Clinical Proteomic Research for the Brain

Case Inclusion and Exclusion Criteria: Inclusion Criteria: 1. Ischemic brain injury within 12 hours of symptom onset; 2. Including primary ischemic brain injury from embolism or arterial occlusion or secondary due to increased ICP after trauma, subarachnoid hemorrhage. Exclusion Criteria: 1. Patients who are hemodynamically unstable for venipunctures; 2. Anemic patients (hemoglobin < 11); 3. Children; 4. Pregnant women. Controls Inclusion and Exclusion Criteria: Inclusion Criteria: 1. Healthy adults without any neurologic or systemic disease; 2. Inpatient or outpatient adults with a chronic stroke (greater than 3 months) or chronic neurologic disease such as neurodegenerative disease, movement disorder, demyelinating disease; 3. Inpatient or outpatient adults with systemic vascular disease. Exclusion Criteria: 1. Patients who are hemodynamically unstable for venipunctures; 2. Anemic patients (hemoglobin < 11); 3. Children; 4. Pregnant women.