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The purpose of this Funding Opportunity Announcement (FOA) aims to speed scientific solutions to stem the national opioid public health crisis by supporting the development of therapies and technologies directed at enhanced pain management through the Small Business Innovation Research (SBIR) program. This FOA is focused on applications directed at improving pain treatment, including the development of new non-addictive medications and devices and objective pain measurement. In addition, NIH is interested in new screening tools and models focused specifically on pain and development of pain therapies.

The purpose of this Funding Opportunity Announcement (FOA) aims to speed scientific solutions to stem the national opioid public health crisis by supporting the development of therapies and technologies directed at enhanced pain management through the Small Business Technology Transfer (STTR) program. This FOA is focused on applications directed at improving pain treatment, including the development of new non-addictive medications and devices and objective pain measurement. In addition, NIH is interested in new screening tools and models focused specifically on pain and development of pain therapies.

The FOA is expected to be published in early 2022 with an expected application due date in Fall 2022. (from NOT-DA-21-085, TJZ 3/11/2022).

The purpose of this funding opportunity announcement is to encourage collaborations between the life and physical sciences that: 1) apply a multidisciplinary bioengineering approach to the solution of a biomedical problem; and 2) integrate, optimize, validate, translate or otherwise accelerate the adoption of promising tools, methods, and techniques for a specific research or clinical problem in basic, translational, or clinical science and practice. An application may propose design-directed, developmental, discovery-driven, or hypothesis-driven research and is appropriate for small teams applying an integrative approach to increase our understanding of and solve problems in biological, clinical, or translational science.

The purpose of this funding opportunity announcement is to encourage collaborations between the life and physical sciences that: 1) apply a multidisciplinary bioengineering approach to the solution of a biomedical problem; and 2) integrate, optimize, validate, translate or otherwise accelerate the adoption of promising tools, methods, and techniques for a specific research or clinical problem in basic, translational, or clinical science and practice. An application may propose design-directed, developmental, discovery-driven, or hypothesis-driven research and is appropriate for small teams applying an integrative approach to increase our understanding of and solve problems in biological, clinical, or translational science.

The Office of Research on Womens Health (ORWH) announces the availability of administrative supplements to support research highlighting health inequities among women in the United States who are understudied, underrepresented and underreported (U3) in biomedical research. Robust studies exploring sex and gender influences and social determinants of health are needed to reduce inequities. The proposed research must address at least one objective from strategic goals 1, 2, or 3 of the 2019-2023 Trans-NIH Strategic Plan for Womens Health Research, Advancing Science for the Health of Women.

This BRAIN Initiative FOA is to further develop molecular tools of high impact that are targetable to brain cell types for the monitoring and manipulation of neural circuits in experimental animals. This FOA is part of the BRAIN Initiative Armamentarium for Brain Cell Access transformative project. This will support iterative improvement of molecular payloads capable of monitoring and manipulating neural cell activity and that can be delivered to specific brain cell types using targeting technologies.

The purpose of this Funding Opportunity Announcement (FOA) is to invite applications for a Laboratory Core for the Environmental influences on Child Health Outcomes (ECHO) program. The ECHO Laboratory Core will provide leadership, project management, and infrastructure for all activities related to ECHO Cohort biospecimens and data generated from biospecimen assays. The main roles of the ECHO Laboratory Core are to: (1) facilitate ECHO Cohort biospecimen collection and processing; (2) manage the ECHO Cohort Biorepository; (3) perform or facilitate a wide range of biospecimen assays to support ECHO Cohort analyses; and (4) coordinate biospecimen information and assay results.

This FOA runs in parallel with companion FOAs that solicit applications for Cohort Study Sites for follow-up of existing ECHO Cohort participants and for recruitment of new pregnant participants (RFA-OD-22-018), for Cohort Study Sites only for follow-up of existing ECHO Cohort participants (RFA-OD-22-019), for Cohort Study Sites only for recruitment of new pregnant participants (RFA-OD-22-017), for an ECHO Coordinating Center (RFA-OD-22-021), for an ECHO Data Analysis Center (RFA-OD-22-022), and for an ECHO Measurement Core (RFA-OD-22-020).

This funding opportunity announcement (FOA) invites applications for new ECHO Cohort Study Sites to extend and expand the capacity of the ECHO Cohort to further investigate the roles of a broad range of early exposures from society to biology, including the preconception period, on ECHOs five key child health outcome areaspre-, peri- and postnatal, upper and lower airways, obesity, neurodevelopment, and positive healthamong diverse populations. The objectives of this FOA are to solicit applications to 1) lead collaborative ECHO Cohort science, 2) recruit new pregnant participants from diverse populations, their resulting offspring, and, if available, the conceiving partner, 3) develop and implement the ECHO Cohort Preconception Pilot Study, and 4) implement the ECHO Cohort Data and Biospecimen Collection Protocol using the ECHO Cohort consortiums central data capture system, e.g., REDCap Central.

This FOA runs in parallel with companion FOAs that solicit applications for Cohort Study Sites only for a limited competition of follow-up of existing ECHO Cohort participants (RFA-OD-22-019), for ECHO Cohort Study Sites only for a limited competition of follow-up of existing ECHO Cohort participants AND of recruitment of new pregnant participants, their resulting offspring, and, if available, the conceiving partner (RFA-OD-22-018), for an ECHO Coordinating Center (RFA-OD-22-021), for an ECHO Data Analysis Center (RFA-OD-22-022), for an ECHO Measurement Core (RFA-OD-22-020), and for an ECHO Laboratory Core (RFA-OD-22-016).

This funding opportunity announcement (FOA) invites applications to renew current ECHO Cohort Study Sites to extend and expand the capacity of the ECHO Cohort to further investigate the roles of a broad range of early exposures from society to biology, including the preconception period, on ECHOs five key child health outcome areaspre-, peri- and postnatal, upper and lower airways, obesity, neurodevelopment, and positive healthamong diverse populations. The objectives of this FOA are to solicit applications to 1) lead collaborative ECHO Cohort science 2) follow up existing ECHO Cohort participants, 3) recruit new pregnant participants from diverse populations, their resulting offspring, and, if available, the conceiving partner, 4) develop and implement the ECHO Cohort Preconception Pilot Study, and 5) implement the ECHO Cohort Data and Biospecimen Collection Protocol using the ECHO Cohort consortiums central data capture system, e.g., REDCap Central. This FOA does not support site-specific analyses and science. Only current ECHO Cohort awardees are eligible to apply. This new funding period will be 7 years in duration provided successful performance in the UG3 phase and the UH3 phase.

This FOA runs in parallel with companion FOAs that solicit applications for Cohort Study Sites only for a limited competition of follow-up of existing ECHO Cohort participants (RFA-OD-22-019), for ECHO Cohort Study Sites only for an open competition of recruitment of new pregnant participants, their resulting offspring, and, if available, the conceiving partner (RFA-OD-22-017), for an ECHO Coordinating Center (RFA-OD-22-021), for an ECHO Data Analysis Center (RFA-OD-22-022), for an ECHO Measurement Core (RFA-OD-22-020), and for an ECHO Laboratory Core (RFA-OD-22-016).