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This Funding Opportunity Announcement (FOA) supports the optimization of promising genome editing-based therapeutic leads for Alzheimer's Disease and Alzheimer's Disease-Related Dementias (AD/ADRD), towards IND-enabling studies. Specifically, it supports the characterization and optimization of therapeutic lead(s) that show promise as potential genome editing therapeutics, as evidenced by convincing proof-of-concept studies in appropriate models. At the end of the funding period, successful projects will have optimized a genome editing therapeutic candidate with demonstrated bioactivity, manufacturability, biodistribution, in vivo efficacy, and/or target engagement (measurement of proximal downstream effects) and optimal dosing, combined with other properties consistent with the desired clinical application. This FOA is not specific for any one or group within the AD/ADRD spectrum of disorders. Disorders, and includes genome editing therapies for: Frontotemporal dementia (FTD), Lewy body dementias (LBD) (including Dementia with Lewy bodies (DLB), Parkinson Disease Dementia (PDD)), Vascular contributions to Cognitive Impairment and Dementia (VCID), Alzheimers Disease (AD) and Multiples Etiology Dementias (MED).

The purpose of this Funding Opportunity Announcement (FOA) is to develop clinical-grade prototypes intended for use as safe, effective, and non-addictive device-based technologies and approaches to treat pain. The goal of the program is to demonstrate treatment using credible neural targets for device-based interventions and/or diagnostics for pain, building upon the latest mechanistic knowledge about the anatomy and physiology of central, spinal, and peripheral pathways involved in pain. Awarded activities will facilitate the translation of new devices up to the stage of readiness for first in human (FIH) clinical trials by overcoming key challenges identified during preliminary proof-of-concept studies. The scope of the program includes technology development and optimization, and studies to prepare for approvals for human use.

This Funding Opportunity Announcement invites applications from established investigators who strive to expand their research trajectories through the acquisition of new knowledge and skills in the areas of traumatic brain injury (TBI) as a risk factor for Alzheimer's Disease and Alzheimer's Disease Related Dementias (AD/ADRD). This funding opportunity encourages applications for short-term (2 yrs.) mentored career enhancement awards to further understand TBI as a risk factor for AD/ADRD. Two categories of candidates are targeted: (a) established TBI investigators who seek training with senior dementia researchers, and (b) established dementia researchers who seek training with senior TBI investigators.

*Note to ICs: Please do not join this announcement. Shared Interest must be completed systematically but the Type 4 submission is for NS R37 applications only. The National Institute of Neurological Disorders and Stroke (NINDS) Javits Neuroscience Investigator Award (R37) provides extended grant support to investigators with a history of exceptional performance and outstanding productivity. The objective of the NINDS Javits Award is to allow Javits awardees to obtain up to seven years of support in two segments: The initial phase of up to four years, and a second phase, providing an additional three years of support. This funding opportunity announcement is specifically for currently funded NINDS Javits recipients to request the second phase of the R37 award.

This Funding Opportunity Announcement (FOA) invites applications to participate as a Research Center as part of the Maternal Health Research Centers of Excellence initiative. The purpose of this initiative is to generate innovative approaches to address preventable maternal mortality, decrease severe maternal morbidity, and promote maternal health equity in partnership with communities that are most affected (i.e., Blacks/African Americans, Hispanics/Latinos, American Indians/Alaska Natives, Asian Americans, Native Hawaiians and other Pacific Islanders, sexual and gender minorities, socioeconomically disadvantaged populations, and underserved rural populations). This initiative will use an integrated multi-level approach encompassing social and biobehavioral research strategies to address the multiple contributing factors that lead to adverse maternal health outcomes and health disparities. Significant contributing factors include comorbid conditions (e.g., hypertension, diabetes, mental illness, and substance use disorders) and social determinants of health, which include structural racism and health care system factors. The goal of this initiative is for trans-disciplinary researchers to conduct multi-layered novel research approaches that will have the potential to drastically reduce pregnancy-related and pregnancy-associated maternal deaths and decrease severe maternal morbidity. Studies may be interventional (including effectiveness, comparative effectiveness, optimization, or dissemination and implementation studies), or observational (including health services studies, natural experiments, policy analyses) and may assess both short-term and long-term maternal health outcomes. The Research Centers will be uniquely poised to collaborate on studies and projects with other networks and initiatives such as the NICHD Neonatal Research Network and the NICHD Maternal and Pediatric Precision in Therapeutics (MPRINT) initiative.

This Funding Opportunity Announcement (FOA) seeks applications for the Data Innovation and Coordinating Hub/Resource Center (hereafter referred to as the Innovation and Data Hub) for the Maternal Health Research Centers of Excellence initiative. This FOA runs in parallel with companion FOAs that seek applications for Research Centers of Excellence (RFA-HD-23-NNN) and an Implementation Science Hub/Resource Center (RFA-HD-23-NNN). It is expected that the Innovation and Data Hub will provide 1) a coordination infrastructure to foster communication and collaboration for participating Research Centers and the Implementation Science Hub under the Maternal Health Centers of Excellence initiative, 2) a centralized resource to support data collection, facilitate curation, and ensure high-quality data, and 3) provide cutting edge biomedical research informatics and data science expertise to maximize data comparability and facilitate data harmonization. The Innovation and Data Hub itself will not generate new experimental data, but rather will serve as a resource, analytical platform, and portal for available analytical and data tools.

This Funding Opportunity Announcement (FOA) seeks applications for the Implementation Science Hub/Resource Center for the Maternal Health Research Centers of Excellence initiative. This FOA runs in parallel with companion FOAs that seek applications for Research Centers of Excellence (RFA-HD-23-NNN) and an Innovation and Coordinating Hub/Resource Center (RFA-HD-23-NNN). It is expected that the Implementation Science Hub will serve as a resource to Maternal Health Research Centers of Excellence, with a particular emphasis on assisting in implementing evidence-informed programs, practices and policies to improve maternal health outcomes. The Implementation Science Hub will help bridge the evidence-to-practice gap to support the development and implementation of strategies to inform integrated efforts involving policy and practice changes to improve pregnancy, perinatal, and postpartum care and advance maternal health and maternal health equity. Studies that promote equitable dissemination and implementation of evidence-based interventions among underrepresented communities are strongly encouraged.

The purpose of this Funding Opportunity Announcement (FOA) is to support studies that expand the use of existing AD/ADRD data resources to drive new discoveries that can lead to better understanding of the relationship between early life social determinants of health (SDOH), adverse childhood experiences (ACEs), AD/ADRD biomarkers, and the development of cognitive impairment and dementia, especially in populations experiencing health disparities.

The purpose of this NINDS-led Alzheimer's Disease and Alzheimer's Disease Related Dementias (AD/ADRD) initiative is to 1) develop tools, standards, and an Open-source software platform that enables a federated (multiple data repository sites with a single access portal) approach for data sharing and analysis of human digital neuropathological slides and 2) perform software testing to validate and verify that the software and tools developed can be used to perform multisite neuropathological analyses using a federated approach. The federated approach requires a single access point of digital slides from multiple geographically distinct brain banks. The resources developed are expected to also enable cross-site annotation and computational image analysis, including advanced analytic approaches. A critical feature of this FOA includes the broad sharing of neuropathological data to further advance research in this area, including the development of a digital resource for distribution and sharing of assessed neuropathological tissue. Software and tools developed under this initiative are expected to be shared using Open Science principles, and the federated digital library is expected to follow FAIR data sharing principles.

This funding opportunity announcement (FOA) invites research to develop, characterize, and rigorously validate non-rodent mammalian models of pain, associated outcome measures and/or endpoints that enable translational research for effective pain management. These models are expected to recapitulate molecular, cellular, pathological, behavioral, and/or cognitive aspects of human pain disorders and conditions. Research supported under this FOA is expected to provide well-validated models and measures that facilitate the development of non-opioid analgesic therapeutic interventions with little or no addiction liability.