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This Request for Information (RFI) seeks input on challenges and opportunities for interdisciplinary research that brings together neuroscientists, environmental health scientists, and scientists from other related disciplines to form new teams to advance understanding of the contribution of environmental toxicants to impaired function of the nervous system across the life span. For the purpose of this RFI, environmental toxicants of primary interest include industrial chemicals or manufacturing byproducts, metals, pesticides, herbicides, air pollutants and other inhaled toxicants, particulates or fibers, plastics, fungal exposures, and bacterial or biologically derived toxins. Expression of toxicity can take many forms across different ages and developmental stages, ranging from neurodevelopmental to neurodegenerative disorders, and encompassing alterations in cognition and behavior that range from subtle to severe. The full range of nervous system outcomes is relevant to this RFI.