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Notice Correct Submission Instructions the Number Scientific Cores Allowed PAR-15-146 Countermeasures Against Chemical Threats CounterACT) Research Centers Excellence U54)" Notice Number: NOT-NS-16-002 Key Dates Release Date:   January 8, 2016 Related Announcements PAR-15-146     Issued National Institute Neurological Disorders Stroke NINDS)  Purpose purpose this notice to correct information the number Scientific Cores allowed PAR-15-146 quot;Countermeasures Against Chemical Threats CounterACT) Research Centers Excellence U54)". Section IV. 2. Content Form Application Submission Currently FOA reads: application should consist the following components: Overall: required Administrative Core: required Scientific Core: optional; Maximum 2 Research Education Core: required Project: Minimum 3 required; Maximum 5 nbsp; FOA modified read: application should consist the following components: Overall: required Administrative Core: required Scientific Core: optional; Maximum 3 Research Education Core: required Project: Minimum 3 required; Maximum 5 nbsp; other aspects the FOA remain unchanged Inquiries Please direct inquiries to: David A. Jett, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-6035 Email: jettd@ninds.nih.gov

Notice Updates the National Robotics Initiative NRI) Notice Number: NOT-EB-15-008 Key Dates Release Date: December 22, 2015 Related Announcements NOT-EB-14-008     Issued National Eye Institute NEI) National Institute Aging NIA) National Institute Biomedical Imaging Bioengineering NIBIB) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Neurological Disorders Stroke NINDS) National Institute Nursing Research NINR) Office Behavioral Social Sciences Research OBSSR) National Science Foundation NSF ) National Aeronautics Space Administration NASA) U.S. Department Agriculture USDA) Defense Advanced Research Projects Agency DARPA) Air Force Office Scientific Research AFOSR) U.S. Department Energy DOE) Purpose Notice updates supersedes previous Guide Notice, NOT-EB-14-008, published the NIH Guide, October 23, 2014. NIH collaborating a multi-agency funding opportunity, National Robotics Initiative NRI), whose goal to accelerate development use robots the United States work beside, cooperatively with, people http://www.nsf.gov/pubs/2016/nsf16517/nsf16517.htm), carry work people dangerous environments.  Innovative robotics research applications emphasizing realization such co-robots working symbiotic relationships human partners supported multiple agencies the federal government including National Science Foundation NSF), National Aeronautics Space Administration NASA), National Institutes Health NIH), U.S. Department Agriculture USDA), U.S. Department Defense DOD) the U.S. Department Energy DOE). purpose this program the development this next generation robotics, advance capability usability such systems artifacts, to encourage existing new communities focus innovative application areas. will address entire life cycle fundamental research development manufacturing deployment. Collaboration between academic, industry, non-profit other organizations strongly encouraged establish better linkages between fundamental science technology development, deployment use. NIH encourages robotics research technology development enhance health, lengthen life reduce illness disability. NIH also supports non-hypothesis driven applications, includes technology-driven problem-driven applications. Specifically, participating NIH Institutes Centers ICs) this solicitation interested targeting solicitation support development assistive robotic technology achieve functional independence humans; improve quality life; assist behavioral therapy personalized care; promote wellness/health. most significant challenges be addressing safety issues, especially applications be used home-based long-term care settings where integration complex systems be required. Additionally, assistive robots need quickly adapt changes the user the environment. Human assistive devices should designed assist healthcare providers as well the individuals needing care. Development robotic applications important NIH because their potential significant impact healthcare the future. Human assistive devices revolutionize healthcare the next 20 years much personal electronics changed our daily lives the past decades. Affordable accessible robotic technology facilitate wellness personalized healthcare. Continual health assessment personalized intervention the potential offset shrinking size the healthcare workforce the growing elderly disabled population. the future, assistive robotics enable people engage all aspects human life endurance dignity. Examples assistive robotic technology development include are limited to: - Homecare long-term personalized care robots - Robotic wellness/health promotion maintenance - Robotic behavioral therapy - Robotic aids mobility, manipulation, human communication cognition, vision non-sighted persons - Assistive robotics eliminate health disparities across populations developing appropriate assistive co-robotic technologies, applicants should consider following basic characteristics: effectiveness, affordability, cultural acceptability, accessibility those need them. Applicants should describe these technologies address healthcare needs the end user healthy individuals, persons disability, or health disparity populations). proposer should compellingly describe healthcare problem being addressed the technology solution being proposed.  is strongly encouraged a healthcare expert included the research team a consultant collaborator, appropriate). robotic applications promoted this solicitation for non-operative settings.  NIH still interested supporting robotics surgical health interventions, robotic exoskeletons, prosthetics, however, in response solicitation. Applicants interested these areas should send inquiries the NIH contacts listed below.  Award Information NIH awards under solicitation be R01 grants.  Award sizes NIH funded research projects expected range approximately 100,000 250,000 per year direct costs, durations one three years. No award exceed 250,000 per year direct costs. Applicants wish submit application NIH more 250,000 direct costs any year should contact Program staff an NIH Institute/Center directly alternate proposal mechanisms.  Estimated program budget, number awards average award size duration subject the availability funds.  Determination awards based three criteria: 1) availability funds, 2) program priorities, 3) scientific merit. Subsequent grant administration procedures be accordance the policies the awarding Institute. Application Preparation Submission Instructions Applications submitted response this solicitation should prepared submitted accordance the general guidelines contained the NSF Grant Proposal Guide GPG).  Applications must submitted the NSF, to NIH.  the full solicitation, are additional instructions listed applicants interested NIH consideration funding e.g. Human/Animal Subjects Protections, Review Criteria, etc.). Applicants reminded identify NSF program announcement number the program announcement block the NSF Cover Sheet Proposal the National Science Foundation.  Compliance this announcement critical determining relevant application processing guidelines. Failure submit information delay processing. Budgetary Information Cost sharing not required applications submitted this funding opportunity. Budgets should include travel funds the PD/PI team members attend annual NRI Principal Investigators' meeting.  NIH Process mission the NIH to support science pursuit knowledge the biology behavior living systems to apply knowledge enhance health, lengthen life reduce illness disability. While of NIH NSF review criteria based the same standards scientific evaluation, scoring mechanisms programmatic emphases vary. example: proposals under consideration NIH be scored their respective review panels using NIH 1-9 scoring system, does include consideration broader impacts. Applicants should pay particular attention NIH evaluation standards represented criteria human protections, inclusion women, minorities, children the study population, animal subjects’ protections, well biohazards. general, NIH funding priorities be directed toward applications best address criteria are used NIH. goal this activity to involve multiple agencies using application one review. meet NIH requirements, those applications are identified potential funding participating NIH ICs, applicant organization be required submit R01 application an NIH-approved format.  PDs/PIs invited submit NIH receive further information submission procedures the NIH. NIH application not allowed increase alter proposed budget change scientific content the application the converted submission the NIH. The summary statement be presented the involved IC's National Advisory Council the second level review. Subsequent the Council review, NIH ICs make funding determinations selected awards. Grant administration procedures NIH awardees, including those related New Early Stage Investigators be accordance the policies NIH. Please note applications be submitted review the NSF March 7, 2016. PDs/PIs applications selected potential funding the participating NIH ICs be notified the end June 2016.  converted submission NIH be due July 15, 2016.  PD/PI should work closely their Sponsored Programs Office assure timely submission during submission window. earliest project start date be September30, 2016. Inquiries Written telephone inquiries encouraged.  NIH Program contacts listed below. Please the NSF NRI website names contact information each the participating NSF Directorates, USDA, NASA, DARPA, AFOSR, DOE.  Grace C.Y. Peng, Ph.D., National Institute Biomedical Imaging Bioengineering NIBIB) Telephone: 301-451-4778;  Email: pengg@mail.nih.gov Tom Greenwell, Ph.D. National Eye Institute NEI) Telephone: 301-451-2020 Email:  greenwellt@nei.nih.gov Lyndon Joseph, Ph.D National Institute Aging NIA) Telephone: 301-496-6926 Email: Josephlj@nia.nih.gov Louis Quatrano, Ph. D. Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) Telephone:  301-402-4221 Email: Quatranl@mail.nih.gov Roger L. Miller, Ph.D. National Institute Deafness Other Communication Disorders NIDCD) Telephone: 301-402-3458 Email:  millerr@nidcd.nih.gov Daofen Chen, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-9964 Email: daofen.chen@nih.gov Augie Diana, Ph.D. National Institute Nursing Research NINR) Telephone: 301-402-6423 Email: dianaa@mail.nih.gov

Notice Extend PAR-13-055 Dissemination Implementation Research Health R01)" Notice Number: NOT-CA-16-006 Key Dates Release Date: December 14, 2015 Related Announcements PAR-13-055     Issued National Cancer Institute NCI) National Center Complementary Integrative Health NCCIH formerly NCCAM) National Heart, Lung, Blood Institute NHLBI) National Human Genome Research Institute NHGRI) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Allergy Infectious Diseases NIAID) Clarification per NOT-AI-13-034) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Dental Craniofacial Research NIDCR) National Institute Diabetes Digestive Kidney Diseases NIDDK) National Institute Drug Abuse NIDA) National Institute Neurological Disorders Stroke NINDS) National Institute Mental Health NIMH) National Institute Minority Health Health Disparities NIMHD) National Institute Nursing Research NINR) Office Behavioral Social Sciences Research OBSSR) Purpose purpose this Notice to extend PAR-13-055 quot;Dissemination Implementation Research Health R01)", encourages investigators submit research grant applications will identify, develop, evaluate refine effective efficient methods, systems, infrastructures, strategies disseminate implement research-tested health behavior change interventions, evidence-based prevention, early detection, diagnostic, treatment management, quality life improvement services, data monitoring surveillance reporting tools public health clinical practice settings focus patient outcomes. current expiration date January 8, 2016. new expiration date May 10, 2016. other aspects this FOA remain same. Inquiries Please direct inquiries to: David A. Chambers, D.Phil. National Cancer Institute NCI) Telephone: 240-276-5090 Email: dchamber@mail.nih.gov

Notice Extend PAR-13-054 Dissemination Implementation Research Health R21)" Notice Number: NOT-CA-16-007 Key Dates Release Date:   December 14, 2015 Related Announcements PAR-13-054     Issued National Institute Mental Health NIMH) National Cancer Institute NCI) National Human Genome Research Institute NHGRI) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Allergy Infectious Diseases NIAID) Clarification per NOT-AI-13-035) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Dental Craniofacial Research NIDCR) National Institute Drug Abuse NIDA) National Institute Neurological Disorders Stroke NINDS) National Institute Nursing Research NINR) National Center Complementary Integrative Health NCCIH formerly NCCAM) Office Behavioral Social Sciences Research OBSSR) Fogarty International Center FIC) Purpose purpose this Notice to extend PAR-13-054 quot;Dissemination Implementation Research Health R21)", encourages investigators submit research grant applications will identify, develop, evaluate refine effective efficient methods, systems, infrastructures, strategies disseminate implement research-tested health behavior change interventions, evidence-based prevention, early detection, diagnostic, treatment management, quality life improvement services, data monitoring surveillance reporting tools public health clinical practice settings focus patient outcomes. current expiration date January 8, 2016. new expiration date May 10, 2016. other aspects this FOA remain same. Inquiries Please direct inquiries to: David A. Chambers, D.Phil. National Cancer Institute NCI) Telephone: 240-276-5090 Email: dchamber@mail.nih.gov

Notice Correct Application Review Date, the Phased Activity Description RFA-NS-16-013 Innovation Grants Nurture Initial Translational Efforts IGNITE): Development Validation Model Systems and/or Pharmacodynamic Markers Facilitate Discovery Neurotherapeutics R21/R33)" Notice Number: NOT-NS-16-001 Key Dates Release Date:   December 2, 2015 Related Announcements RFA-NS-16-013       Issued National Institute Neurological Disorders Stroke NINDS)  Purpose purpose this Notice to correct review date the activity description section NINDS RFA-NS-16-013 Innovation Grants Nurture Initial Translational Efforts IGNITE): Development Validation Model Systems and/or Pharmacodynamic Markers Facilitate Discovery Neurotherapeutics R21/R33)". Part 1. Overview Information Key Dates FOA currently reads: Scientific Merit Review June 2016; October 2106; February 2017; June 2017; October 2107; February 2018    FOA now changed read: Scientific Merit Review June 2016; October 2016; February 2017; June 2017; October 2017; February 2018    Part 2. Full Text Announcement Section I. Funding Opportunity Description FOA currently reads: Activities the R21 Phase Initial development the model, testing paradigm, ex vivo system PD measure Any optimization the above related feasibility, endpoint range sensitivity, potential scale for validation studies breeding, aging, etc.), specificity the model system/PD measure it relates the disease endpoint measures, identification confounding variables, etc. Activities the R33 Phase Complete internal validation endpoints used the model system PD measure Scale-up external validation studies external validation studies, including comparisons phenotype human disease, comparisons disease etiology preclinical species what known the human disease efficacy clinically tested therapeutic agents available) the new model system FOA now changed read:             Activities the R21 Phase: Initial development the model, testing paradigm, ex vivo system PD measure Any optimization the above related feasibility, endpoint range sensitivity, potential scale for validation studies breeding, aging, etc.), specificity the model system/PD measure it relates the disease endpoint measures, identification confounding variables, etc. Activities the R33 Phase: Complete internal validation endpoints used the model system PD measure Scale-up external validation studies external validation studies, including comparisons phenotype human disease, comparisons disease etiology preclinical species what known the human disease efficacy clinically tested therapeutic agents available) the new model system other aspects the FOA remain unchanged. Inquiries Please direct inquiries to: Mary Ann Pelleymounter, PhD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-1779 Email: mary.pelleymounter@mail.nih.gov

Notice Correction Review Locus PAR-15-278 NINDS Exploratory Clinical Trials Small Business R42)" Notice Number: NOT-NS-15-049 Key Dates Release Date:   November 19, 2015 Related Announcements PAR-15-278     Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this notice to correct information regarding locus review applications submitted PAR-15-278 quot;NINDS Exploratory Clinical Trials Small Business R42)". Part 2. Section V. 2. Review Selection Process FOA currently reads: Applications be evaluated scientific technical merit an) appropriate Scientific Review Group(s) convened Center Scientific Review, accordance NIH peer review policy procedures, using stated review criteria. Assignment a Scientific Review Group be shown the eRA Commons. FOA modified read: Applications be evaluated scientific technical merit an appropriate Scientific Review Group(s) convened NINDS, accordance NIH peer review policy procedures, using stated review criteria. Assignment a Scientific Review Group be shown the eRA Commons. Part 2. Section VII. Agency Contacts FOA currently reads: Peer Review Contact(s) Joseph Rudolph, PhD Center Scientific Review CSR) Telephone: 301-408-9098 Email: josephru@mail.nih.gov FOA modified read: Peer Review Contact(s) Chief, Scientific Review Branch National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-9223 Email: nindsreview.nih.gov@mail.nih.gov other aspects the FOA remain unchanged Inquiries Please direct inquiries to: Stephanie Fertig, MBA National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-1779 Email: fertigs@ninds.nih.gov

Notice Correction Review Locus PAR-15-277 NINDS Exploratory Clinical Trials Small Business R44)" Notice Number: NOT-NS-15-050 Key Dates Release Date:   November 19, 2015 Related Announcements PAR-15-277 Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this Notice to correct information regarding locus review applications submitted PAR-15-277 quot;NINDS Exploratory Clinical Trials Small Business R44)". Part 2. Section V. 2. Review Selection Process FOA currently reads: Applications be evaluated scientific technical merit an) appropriate Scientific Review Group(s) convened Center Scientific Review, accordance NIH peer review policy procedures, using stated review criteria. Assignment a Scientific Review Group be shown the eRA Commons. FOA modified read: Applications be evaluated scientific technical merit an appropriate Scientific Review Group(s) convened NINDS, accordance NIH peer review policy procedures, using stated review criteria. Assignment a Scientific Review Group be shown the eRA Commons. Part 2. Section VII. Agency Contacts FOA currently reads: Peer Review Contact(s) Joseph Rudolph, PhD Center Scientific Review CSR) Telephone: 301-408-9098 Email: josephru@mail.nih.gov . FOA modified read: Peer Review Contact(s) Chief, Scientific Review Branch National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-9223 Email: nindsreview.nih.gov@mail.nih.gov other aspects the FOA remain unchanged. Inquiries Please direct inquiries to: Stephanie Fertig, MBA National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-1779 Email: fertigs@ninds.nih.gov

Notice NINDS Encourages Clinicians Excellent Pre-residency Research Publication Records Apply Mentored Career Development K08/K23) Awards without Waiting Post-Residency Publications Notice Number: NOT-NS-15-048 Key Dates Release Date:   November 17, 2015 Related Announcements None     Issued National Institute Neurological Disorders Stroke NINDS)  Purpose Background. development outstanding clinician-scientists critical the mission NIH and, specifically related neurological disorders, NINDS. pathway this development for individuals 1) obtain both clinical research training an integrated MD/PhD program, 2) join residency program intensive clinical training, 3) obtain fellowship training, least part which directed re-engaging scientific research will position to obtain NIH career development K) award, then 4) obtain 5 year mentored K award will protect time research help launch independent research career. average, integrated MD/PhD program takes 8 years complete, residencies such neurology take 4 years complete, the standard NINDS mentored K award lasts 5 years. average time the end residency an NINDS K award a dual degree applicant 45 months. Thus, average training duration time the start medical school research independence) an individual an MD/PhD degree 21 years. NINDS made a high priority decrease time takes develop outstanding, independent, clinician-scientists.  help accomplish this, NINDS implementing programs reduce time residency K award. Change guidance NINDS K application reviewers. Prior residency, clinically-trained individuals, most PhD training also without, conducted or outstanding research projects published results highly regarded journals. Following residency, includes little time research, individuals must re-establish research programs, often a completely different research area. part the K application review process, reviewers have, the past, evaluated candidates part whether have published during after residency their proposed research topic an indicator they re-established research program). Consequently, time training a clinician-scientist extended  only the time takes obtain high quality preliminary data this new research project also delays associated completion the study publication the results a top journal. Effective immediately, NINDS provide guidance the NST-1 study section, reviews K08 K23 applications NINDS, is intended minimize impact delays associated final completion publication manuscripts related the proposed research project. premise this review guidance that publication important, high quality research prior residency be taken evidence the candidate's ability conduct, see completion, high quality research project. Consequently, NINDS suggest reviewers consider lack publication during and/or subsequent residency be limited concern under following set conditions, applicants are within approximately 18 months their residency training: 1. Applicants have, their prior record, demonstrated they conduct complete outstanding, significant, research project. record must include peer-reviewed research publications highly regarded journals, which applicants lead authors. 2. Applicants submitted well-organized, well-written application a significant topic i.e. science highly significant, application includes compelling, high quality preliminary data, approach excellent, etc.). 3. Applicants presented excellent career development plan. 4. Applicants outstanding mentors mentorship plans; strong mentorship becomes even important funding applicants earlier their research careers. 5. Applicants made convincing presentation the proposed project the potential provide significant information during K award period will form basis future, independently funded research. 6. Applicants provided reviewers confidence via aspects the application, than having residency post-residency publications, they be successful their K application research subsequent transition an independent research career. Inquiries Please direct inquiries to: Stephen Korn, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-4188 Email: korns@ninds.nih.gov

Notice National Institute Neurological Disorders Stroke NINDS) Participation PAR-15-349 Health Disparities Alzheimer's Disease R01)" Notice Number: NOT-NS-15-047 Key Dates Release Date:   November 10, 2015 Related Announcements PAR-15-349  Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this Notice to inform potential applicants the National Institute Neurological Disorders Stroke NINDS) participating, effective immediately, PAR-15-349 quot;Health Disparities Alzheimer's Disease R01)". following sections PAR-15-349 been updated reflect participation NINDS this Funding Opportunity Announcement FOA). Part 1. Overview Information Components Participating Organizations National Institute Aging NIA) National Institute Neurological Disorders Stroke NINDS) National Institute Nursing Research NINR) Catalog Federal Domestic Assistance CFDA) Numbers 93.866, 93.361, 93.853 Part 2. Full Text AnnouncementSection I. Funding Opportunity Description Objectives following text added the end this section. While applications submitted response this FOA address broader interests other institutes listed the FOA, NINDS interested the analyses pathways create sustain Alzheimer's Disease-Related Dementias ADRD) disparities well ADRD applications address health disparities recommendations the 2013 ADRD Conference.  recommendations be found the ADRD 2013 Report http://www.ninds.nih.gov/funding/areas/neurodegeneration/workshops/adrd… NINDS' interests under FOA limited applications where clear main focus on ADRDs: vascular dementia, vascular contributions cognitive impairment dementia, Fronto-Temporal Dementia FTD), Lewy Body Dementia LBD). NINDS not consider applications are primarily Alzheimer's disease, example. Health Disparities HD) defined Public Law 106-525 occurs there a significant disparity the overall rate disease incidence, prevalence, morbidity, mortality, survival rates the health disparities population compared the health status the general population. NIH determined the following populations constitute health disparity populations: a) racial/ethnic minority, 2) low socio-economic status, 3) rural populations. recommendations the ADRD 2013 Report are directly relevant this FOA, that of interest the NINDS terms applications response this FOA, include those address HD Recruitment well HD Treatment Prevention: Health Disparities Recruitment: Initiate leverage ongoing longitudinal community-based cohort studies incident dementia diverse populations incorporating imaging, fluid biomarkers, autopsy. mixed methodology studies improve assessment tools disparities populations. community outreach methods facilitate recruiting disparities populations FTD LBD clinical studies. Health Disparities Treatment Prevention: Enhance design all trials vascular health interventions improve application diverse populations. Assess life course risk factors cognitive decline ADRDs among disparities populations. Estimate disparities health burden ADRDs risk factors among disparities populations. Section VII. Agency Contacts Scientific/ Research Contact Salina P. Waddy, MD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-9135 Email: waddysp@mail.nih.gov Financial/Grants Management Contact Tijuanna DeCoster, PhD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-9231 Email: decostert@ninds.nih.gov other aspects this FOA remain same. Inquiries Please direct inquiries to: Salina P. Waddy, MD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-9135 Email: waddysp@mail.nih.gov

Notice Change the Application Due Date to Allow Foreign Components Applications RFA-NS-16-008 BRAIN Initiative: Research Opportunities Using Invasive Neural Recording Stimulating Technologies the Human Brain U01)" Notice Number: NOT-NS-15-044 Key Dates Release Date:   November 5, 2015 Related Announcements RFA-NS-16-008       Issued National Institute Neurological Disorders Stroke NINDS) National Eye Institute NEI) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Biomedical Imaging Bioengineering NIBIB) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Drug Abuse NIDA) National Institute Mental Health NIMH) National Center Complementary Integrative Health NCCIH)  Purpose Notice to change application due date, to correct information eligible organizations RFA-NS-16-008 BRAIN Initiative:  Research Opportunities Using Invasive Neural Recording Stimulating Technologies the Human Brain U01).”  new due date be January 13, 2016.  Also changed Funding Opportunity Announcement FOA) allow applications include foreign components, such sub-contracts foreign organizations and/or activities performed foreign organizations.  Currently FOA reads: Key Dates Open Date Earliest Submission Date) November 15, 2015 Letter Intent Due Date(s) November 15, 2015 Application Due Date(s) December 15, 2015, 5:00 PM local time applicant organization. types non-AIDS applications allowed this funding opportunity announcement due this date. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. late applications be accepted this Funding Opportunity Announcement. AIDS Application Due Date(s) Not  Applicable Scientific Merit Review February 2016 Advisory Council Review 2016 Earliest Start Date June 2016 Expiration Date December 16, 2015  Foreign Institutions Non-domestic non-U.S.) Entities Foreign Institutions) not eligible apply. Non-domestic non-U.S.) components U.S. Organizations not eligible apply. Foreign components, defined the NIH Grants Policy Statement, not allowed. FOA now changed read: Key Dates Open Date Earliest Submission Date) December 13, 2015 Letter Intent Due Date(s) December 13, 2015 Application Due Date(s) January 13, 2016, 5:00 PM local time applicant organization. types non-AIDS applications allowed this funding opportunity announcement due this date. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. late applications be accepted this Funding Opportunity Announcement. AIDS Application Due Date(s) Not  Applicable Scientific Merit Review April 2016 Advisory Council Review August 2016 Earliest Start Date September 2016 Expiration Date January 14, 2016  Foreign Institutions Non-domestic non-U.S.) Entities Foreign Institutions) not eligible apply. Non-domestic non-U.S.) components U.S. Organizations not eligible apply. Foreign components, defined the NIH Grants Policy Statement,are allowed. other aspects this FOA remain unchanged. Inquiries Please direct inquiries to: James Gnadt, PhD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-9964 Email: BRAIN_ResOppHu@mail.nih.gov