The National Institute of Neurological Disorders and Stroke, part of the National Institutes of Health, is looking for individuals to participate in clinical studies. Participating in clinical trials allows you to play an active role in research on the nature and causes of many disorders of the brain and nervous system, and to possibly help physician-scientists develop future treatments. The information below is designed to help you quickly learn about actively recruiting research studies for which you or someone you know may be eligible.

Description:

NABIS:HIIR was a randomized clinical trial conducted in patients with severe brain injury, age 16-45. Patients were randomized to standard treatment at normothermia or to standard treatment with moderate hypothermia (32.5-34C for 48 hours). An intent to treat analysis was used with the primary outcome measure as the Glasgow Outcome Scale at six months after injury. GOS is dichotomized into good outcome (Good Recovery/Moderate Disability) and poor outcome (Severe Disability, Vegetative, Dead).

Eligibility Criteria:

Inclusion Criteria: 1. Non-penetrating brain injury with post-resuscitation Glasgow Coma Score (GCS) 16 and 9 post- randomization 2. GCS = 3 AND bilaterally non-reactive pupils 3. Abbreviated Injury Score (AIS) > 4 for any body area except head 4. Positive abdominal ultrasound or CT scan 5. Persistent hypotension (systolic blood pressure

Study Design:

Study Location:

Multiple U.S. Locations