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The National Institute of Neurological Disorders and Stroke (NINDS) announces the early termination of PAR-21-152, NINDS Faculty Development Award to Promote Diversity in Neuroscience Research (K01 Independent Clinical Trial Not Allowed).

This Notice is to inform potential applicants that the National Center for Complementary and Integrative Health (NCCIH) and the National Institute of Neurological Disorders and Stroke (NINDS) will hold a pre-application technical assistance webinar on RFA-AT-21-006, "Neural Mechanisms of Force-Based Manipulations: High Priority Research Networks (U24 Clinical Trial Optional)". The date and time for the webinar are listed below. The intent of this webinar is to provide an overview of the initiative and guidance on application preparation and to address applicant questions. The webinar is optional and not required for application submission.

The purpose of this Notice is to inform interested applicants that the expiration date in PAR-18-205 " NIBIB Biomedical Technology Resource Centers (P41 Clinical Trials Optional)" will be extended by one receipt cycle (See changes in bold italics below). Part 1. Overview Key Dates Currently Reads: Expiration Date January 8, 2021 Modified to Read: Expiration Date May 8, 2021 All other aspects of this FOA remain unchanged.

The purpose of this Request for Information (RFI) is to gain feedback, comments, and novel ideas from the members of scientific communities in the United States (U.S.) and abroad as well as from persons representing other segments of American public to help identify the needs and priorities in this area of science, and plan future activities and initiatives that can most significantly enhance the research in chronotherapy, circadian-based medicine or chronomedicine and greater benefit of the biomedical research community.

The National Institutes of Health Blueprint for Neuroscience Research (Blueprint) is a collaboration among 14 participating NIH Institutes, Centers, and Offices to support cross-cutting programs to advance research on the nervous system. The purpose of this Request for Information (RFI) is to seek input from the scientific community for the Blueprint to advance the fundamental understanding of neuroimmune interactions in the healthy CNS by integrative studies on dynamic interactions of non-neuronal cells and neurons.

This NOTICE is to alert the extramural community that, as of the September 2020 NANDS Council round, NINDS will no longer apply administrative reductions to modular investigator-initiated R01 grants. However, non-modular R01 awards will continue to receive a 17.5% administrative reduction applied to IRG and NANDS Council budget recommendations (see: NINDS Funding Strategy). Investigators and recipient organizations should carefully consider this NIH guidance when developing budgets for R01 submissions (see Develop Your Budget). In accordance with the NIA Funding Strategy for AD/ADRD research, NINDS will continue to award the level of support recommended by the study section for applications funded through the Alzheimer's allocation, with adjustments deemed appropriate by NIH staff.

The purpose of this Funding Opportunity Announcement (FOA) is to encourage grant applications for investigator-initiated exploratory clinical trials to the National Institute of Neurological Disorders and Stroke (NINDS). The trials must address questions within the mission and research interests of the NINDS and may evaluate drugs, biologics, and devices, as well as surgical, behavioral and rehabilitation therapies. Information about the mission and research interests of the NINDS can be found at the NINDS website (http://www.ninds.nih.gov/)

Reissue of RFA-NS-18-020: Understanding the dynamic activity of brain circuits is central to the NIH BRAIN Initiative. This FOA seeks applications for proof-of-concept testing and development of new technologies and novel approaches for recording and modulation (including various modalities for stimulation/activation, inhibition and manipulation) of cells (i.e., neuronal and non-neuronal) and networks to enable transformative understanding of dynamic signaling in the central nervous system (CNS). This FOA seeks exceptionally creative approaches to address major challenges associated with recording and modulating CNS activity, at or near cellular resolution, at multiple spatial and/or temporal scales, in any region and throughout the entire depth of the brain. It is expected that the proposed research may be high-risk, but if successful, could profoundly change the course of neuroscience research. Proposed technologies should be compatible with experiments in behaving animals, validated under in vivo experimental conditions, and capable of reducing major barriers to conducting neurobiological experiments and making new discoveries about the CNS. Technologies may engage diverse types of signaling beyond neuronal electrical activity such as optical, magnetic, acoustic and/or genetic recording/manipulation. Applications that seek to integrate multiple approaches are encouraged. If suitable, applications are expected to integrate appropriate domains of expertise, including biological, chemical and physical sciences, engineering, computational modeling and statistical analysis.

Reissue of RFA-NS-18-019: Understanding the dynamic activity of neural circuits is central to the NIH BRAIN Initiative. The invention, proof-of-concept investigation, and optimization of new technologies through iterative feedback from end users are key components of the BRAIN Initiative. This FOA seeks applications to optimize existing or emerging technologies through iterative testing with end users. The technologies and approaches should have potential to address major challenges associated with recording and modulation (including various modalities for stimulation/activation, inhibition and manipulation) of cells (i.e., neuronal and non-neuronal) and networks to enable transformative understanding of dynamic signaling in the central nervous system (CNS). These technologies and approaches should have previously demonstrated their transformative potential through initial proof-of-concept testing and are now ready for accelerated refinement. In conjunction, the manufacturing techniques should be scalable towards sustainable, broad dissemination and user-friendly incorporation into regular neuroscience research. Proposed technologies should be compatible with experiments in behaving animals, validated under in vivo experimental conditions, and capable of reducing major barriers to conducting neurobiological experiments and making new discoveries about the CNS. Technologies may engage diverse types of signaling beyond neuronal electrical activity such as optical, electrical, magnetic, acoustic or genetic recording/manipulation. Applications that seek to integrate multiple approaches are encouraged. If suitable, applications are expected to integrate appropriate domains of expertise, including biological, chemical and physical sciences, engineering, computational modeling and statistical analysis.

The purpose of this Funding Opportunity Announcement (FOA) is to encourage grant applications for investigator-initiated efficacy clinical trials to the National Institute of Neurological Disorders and Stroke (NINDS). The trials must address questions within the mission and research interests of the NINDS and may evaluate drugs, biologics, and devices, as well as surgical, behavioral and rehabilitation therapies. Information about the mission and research interests of the NINDS can be found at the NINDS website (http://www.ninds.nih.gov/)