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Purpose. This FOA issued by the Office of Strategic Coordination, National Institutes of Health, solicits grant applications from institutions/ organizations that propose to convert the International Knockout Mouse Consortiums knockout embryonic stem (ES) cell libraries (www.komp.org and www.eummcr.org), into mice, perform quality control (QC) on the imported materials and subsequent products, cooperatively send the mice to the successful grantees under RFA-RM-10-011 for phenotyping, and cryopreserve germplasm of those mice and send aliquots to the KOMP repository. The overall objective of this FOA is to generate the resources needed by NIH-funded Mouse Phenotyping Centers to produce functional information for each protein coding gene in the mammalian genome as described in RFA-RM-10-011. Mechanism of Support. This FOA will utilize the U42 award mechanism and runs in parallel with two additional FOAs that solicits applications under the U54 award mechanism (RFA-RM-10-012, RFA-RM-10-011). Funds Available and Anticipated Number of Awards. Up to $12.4 million in total costs per year for periods up to 5 years may be requested. It is anticipated that 1-3 awards will be made contingent upon receiving scientifically meritorious proposals.

Purpose. This funding opportunity announcement (FOA) solicits Research Conference Grant (R13) applications for scientific meetings aimed at building interdisciplinary research teams in basic behavioral and social science research (b-BSSR). Applicants must propose developmental activities (i.e., meetings/workshops) that will build the capacity of interdisciplinary teams to accelerate, expand, and/or strengthen fundamental knowledge in b-BSSR as relevant to the Nations health and well-being. Proposed interdisciplinary teams must include at least one investigator from the basic social and/or behavioral sciences, and must include investigators from at least one additional discipline. Applicants are encouraged to either: (1) accelerate, expand, and/or strengthen the scope of investigation of a specific b-BSSR research domain through the integration of disparate approaches from b-BSSR and allied disciplines; or (2) increase the sophistication of theoretical, methodological, and analytical approaches in b-BSSR. These goals may be accomplished by fostering the development of shared scientific terminology, approaches, and methodologies across disciplines in order to address a common b-BSSR research question. Investigators may submit applications to support multiple meetings over a period of up to two years. Mechanism of Support. This FOA will utilize the R13 grant mechanism. Funds Available and Anticipated Number of Awards. The NIH Basic Behavioral and Social Science Opportunity Network (OppNet) intends to commit approximately $325,000 in total costs (direct costs plus Facilities and Administrative [F&A] costs) in FY 2011 to fund four to six new grants in response to this FOA.

The Paul B. Beeson Clinical Scientist Development Award in Aging (K08) program provides three to five years of mentored career development support to clinically trained faculty members in strong research environments to enable them to gain skills and experience in basic aging (i.e., not patient-oriented) research under the guidance of a mentor or mentors, and to establish an independent program of research in this field. The program also includes an annual meeting that allows opportunities to partner with national mentors and fellow awardees. Clinically trained professionals or individuals with a clinical degree who are interested in further career development in biomedical research that is patient-oriented should refer to the Paul B. Beeson Mentored Patient-Oriented Research Development (K23) Award in Aging[RFA-AG-11-009]. Mechanism of Support This FOA will utilize the NIH Research Career Development Award K08 award mechanism Funds Available and Anticipated Number of Awards. The FY 2011 anticipated amount is $1 million. The anticipated number of awards is 5 to 7. Budget and Project Period. Applicants may seek up to $200,000 (direct costs) per year. Direct costs requested across all years may be no more than $600,000 for three year awards; $700,000 for four year awards; and $800,000 for five year awards. Awarded amounts may be significantly lower than these amounts. Although the financial plans of NIA, NIMH and NINDS provide support for this program, awards pursuant to this funding opportunity are contingent upon the availability of funds and the receipt of a sufficient number of meritorious applications.

The Paul B. Beeson Patient-Oriented Research Career Development Award in Aging (K23) program provides three to five years of mentored career development support to clinically trained faculty members in strong research environments to enable them to gain skills and experience in patient-oriented research on aging under the guidance of a mentor or mentors, and to establish an independent program of research in this field. The program also includes an annual meeting that allows opportunities to partner with national mentors and fellow awardees Clinically trained professionals or individuals with a clinical degree who are interested in a career in basic science should refer to the Paul B. Beeson Clinical Scientist Career Development Award in Aging (K08) [RFA-AG-11-008]. Mechanism of Support This FOA will utilize the NIH Patient-Oriented Career Development Award (K23) award mechanism Funds Available and Anticipated Number of Awards. The FY 2011 anticipated amount is $1 million. The anticipated number of awards is 5 to 7. Budget and Project Period. Applicants may seek up to $200,000 (direct costs) per year. Direct costs requested across all years may be no more than $600,000 for three year awards; $700,000 for four year awards; and $800,000 for five year awards. Awarded amounts may be significantly lower than these amounts. Although the financial plans of NIA, NIMH and NINDS provide support for this program, awards pursuant to this funding opportunity are contingent upon the availability of funds and the receipt of a sufficient number of meritorious applications.

Purpose. This Funding Opportunity Announcement (FOA) issued by the NIH Basic Behavioral and Social Sciences Opportunity Network (OppNet) solicits Research Project Grant (R01) applications from institutions and organizations that propose to investigate the mechanistic pathways linking psychosocial stressors and behavior. This research will facilitate investigation of multiple and potentially bidirectional pathways underlying the link between psychosocial stressors and behaviors that may ultimately impact biological function, health, and disease. Applicants are encouraged to use model systems and longitudinal approaches to design innovative and integrative studies to elucidate how psychological factors, social factors, and environments impact the processes by which stressors are coupled with and influenced by various behaviors. Applications examining moderating factors such as individual demographic (age, gender/sex, ethnicity) and psychological (vulnerabilities, resilience) differences, risk factors, early exposure, and environments (including toxicants) are desirable. This research will provide a deeper understanding of the psychological, environmental, and social processes that ultimately connect psychosocial stress to behaviors, physiological processes, health, and disease. Mechanism of Support. This FOA will utilize the R01 award mechanism. Funds Available and Anticipated Number of Awards. OppNet intends to commit approximately $1,325,000 million in total costs (Direct plus Facilities and Administrative [F&A] costs) in FY 2011 to fund 2-3 new grants in response to this FOA, pending the number and quality of applications and availability of funds.

Purpose. This FOA issued by the NIH Basic Behavioral and Social Sciences Opportunity Network (OppNet) solicits Research Project Grant (R21) applications from institutions and organizations that propose to develop and test conceptually-based and comprehensive measures of psychosocial stress that can be applied across species and across the lifespan. Applicants submitting proposals under this FOA are encouraged to incorporate variations in exposures, chronicity, environments (including toxicants and social environments), cognitions, and responses, as well as capture important factors for measuring stress in both humans and animals, in men and women, and across the lifespan. Such studies should demonstrate that the measures, coupled with appropriate bridges between laboratory and population-based designs, advance our understanding of the components of psychosocial stressors that are most relevant to disease, and provide comparability across studies. Mechanism of Support. This FOA will utilize the R21 award mechanism. Funds Available and Anticipated Number of Awards. OppNet intends to commit approximately $1,050,000 million in total costs (Direct plus Facilities and Administrative [F and A] costs) in FY 2011 to fund 4-6 new grants in response to this FOA, pending the number and quality of applications and availability of funds. A period of up to 2 years of funding may be requested. Applicants should budget travel expenses for Principal Investigators (PIs) to attend one 2-day meeting of FOA grantees per year.

Purpose. This Funding Opportunity Announcement (FOA) issued by the NIH Basic Behavioral and Social Science Opportunity Network (OppNet) solicits research applications examining basic mechanisms of behavioral maintenance. The intent of this FOA is to advance research on basic processes and mechanisms involved in sustaining learned behavior over time and in the context of dynamic environmental influences and changing psychological and biological states. Maintenance of health behavior change is a critical problem in applied clinical research, and innovative strategies to address this problem require a better understanding of basic processes and mechanisms involved in long-term behavior maintenance. This FOA requests applications that will improve our understanding of how newly learned, effortful, and goal-directed behaviors transition to less effortful, automatic, and essentially non-goal-directed behaviors that are more easily maintained over time. A range of possible processes and mechanisms (e.g., neurobiological, cognitive, and environmental) may be proposed for study, and applicants are encouraged to study multiple mechanisms and their potential interactions. Regardless of mechanisms or processes of interest, however, applications should test how these mechanisms and processes facilitate or impede the transition from newly learned, effortful, and goal-directed behaviors to less effortful, automatic, and essentially non-goal-directed behaviors. A wide array of research proposals are potentially appropriate under this FOA, ranging from animal neurobehavioral models to human learning studies of social and environmental influences that facilitate or impede the transition to habitually maintained behaviors. Mechanism of Support. This FOA will utilize the R01 award mechanism. Funds Available and Anticipated Number of Awards. OppNet intends to commit approximately $3,750,000 in total costs (Direct plus Facilities and Administrative [F&A] costs) in FY 2011 to fund approximately 5 new grants in response to this FOA.

Purpose. This FOA solicits Research Project Grant (R01) applications from institutions/organizations proposing exceptionally innovative research on novel hypotheses or difficult problems, solutions to which would have an extremely high impact on biomedical or biobehavioral research that is germane to the mission of one or more of the participating NIH Institutes. This FOA is for support of new projects, not continuation of projects that have already been initiated. It does not support pilot projects, i.e., projects of limited scope that are designed primarily to generate data that will enable the PD/PI to seek other funding. Mechanism of Support. This FOA will utilize the NIH Research Project Grant (R01) award mechanism. Funds Available and Anticipated Number of Awards. NIGMS ($6 million, 18-22 awards), NCI ($3 million, 10-12 awards), NCCAM ($400,000, 1 award), NIAAA $600,000, 2 awards), NIDCR $800,000, 1-2 awards), NIDA ($1 million, 3-4 awards), NIMH ($2 million, 6-9 awards), and NINDS ($2 million, 6 awards) are participating in this initiative. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications. Budget and Project Period. Support may be requested for up to $800,000 in direct costs (excluding consortium Facilities and Administrative [F&A] costs) over a four-year period, prorated for shorter terms ($600,000 for three years, $400,000 for two years). Regardless of the term of support, direct costs (excluding consortium F&A costs) may not exceed $250,000 in any one year.

Purpose. This Funding Opportunity Announcement (FOA) encourages research grant applications from institutions/organizations to develop novel, robust analytical platforms using in vitro assays to reveal changes in neuronal and/or glial function. The goal is to adapt state-of-the-art measures of basic cellular processes or molecular events that are key mediators of brain function with the intent to probe mechanisms and/or perturbations in an unbiased and efficient manner. The novel assay platforms would provide opportunities to measure neurobiological endpoints and build a pipeline to be used in the context of target identification and drug discovery. Mechanism of Support. This FOA will utilize the NIH Research Project Grant (R01) award mechanism Funds Available and Anticipated Number of Awards. The NIMH intends to commit approximately $3 million total costs in FY 2011 to fund 5-10 awards and NINDS intends to commit approximately $2 million total costs in FY 2011 to fund 3-6 awards.

Purpose. This Funding Opportunity Announcement (FOA) is a program announcement (PA) issued by the National Institute of Neurological Disorders and Stroke (NINDS), National Institute on Deafness and Other Communication Disorders (NIDCD), National Institute of Dental and Craniofacial Research (NIDCR), and National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH). It encourages R01 grant applications from institutions/organizations that intend to perform innovative research that will expand our current knowledge of neurobiological mechanisms underlying migraine headache, examine the role of neuromodulators, genetic and environmental influences in migraine susceptibility, and explore new targets for therapy development. Mechanism of Support. This FOA will utilize the NIH Research Project Grant (R01) award mechanism and runs in parallel with a FOA of identical scientific scope, PA-10-259, that encourages applications under the NIH Exploratory/Developmental (R21) mechanism. Funds Available and Anticipated Number of Awards. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications. Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the mechanism numbers, quality, duration, and costs of the applications received.