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This Funding Opportunity Announcement (FOA) supports Comprehensive Centers to develop and test technologies that can be scaled to brain-wide atlases of human and non-human primate circuit connectivity. Centers will establish data collection, analysis, and dissemination pipelines to demonstrate the feasibility of mapping region-to-region connectivity with a minimum resolution of individual cells and/or axon fibers. They will demonstrate the significance of the approach within the context of a chosen CNS sub-volume, by testing specific hypotheses relating circuit structure to function. They will also incorporate toolsets and infrastructure for integrating separately collected data from smaller volumes, as well as from other data collection modalities, and for enabling the neuroscience community to interact with and mine the data for new research questions. Centers will be integrated into the BRAIN CONNECTS Network, consisting of projects from this FOA and its companion announcements, as a coordinated effort aimed at developing wiring diagrams that can span entire brains across multiple scales.

This Funding Opportunity Announcement (FOA) supports Comprehensive Centers to develop and test technologies that can be scaled to brain-wide atlases of mouse circuit connectivity. Centers will establish data collection, analysis, and dissemination pipelines to demonstrate the feasibility of mapping cell-to-cell connectivity with a minimum resolution of synaptic connections. They will demonstrate the significance of the approach within the context of a chosen CNS sub-volume, by testing specific hypotheses relating circuit structure to function. They will also incorporate toolsets and infrastructure for integrating separately collected data from smaller volumes, as well as from other data collection modalities, and for enabling the neuroscience community to interact with and mine the data for new research questions. Centers will be integrated into the BRAIN CONNECTS Network, consisting of projects from this FOA and its companion announcements, as a coordinated effort aimed at developing wiring diagrams that can span entire brains across multiple scales.

This funding opportunity announcement (FOA) provides support to eligible, domestic institutions to develop and implement effective, approaches to biomedical research education and mentoring that will keep pace with the rapid evolution of the research enterprise. This NIH Neuroscience Doctoral Readiness Program (DR Program) expects that the proposed research education programs will incorporate extensive research experiences within the NINDS mission and well-designed courses for skills development and education to prepare recent baccalaureates from diverse backgrounds to transition into and complete rigorous, research-focused doctoral degree programs (e.g., Ph.D. or M.D./Ph.D.) in biomedical fields. This is a limited competition funding opportunity announcement to support postbaccalaureate programs that will be affiliated with a funded NIH T32 program. Eligibility is limited to PD(s)/PI(s) or MPI teams that include at least one PD/PI of a grant supported by the following FOAs: T32 - Jointly Sponsored Institutional Predoctoral Training Program (JSPTPN), PAR-20-076;NINDS T32 - Institutional Research Training Grant, PAR-21-149; or NINDS T32 - Institutional Translational Research Training Program, PAR-19-228. In all cases, a PD/PI of the T32 grant from a FOA cited above, must be the PD/PI or an MPI of this R25. This Funding Opportunity Announcement (FOA) does not allow appointed participants to lead an independent clinical trial but does allow them to obtain research experience in a clinical trial led by a mentor or co-mentor.

Request for Information (RFI): Joint Pain and Intervention Research

The purpose of this notice is to clarify the Award Budget for RFA-NS-22-009.

The National Institute of Neurological Disorders and Stroke (NINDS) will be hosting a pre-application technical assistancewebinar on October 27, 2021 from 1PM 2PM (Eastern Time) for all potential applicants interested in the following Funding Opportunity Announcement (FOA): RFA-NS-22-002 HEAL Initiative: Advancing Health Equity in Pain Management (R61/R33 Clinical Trial Required) This FOA aims to accelerate development, testing and implementation of evidence-based interventionsthat are culturally and linguistically appropriate for NIH-designated populations that experience health disparities (HDPs) in the United Statesto mitigate disparities in provision of care and treatment decisions, reduce susceptibility to chronic pain and improve patient outcomes. NIH program and review staff will ?provide an overview of the RFA, including objectives, application instructions and review criteria and will be available to answer questions. Potential applicants must register for the webinar using the link below. Following the webinar, a recording of the webinar, frequently asked questions (FAQs), and additional information may be found here: https://heal.nih.gov/news/events We request that participants carefully review the funding opportunities and the FAQs for this initiative prior to submitting a question for the webinar. Participation in the webinar is optional and is not required for the submission of an application.

The purpose of this Notice is to inform the community that the National Institute of Neurological Disorders and Stroke (NINDS) intends to publish a Funding Opportunity Announcement (FOA) that will solicit applications for the Stroke Preclinical Assessment Network (SPAN) Testing Laboratories. SPAN supports late-stage preclinical efficacy studies of putative cerebroprotectants to be given prior to or at the time of reperfusion in experimental stroke models. Parallel testing of the most promising interventions in a network structure will help to determine if an intervention can improve outcome as compared to reperfusion alone and/or extend the therapeutic window for reperfusion, with the overall end goal of guiding the selection of the most promising agent(s) to transition to future Phase II clinical trials (to be conducted through StrokeNet). SPAN will consist of one Coordinating Center (CC), several testing laboratories, and intervention contributors. This infrastructure is expected to test multiple interventions in animal models of transient cerebral ischemia.

The purpose of this Notice is to inform the community that the National Institute of Neurological Disorders and Stroke (NINDS) intends to publish a Limited Competition Funding Opportunity Announcement (FOA) that will solicit an application for the Stroke Preclinical Assessment Network (SPAN) Coordinating Center. SPAN supports late-stage preclinical efficacy studies of putative cerebroprotectants to be given prior to or at the time of reperfusion in experimental stroke models. Parallel testing of the most promising interventions in a network structure will help to determine if an intervention can improve outcome as compared to reperfusion alone and/or extend the therapeutic window for reperfusion, with the overall goal of guiding the selection of the most promising agent(s) to transition to future Phase II clinical trials (to be conducted through StrokeNet). SPAN will consist of one Coordinating Center (CC), several testing sites, as well as intervention contributors. This infrastructure is expected to test multiple interventions in animal models of transient cerebral ischemia.

The purpose of this Notice is to inform the community that the National Institute of Neurological Disorders and Stroke (NINDS) intends to publish a Funding Opportunity Announcement (FOA) that will solicit applications for Stroke Preclinical Assessment Network (SPAN) Interventions. SPAN supports late-stage preclinical efficacy studies of putative cerebroprotectants to be given prior to or at the time of reperfusion in experimental stroke models. Parallel testing of the most promising interventions in a network structure will help to determine if an intervention can improve outcome as compared to reperfusion alone and/or extend the therapeutic window for reperfusion, with the overall end goal of guiding the selection of the most promising agent(s) to transition to future Phase II clinical trials (to be conducted through StrokeNet). SPAN will consist of one Coordinating Center (CC), several testing laboratories, and intervention contributors. This infrastructure is expected to test multiple interventions in animal models of transient cerebral ischemia.

The purpose of this Notice is to inform the community that the National Institute of Neurological Disorders and Stroke (NINDS) intends to publish a Funding Opportunity Announcement (FOA) that will solicit applications for the Stroke Preclinical Assessment Network (SPAN)- Interventions from Small Businesses. SPAN supports late-stage preclinical efficacy studies of putative cerebroprotectants to be given prior to or at the time of reperfusion in experimental stroke models. Parallel testing of the most promising interventions in a network structure will help to determine if an intervention can improve outcome as compared to reperfusion alone and/or extend the therapeutic window for reperfusion, with the overall end goal of guiding the selection of the most promising agent(s) to transition to future Phase II clinical trials (to be conducted through StrokeNet). SPAN will consist of one Coordinating Center (CC), several testing laboratories, and intervention contributors. This infrastructure is expected to test multiple interventions in animal models of transient cerebral ischemia.