Ohtahara Syndrome Information Page

Ohtahara Syndrome Information Page


What research is being done?

The NINDS conducts and supports an extensive research program on seizures and seizure-related disorders.  Much of this research is aimed at increasing scientific understanding of these disorders and finding ways to prevent, treat, and potentially cure them.

Information from the National Library of Medicine’s MedlinePlus
Seizures

×
What research is being done?

The NINDS conducts and supports an extensive research program on seizures and seizure-related disorders.  Much of this research is aimed at increasing scientific understanding of these disorders and finding ways to prevent, treat, and potentially cure them.

Information from the National Library of Medicine’s MedlinePlus
Seizures

The NINDS conducts and supports an extensive research program on seizures and seizure-related disorders.  Much of this research is aimed at increasing scientific understanding of these disorders and finding ways to prevent, treat, and potentially cure them.

Information from the National Library of Medicine’s MedlinePlus
Seizures

Search Disorders

Definition
Definition
Treatment
Treatment
Prognosis
Prognosis
Clinical Trials
Clinical Trials
Organizations
Organizations
Publications
Publications
Definition
Definition

Ohtahara syndrome is a neurological disorder characterized by seizures.  The disorder affects newborns, usually within the first three months of life (most often within the first 10 days) in the form of epileptic seizures.  Infants have primarily tonic seizures, but may also experience partial seizures, and rarely, myoclonic seizures.  Ohtahara syndrome is most commonly caused by metabolic disorders or structural damage in the brain, although the cause or causes for many cases can’t be determined.  Most infants with the disorder show significant underdevelopment of part or all of the cerebral hemispheres.  The EEGs of infants with Ohtahara syndrome reveal a characteristic pattern of high voltage spike wave discharge followed by little activity.  This pattern is known as “burst suppression.” Doctors have observed that boys are more often affected than girls.

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Definition

Ohtahara syndrome is a neurological disorder characterized by seizures.  The disorder affects newborns, usually within the first three months of life (most often within the first 10 days) in the form of epileptic seizures.  Infants have primarily tonic seizures, but may also experience partial seizures, and rarely, myoclonic seizures.  Ohtahara syndrome is most commonly caused by metabolic disorders or structural damage in the brain, although the cause or causes for many cases can’t be determined.  Most infants with the disorder show significant underdevelopment of part or all of the cerebral hemispheres.  The EEGs of infants with Ohtahara syndrome reveal a characteristic pattern of high voltage spike wave discharge followed by little activity.  This pattern is known as “burst suppression.” Doctors have observed that boys are more often affected than girls.

Treatment
Treatment

Antiepileptic drugs are used to control seizures, but are unfortunately not usually very effective for this disorder.  Corticosteroids are occasionally helpful.  In cases where there is a focal brain lesion (damage contained to one area of the brain) surgery may be beneficial.  Other therapies are symptomatic and supportive. 

×
Treatment

Antiepileptic drugs are used to control seizures, but are unfortunately not usually very effective for this disorder.  Corticosteroids are occasionally helpful.  In cases where there is a focal brain lesion (damage contained to one area of the brain) surgery may be beneficial.  Other therapies are symptomatic and supportive. 

Definition
Definition

Ohtahara syndrome is a neurological disorder characterized by seizures.  The disorder affects newborns, usually within the first three months of life (most often within the first 10 days) in the form of epileptic seizures.  Infants have primarily tonic seizures, but may also experience partial seizures, and rarely, myoclonic seizures.  Ohtahara syndrome is most commonly caused by metabolic disorders or structural damage in the brain, although the cause or causes for many cases can’t be determined.  Most infants with the disorder show significant underdevelopment of part or all of the cerebral hemispheres.  The EEGs of infants with Ohtahara syndrome reveal a characteristic pattern of high voltage spike wave discharge followed by little activity.  This pattern is known as “burst suppression.” Doctors have observed that boys are more often affected than girls.

Treatment
Treatment

Antiepileptic drugs are used to control seizures, but are unfortunately not usually very effective for this disorder.  Corticosteroids are occasionally helpful.  In cases where there is a focal brain lesion (damage contained to one area of the brain) surgery may be beneficial.  Other therapies are symptomatic and supportive. 

Prognosis
Prognosis

The course of Ohtahara syndrome is severely progressive.  Seizures become more frequent, accompanied by delays in physical and cognitive development.  Some children will die in infancy; others will survive but be profoundly handicapped.  As they grow, some children will progress into other epileptic disorders such as West syndrome and Lennox-Gestaut syndrome. 

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The course of Ohtahara syndrome is severely progressive.  Seizures become more frequent, accompanied by delays in physical and cognitive development.  Some children will die in infancy; others will survive but be profoundly handicapped.  As they grow, some children will progress into other epileptic disorders such as West syndrome and Lennox-Gestaut syndrome. 

Prognosis
Prognosis

The course of Ohtahara syndrome is severely progressive.  Seizures become more frequent, accompanied by delays in physical and cognitive development.  Some children will die in infancy; others will survive but be profoundly handicapped.  As they grow, some children will progress into other epileptic disorders such as West syndrome and Lennox-Gestaut syndrome. 

Definition

Ohtahara syndrome is a neurological disorder characterized by seizures.  The disorder affects newborns, usually within the first three months of life (most often within the first 10 days) in the form of epileptic seizures.  Infants have primarily tonic seizures, but may also experience partial seizures, and rarely, myoclonic seizures.  Ohtahara syndrome is most commonly caused by metabolic disorders or structural damage in the brain, although the cause or causes for many cases can’t be determined.  Most infants with the disorder show significant underdevelopment of part or all of the cerebral hemispheres.  The EEGs of infants with Ohtahara syndrome reveal a characteristic pattern of high voltage spike wave discharge followed by little activity.  This pattern is known as “burst suppression.” Doctors have observed that boys are more often affected than girls.

Treatment

Antiepileptic drugs are used to control seizures, but are unfortunately not usually very effective for this disorder.  Corticosteroids are occasionally helpful.  In cases where there is a focal brain lesion (damage contained to one area of the brain) surgery may be beneficial.  Other therapies are symptomatic and supportive. 

Prognosis

The course of Ohtahara syndrome is severely progressive.  Seizures become more frequent, accompanied by delays in physical and cognitive development.  Some children will die in infancy; others will survive but be profoundly handicapped.  As they grow, some children will progress into other epileptic disorders such as West syndrome and Lennox-Gestaut syndrome. 

What research is being done?

The NINDS conducts and supports an extensive research program on seizures and seizure-related disorders.  Much of this research is aimed at increasing scientific understanding of these disorders and finding ways to prevent, treat, and potentially cure them.

Information from the National Library of Medicine’s MedlinePlus
Seizures

Patient Organizations
Epilepsy Foundation
8301 Professional Place East, Suite 200
Landover
MD
Landover, MD 20785-7223
Tel: 301-459-3700; 800-EFA-1000 (332-1000)
Patient Organizations