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Purpose. The NIH Blueprint for Neuroscience Research is a framework to enhance cooperative activities among the NIH Office of the Director and 15 NIH Institutes and Centers that support research on the nervous system. By pooling resources and expertise, the Blueprint takes advantage of economies of scale, confronts challenges too large for any single Institute or Center, and develops research tools and infrastructure that serve the entire neuroscience community. In FY 2007, the Blueprint is focusing on neurodegeneration. Mechanism of Support. This funding opportunity will utilize the Exploratory/Developmental (R21) to solicit grant applications from applicant organizations that propose to develop biomarkers of neurodegenerative disease. Funds Available and Anticipated Number of Awards. The participating organizations intend to commit a total of $2,750,000 to this RFA for payment of applications responsive to this announcement. The anticipated number of awards is 12-14. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications. 

Purpose: The goal of the NIH-funded Knockout Mouse Project (KOMP) is to generate a comprehensive resource of null mutant alleles, with a reporter, using gene targeting mutagenesis in mouse strain C57BL/6. The construction of the KOMP mutant collection is being funded in projects submitted in response to RFA-HG-05-007 and RFA-DA-06-009. The purpose of this Funding Opportunity Announcement (FOA) is to establish a resource repository to collect and archive the null mutant alleles, primarily in the form of cryo-preserved embryonic stem (ES) cells, as well as associated DNA constructs, and cryo-preserved embryos or live mice created by the KOMP. The successful KOMP repository should aim to become self supporting over time. The KOMP Repository will distribute ES cells, embryos and/or live mice to eligible scientists, and provide reanimation services to establish and distribute live mice from archived ES cell lines or other cryo-preserved materials. The Repository will provide data on new KOMP-generated resources to the Data Coordination Center that was funded on the basis of an application submitted to RFA-HG-05-008. The Repository will also provide a public website, maintain an internal tracking database, operate a customer service and technical assistance center, interact with the other KOMP grantees, and coordinate with other national and international mouse resources. Applicants for this FOA must have a proven track record of establishing and managing a cryopreserved archive of murine ES cells, embryos, and DNA constructs, a colony of live mice, and successful distribution of these materials to qualified investigators. Documentation of this track record must be provided Mechanism of Support: This Funding Opportunity Announcement (FOA) will utilize the U42 cooperative agreement (Animal Models, and Animal and Biological Material Resource Cooperative Agreement) grant mechanism

-The purpose of this Funding Opportunity Announcement (FOA), Mechanisms, Models, Measurement, & Management in Pain Research, issued by the National Institute of Nursing Research (NINR) is to inform the scientific community of the pain research interests of the various Institutes and Centers (ICs) at the National Institutes of Health (NIH) and to stimulate and foster a wide range of basic, clinical, and translational studies on pain as they relate to the missions of these ICs. -New advances are needed in every area of pain research, from the micro perspective of molecular sciences to the macro perspective of behavioral and social sciences.Although great strides have been made in some areas, such as the identification of neural pathways of pain, the experience of pain and the challenge of treatment have remained uniquely individual and unsolved.Research to address these issues conducted by interdisciplinary and multidisciplinary research teams is strongly encouraged, as is research from underrepresented, minority, disabled, or women investigators. -This FOA will use the NIH Exploratory/Developmental (R21) grant mechanism and runs in parallel with FOAs of identical scientific scope, PA-06-544, that utilizes the R01 mechanism and PA-06-543, that utilizes the R03 mechanism.

-The purpose of this Funding Opportunity Announcement (FOA), Mechanisms, Models, Measurement, & Management in Pain Research, issued by the National Institute of Nursing Research (NINR) is to inform the scientific community of the pain research interests of the various Institutes and Centers (ICs) at the National Institutes of Health (NIH) and to stimulate and foster a wide range of basic, clinical, and translational studies on pain as they relate to the missions of these ICs. -New advances are needed in every area of pain research, from the micro perspective of molecular sciences to the macro perspective of behavioral and social sciences.Although great strides have been made in some areas, such as the identification of neural pathways of pain, the experience of pain and the challenge of treatment have remained uniquely individual and unsolved.Research to address these issues conducted by interdisciplinary and multidisciplinary research teams is strongly encouraged, as is research from underrepresented, minority, disabled, or women investigators. -This FOA will use the NIH Small Research Grant (R03) award mechanism and runs in parallel with FOAs of identical scientific scope, PA-06-544, that solicits applications under the R01 mechanism and PA-06-542, that solicits applications under the R21 mechanism.

-The purpose of this Funding Opportunity Announcement (FOA), “Mechanisms, Models, Measurement, & Management in Pain Research,” issued by the National Institute of Nursing Research (NINR) is to inform the scientific community of the pain research interests of the various Institutes and Centers (ICs) at the National Institutes of Health (NIH) and to stimulate and foster a wide range of basic, clinical, and translational studies on pain as they relate to the missions of these ICs.  -New advances are needed in every area of pain research, from the micro perspective of molecular sciences to the macro perspective of behavioral and social sciences. Although great strides have been made in some areas, such as the identification of neural pathways of pain, the experience of pain and the challenge of treatment have remained uniquely individual and unsolved. Research to address these issues conducted by interdisciplinary and multidisciplinary research teams is strongly encouraged, as is research from underrepresented, minority, disabled, or women investigators. -This FOA will utilize the R01 grant mechanism and runs in parallel with FOAs of identical scientific scope, PA-06-542, that solicits applications under the R21 mechanism, and PA-06-543, that solicits applications under the R03 mechanism.

This funding opportunity announcement (FOA) solicits Small Business Technology Transfer (STTR) grant applications from small business concerns (SBCs) that propose innovative research in biomedical computational science and technology to promote the progress of biomedical research. There exists an expanding need to speed the progress of biomedical research through the power of computing to manage and analyze data and to model biological processes. The NIH is interested in promoting research and developments in biomedical computational science and technology that will support rapid progress in areas of scientific opportunity in biomedical research. As defined here biomedical computing or biomedical information science and technology includes, database design, graphical interfaces, querying approaches, data retrieval, data visualization and manipulation, data integration through the development of integrated analytical tools, and tools for electronic collaboration, as well as computational research including the development of structural, functional, integrative, and analytical models and simulations.

This funding opportunity announcement (FOA) solicits Small Business Innovation Research (SBIR) grant applications from small business concerns (SBCs) that propose innovative research in biomedical computational science and technology to promote the progress of biomedical research. There exists an expanding need to speed the progress of biomedical research through the power of computing to manage and analyze data and to model biological processes. The NIH is interested in promoting research and developments in biomedical computational science and technology that will support rapid progress in areas of scientific opportunity in biomedical research. As defined here biomedical computing or biomedical information science and technology includes, database design, graphical interfaces, querying approaches, data retrieval, data visualization and manipulation, data integration through the development of integrated analytical tools, and tools for electronic collaboration, as well as computational research including the development of structural, functional, integrative, and analytical models and simulations.

-The National Institute of Mental Health (NIMH), National Institute on Aging (NIA), National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institute on Drug Abuse (NIDA), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institute on Neurological Disorders and Stroke (NINDS), and National Cancer Institute (NCI) request research grant applications to study neuroimmune molecules and mechanisms involved in regulating normal and pathological central nervous system (CNS) function. -This FOA will use the Exploratory/Development (R21) grant mechanism and runs in parallel with a FOA of identical scientific scope, PA-05-054, that solicits applications under the NIH Research Project (R01). -Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications.

The National Institute of Mental Health (NIMH) and its Center for Mental Health Research on AIDS as well as the National Institute on Drug Abuse (NIDA) and the National Institute of Neurological Disorders and Stroke (NINDS) invite applications proposing novel models of HIV-related central or peripheral nervous system damage that can be used to screen for compounds showing promise as treatments in the patient population.

The National Institute of Mental Health (NIMH) and its Center for Mental Health Research on AIDS as well as the National Institute on Drug Abuse (NIDA) and the National Institute of Neurological Disorders and Stroke (MINDS) invite applications proposing novel models of HIV-related central or peripheral nervous system damage that can be used to screen for compounds showing promise as treatments in the patient population.