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The purpose of this notice is to inform applicants of a correction to the open date for PAR-21-267 "NINDS Exploratory Clinical Trials for Small Business (R41/R42 Clinical Trial Required)".

This notice informs the research community that the NINDS and NIA intend to publish a joint Funding Opportunity Announcement on the Clinical Relevance of the Linkage between Environmental Toxicant Exposures and Alzheimers Disease and Alzheimers Disease Related Dementias. This Notice is being provided to allow potential applicants sufficient time to develop meaningful multidisciplinary collaborations and responsive projects. The FOA is expected to be published in January 2022 with an expected application due date in March 2022. This FOA will utilize the R01 activity code. Details of the planned FOA are provided below.

The National Institutes of Health (NIH) intends to publish one Funding Opportunity Announcement (FOA) to solicit applications on the development of innovative quantitative imaging and other relevant biomarkers of myofascial tissues for pain management in human subjects using a two-phase grant funding mechanism. Candidates for such biomarkers may include objective measures based on minimally invasive imaging technologies, electrophysiological recordings, integration of multiparametric imaging and electrophysiological approaches, or their integration with other markers (e.g., immune factors, genomic markers, physiological factors, etc.) through multiscale modeling or machine learning analysis. The first phase of the award will provide funding for up to 2 years to develop quantitative measures that can differentiate myofascial tissue abnormalities in healthy, versus latent, versus active myofascial pain stages using cross-sectional correlations with clinical signs/symptoms. The second phase will provide up to 3 years of support to assess the ability of the measures developed in Phase 1 to monitor responses and/or predict outcomes in response to specified therapies to relieve myofascial pain in longitudinal interventional studies. Transition between the two phases of the award will be administratively reviewed and will be determined by successful completion of quantifiable transition milestones that need to be clearly specified in the application. The purpose of this notice is to allow potential applicants sufficient time to develop meaningful collaborations among technology developers, myofascial tissue experts, pain researchers, and clinicians. It will also allow potential applicants sufficient time to develop responsive projects to the two-phased FOA. The FOA is expected to be published in September 2021, with an expected application due date in December 2021. Details of the planned FOA are provided below.

This FOA will support integrated, interdisciplinary research teams from prior BRAIN technology and/or integrated approaches teams, and/or new projects from the research community that focus on examining circuit functions related to behavior, using advanced and innovative technologies. The goal will be to support programs with a team science approach that can realize meaningful outcomes within 5-plus years. Awards will be made for 5 years, with a possibility of one competing renewal. Applications should address overarching principles of circuit function in the context of specific neural systems underlying sensation, perception, emotion, motivation, cognition, decision-making, motor control, communication, or homeostasis. Applications should incorporate theory-/model-driven experimental design and should offer predictive models as deliverables. Applications should seek to understand circuits of the central nervous system by systematically controlling stimuli and/or behavior while actively recording and/or manipulating relevant dynamic patterns of neural activity and by measuring the resulting behaviors and/or perceptions. Applications are expected to employ approaches guided by specified theoretical constructs, and are encouraged to employ quantitative, mechanistic models where appropriate. Applications will be required to manage their data and analysis methods in a prototype framework that will be developed and used in the proposed U19 project and exchanged with other U19 awardees for further refinement and development. Model systems, including the possibility of multiple species ranging from invertebrates to humans, can be employed and should be appropriately justified. Budgets should be commensurate with multi-component teams of research expertise including neurobiologists, statisticians, physicists, mathematicians, engineers, computer scientists, and data scientists, as appropriate - that seek to cross boundaries of interdisciplinary collaboration.

This FOA will support integrated, interdisciplinary research teams from prior BRAIN technology and/or integrated approaches teams, and/or new projects from the research community that focus on examining circuit functions related to behavior, using advanced and innovative technologies. The goal will be to support programs with a team science approach that can realize meaningful outcomes within 5-plus years. Awards will be made for 5 years, with a possibility of one competing renewal. Applications should will incorporate overarching principles of circuit function in the context of specific neural systems underlying sensation, perception, emotion, motivation, cognition, decision-making, motor control, communication, or homeostasis. Applications should incorporate theory-/model-driven experimental design and should offer predictive models as deliverables. Applications should seek to understand circuits of the central nervous system by systematically controlling stimuli and/or behavior while actively recording and/or manipulating relevant dynamic patterns of neural activity and by measuring the resulting behaviors and/or perceptions. Applications are expected to employ approaches guided by specified theoretical constructs, and are encouraged to employ quantitative, mechanistic models where appropriate. Applications will be required to manage their data and analysis methods in a prototype framework that will be developed and used in the proposed U19 project and exchanged with other BRAIN U19 awardees for further refinement and development. Model systems, including the possibility of multiple species ranging from invertebrates to humans, can be employed and should be appropriately justified. Programs should employ multi-component teams of research expertise including neurobiologists, statisticians, physicists, mathematicians, engineers, computer scientists, and data scientists, as appropriate - that seek to cross boundaries of interdisciplinar

Invasive surgical procedures provide the unique ability to record and stimulate neurons within precisely localized brain structures in humans. Human studies using invasive technology are often constrained by a limited number of patients and resources available to implement complex experimental protocols and are rarely aggregated in a manner that addresses research questions with appropriate statistical power. Therefore, this RFA seeks applications to assemble diverse, integrated, multi-disciplinary teams that cross boundaries of interdisciplinary collaboration to overcome these fundamental barriers and to investigate high-impact questions in human neuroscience. Projects should maximize opportunities to conduct innovative in vivo neuroscience research made available by direct access to brain recording and stimulating from invasive surgical procedures. Projects should employ approaches guided by specified theoretical constructs and quantitative, mechanistic models where appropriate. Awardees will join a consortium work group, coordinated by the NIH, to identify consensus standards of practice, including neuroethical considerations, to collect and provide data for ancillary studies, and to aggregate and standardize data for dissemination among the wider scientific community.

Excellent mentorship and superior training are critical to the development of exceptional future scientists. To recognize the crucial role great mentors play in the development of future leaders in neuroscience, the National Institute of Neurological Disorders and Stroke (NINDS) created the Landis Award for Outstanding Mentorship. This award provides $100,000.00 (direct costs) to up to five (5) faculty members, who have demonstrated a dedication to outstanding mentorship and training, to help foster the research career development of additional students and post-doctorates. NINDS hopes that this tangible award will impress upon the scientific community as a whole, and faculty and institutional leaders in particular, the high value NINDS places on outstanding training and mentorship. Further, NINDS hopes that it encourages institutions to reward individuals not only for outstanding research accomplishments but also for their impact on the lives of others, and the future of neuroscience, through outstanding mentorship and training.

In April 2018, the National Institutes of Health (NIH) launched theHelping to End Addiction Long-termSMInitiative or HEAL InitiativeSM, an aggressive, trans-agency effort to speed scientific solutions to stem the national opioid public health crisis. As part of this initiative, the National Institute of Neurological Disorders and Stroke (NINDS), with other NIH Institutes and Centers (ICs) of the HEAL Initiative, intends to promote a new initiative by publishing a Funding Opportunity Announcement (FOA) to solicit applications from interdisciplinary teams to elucidate the mechanisms of device-based pain relief. This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. The FOA is expected to be published in summer 2021 with an expected application due date in fall 2021. This FOA will utilize the RM1 activity code. Details of the planned FOA are provided below.

The purpose of this notice is to inform potential applicants of an Informational Webinar on the Summer Research Education Experience Program (R25).

The purpose of this Notice is to alert the community that the National Institute of Neurological Disorders and Stroke (NINDS) plans to publish a Funding Opportunity Announcement (FOA) to solicit applications for Creating an Educational Nexus for Training in Experimental Rigor (CENTER), which will build, evaluate, and disseminate a user-friendly, harmonized, and openly accessible educational resource to promote awareness, understanding, and utilization of the principles of rigorous biomedical research. CENTER will provide comprehensive administrative oversight, expertise required to establish and maintain the educational platform, and infrastructure to create cutting-edge digital educational components (e.g. videos, interactive activities, relevant scientific examples). A companion FOA will solicit applications for Materials to Enhance Training in Experimental Rigor (METER) to support subject matter experts to develop content for the educational resource (see related Notice). It is expected that CENTER and METER awardees will work collaboratively to evaluate, improve, and disseminate the educational resource. This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. The FOA is expected to be published in Summer 2021 with an expected application due date in October 2021. This FOA will utilize the UC2 activity code. Details of the planned FOA are provided below.