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… encode two distinct proteins: a calcium channel protein and a novel transcription factor. For this project, he will … how mutations might lead their cooperation to break down, and how this coordination can be rescued. By understanding the role and function of these calcium channel genes, Dr. Gomez will …
… common form of muscular dystrophy that begins in adulthood and is characterized by progressive muscle wasting and weakness. For this project, he focuses on myotonic … Expanding the understanding of these reagents will inform and guide their use in therapeutic trials and in clinical …
… nerve fibers that facilitates rapid signal conduction and provides essential support for neuronal growth and survival. Diseases associated with myelin damage or loss, … neuronal survival, how demyelination affects neurons and synapses, and how demyelination occurs. …
… DiAntonio combines genetics, cell biology, biochemistry, and physiology in both Drosophila and mice to investigate molecular mechanisms that control the formation, maintenance, and repair of neural circuits in development and disease. For …
… response of neurons in the peripheral nervous system and to relate this information to the lack of regenerative capacity in the … For this project, she will combine single-cell approaches and epigenomic approaches in mouse and human sensory neurons …
… CA Homeostatic stabilization of neural function in health and disease Changes in neural circuits that allow us to learn and adapt are known as neuronal plasticity. While essential …
… the molecular mechanisms that are responsible for assembly and maintenance of electrogenic compartments of axons in normal health, and during disease or injury. His mentoring approach …
… Management Specialist Image Office of Research Operations and Analysis Division of Extramural Activities Grants … years as a Grants Management Specialist/Officer at NIDDK and NIAMS. Prior to becoming a Grants Management Specialist in October 2006, Mark was an Information Technology Specialist at NIAMS. Mark began his …
… Glutamate transporters move glutamate back into neurons and glial cells after its release, ensuring precise signaling between neurons and limiting toxic overactivation, or excitotoxicity. … work will shed light on their roles in disease and may inform new avenues in drug development. …
… in the mechanisms by which cells acquire glial fate and function and maintain their functionality throughout life, because … For this project, he will utilize an in vitro mouse and human stem cell platform to define mechanisms responsible …