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The purpose of this Notice of Funding Opportunity is to solicit applications for clinical sites that will provide expert diagnostic services for undiagnosed diseases across the nation. The clinical sites known as Diagnostic Centers of Excellence (DCoEs) will partner with the Undiagnosed Diseases Network (UDN) to sustain some of the key research activities currently performed by the Phase II UDN Clinical sites (see:RFA-RM-17-019) and facilitate its transition to a larger network that serves diverse undiagnosed patient populations. The DCoEs will establish collaborations and efficient processes with the Data Management and Coordinating Center (DMCC; see: RFA-NS-22-051); enroll and evaluate new participants; and foster scientific discovery. This NOFO requires a Plan for Enhancing Diverse Perspectives (PEDP), which will be assessed as part of the scientific and technical peer review evaluation. Applications that fail to include a PEDP will be considered incomplete and will be withdrawn. Applicants are strongly encouraged to read the FOA instructions carefully and view the available PEDP guidance material.

HIV associated CNS complications are a significant problem for people living with HIV despite suppressive anti-retroviral therapy. HIV enters the CNS as early as 8 days after infection and can cause several complications including cognitive, neurological and mental health related issues. Although experts have gathered much data on underlying HIV-induced CNS pathophysiology, specific targeted causality remains elusive, and no effective therapies exist to slow, stop, or reverse these adverse outcomes. This initiative is to comprehend the actionable biotypes of CNS complications in people living with HIV based on underlying mechanisms to help capture the heterogeneity of outcomes. Identifying biotypes can inform the development of precision treatment strategies for CNS complications seen in people living with HIV.

As part of the NIH's Helping to End Addiction Long-term (HEAL) Initiative, the Eunice Kennedy Shriver National Institute of Child Health and Human Development and participating NIH Institutes and Centers invite applications to this U01 Cooperative Agreement funding opportunity to support innovative, multi-site, large-scale investigator-initiated clinical trials to advance the understanding, assessment, measurement, treatment, and prevention of acute pain in infants, children, and adolescents, including those with disabilities and/or experiencing health disparities. Clinical trials testing behavioral interventions to manage pain as the primary outcome(s) will not be considered as high priority projects. This Notice of Funding Opportunity (NOFO) runs in parallel with a companion NOFO (RFA-HD-24-012) that invites applications for a single HEAL KIDS Pain Resource and Data Center (RDC) to provide the following: leadership in data management, data curation, data harmonization, and the development of data standards; administrative and logistical support including oversight of NIH HEAL-related requirements; and coordination of shared research-related resources for all of the HEAL KIDS Pain research activities.

As part of the NIH's Helping to End Addiction Long-term (HEAL) Initiative, the Eunice Kennedy Shriver National Institute of Child Health and Human Development and participating NIH Institutes and Centers invite applications for a single HEAL KIDS Pain Resource and Data Center (RDC) to provide the following: leadership in data collection and management, data curation, data harmonization, and the development of data standards; administrative and logistical support including oversight of NIH HEAL-related requirements; and coordination of shared research-related resources all for the HEAL KIDS Pain research activities. This Notice of Funding Opportunity (NOFO) runs in parallel with a companion NOFO (RFA-HD-24-011) that invites applications to support innovative, multi-site, large-scale clinical trials to advance the understanding, assessment, measurement, treatment, and prevention of acute pain in infants, children, and adolescents, including those with disabilities and/or experiencing health disparities.

The purpose of the Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral Fellowship (Parent F31) award is to enable promising predoctoral students to obtain individualized, mentored research training from outstanding faculty sponsors while conducting dissertation research in scientific health-related fields relevant to the missions of the participating NIH Institutes and Centers. The proposed mentored research training must reflect the candidates dissertation research project and is expected to clearly enhance the individuals potential to develop into a productive, independent research scientist. This Notice of Funding Opportunity (NOFO) is designed specifically for candidates proposing research that does not involve leading an independent clinical trial, a clinical trial feasibility study, or an ancillary clinical trial, but does allow candidates to propose research experience in a clinical trial led by a sponsor or co-sponsor.

The goal of this NOSI is to accelerate the scientific impact of the BRAIN Initiative through rapid dissemination of promising technologies and resources to the neuroscience research community. This NOSI will support small dissemination efforts for which a clear value to the identified user group is demonstrated in the application. The proposed work must be within the scope of the original project of the eligible parent award but beyond the original dissemination plans included in the parent application.

The purpose of the Clinical Trial Methods in Clinical Neurological Disorders Course" Notice of Funding Opportunity Announcement (NOFO) is to increase the reliability and effectiveness of clinical trials and to enhance the training of investigators new to clinical trials.

TBD

This NOFO solicits applications for planning grants to assess feasibility and/or determine best practices to conduct community-engaged health equity research in neurological disorders with populations that experience health disparities (HDPs). If successful, these planning grants would support, enable and/or lay the groundwork for future clinical studies or trials.In addition to posing a research question related to addressing health disparities in neurological disorders, applicants must also be filling a gap in 1) Engagement with one or more HDP communities; and/or 2) Multidisciplinary research team expertise in neurological disorders, health disparities research and/or community-engaged research.Expected outcomes would advance understanding of drivers of health disparities and barriers to neurological health equity and establish collaborative research teams, including community partners, with appropriate expertise in community engagement with HDPs, health disparities research and neurological disorders.

TBD