Find Funding Opportunities

RE-JOIN Technical Assistance Webinar

This notice describes opportunities available to CRCNS grantees to support the use of such resources. The Cloud Access Program (NSF) and the STRIDES Initiative (NIH) have established partnerships with commercial cloud service providers to provide awardees with cost-effective, flexible access to cloud-based resources. The Partnership to Advance Throughput Computing (PATh) facilitates access to distributed high throughput computing technologies and services. These opportunities are now available to active CRCNS grantees as described below.

The purpose of this time-sensitive Request for Information (RFI) is to seek input from people living with amyotrophic lateral sclerosis (ALS), families, caregivers, advocates, scientists, clinicians, and the broader community on the most important knowledge gaps and promising research opportunities that will lead to the discovery of effective interventions for the diagnosis, treatment, management, prevention, or cure of ALS.

The goal of this funding opportunity announcement is to support a Human Pain-associated Genes & Cells Data Coordination and Integration Center as part of the NIH HEAL Initiatives Program to Reveal and Evaluate Cells-to-gene Information that Specify Intricacies, Origins and the Nature of Human Pain (PRECISION Human Pain). The Data Coordination and Integration Center will extract, accumulate, organize, annotate, and link growing bodies of information related to core datasets generated by companion U19 Centers for Discovery and Functional Evaluation of Human Pain-associated Genes & Cells, which include the characterization of functional genetic elements, epigenetic signatures, and molecular/cellular pathways that underlie human pain signal transduction, transmission and processing. The Human Pain-associated Genes & Cells Data Coordination and Integration Center will lead efforts to establish spatial and semantic standards for managing heterogeneous human pain-associated data types and information, collect and register multimodal human pain-associated data to common neural tissue coordinate systems, and establish a web-accessible information system that can be widely used throughout the research community. A central goal of the PRECISION Human Pain network is to act as a data repository and generate a comprehensive, integrated datasets on human genes and cellular function phenotypes underlying the heterogeneity, pathogenesis and susceptibility to specific pain conditions.

The purpose of this funding opportunity announcement is to support research that uses human tissue or cells to generate comprehensive datasets for the discovery and characterization of functional genetic elements, epigenetic signatures, and molecular/cellular pathways that underlie human pain transduction, transmission, and processing. This FOA will support concerted multidisciplinary team science efforts that apply large-scale high-throughput approaches on tissues involved in human pain processing as part of the NIH HEAL Initiatives Program to Reveal and Evaluate Cells-to-gene Information that Specify Intricacies, Origins, and the Nature of Human Pain (PRECISION Human Pain). U19 Centers will operate as a cooperative network to promote collaboration and coordination of research activities. U19 Centers will also coordinate with the U24 HEAL Initiative: Human Pain-associated Genes & Cells Data Coordination and Integration Center in order to extract, accumulate, organize, annotate, and link the datasets generated by this U19 research program.

The purpose of this notice is to inform potential applicants to the National Institute on Aging (NIA); National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS); National Center for Complementary and Integrative Health (NCCIH); National Institute of Dental and Craniofacial Research (NIDCR); National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); and the National Institute of Neurological Disorders and Stroke (NINDS) of areas of pain research that are of special interest to these Institutes. The Institutes are interested in receiving applications for potential funding in FY22 that seek to provide new knowledge of the mechanistic complexity of pain that may lead to more effective, non-addictive treatments for pain conditions related to the missions of these Institutes. This Notice is also intended to inform investigators of the special research opportunities available through the multi-Institute and Center Helping to End Addiction Long-term (HEAL) Initiative.

HEAL Initiative: Restoring Joint Health and Function to Reduce Pain Consortium (RE-JOIN) (UC2 Clinical Trial Not Allowed) - The purpose of this Funding Opportunity Announcement is to solicit cooperative agreement applications to support interdisciplinary teams that will work together to form the Restoring Joint Health and Function to Reduce Pain Consortium (RE-JOIN). The goal of RE-JOIN will be to define the innervation of the different tissues, which collectively form the joints, by sensory neurons that mediate the sensation of pain. Knowledge about the types and distribution of neurites in joint tissues will facilitate the identification of key receptors and mediators that induce pain by activating specific sensory neurons. These mediators or their receptors will provide novel targets for reducing pain.

The purpose of this Funding Opportunity Announcement is to solicit applications to develop, test, and implement, novel, multi-level, culturally appropriate interventions and/or adapt, test and evaluate efficacy and effectiveness of existing interventions in NIH designated populations that disproportionately experience negative health outcomes (HDP). Desired outcomes of these interventions include reduction of pain and pain-related symptoms and improvement in patient satisfaction, and overall health outcomes, including function and quality of life. Interventions that target HDPs with chronic pain in addition to at least one comorbid condition (OUD, mental health disorders and/or chronic health conditions) are of the highest priority.

This Funding Opportunity Announcement (FOA) supports Specialized Projects to develop current or emerging technologies to generate comprehensive atlases of brain connectivity, with an emphasis on human, non-human primate (NHP), and mouse. Projects validating approaches using other species are also permitted if well justified. Applications may address any aspects of the data collection, analysis, and dissemination pipelines, to enable faster and more cost-effective generation and interpretation of brain-wide wiring diagrams. Projects will offer distinct capabilities and competencies aimed at developing and optimizing current technologies or entirely new and potentially risky approaches. They will be integrated into the BRAIN CONNECTS Network, consisting of other Specialized Projects from this FOA, and Comprehensive Centers from its companion announcements, as a coordinated effort aimed at developing wiring diagrams that can span entire brains across multiple scales.

The purpose of this notice is to inform applicants of a correction to the due dates for PAR-22-028 "Ultra-Rare Gene-based Therapy (URGenT) Network Resource Access (X01, Clinical Trial Not Allowed)".