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Updated Application Forms FORMS-D) Available PAR-15-195 NeuroNEXT Infrastructure Resource Access X01)" May 25, 2016 Notice Number: NOT-NS-16-014 Key Dates Release Date:   April 14, 2016 Related Announcements PAR-15-195    Issued National Institute Neurological Disorders Stroke NINDS) Purpose PAR-15-195 quot;NeuroNEXT Infrastructure Resource Access X01)" set-up accept applications a continuous basis November 13, 2015 until November 13, 2017 rather specifying exact due dates. are updating our grant application forms implement new requirements grant applications due dates or after 25, 2016 FORMS-D; NOT-OD-16-004). Notice announces our plans update PAR-15-195 FORMS-D application forms. FORMS-C: May 25, 2016 will close FORMS-C application package it no longer show an option download Grants.gov to initiate application ASSIST. Since X01 applications not compete against other, have configured our systems continue accept FORMS-C applications these FOAs through July 12, 2016. allows applications started before 25 complete submission process the October council round without disruption. FORMS-D: May 25, 2016 will post new FORMS-D application package. Any applications initiated or after 25, 2016 must the FORMS-D application package. of FORMS-D not impact Council round which application assigned. Inquiries Please direct inquiries to: NIH Grants Information Email: grantsinfo@od.nih.gov (preferred method contact) Telephone: 301-435-0714

Updated Application Forms FORMS-D) Available PAR-14-340 Request Access Parkinson's Disease Related-Biospecimens X01)" May 25, 2016 Notice Number: NOT-NS-16-015 Key Dates Release Date:   April 14, 2016 Related Announcements PAR-14-340     Issued National Institute Neurological Disorders Stroke NINDS) Purpose PAR-14-340 quot;Request Access Parkinson's Disease Related-Biospecimens X01)" set-up accept applications a continuous basis November 13, 2014 until November 13, 2017 rather specifying exact due dates. are updating our grant application forms implement new requirements grant applications due dates or after 25, 2016 FORMS-D; NOT-OD-16-004). Notice announces our plans update PAR-14-340 FORMS-D application forms. FORMS-C: May 25, 2016 will close FORMS-C application package it no longer show an option download Grants.gov to initiate application ASSIST. Since X01 applications not compete against other, have configured our systems continue accept FORMS-C applications these FOAs through July 12, 2016. allows applications started before 25 complete submission process the October council round without disruption. FORMS-D: May 25, 2016 will post new FORMS-D application package. Any applications initiated or after 25, 2016 must the FORMS-D application package. of FORMS-D not impact Council round which application assigned. Inquiries Please direct inquiries to: NIH Grants Information Email: grantsinfo@od.nih.gov (preferred method contact) Telephone: 301-435-0714

Updated Application Forms FORMS-D) Available PAR-14-253 NIH StrokeNet Clinical Trials Biomarker Studies Stroke Treatment, Recovery, Prevention Infrastructure Resource Access X01)" May 25, 2016 Notice Number: NOT-NS-16-016 Key Dates Release Date:   April 14, 2016 Related Announcements PAR-14-253     Issued National Institute Neurological Disorders Stroke NINDS) Purpose PAR-14-253 quot;NIH StrokeNet Clinical Trials Biomarker Studies Stroke Treatment, Recovery, Prevention Infrastructure Resource Access X01)" set-up accept applications a continuous basis November 13, 2014 until November 13, 2017 rather specifying exact due dates. are updating our grant application forms implement new requirements grant applications due dates or after 25, 2016 FORMS-D; NOT-OD-16-004). Notice announces our plans update PAR-14-253 FORMS-D application forms. FORMS-C: May 25, 2016 will close FORMS-C application package it no longer show an option download Grants.gov to initiate application ASSIST. Since X01 applications not compete against other, have configured our systems continue accept FORMS-C applications these FOAs through July 12, 2016. allows applications started before 25 complete submission process the October council round without disruption. FORMS-D: May 25, 2016 will post new FORMS-D application package. Any applications initiated or after 25, 2016 must the FORMS-D application package. of FORMS-D not impact Council round which application assigned. Inquiries Please direct inquiries to: NIH Grants Information Email: grantsinfo@od.nih.gov (preferred method contact) Telephone: 301-435-0714

Request Information RFI): Input Revisions the NIH Sleep Disorders Research Plan Notice Number: NOT-HL-16-312 Key Dates Release Date: April 8, 2016 Response Date: 8, 2016 Related Announcements NOT-HL-16-316   Issued National Heart, Lung, Blood Institute NHLBI) National Institute Neurological Disorders Stroke NINDS)National Cancer Institute NCI) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Mental Health NIMH) National Institute Nursing Research NINR) National Center Complementary Integrative Health NCCIH) National Institite Diabetes Digestive Kidney Diseases NIDDK) Purpose is time-sensitive Request Information RFI) solicit input regarding revisions the NIH Sleep Disorders Research Plan. NIH Revitalization Act 1993 42 USC Sec. 285b-7) calls the development a comprehensive plan identifies priorities respect sleep disorders research the revision the plan appropriate. last Sleep Disorders Research Plan published 2011 is undergoing revision.  Background Planning Process Overview Comments submitted response this RFI inform National Centers Sleep Disorders Research NCSDR) participating NIH Institutes Centers the public perspective need biomedical sleep disorders research. summary public comments a preliminary planning document be presented discussion the Sleep Disorders Research Advisory Board SDRAB), then disseminated public comment the NCSDR website www.nhlbi.nih.gov/sleep). plan undergo further revision subsequent public SDRAB meetings during 2016. NCSDR coordinates revision process a Trans-NIH Sleep Research Coordinating Committee. strategic planning process aims achieve following objectives: identify potential scientific programmatic goals priorities participating NIH sleep circadian research programs during next five years. enhance research translation, community engagement, commitments toward improving sleep health. identify implementable strategies support specific scientific goals. Definition Sleep disorders research, the purposes this Request Information, defined the basic science sleep circadian biology it applies all tissues organs; function(s) sleep circadian biology development, across levels biological organization across lifespan; basic behavioral pathophysiological implications sleep loss untreated sleep disorders; societal social science relationships between sleep health including socioeconomic, racial/ethnic, gender disparities; safety performance; role sleep psychiatric, alcohol, substance abuse disorders; sleep chronic disease conditions; need training researchers health care providers; the need educate patients, communities, the general public sleep sleep disorders. Information Requested Members the health scientific community large, state local government officials, patient advocates, public interest organizations, community-based organizations, industry stakeholders, the general public invited respond any all the items listed below. Facts opinions linking circadian sleep disorders sciences opportunities improved public health broadly relevant the mission individual NIH Institutes Centers participating this RFI also welcomed. 1.  Ideas the highest impact biomedical sciences public health research – research opportunities be any level scientific inquiry including: knowledge acquisition basic, discovery, applied research), knowledge validation clinical trials comparative effective research), knowledge transfer education dissemination research), new technology development. Transformative directions include advancing personalized medicine elucidating biological basis individual differences vulnerabilities sleep deprivation, the psychosocial cognitive determinants increasing vulnerability sleep health risks. 2.  Major impediments critical scientific advances basic research, clinical research sleep medicine, translational research.  Describe emerging research opportunities are well served existing programs offer highest value transformative scientific advances. 3.  Describe studies would promote uptake research findings sustainable scalable routine health care practices. 4.  comments, suggestions, considerations relevant this RFI. Responses Comments response this notice be submitted email later May 8, 2016 to:  NCSDR-RFI2016@spmail.nih.gov. Please mark responses this RFI identifier NOT-HL-16-312 the subject line the email. each suggested high priority area adherence research, please provide brief background information, define challenge outline potential solution. Reponses expected be less 1,000 words. Respondents receive automated email confirmation acknowledging receipt their response, will receive individualized feedback. Significance Public Health Sleep, nutrition physical activity, a critical determinant health well-being. Adequate sleep necessary maintain resistance infection, support metabolism sugar prevent diabetes, perform our best the job in school, sustain vigilance necessary workplace driving safety. Sleep disorders sleep restriction due lifestyle choices associated fatigue, psychological disturbances, decrements performance vigilance, compromising safety oneself others. Sleep also basic requirement infant, child, adolescent health development recent evidence points toward long-term trends decreased sleep during first decades. Further, sleep loss untreated sleep disorders influence basic patterns behavior stress family health interpersonal relationships. Sleep timing duration coupled an array endocrine, metabolic neurological functions are critical the maintenance individual health well-being.  than 20% US adults report insufficient sleep rest least 15 of every 30 days. Sleep disorders including insomnia, circadian phase disorder, restless legs syndrome relatively common present challenges detection, prevention, therapy, management. Sleep disordered breathing sleep apnea) affects than 20 million US adults, if left untreated associated a 2-3 fold increased risk stroke mortality all causes. Sleep health also pervasive challenge individuals chronic disabilities disorders cause pain fatigue such arthritis, kidney disease, HIV, depression. elderly populations, medical mental health consequences untreated sleep disorders include sharply increase rates diminished health-related quality life, physical functional limitations, ability remain independent, an increased risk death any cause.  Confidentiality Responses RFI voluntary may anonymous. Any identifiers e.g., names, institutions, e-mail addresses, etc.) be removed responses compiled. Only processed, anonymized results be shared internally scientific working groups convened the NIH, appropriate. Proprietary, classified, confidential, sensitive information should be included your response. Government reserves right use any non-proprietary technical information any resultant solicitation(s).  RFI for information planning purposes only should be construed a solicitation as obligation the part the Federal Government, the National Institutes Health NIH). NIH does intend award grant contract pay the preparation any information submitted for NIH’s of such information. Respondents not notified the NIH evaluation the information received. basis claims against NIH shall arise a result a response this request information the NIH’s of such information either part our evaluation process in developing specifications any subsequent announcement. Responses be held confidential. Proprietary information should be sent.  Inquiries Please direct inquiries to: Michael Twery, PhD National Heart, Lung, Blood Institute NHLBI)   Telephone: 301-435-0199 Email: TweryM@nhlbi.nih.gov

Notice Availability Administrative Supplements Myalgic Encephalomyelitis/Chronic Fatigue Syndrome ME/CFS) Notice Number: NOT-AI-16-046 Key Dates Release Date:   April 7, 2016 Related Announcements PA-14-077 Issued National Institute Allergy Infectious Diseases NIAID) National Institute Dental Craniofacial Research NIDCR) National Institute Neurological Disorders Stroke NINDS) National Institute Nursing Research NINR) National Center Complementary Integrative Health NCCIH) Purpose Myalgic encephalomyelitis / chronic fatigue syndrome ME/CFS) a debilitating complex illness. are still knowledge gaps ME/CFS, including key aspects the etiology, diagnosis, pathophysiology, treatment. NIH committed supporting research better understand ME/CFS. notice one component this effort. Multiple Institutes Centers interested accepting investigator-initiated administrative supplement requests existing awards expand ME/CFS research within scope the parent award. For purpose this Notice, within scope” include addition assays, bioinformatics/modeling approaches, human cohorts the parent studies e.g., adding ME/CFS cohort a fibromyalgia study humans). However, supplement requests studies are a substantially different direction the parent award be deemed of scope."  such situations, applicants strongly encouraged discuss aims the proposed work the scope the parent grant NIH program staff below). Areas interest include, are limited to, following: Characterization CNS-related biomarkers between new onset established ME/CFS patients appropriate comparison groups Identification biomarkers cerebrospinal fluid, blood, urine, etc. can identify physiologically relevant subgroups ME/CFS Studies elucidating autonomic abnormalities seen the central peripheral nervous system patients ME/CFS Studies provide better understanding ME/CFS, prevalence, pathogenesis, pathophysiology Identification potential triggers modifiers immune responses immune cell metabolism contribute ME/CFS Application current methodologies e.g., immune phenotyping) computational modeling better characterize human immune responses triggered ME/CFS Elucidation etiology ME/CFS physiological determinants involved ME/CFS manifestations including not limited microbiome-related studies NIAID:  requested award budget cannot exceed 150,000 direct costs up 12 months.  applicants strongly encouraged discuss potential requests the contacts listed below, well their assigned program officer.  Additionally, NIAID applicants must review NIAID requirements administrative supplements grants cooperative agreements prior submission. additional reference, the NIH Administrative Supplement Program Announcement PA-14-077 NIDCR: requested award budget cannot exceed 100,000 direct costs up 12 months. applicants strongly encouraged discuss potential requests the contacts listed below, well their assigned program officer. NIDCR not support clinical trials prospective enrollment individuals ME/CFS.  supplement support studies well-phenotyped cohorts, analysis banked biospecimens well-phenotyped cohorts, the supplement must relevance temporomandibular disorders TMD) orofacial pain.  Additionally, NIDCR applicants must review requirements administrative supplements grants cooperative agreements http://grants.nih.gov/grants/guide/pa-files/PA-14-077.html) prior submission.  NINDS:  requested award budget cannot exceed 100,000 direct costs up 12 months.  applicants strongly encouraged discuss potential requests the contacts listed below, well their assigned program officer.  Additionally, NINDS applicants must review NINDS requirements administrative supplements grants cooperative agreements http://www.ninds.nih.gov/funding/funding_announcements/supplements.htm ) prior submission.  NINR: requested award budget cannot exceed 100,000 direct costs up 12 months.  applicants strongly encouraged discuss potential requests the contacts listed below, well their assigned program officer.  Additionally, NINR applicants must review NINR requirements administrative supplements grants cooperative agreements http://grants.nih.gov/grants/guide/pa-files/PA-14-077.html) prior submission. NCCIH:  requested award budget cannot exceed 100,000 direct costs up 12 months. applicants strongly encouraged discuss potential requests the contacts listed below, well their assigned program officer. Additionally NCCIH applicants must review requirements administrative supplements grants cooperative agreements http://grants.nih.gov/grants/guide/pa-files/PA-14-077.html) prior submission. Inquiries Please direct inquiries to: Joseph Breen, Ph.D. National Institute Allergy Infectious Diseases NIAID) Telephone: 240-292-4123 Email: jbreen@niaid.nih.gov Yolanda F. Vallejo-Estrada, Ph.D. National Institute Dental Craniofacial Research NIDCR) Telephone: 301-594-8926 Email: Yolanda.Vallejo-Estrada@nih.gov Vicky Whittemore, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-1917 Email: vicky.whittemore@nih.gov Martha Matocha, PhD National Institute Nursing Research NINR) Telephone: 301-594-2775 Email: matocham@mail.nih.gov Wen Chen, Ph.D. National Center Complementary Integrative Health NCCIH) Telephone: 301-451-1989 Email: chenw@mail.nih.gov

Notice the Increase Budget Caps Applications PAR-14-287 NINDS CREATE Bio Discovery Track: Optimization Preparation Development Biotechnology Products Biologics U44)" Notice Number: NOT-NS-16-010 Key Dates Release Date:   March 29, 2016 Related Announcements PAR-14-287 Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this notice to modify information regarding application budgets PAR-14-287 NINDS CREATE Bio Discovery Track: Optimization Preparation Development Biotechnology Products Biologics U44)". FOA currently reads: Part 2. Section II. Award Information  Award Budget Application budgets not limited must reflect actual needs the proposed project. Budgets these projects normally remain under 500,000 total cost Phase and 2,000,000 total cost Phase II. FOA modified read:  Part 2. Section II. Award Information  Award Budget Application budgets not limited must reflect actual needs the proposed project. Budgets these projects normally remain under 700,000 total cost Phase and 4,000,000 total cost Phase II. other aspects the FOA remain unchanged. Inquiries Please direct inquiries to: Chris Boshoff, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-1779 Email: christoffel.boshoff@nih.gov

Resources Technology Webinar RFA-NS-16-023 Center without Walls the Identification Validation Molecular Mechanisms Contributing Tau Pathogenesis Associated Neurodegeneration Frontotemporal Degeneration FTD) U54)" Notice Number: NOT-NS-16-009 Key Dates Release Date:   March 23, 2016 Related Announcements RFA-NS-16-023     Issued National Institute Neurological Disorders Stroke NINDS) Purpose National Institute Neurological Disorders Stroke NINDS) be holding pre-application Technology Resources webinar March 25, 2016 1-3 pm EST the Funding Opportunity Announcement FOA) RFA-NS-16-023, entitled quot;Center without Walls the Identification Validation Molecular Mechanisms Contributing Tau Pathogenesis Associated Neurodegeneration Frontotemporal Degeneration FTD) U54)". webinar provide brief introduction the FOA, primarily focus technologies available resources could applied identify validate molecular mechanisms contributing tau toxicity associated neurodegeneration characteristic FTD. information how join webinar video audio coordinates, including passwords), please register https://meetings.ninds.nih.gov/meetings/TauCWOW/.   Participation this webinar, although encouraged, optional is required the submission an application. Inquiries Please direct inquiries to: Margaret Sutherland, PhD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-5680 Email: sutherlandm@ninds.nih.gov

Notice Intent Publish Funding Opportunity Announcement Dissemination Implementation Research Health R01) Notice Number: NOT-CA-16-025 Key Dates Release Date:   March 7, 2016 Estimated Publication Date Announcement: 2016  First Estimated Application Due Date: June 2016  Earliest Estimated Award Date: April 2017  Earliest Estimated Start Date: April 2017 Related Announcements NOT-CA-16-026 NOT-CA-16-027 Issued National Institutes Health NIH) National Cancer Institute NCI) National Heart, Lung, Blood Institute NHLBI) National Human Genome Research Institute NHGRI) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Deafness Other Communication Disorders NIDCD) National Institute Drug Abuse NIDA) National Institute Environmental Health Sciences NIEHS) National Institute Mental Health NIMH) National Institute Neurological Disorders Stroke NINDS) National Institute Minority Health Health Disparities NIMHD) National Center Complementary Integrative Health NCCIH) Office Disease Prevention ODP) Agency Healthcare Research Quality AHRQ) Purpose National Cancer Institute NCI), other participating NIH Institutes Centers ICs), intends reissue Funding Opportunity Announcement FOA) solicit applications dissemination implementation D&I) research health. Notice being provided allow potential applicants sufficient time develop meaningful collaborations responsive projects.  FOA expected be published May 2016 an expected application due date June 2016. FOA utilize R01 activity code. Details the planned FOA provided below. Research Initiative Details purpose this Funding Opportunity Announcement FOA) to support innovative approaches identifying, developing, testing, evaluating and/or refining strategies disseminate implement evidence-based practices e.g. behavioral interventions; prevention, early detection, diagnostic, treatment disease management interventions; quality improvement programs) public health, clinical practice, community settings. Conversely, is benefit understanding circumstances create need de-implement” reduce use strategies interventions are evidence-based, been prematurely widely adopted, yield sub-optimal benefits patients, are harmful wasteful. addition, studies advance dissemination implementation research methods measures encouraged. Examples relevant research directions include are limited to: Studies strategies implement health promotion, prevention, screening, early detection, diagnostic interventions, well effective treatments, clinical procedures guidelines existing care systems. Studies the implementation multiple evidence-based practices within community clinical settings meet needs complex patients diverse systems care. Studies the local adaptation evidence-based practices the context implementation systematically identify intervention components surpass fall short expected intervention effects. Longitudinal follow-up studies the factors contribute the sustainability evidence-based interventions public health clinical practice. Studies testing effectiveness cost-effectiveness dissemination implementation strategies reduce health disparities improve quality care among rural, minority, low literacy numeracy, other underserved populations. Studies the de-implementation clinical community practices are evidence-based, been prematurely widely adopted, yield sub-optimal benefits patients, are harmful wasteful. Studies the relationship context local capacity clinical community settings adoption, implementation sustainability evidence-based practices. Prospective retrospective studies the adoption, implementation sustainability health policies their interaction programs contextual factors. Studies influences the creation, packaging, transmission reception valid health research knowledge. Studies systems interventions impact organizational structure, climate, culture, processes enable dissemination implementation clinical/public health information effective clinical/public health interventions. Studies focus the development testing theoretical evaluation models D&I processes. Development D&I relevant outcome process measures suitable methodologies dissemination implementation approaches.  Studies the dissemination varied strategies promote effective patient caregiver communication, leading improved healthcare delivery outcomes. Studies the dissemination implementation effective cost-effective strategies incorporating genomic medicine, sequence-based diagnostics therapeutics clinical care. Studies testing implementation use genomic information, family history risk information, and/or pharmacogenetic information improved diagnosis treatment. APPLICATIONS NOT BEING SOLICITED THIS TIME. Inquiries Please direct inquiries to: David Chambers, D.Phil. National Cancer Institute NCI) Telephone: 240-276-5090 Email:  dchamber@mail.nih.gov

Notice Intent Publish Funding Opportunity Announcement Dissemination Implementation Research Health R21) Notice Number: NOT-CA-16-026 Key Dates Release Date:   March 7, 2016 Estimated Publication Date Announcement: 2016  First Estimated Application Due Date: June 2016  Earliest Estimated Award Date: April 2017  Earliest Estimated Start Date: April 2017 Related Announcements NOT-CA-16-025 NOT-CA-16-027 Issued National Institutes Health NIH) National Cancer Institute NCI) National Human Genome Research Institute NHGRI) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Deafness Other Communication Disorders NIDCD) National Institute Drug Abuse NIDA) National Institute Environmental Health Sciences NIEHS) National Institute Mental Health NIMH) National Institute Neurological Disorders Stroke NINDS) National Center Complementary Integrative Health NCCIH) Office Disease Prevention ODP) Agency Healthcare Research Quality AHRQ) Purpose National Cancer Institute NCI), other participating NIH Institutes Centers ICs) the Agency Healthcare Research Quality AHRQ), intends reissue Funding Opportunity Announcement FOA) solicit applications dissemination implementation D&I) research health. Notice being provided allow potential applicants sufficient time develop meaningful collaborations responsive projects.  FOA expected be published May 2016 an expected application due date June 2016. FOA utilize R21 activity code. Details the planned FOA provided below. Research Initiative Details purpose this Funding Opportunity Announcement FOA) to support innovative approaches identifying, developing, testing, evaluating and/or refining strategies disseminate implement evidence-based practices e.g. behavioral interventions; prevention, early detection, diagnostic, treatment disease management interventions; quality improvement programs) public health, clinical practice, community settings. Conversely, is benefit understanding circumstances create need ldquo;de-implement” reduce use strategies interventions are evidence-based, been prematurely widely adopted, yield sub-optimal benefits patients, are harmful wasteful. addition, studies advance dissemination implementation research methods measures encouraged. Examples relevant research directions include are limited to: Studies strategies implement health promotion, prevention, screening, early detection, diagnostic interventions, well effective treatments, clinical procedures guidelines existing care systems. Studies the implementation multiple evidence-based practices within community clinical settings meet needs complex patients diverse systems care. Studies the local adaptation evidence-based practices the context implementation systematically identify intervention components surpass fall short expected intervention effects. Longitudinal follow-up studies the factors contribute the sustainability evidence-based interventions public health clinical practice. Studies testing effectiveness cost-effectiveness dissemination implementation strategies reduce health disparities improve quality care among rural, minority, low literacy numeracy, other underserved populations. Studies the de-implementation clinical community practices are evidence-based, been prematurely widely adopted, yield sub-optimal benefits patients, are harmful wasteful. Studies the relationship context local capacity clinical community settings adoption, implementation sustainability evidence-based practices. Prospective retrospective studies the adoption, implementation sustainability health policies their interaction programs contextual factors. Studies influences the creation, packaging, transmission reception valid health research knowledge. Studies systems interventions impact organizational structure, climate, culture, processes enable dissemination implementation clinical/public health information effective clinical/public health interventions. Studies focus the development testing theoretical evaluation models D&I processes. Development D&I relevant outcome process measures suitable methodologies dissemination implementation approaches.  Studies the dissemination varied strategies promote effective patient caregiver communication, leading improved healthcare delivery outcomes. Studies the dissemination implementation effective cost-effective strategies incorporating genomic medicine, sequence-based diagnostics therapeutics clinical care. Studies testing implementation use genomic information, family history risk information, and/or pharmacogenetic information improved diagnosis treatment. APPLICATIONS NOT BEING SOLICITED THIS TIME. Inquiries Please direct inquiries to: David Chambers, D.Phil. National Cancer Institute NCI) Telephone: 240-276-5090 Email:  dchamber@mail.nih.gov

Notice Intent Publish Funding Opportunity Announcement Dissemination Implementation Research Health R03) Notice Number: NOT-CA-16-027 Key Dates Release Date:   March 7, 2016 Estimated Publication Date Announcement: 2016  First Estimated Application Due Date: June 2016  Earliest Estimated Award Date: April 2017  Earliest Estimated Start Date: April 2017 Related Announcements NOT-CA-16-025 NOT-CA-16-026 Issued National Institutes Health NIH) National Cancer Institute NCI) National Human Genome Research Institute NHGRI) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Drug Abuse NIDA) National Institute Environmental Health Sciences NIEHS) National Institute Mental Health NIMH) National Institute Neurological Disorders Stroke NINDS) Fogarty International Center FIC) Office Disease Prevention ODP) Agency Healthcare Research Quality AHRQ) Purpose National Cancer Institute NCI), other participating NIH Institutes Centers ICs) the Agency Healthcare Research Quality AHRQ), intends reissue Funding Opportunity Announcement FOA) solicit applications dissemination implementation D&I) research health. Notice being provided allow potential applicants sufficient time develop meaningful collaborations responsive projects.  FOA expected be published May 2016 an expected application due date June 2016. FOA utilize R03 activity code. Details the planned FOA provided below. Research Initiative Details purpose this Funding Opportunity Announcement FOA) to support innovative approaches identifying, developing, testing, evaluating and/or refining strategies disseminate implement evidence-based practices e.g. behavioral interventions; prevention, early detection, diagnostic, treatment disease management interventions; quality improvement programs) public health, clinical practice, community settings. Conversely, is benefit understanding circumstances create need ldquo;de-implement” reduce use strategies interventions are evidence-based, been prematurely widely adopted, yield sub-optimal benefits patients, are harmful wasteful. addition, studies advance dissemination implementation research methods measures encouraged. Examples relevant research directions include are limited to: Studies strategies implement health promotion, prevention, screening, early detection, diagnostic interventions, well effective treatments, clinical procedures guidelines existing care systems. Studies the implementation multiple evidence-based practices within community clinical settings meet needs complex patients diverse systems care. Studies the local adaptation evidence-based practices the context implementation systematically identify intervention components surpass fall short expected intervention effects. Longitudinal follow-up studies the factors contribute the sustainability evidence-based interventions public health clinical practice. Studies testing effectiveness cost-effectiveness dissemination implementation strategies reduce health disparities improve quality care among rural, minority, low literacy numeracy, other underserved populations. Studies the de-implementation clinical community practices are evidence-based, been prematurely widely adopted, yield sub-optimal benefits patients, are harmful wasteful. Studies the relationship context local capacity clinical community settings adoption, implementation sustainability evidence-based practices. Prospective retrospective studies the adoption, implementation sustainability health policies their interaction programs contextual factors. Studies influences the creation, packaging, transmission reception valid health research knowledge. Studies systems interventions impact organizational structure, climate, culture, processes enable dissemination implementation clinical/public health information effective clinical/public health interventions. Studies focus the development testing theoretical evaluation models D&I processes. Development D&I relevant outcome process measures suitable methodologies dissemination implementation approaches.  Studies the dissemination varied strategies promote effective patient caregiver communication, leading improved healthcare delivery outcomes. Studies the dissemination implementation effective cost-effective strategies incorporating genomic medicine, sequence-based diagnostics therapeutics clinical care. Studies testing implementation use genomic information, family history risk information, and/or pharmacogenetic information improved diagnosis treatment. APPLICATIONS NOT BEING SOLICITED THIS TIME. Inquiries Please direct inquiries to: David Chambers, D.Phil. National Cancer Institute NCI) Telephone: 240-276-5090 Email:  dchamber@mail.nih.gov