Find Funding Opportunities

Request Information RFI): Well Characterized Brain Bank Resources Alzheimer's Disease-Related Dementias ADRD) PET Ligand development Cryo-EM Structural Analysis Protein Species. Notice Number: NOT-NS-18-018 Key Dates Release Date: November 30, 2017 Related Announcements None Issued National Institute Neurological Disorders Stroke NINDS) Purpose National Institute Neurological Disorders Stroke NINDS) seeks brain tissue resource information new ADRD initiatives will focus the development PET ligands Alzheimer’s Disease Related Dementias ADRDs) Cryo-Electron Microscopy Cryo-EM) structural analysis protein species related ADRD pathogenesis. Resources identified through RFI be posted the NINDS Resource webpage investigators applying the new ADRD initiatives be encouraged integrate resources through collaborations their research plan. Background   2016, NINDS organized conference Alzheimer's Disease Related Dementias ADRDs) focused on  frontotemporal degeneration FTD), Lewy body dementias LBD) including dementia Lewy bodies DLB) Parkinson disease dementia PDD), vascular contributions cognitive impairment dementia VCID), mixed diseases including associated diagnostic challenges multiple etiology dementias MED), issues related health disparities. conference complemented National Institute Aging’s ldquo;Alzheimer’s Disease Research Summit 2015: Path Treatment Prevention.” Both conferences responded the National Alzheimer’s Project Act was signed law January 2011. objective the ADRD conference to contribute the efforts directed preventing effectively treating Alzheimer’s disease, including Alzheimer’s disease-related dementias, 2025.  Alzheimer’s Disease-Related Dementias steering committee solicited input internationally recognized experts develop prioritized recommendations guide scientific research the next 5 10 years.  Cross-cutting recommendations the ADRD working groups focused basic science biomarker developments can further our understanding protein species associated ADRD pathogenesis, well to advance tool development.  Biomarker development crucial patient stratification disease progression.  Although recent advances Tau PET ligand development look promising Alzheimer’s disease, specificity selectivity PET ligands non-AD tauopathies not yet achieved PET ligands alpha-synuclein TDP43 still elusive. accelerate development characterization PET ligands structural analyses ADRD protein species related disease pathogenesis, NINDS requests information human postmortem biopsy) brain tissue would available sharing the research community.  Tissue be shared ideally linked de-identified clinical data e.g., neurological, neuropsychological neuroimaging data) the development these tools resources.  Typically, several grams tissue depending the pathogenic protein load brain region needed these studies. Information Requested NINDS invites researchers, clinicians programs collections well characterized brain tissue interested the development collaborations FY18 ADRD Funding Opportunity Announcements FOAs) submit information brain tissue associated de-identified clinical data availability. Key information regarding brain tissue collections associated de-identified clinical data available PET ligand development protein structural analysis include: Average post-mortem interval 10-76 hours desirable), available measures tissue quality e.g., tissue pH RIN) Availability frozen tissue number brains), average amount tissue available sharing respect brain region(s) provided; Method freezing e.g., flash frozen) Indication availability corresponding fixed tissue including nature duration fixation methods storing fixed tissue e.g., cryo-preservation); Antemortem clinical diagnosis, age diagnosis, age death, sex, ethnicity: Number brains genetic characterization – family history related neurologic diseases, known causative risk gene mutations, common genetic risk factors e.g., APOE, MAPT, GBA, GRN, C9ORF72, SCNA, etc.), availability whole exome genome data; and/or data genome-wide significant risk factors; Pathological characterization primary associated disease processes using consensus neuropathological criteria ADRD. Diagnostic criteria used Examples past sharing the resource Requirements resource sharing e.g. MOU, MTA any key restrictions Name individual email contact the brain tissue resource. to Submit Response Response this RFI must submitted ADRDTissueResources@ninds.nih.gov January 15th, 2017]. Responses should provided a narrative links pertinent supplemental information needed. attachments be accepted. proprietary, classified, confidential, sensitive information should included your response Responses this RFI voluntary. RFI seeks input planning purposes only should be construed a solicitation applications an obligation the part the Federal Government, National Institutes Health, individual NIH Institutes Centers. information collected not considered confidential. Processed results be shared internally with members health-related scientific work groups, will posted the NINDS Resource webpage, appropriate. NIH acknowledges receipt information submitted, will comment the content.   Inquiries Please direct inquiries to: Margaret Sutherland, PhD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-5680 Email:sutherlandm@ninds.nih.gov

Countermeasures Against Chemical Threats CounterACT): Opportunities Opioid Research Notice Number: NOT-NS-18-019 Key Dates Release Date: November 27, 2017 Related Announcements PAR-15-315 PAR-16-330 PAR-16-331 Issued National Institute Neurological Disorders Stroke NINDS) National Institute Drug Abuse NIDA) Purpose purpose this notice to highlight NIH/NINDS Countermeasures Against Chemical Threats CounterACT) program's interest developing safe effective therapeutics would prevent morbidity mortality following exposure the opioids fentanyl, carfentanil, acetylfentanyl, alfentanil, and/or diacetylmorphine heroin). program concentrates developing therapeutics treat and/or prevent injuries deaths may result exposure chemical threats a variety scenarios. Applications being accepted under three specific Funding Opportuntiy Announcements FOAs) issued the NIH CounterACT program PAR-15-315, PAR-16-330, PAR-16-331). be considered appropriate these FOAs, applications must follow instructions general descriptions found these FOAs well the following requirements related the specialized mission the NIH CounterACT program. Research supported these FOAs must relevant chemical emergencies where general civilian population might exposed opioids. research might include industrial accidents, natural disasters causing casualties, deliberate attacks again civilians. examples research could supported include, are limited to, following: Safety efficacy studies naloxone other FDA-approved drugs use against opioids listed above, especially they relate potential respiratory problems Safety efficacy studies naloxone other FDA-approved drugs use against opioids listed above these opioids administered a method consistent a deliberate attack against civilians, by industrial accidents natural disasters causing mass casualties e.g. aerosolized, food water, etc.) opioid overdose antidotes greater safety efficacy naloxone other FDA- approved drugs match higher potency fentanyl analogues, including naloxone-related antidotes those based new therapeutic targets Antidotes longer half-lives that multiple doses not needed rapid succession, many people be treated once during mass casualty event; includes increases serum half-life well alteration degradative metabolism Single antidotes acceptable activity against least or of opioids listed above NIH CounterACT program support exploratory developmental research PAR-15-315) well the identification PAR-16-330) optimization PAR-16-331) therapeutic lead compounds. Potential applicants should the descriptions scientific scope found these FOAs. Applicants strongly urged contact NIH representatives listed below prior submission. Inquiries Please direct general NIH CounterACT inquiries to: David A. Jett, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-6035 Email: david.jett@nih.gov Please direct specific opioid research inquiries: Kristopher J. Bough, Ph.D. National Institute Drug Abuse NIDA) Telephone: 301-443-9800 Email: boughk@nih.gov nbsp;

Notice Informational Webinar Using Parent T32 Funding Opportunity Announcement PA-18-403) Create NINDS-Targeted Institutional Translational Training Programs Notice Number: NOT-NS-18-021 Key Dates Release Date: November 27, 2017 Related Announcements None Issued National Institute Neurological Disorders Stroke NINDS) Purpose Notice to inform potential applicants an upcoming informational webinar using parent T32 PA-18-403) its reissues support NINDS-targeted institutional training programs translational research.  NINDS welcomes applications the parent T32 institutional training programs basic, clinical translational research falls within NINDS mission. NINDS currently receives few applications translational training programs. Consequently, NINDS hosting webinar discuss approaches potential applicants might to develop training programs designed equip trainees expertise basic clinical research well an understanding the translational processes used advance basic clinical research potential therapies. webinar cover creation training environments involve basic clinical researchers working concert address research problems an eye toward development viable health-relevant therapies, technologies, devices.  webinar recommended established investigators expertise insights translational research are interested learning the NINDS philosophy creating T32 institutional training programs. webinar optional not required submission applications. WEBINAR INFORMATION Informational Webinar Using Parent T32 Funding Opportunity Announcement PA-18-403) Create NINDS-Targeted Institutional Translational Training Programs January 18, 2018 11 a.m.- noon Eastern Time Please visit following link register the webinar: Link webinar registration button available the bottom the page. Inquiries Please direct inquiries to: Stephen J. Korn, Ph.D. National Institute Neurological Disorders Stroke Email: korns@ninds.nih.gov

Notice Change Application Due dates PAR-17-001 Emerging Global Leader Award K43)" Notice Number: NOT-TW-18-001 Key Dates Release Date: November 8, 2017 Related Announcements PAR-17-001 Issued Fogarty International Center FIC) National Cancer Institute NCI) National Human Genome Research Institute NHGRI) National Institute Dental Craniofacial Research NIDCR) National Institute Environmental Health Sciences NIEHS) National Institute Mental Health NIMH) National Institute Neurological Disorders Stroke NINDS) Office Research Women’s Health ORWH) Purpose purpose this Notice to inform scientific community changes the Application Due Dates for PAR-17-001 "Emerging Global Leader Award K43)". Due a technical error the NIH guide, potential applicants have seen incorrect version the FOA application due dates were longer valid. fairness those may seen incorrect dates are modifying quot;Key Dates" section below. Applicants have already submitted grant application the option withdraw resubmit the new deadline. Part 1. Overview Information Key Dates Current Key Dates Letter Intent Due Date: 30 days before application due date Application Due Date(s): December 14, 2016; November 7, 2017; November 7, 2018 AIDS Application Due Date(s): December 14, 2016; November 7, 2017; November 7, 2018 Scientific Merit Review: March 2017, March 2018, March 2019 Advisory Council Review: 2017, 2018, 2019 Earliest Start Date: July 2017, July 2018, July 2019 Expiration Date: November 8, 2018 Modified Key Dates Letter Intent Due Date: 30 days before application due date Application Due Date(s): December 14, 2016; December 14, 2017; and November 7, 2018 AIDS Application Due Date(s): December 14, 2016; December 14, 2017; November 7, 2018 Scientific Merit Review: March 2017, March 2018, March 2019 Advisory Council Review: May 2017, 2018, 2019 Earliest Start Date: July 2017, July 2018, July 2019 Expiration Date: November 8, 2018 Inquiries Please direct inquiries to: Christine Jessup, Ph.D Fogarty International Center FIC) Telephone: 301-496-1653  Email: Christine.Jessup@nih.gov nbsp;

Notice Change Eligibility PAR-17-001 Emerging Global Leader Award K43)" Notice Number: NOT-TW-18-002 Key Dates Release Date: November 8, 2017 Related Announcements PAR-17-001 Issued Fogarty International Center FIC) National Cancer Institute NCI) National Human Genome Research Institute NHGRI) National Institute Dental Craniofacial Research NIDCR) National Institute Environmental Health Sciences NIEHS) National Institute Mental Health NIMH) National Institute Neurological Disorders Stroke NINDS) Office Research Women’s Health ORWH) Purpose purpose this Notice to inform applicants a change the Eligibility Information PAR-17-001 quot;Emerging Global Leader Award K43)". Notice removes specific eligibility language regarding applicants Medical Education Partnership Initiative MEPI) Institutions. Part 2. Section III. Eligibility Information 1. Eligible Applicants Currently reads: Eligible Individuals Program Director/Principal Investigator) Any candidate the skills, knowledge, resources necessary carry the proposed research the Program Director/Principal Investigator PD/PI) invited work his/her primary mentors U.S.-based one LMIC-based) organization develop application support. Individuals underrepresented racial ethnic groups well individuals disabilities always encouraged apply NIH support. Multiple PDs/PIs not allowed. applicant must an LMIC citizen and, the time award, not a citizen a non-citizen national the United States have lawfully admitted permanent residence i.e., possess currently valid Permanent Resident Card USCIS Form I-551, other legal verification such status). Degree Research Experience Requirements: candidate should the PD/PI the proposed activities.  Candidates must hold least masters degree required research thesis. Candidates doctoral research training preferred. award cannot support advanced degree training. Individuals are have the PD/PI direct recipient/grantee) a multi-year independent research grant an external research funding organization awarded the application due date not eligible. Faculty Position Requirement:  Applicants must currently hold academic junior faculty position research scientist appointment supported the applicant LMIC academic research institution have in position at least year the time application submitted.   this FOA, junior faculty defined those hold entry mid-level academic research scientist positions, including not limited instructors, lecturers assistant professors Applicants Medical Education Partnership Initiative MEPI): Junior faculty institutions awarded under RFA-TW-14-003 "Research Training Career Development Junior Faculty Medical Education Partnership Initiative MEPI) Institutions D43)" may submit applications focused HIV/AIDS the scientific research areas supported this FOA. nbsp; Modified remove italicized language above. modified quot;Eligible Individuals" section reads: Eligible Individuals Program Director/Principal Investigator) Any candidate the skills, knowledge, resources necessary carry the proposed research the Program Director/Principal Investigator PD/PI) invited work his/her primary mentors U.S.-based one LMIC-based) organization develop application support. Individuals underrepresented racial ethnic groups well individuals disabilities always encouraged apply NIH support. Multiple PDs/PIs not allowed. applicant must an LMIC citizen and, the time award, not a citizen a non-citizen national the United States have lawfully admitted permanent residence i.e., possess currently valid Permanent Resident Card USCIS Form I-551, other legal verification such status). Degree Research Experience Requirements: candidate should the PD/PI the proposed activities.  Candidates must hold least masters degree required research thesis. Candidates doctoral research training preferred. award cannot support advanced degree training. Individuals are have the PD/PI direct recipient/grantee) a multi-year independent research grant an external research funding organization awarded the application due date not eligible. Faculty Position Requirement:  Applicants must currently hold academic junior faculty position research scientist appointment supported the applicant LMIC academic research institution have in position at least year the time application submitted.   this FOA, junior faculty defined those hold entry mid-level academic research scientist positions, including not limited instructors, lecturers assistant professors. other aspects this FOA remain unchanged. Inquiries Please direct inquiries to: Christine Jessup, Ph.D Fogarty International Center FIC) Telephone: 301-496-1653  Email: Christine.Jessup@nih.gov nbsp;

Request Information Developing Experimental Design Emoji" Symbols Use Scientific Presentations Notice Number: NOT-NS-18-014 Key Dates Release Date: November 7, 2017 Response Deadline: December 15, 2017   Related Announcements None Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this Request Information RFI) to solicit feedback the scientific community the potential utility creating freely available, simple symbols ("emojis" icons) represent various aspects experimental rigor design use oral poster presentations. Responding this RFI completely voluntary. Responses address any all aspects the information requested, is outlined below, other relevant topics pertinent consideration the National Institute Neurological Disorders Stroke NINDS). Background Transparently reporting experiments designed, conducted, analyzed vital the interpretation replication scientific results. this reason, NIH https://grants.nih.gov/grants/guide/notice-files/NOT-OD-16-011.html) several journals http://science.sciencemag.org/content/346/6210/679.full?sid=0377bc54-cd…) emphasize rigor transparency grant applications publications, respectively. Earlier year NINDS met conference organizers discuss potential new efforts increase transparency the communication scientific results scientific conferences https://www.nature.com/news/shake-up-conferences-1.22420). Participants concluded further transparency regarding experimental design, conduct, analysis scientific talks poster presentations warranted improve both communication early scientific studies attention scientific rigor. suggestion improving transparency came this meeting to incorporate easy-to-interpret symbols (“emojis”) scientific presentations https://www.nature.com/news/shake-up-conferences-1.22420). Through RFI, NINDS seeks public feedback the potential development such emojis use the scientific community. Information Requested NINDS invites public feedback regarding use emoji icons represent various aspects experimental design, data analysis, rigorous scientific practices. Comments should relate one more the following topics: 1) potential utility emojis a simple, time-saving means convey information study design during oral poster presentations. Please provide comments the likely adoption or concerns regarding use emojis. Examples include, are limited to, thoughts potential burden, standardization, field-specific issues surrounding use emojis. 2) list experimental design elements would benefit having such emoji. Examples include, are limited to, emojis indicate blinding, randomization, exploratory vs. confirmatory experiments described this Comment: https://www.nature.com/news/shake-up-conferences-1.22420). welcome widely applicable and/or field-specific emoji suggestions. 3) Ideas the visual design suggested emojis. Examples include, are limited to, proposal a playing die indicate randomization, covered eye indicate blinding experimental groups, a check-mark indicate confirmatory rather exploratory study described this Comment: https://www.nature.com/news/shake-up-conferences-1.22420). Comments pertaining general formatting considerations e.g. color schemes potential integration the Unicode standard) emojis also welcome. to Submit Response Responses be considered NINDS submitted later December 15, 2017. After public comment period closed, comments received be considered a timely manner. may respond this RFI submitting email NINDS-emojis@nih.gov. Please include Notice number NOT-NS-18-014) the subject line your contact information the body the email. Proprietary, classified, confidential, sensitive information should be included your response. Government reserves right use non-proprietary technical information any resultant solicitation(s), summaries, other materials. Respondents not receive individualized feedback concerning responses. RFI for information planning purposes only should be construed a policy, solicitation applications, an obligation the part the Federal Government, National Institutes Health NIH), NINDS provide support any ideas identified response it. Please note NINDS does intend make any awards based responses this RFI to otherwise pay the preparation any information submitted for Government's of such information. Inquiries Please direct inquiries to: Shai Silberberg, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-1917 Email: silberbs@ninds.nih.gov Devon Crawford, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-1917 Email: devon.crawford@nih.gov

Notice Change Eligibility Requirements PAR-17-001 Emerging Global Leader Award K43)" Notice Number: NOT-TW-17-008 Key Dates Release Date:   October 6, 2017 Related Announcements NOT-TW-17-002 Issued Fogarty International Center FIC) National Cancer Institute NCI) National Human Genome Research Institute NHGRI) National Institute Dental Craniofacial Research NIDCR) National Institute Environmental Health Sciences NIEHS) National Institute Mental Health NIMH) National Institute Neurological Disorders Stroke NINDS) Office Research Women's Health ORWH) Purpose purpose this Notice to inform applicants a change the Eligibility Information PAR-17-001 Emerging Global Leader Award K43)". Notice removes specific eligibility language regarding applicants Medical Education Partnership Initiative MEPI) Institutions. Part 2. Section III. Eligibility Information 1. Eligible Applicants Eligible Individuals Program Director/Principal Investigator) Currently reads Degree Research Experience Requirements: candidate should the PD/PI the proposed activities.  Candidates must hold least masters degree required research thesis. Candidates doctoral research training preferred. award cannot support advanced degree training. Individuals are have the PD/PI direct recipient/grantee) a multi-year independent research grant an external research funding organization awarded the application due date not eligible.> Faculty Position Requirement:  Applicants must currently hold academic junior faculty position research scientist appointment supported the applicant LMIC academic research institution have in position at least year the time application submitted.   this FOA, junior faculty defined those hold entry mid-level academic research scientist positions, including not limited instructors, lecturers assistant professors. Applicants Medical Education Partnership Initiative MEPI): Junior faculty institutions awarded under RFA-TW-14-003 "Research Training Career Development Junior Faculty Medical Education Partnership Initiative MEPI) Institutions D43)" may submit applications focused HIV/AIDS the scientific research areas supported this FOA.   Modified remove italicized language above: Degree Research Experience Requirements: candidate should the PD/PI the proposed activities.  Candidates must hold least masters degree required research thesis. Candidates doctoral research training preferred. award cannot support advanced degree training. Individuals are have the PD/PI direct recipient/grantee) a multi-year independent research grant an external research funding organization awarded the application due date not eligible. Faculty Position Requirement:  Applicants must currently hold academic junior faculty position research scientist appointment supported the applicant LMIC academic research institution have in position at least year the time application submitted.   this FOA, junior faculty defined those hold entry mid-level academic research scientist positions, including not limited instructors, lecturers assistant professors. other aspects this FOA remain unchanged. Inquiries Please direct inquiries to: Christine Jessup, Ph.D. Fogarty International Center FIC) Telephone: 301-496-1653 Email: Christine.Jessup@nih.gov

Notice Change Foreign Component Eligibility RFA-NS-18-001 Centers Without Walls Collaborative Research the Epilepsies: Functional Evaluation Human Genetic Variants U54)" Notice Number: NOT-NS-18-013 Key Dates Release Date: September 26, 2017 Related Announcements RFA-NS-18-001 Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this Notice to change Foreign Component Eligibility RFA-NS-18-001 quot;Centers Without Walls Collaborative Research the Epilepsies: Functional Evaluation Human Genetic Variants U54)" allow Foreign components, defined the NIH Grants Policy Statement.  Section III.1 Eligible Applicants, Eligible Organizations, Foreign Institutions subsection been updated reflect change: Currently: Foreign Institutions Non-domestic non-U.S.) Entities Foreign Institutions) not eligible apply. Non-domestic non-U.S.) components U.S. Organizations not eligible apply. Foreign components, as defined the NIH Grants Policy Statement, not allowed. Modified read: Foreign Institutions Non-domestic non-U.S.) Entities Foreign Institutions) are not eligible apply. Non-domestic non-U.S.) components U.S. Organizations are not eligible apply. Foreign components, as defined the NIH Grants Policy Statement, are allowed. other aspects this Funding Opportunity Announcement remain same. Inquiries Please direct inquiries to: Randall R. Stewart, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-1917 Email: Randall.Stewart@nih.gov

Notice Change Application Due Dates RFA-NS-18-001 Center Without Walls Collaborative Research the Epilepsies: Functional Evaluation Human Genetic Variants U54)" Notice Number: NOT-NS-18-010 Key Dates Release Date:   September 22, 2017 Related Announcements RFA-NS-18-001 Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this Notice to change Key Dates RFA-NS-18-001 Center Without Walls Collaborative Research the Epilepsies: Function Evaluation Human Genetic Variants U54)". Part 1. Overview Information Key Dates Currently Reads: Open Date October 15, 2017 Application Due Date(s) November 15, 2017, 5:00 PM local time applicant organization. types non-AIDS applications allowed this funding opportunity announcement due this date. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. Scientific Merit Review March 10, 2018 Advisory Council Review 2018 Earliest Start Date July 1, 2018 Expiration Date November 16, 2017 Modified read: Open Date December 16, 2017 Application Due Date(s) January 16, 2018, 5:00 PM local time applicant organization. types non-AIDS applications allowed this funding opportunity announcement due this date. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. Scientific Merit Review June 2018 Advisory Council Review August 2018 Earliest Start Date September 2018 Expiration Date January 17, 2018   other aspects this FOA remain same. Inquiries Please direct inquiries to: Randall R Stewart, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-1917 Email: stewartr@ninds.nih.gov

Notice Intent Publish Funding Opportunity Announcement Countermeasures Against Chemical Threats CounterACT) Research Centers Excellence U54) Notice Number: NOT-NS-18-009 Key Dates Release Date: September 19, 2017 Estimated Publication Date Announcement: December 2017  First Estimated Application Due Date: September 2018 Earliest Estimated Award Date: July 2019  Earliest Estimated Start Date: July 2019  Related Announcements None Issued National Institute Neurological Disorders Stroke NINDS) Purpose National Institute Neurological Disorders Stroke NINDS), intends re-issue Program Announcement Special Review Considerations PAR) solicit applications quot;Countermeasures Against Chemical Threats CounterACT) Research Centers Excellence U54)". goal this initiative to provide support translational research develop therapeutics reducing mortality morbidity caused acute exposures chemical threat agents. Chemical threats toxic chemicals could used a terrorist attack accidentally released industrial production, storage shipping.  scope the research includes target candidate identification characterization, through candidate optimization demonstration in vivo efficacy consistent the product's intended in humans. applicants submitting U54 renewal applications, research under FOA should culminate an optimized lead compound ready advanced development.  www.ninds.nih.gov/counteract a description the NIH CounterACT research program. Notice being provided allow potential applicants sufficient time develop meaningful collaborations responsive projects.  general description the planned FOA provided below. sure follow guidance specific instructions the final published FOA once is released.  Research Initiative Details planned FOA encourage collaborative multidisciplinary investigations, combining expertise toxicology drug discovery development, discover develop new improved therapeutics treating victims acute chemical exposures. NIH CounterACT research program utilize Specialized Center Cooperative Agreements U54) support Research Centers Excellence up 5 years.  Center include several individual research projects scientific administrative cores create interdisciplinary multifaceted research approach. should a unifying well-defined goal problem area research which project relates contributes, thereby producing synergistic research environment allows research effort share resources creative strengths the others. is expectation support inter-related projects collaborating investigators yield results beyond those achievable each project pursued separately without formal interaction among participating investigators. civilian chemical threat spectrum includes chemical warfare agents e.g., sarin), toxic industrial chemicals e.g., cyanide), pesticides e.g., parathion), other chemicals.  agents included the current Department Homeland Security DHS) Chemical Terrorism Risk Assessment CTRA) list, is USG official only will be included the planned FOA.  Therefore, applicants strongly urged contact Scientific/Research staff listed this Notice determine their proposed threat agent(s) of interest the NIH.    Research Center must establish milestones include discrete quantitative goals create or no-go decision points the project. APPLICATIONS NOT BEING SOLICITED THIS TIME. Inquiries Please direct inquiries to: David A. Jett, Ph.D. National Institute Neurological Disorders Stroke, NINDS Telephone: 301-496-6035 Email: jettd@ninds.nih.gov