates PAR-18-665 NINDS Renewal Awards SBIR Phase II Grants Phase IIB) Clinical Trials Clinical Research R44 Clinical Trial Optional)" Notice Number: NOT-NS-20-077 Key Dates Release Date: June 26, 2020 Related Announcements PAR-18-665 - NINDS Renewal Awards SBIR Phase II Grants Phase IIB) Clinical Trials Clinical Research R44 Clinical Trial Optional) Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this notice to inform interested applicants a change the Key Dates PAR-18-665 "NINDS Renewal Awards SBIR Phase II Grants Phase IIB) Clinical Trials Clinical Research R44 Clinical Trial Optional)". Funding Opportunity Announcement been extended one additional council round. dates been modified add following New Application Due Date:April 5, 2021. Changes shown below bold italics. Currently Reads: Part 1. Overview Key Dates: Application Due Date(s) April 16th thenStandard datesapply , 5:00 PM local time applicant organization. *** Note new SBIR/STTR Standard Due Dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. Scientific Merit Review Standard datesapply Advisory Council Review Standard datesapply Earliest Start Date Standard datesapply Expiration Date January 6, 2021 Modified Read: Part 1. Overview Key Dates: Application Due Date(s) April 16th thenStandard datesapply , 5:00 PM local time applicant organization. *** Note new SBIR/STTR Standard Due Dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. Scientific Merit Review Standard datesapply Advisory Council Review Standard datesapply Earliest Start Date Standard datesapply Expiration Date April 6, 2021 other aspects this FOA remain unchanged. Inquiries Please direct inquiries to: Emily Caporello, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-1778 Email:Emily.caporello@nih.gov

Notice Intent Publish Funding Opportunity Announcement BRAIN Initiative Fellows: Ruth L. Kirschstein National Research Service Award NRSA) Individual Postdoctoral Fellowship F32)" Notice Number: NOT-MH-20-062 Key Dates Release Date: June 17, 2020 Estimated Publication Date Funding Opportunity Announcement: August 14, 2020 First Estimated Application Due Date: December 08, 2020 Earliest Estimated Award Date: July 01, 2021 Earliest Estimated Start Date: July 01, 2021 Related Announcements Reissue RFA-MH-18-510 - BRAIN Initiative Fellows: Ruth L. Kirschstein National Research Service Award NRSA) Individual Postdoctoral Fellowship F32) Issued National Institute Mental Health NIMH) National Eye Institute NEI) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Biomedical Imaging Bioengineering NIBIB) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Drug Abuse NIDA) National Institute Neurological Disorders Stroke NINDS) National Center Complementary Integrative Health NCCIH) Purpose NIMH, other NIH Institutes Centers participating theBrain Research through Advancing Innovative Neurotechnologies®(BRAIN) Initiative, intends reissue "BRAIN Initiative Fellows: Ruth L. Kirschstein National Research Service Award NRSA) Individual Postdoctoral Fellowship F32)." Notice being provided allow potential applicants sufficient time develop meaningful mentoring teams responsive projects. Funding Opportunity Annoucement FOA) expected be published Summer 2020 an initial expected application due date December 2020. FOA utilize F32 activity code. Details the planned FOA provided below. Research Initiative Details purpose the BRAIN Initiative Fellows F32) program to enhance research training promising postdoctorates, early their postdoctoral training period, have potential become productive investigators research areas will advance goals the BRAIN Initiative. Applications encouraged any research area is aligned one more the seven high-priority areas the BRAIN Initiative, including neuroethics. Applicants expected propose research training an area clearly complements predoctoral research. Formal training analytical tools appropriate the proposed research expected be integral component the research training plan. order maximize training potential the F32 award, program encourages applications individuals have yet completed terminal doctoral degree who expect do within 12 months the application due date. the application due date, candidates not completed than 12 months postdoctoral training. Funding Information Estimated Total Funding TBD Expected Number Awards TBD Estimated Award Ceiling TBD Primary CFDA Numbers 93.242, 93.173, 93.866, 93.853, 93.286, 93.213, 93.867, 93.865, 93.279, 93.273 Anticipated Eligible Organizations Public/State Controlled Institution Higher EducationPrivate Institution Higher EducationNonprofit 501(c)(3) IRS Status than Institution Higher Education)Small BusinessFor-Profit Organization than Small Business)Eligible Agencies the Federal GovernmentNon-domestic non-U.S.) Entity Foreign Organization) Applications not being solicited this time. Inquiries Please direct inquiries to: Ashlee Van’t Veer, PhD National Institute Mental Health NIMH) 301-443-3107 BRAIN.Initiative.Training@nih.gov

Notice Extension the Response Date NOT-NS-20-026 Request Information: Soliciting Input Areas Health Disparities Inequities Neurological Disease and/or Care the United States Across Lifespan" Notice Number: NOT-NS-20-075 Key Dates Release Date: June 8, 2020 Related Announcements NOT-NS-20-026 - Request Information: Soliciting Input Areas Health Disparities Inequities Neurological Disease and/or Care the United States Across Lifespan Issued National Institute Neurological Disorders Stroke NINDS) Purpose Purpose Notice extends response date NOT-NS-20-026 " Request Information: Soliciting Input Areas Health Disparities Inequities Neurological Disease and/or Care the United States Across Lifespan." following section NOT-NS-20-026 been updated: Key Dates Current Response Date: June 15, 2020 New Response Date:July 15, 2020 other aspects the RFI remain same. Inquiries Please direct inquiries to: NINDS Office Global Health Health Disparities Email:OGHHDRFI@NINDS.NIH.GOV